Month: December 2022

Zaksauskas, Audrius published the artcileMethyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX, Quality Control of 4410-99-5, the publication is International Journal of Molecular Sciences (2022), 23(1), 130, database is CAplus and MEDLINE.

Among the twelve catalytically active carbonic anhydrase isoenzymes present in the human body, the CAIX is highly overexpressed in various solid tumors. Many attempts have been made to design chem. compounds that would exhibit high affinity and selective binding to CAIX over the remaining eleven catalytically active CA isoenzymes to limit undesired side effects. Herein, a series of compounds, Me 5-sulfamoyl-benzoates, which bear a primary sulfonamide group, a well-known marker of CA inhibitors is designed and their affinities for all twelve CA isoenzymes has been determined. Variations of substituents on the benzenesulfonamide ring led to compound Me 2-bromo-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate, which exhibited an extremely high observed binding affinity to CAIX; the K_d was 0.12 nM. The intrinsic dissociation constant, where the binding-linked protonation reactions have been subtracted, reached 0.08 pM. The compound also exhibited more than 100-fold selectivity over the remaining CA isoenzymes. The X-ray crystallog. structure of compound Me 2-chloro-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate bound to CAIX showed the structural position, while several structures of compounds bound to other CA isoenzymes showed structural reasons for compound selectivity towards CAIX. Since this series of compounds possess physicochem. properties suitable for drugs, they may be developed for anticancer therapeutic purposes.

International Journal of Molecular Sciences published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H6BF3O3, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wen, Xin published the artcilePreparation of a novel two-dimensional carbon material and enhancing Pb(II) removal by tri-isopropanolamine, Recommanded Product: Triisopropanolamine, the publication is Desalination and Water Treatment (2018), 253-262, database is CAplus.

A novel tri-isopropanolamine functionalized graphene oxide (TI-GO) adsorbent was synthesized by one-step reaction at 358K. Then the prepared TI-GO was characterized by SEM-EDS, FTIR, Raman spectra, TG, BET and XPS. The characterization results indicated the TI-GO has been synthesized successfully and it interact with Pb(II) ions through its nitrogen and oxygen-containing functional groups. Batch adsorption experiments were applied to evaluate the optimized conditions of adsorption. The results indicated that the TI-GO can reach equilibrium adsorption in 30 min and get maximum adsorption capacity at 293 K, pH 5.0. Besides, the adsorption kinetic and adsorption isotherm research indicated that the adsorption of TI-GO fit pseudo-second-order (PSO) kinetic and Langmuir adsorption isotherm model. In addition, the maximum adsorption capacity evaluated by Langmuir adsorption isotherm equation is 1478 mg/g.

Desalination and Water Treatment published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C37H30ClIrOP2, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zong, Fang published the artcileEfficacy of carboprost tromethamine combined with leonurus japonicus for prevention of postpartum hemorrhage in high-risk pregnant women: A protocol for systematic review and meta-analysis, Related Products of alcohols-buliding-blocks, the publication is Medicine (Philadelphia, PA, United States) (2021), 100(30), e26792, database is CAplus and MEDLINE.

No well-designed and systematic evaluation of the efficacy and safety of leonurus japonicus injection (LJI) in combination with carboprost tromethamine has been found. Therefore, we undertook a meta-anal. to assess the efficacy and safety of carboprost tromethamine combined with LJI for the prevention of postpartum hemorrhage in high-risk pregnant women to provide new evidence-based medical evidence for clin. treatment. This systematic review and meta-anal. would be performed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The following databases including EMBASE, MEDICINE, Wanfang, China National Knowledge Infrastructure database, and Cochrane central controlled trial registries were searched by 2 reviewers from inception to July 2021. Mesh and keyword search terms were “motherwort,” “Yimucao,” “leonurus japonicas,””carboprost tromethamine,” and “postpartum hemorrhage”. Any cohort studies that assessed the efficacy and safety of carboprost tromethamine combined with LJI for the prevention of postpartum hemorrhage would be included. P05 was set as the level of significance. The review would add to the existing literature by showing compelling evidence and improved guidance in clinic settings.

Medicine (Philadelphia, PA, United States) published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10N2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiao, Zuobing published the artcileCharacterization of the key aroma compounds in three world-famous black teas, Application In Synthesis of 106-25-2, the publication is European Food Research and Technology (2022), 248(9), 2237-2252, database is CAplus.

The volatile compounds of three world-famous black teas (Darjeeling, DJL, Keemun, KM, and Ceylon, CL) were extracted by stir bar sorptive extraction (SBSE), and analyzed by gas chromatog.-olfactometry (GC-O), gas chromatog.-mass spectrometry (GC-MS). The results indicated that 78, 76, and 69 volatile compounds were detected in the three tea infusions. And 9 sulfur compounds in black teas were identified by gas chromatog.-flame photometric detection (GC-FPD). In addition, a total of 42 aroma compounds were perceived and 38 compounds were identified as important aroma compounds due to their high odor activity values (OAVs), such as 3-methylbutanal (OAV: 24-82), linalool (OAV: 24-64), geraniol (OAV: 2-97), β-ionone (OAV: 54-122), and cis-jasmone (OAV: 2-119). According to the results of aroma recombination and omission experiments, 2-methylbutanal, linalool, Me salicylate and β-cyclocitral were confirmed to be the key aroma compounds in Darjeeling black tea, 3-methylbutanal, hexanal, β-myrcene, and Me salicylate were the key aroma compounds in Keemun, while β-ionone, linalool, 2-methylbutanal, and salicylaldehyde were the key aroma compounds in Ceylon black tea.

