Month: December 2022

Dissette, Valeria published the artcileEvaluation of the transepidermal penetration of a carnosine complex in gel formulation by 3D skin models, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Cosmetics (2018), 5(4), 67, database is CAplus.

Carnosine has several physiol. roles, from intracellular pH buffering to antioxidant activities, which all depend on bioavailability. This study was conducted in a human skin 3D model and focuses on the effects of the topical delivery of carnosine, from a dermo-cosmetic gel, through the stratum corneum in the presence of a magnesium ion as a complexing agent. To evaluate possible enhancement for small peptide delivery to the skin from simple cosmetic formulations, we discovered that complexation was able to improve the delivery of carnosine into human skin 3D models by application in gel formulation. The concentrations of carnosine released in the underlying media and those that remained in the reconstructed human epidermis (RHE) tissues after 24 and 48 h exposure were measured. Moreover, the influence of magnesium ions was also evaluated comparing the same formulation with and without the salt. The results obtained in this study support hypothesis that magnesium can influence the delivery of small peptides and that the gel formulation based on the carnosine-magnesium complex allows for superior delivery of carnosine in the lower skin layer at a concentration up to 60% more than carnosine alone.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wiechers, S. published the artcileTitanium dioxide particle size vs. sun protection performance, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Cosmetics & Toiletries (2013), 128(5), 332, 334, 336, 338-339, database is CAplus.

The article compares the performance of titanium dioxide as a UV filter in cosmetic formulations as a function of its primary particle size. It was found that with increasing primary particle size, even below 100 nm, the effectiveness of the inorganic (mineral) UV filter was clearly reduced.

Cosmetics & Toiletries published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C4H6BrFO2, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naykodi, Pradnya S. published the artcileTaste masking of bitter drugs by using ion exchange resin method, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is World Journal of Pharmaceutical Research (2020), 9(2), 562-597, database is CAplus.

The various organoleptic properties such as taste, smell, texture also these are important factor in development of oral dosage forms. The taste is the major factor that affect the patient compliance and product quality. Acceptability of any dosage form mainly depends over its taste i.e. mouth feel. Drug mol. interact with taste receptor on the tongue to give bitter, sweet or other taste sensation, when they dissolve in saliva. The taste buds shows the sensation of taste by signal transduction from the receptor organs. Now a days most of the potent drugs that are cardiac, analgesic, anti-inflammatory, anti-tubercular, antibacterial, anthalmetics, antimalarial, antiepileptics, anticoagulants, histamine receptor agonist, antithyroids, antineoplastic, antiprotozoal, diuretics, nutritional agents, opioid analgesic, sex hormones, vaccines most of them are bitter in taste. So it become a necessary to develop such a dosage form that is acceptable for its taste by patients especially children or geriatrics. It becomes a challenge for pharmacist to make palatable formulation by masking the bitter taste of the drug.

World Journal of Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Yuan-Yuan published the artcileSolvent regulation and template-free synthesis of β-cyclodextrin-based microporous organic network nanosheets for ultrafast and efficient removal of aromatic pollutants, Name: 4,4′-Sulfonyldiphenol, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 435(Part_1), 134829, database is CAplus.

Layer-stacking structures via the template-free synthesis are rare in two-dimensional microporous organic networks (2D MONs). Herein, we report a facile solvent regulation and template-free strategy by tuning the aggregation degree of 2D β-cyclodextrin (CD)-based MONs nanosheets. The 2D MON nanosheets provided larger uptake capacity and faster kinetics than the aggregated CD-MONs, revealing the significance of morphol. control for the removal of pollutants. The prepared 2D CD-MON-DMF gave ultrafast adsorption kinetics and exhibited much larger saturation sorption capacity (327.9 mg g^-1) than previous adsorbents for bisphenol AF. The developed strategy not only provides a novel way to construct 2D MON nanosheets for highly efficient removal of organic pollutants from water but also promotes the utilization of MONs in material and environmental sciences.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Qian published the artcileIntegrated proteomic and metabolomic analysis of a reconstructed three-species microbial consortium for one-step fermentation of 2-keto-L-gulonic acid, the precursor of vitamin C, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Industrial Microbiology & Biotechnology (2019), 46(1), 21-31, database is CAplus and MEDLINE.

Microbial consortia, with the merits of strong stability, robustness, and multi-function, played critical roles in human health, bioenergy, and food manufacture, etc. On the basis of ‘build a consortium to understand it’, a novel microbial consortium consisted of Gluconobacter oxydans, Ketogulonicigenium vulgare and Bacillus endophyticus was reconstructed to produce 2-keto-L-gulonic acid (2-KGA), the precursor of vitamin C. With this synthetic consortium, 73.7 g/L 2-KGA was obtained within 30 h, which is comparable to the conventional industrial method. A combined time-series proteomic and metabolomic anal. of the fermentation process was conducted to further investigate the cell-cell interaction. The results suggested that the existence of B. endophyticus and G. oxydans together promoted the growth of K. vulgare by supplying addnl. nutrients, and promoted the 2-KGA production by supplying more substrate. Meanwhile, the growth of B. endophyticus and G. oxydans was compromised from the competition of the nutrients by K. vulgare, enabling the efficient production of 2-KGA. This study provides valuable guidance for further study of synthetic microbial consortia.

Journal of Industrial Microbiology & Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Jian-Dong published the artcileWettability-Driven Palladium Catalysis for Enhanced Dehydrogenative Coupling of Organosilanes, Quality Control of 597-52-4, the publication is ACS Catalysis (2017), 7(3), 1720-1727, database is CAplus.