European Food Research and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C11H16BNO3, Application In Synthesis of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hao, Zhi-Qiang published the artcilePreparation of porous carbon sphere from waste sugar solution for electric double-layer capacitor, Formula: C6H10O7, the publication is Journal of Power Sources (2017), 249-258, database is CAplus.

Waste sugar solution (WSS), which contains abundant 2-keto-L-gulonic acid, is harmful to the environment if discharged directly. For value-added use of the waste resource, a novel process is developed for preparation of porous C spheres by hydrothermal carbonization (HTC) of WSS followed by KOH activation. Addnl., the possible preparation mechanism of C spheres is proposed. The effects of hydrothermal and activation parameters on the properties of the C sphere are also studied. The C sphere is applied to elec. double-layer capacitor and its electrochem. performance is studied. The C sphere obtained by HTC at 180° for 12 h with the WSS/deionized H₂O volume ratio of 2/3 possess the highest specific capacitance under identical activation conditions. The specific capacitance of the C spheres can reach 296.1 F g^-1 at a c.d. of 40 mA g^-1. Besides, excellent cycle life and good capacitance retention (89.6%) are observed at 1.5 A g^-1 after 5000 cycles. This study not only provides a facile and potential method for the WSS treatment, but also achieves the high value-added recycling of WSS for the preparation of porous C spheres with superior electrochem. properties.

Journal of Power Sources published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hao, Zhi-Qiang published the artcilePreparation of porous carbon spheres from 2-keto-L-gulonic acid mother liquor by oxidation and activation for electric double-layer capacitor application, Quality Control of 526-98-7, the publication is Journal of Colloid and Interface Science (2018), 20-27, database is CAplus and MEDLINE.

A strategy is proposed for the increase of sp. surface area (SSA) of porous carbon sphere (PCS) by oxidation and activation. 2-keto-L-gulonic acid mother liquor (GAML) as a high-pollution waste has a relatively high value of reutilization. For its high value-added utilization, GAML is used as the precursor for preparation of PCS as carbon-based electrode materials for elec. double-layer capacitor. PCS is prepared by hydrothermal carbonization, carbonization and KOH activation, and Fe(NO₃)₃ 9H₂O is used as an oxidizing agent during carbonization. The as-prepared PCS has excellent porosity and high SSA of 2478 m² g^-1. Meanwhile, the pore structure of PCS can be controlled by the adjustment of carbonization parameters (carbonization temperature and the loading of Fe(NO₃)₃ 9H₂O). Besides, the SSA and specific capacitance of PCS can be increased remarkably when Fe(NO₃)₃ 9H₂O is added in carbonization. The specific capacitance of PCS can reach 303.7 F g^-1 at 40 mA g^-1. PCSs as electrode material have superior electrochem. stability. After 8000 cycles, the capacitance retention is 98.3% at 2 A g^-1. The elec. double-layer capacitance of PCS is improved when CS is carbonized with Fe(NO₃)₃ 9H₂O, and the economic and environmental benefits are achieved by the effective recycle of GAML.

Journal of Colloid and Interface Science published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Quality Control of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dang, Ya-Li published the artcilePreparation of porous carbon spheres under different activation conditions from 2-keto-L-gulonic acid mother liquor for electric double-layer capacitor, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Waste and Biomass Valorization (2020), 11(8), 4429-4440, database is CAplus.

2-Keto-L-gulonic acid mother liquor (GAML) as an organic waste solution contained highly polluting contents would pollute the environment if discharged directly. As reported in our previous paper, GAML was used as the precursor to prepare porous carbon sphere (PCS) as carbon-based electrode materials of elec. double-layer capacitor (EDLC) to create its high value-added utilization, and in the carbonization process, Fe(NO₃)₃·9H₂O acted as an oxidizing agent. Since the carbon sphere was a carbon material with a special morphol., the effect of activation conditions (activation ratio, activation temperature and activation time) on the pore structure and the electrochem. performance of PCS were explored in this paper. PCS was derived via hydrothermal carbonization, carbonization and KOH activation successively, and the as-prepared samples had excellent porosity and high SSA of 2747 m² g^-1. Besides, the specific capacitance of PCS-7-700-1 could reach as high as 303.7 F g^-1 (206.5 F cm^-3) in 6 M KOH electrolyte at 40 mA g^-1.

Waste and Biomass Valorization published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shu, Bing published the artcileSyntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation, SDS of cas: 622-40-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(16), 2036-2039, database is CAplus and MEDLINE.

We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 (I) could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis.

Chemical Communications (Cambridge, United Kingdom) published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H4ClNO2, SDS of cas: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Li-hua published the artcileClinical observation of