Direct coupling of Si-H bonds has emerged as a promising strategy for designing chem. and biol. useful organosilicon compounds Heterogeneous catalytic systems sufficiently active, selective, and durable for dehydrosilylation reactions under mild conditions have been lacking to date. Herein, we report that the hydrophobic characteristics of the underlying supports can be advantageously utilized to enhance the efficiency of palladium nanoparticles (Pd NPs) for the dehydrogenative coupling of organosilanes. As a result of this prominent surface wettability control, the modulated catalyst showed a significantly higher level of efficiency and durability characteristics toward the dehydrogenative condensation of organosilanes with water, alcs., or amines in comparison to existing catalysts. In a broader context, this work illustrates a powerful approach to maximize the performance of supported metals through surface wettability modulation under catalytically relevant conditions.

ACS Catalysis published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Quality Control of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Jian-Dong published the artcileWettability-Driven Palladium Catalysis for Enhanced Dehydrogenative Coupling of Organosilanes, Name: Triisopropylsilanol, the publication is ACS Catalysis (2017), 7(3), 1720-1727, database is CAplus.

Direct coupling of Si-H bonds has emerged as a promising strategy for designing chem. and biol. useful organosilicon compounds Heterogeneous catalytic systems sufficiently active, selective, and durable for dehydrosilylation reactions under mild conditions have been lacking to date. Herein, we report that the hydrophobic characteristics of the underlying supports can be advantageously utilized to enhance the efficiency of palladium nanoparticles (Pd NPs) for the dehydrogenative coupling of organosilanes. As a result of this prominent surface wettability control, the modulated catalyst showed a significantly higher level of efficiency and durability characteristics toward the dehydrogenative condensation of organosilanes with water, alcs., or amines in comparison to existing catalysts. In a broader context, this work illustrates a powerful approach to maximize the performance of supported metals through surface wettability modulation under catalytically relevant conditions.

ACS Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Name: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Shuqiang published the artcileWater-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound, Category: alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2021), 113544, database is CAplus and MEDLINE.

10-Hydroxyevodiamine is a multitargeting antitumor lead compound with excellent in vitro activity. However, its in vivo antitumor potency is rather limited, which has hampered its further clin. development. To overcome this obstacle, a series of novel water-soluble derivatives of 10-hydroxyevodiamine were designed and synthesized. Most of them exhibited good to excellent antitumor activities against several cancer cell lines. In particular, phosphate derivative I was orally active and showed improved in vivo antitumor efficacy in HCT116 xenograft models. Further antitumor mechanism studies indicated that compound I acted by triple Top1/Top2/tubulin inhibition and induced apoptosis with G₂/M cell cycle arrest. Taken together, this study extended the structure-activity relationship of evodiamine and identified phosphate derivative I as a promising antitumor lead compound

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Na-Na published the artcileA bifunctional probe based on naphthalene derivative for absorbance-ratiometic detection of Ag⁺ and fluorescence “turn-on” sensing of Zn²⁺ and its practical application in water samples, walnut and living cells, Application of 1-Hydroxy-2-naphthoic acid, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2020), 112299, database is CAplus.

In this work, naphthalene with good biocompatibility was selected, and the probe NBOS was synthesized with 2-Amino-phenol and 2-Amino-benzenethiol. The structure of probe NBOS was confirmed by X-ray Crystallog. Furthermore, the probe showed absorbance-ratiometic sensing for Ag⁺ over a pH range from 6 to 7.5 and fluorescence “turn on” signal response towards Zn²⁺ in the pH range of 6-10 in EtOH/H₂O (9/1, V/V, pH = 7.4) mixture The detection limit was obtained to be 4.24μM for Ag⁺ and 3.17 nM for Zn²⁺. Moreover, it could be efficiently recycled by treating Na₂EDTA. The sensing mechanism of probe NBOS toward Ag⁺ and Zn²⁺ was investigated by FT-IR, HNMR, job’plot and ESI-MS. Typically, the coordination mode of NBOS with Zn²⁺ was confirmed by DFT calculation Moreover, probe NBOS was successfully applied in the detection Ag⁺ and Zn²⁺ in real water samples. Importantly, probe NBOS could be used to detect Zn²⁺ in walnut and living cells. Based on the high throughput anal. strategy, absorbance and fluorescence signals of NBOS could be designed as a NOT and OR logic gate controlled by Ag⁺ (Input 1) and Zn²⁺ (Input 2).

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brahmachari, Goutam published the artcileVisible Light-Driven and Singlet Oxygen-Mediated Photochemical Cross-Dehydrogenative C₃-H Sulfenylation of 4-Hydroxycoumarins with Thiols Using Rose Bengal as a Photosensitizer, Synthetic Route of 4410-99-5, the publication is Journal of Organic Chemistry (2021), 86(14), 9658-9669, database is CAplus and MEDLINE.

A visible light (white light-emitting diode/direct sunlight)-driven photochem. synthesis of a new series of biol. interesting 3-(alkyl/benzylthio)-4-hydroxy-2H-chromen-2-ones has been achieved through a cross-dehydrogenative C₃-H sulfenylation of 4-hydroxycoumarins with thiols at ambient temperature in the presence of rose bengal in acetonitrile under an oxygen atm. The notable features of this newly developed method are mild reaction conditions, energy efficiency, metal-free synthesis, good to excellent yields, use of low-cost materials, and eco-friendliness.

Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Synthetic Route of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts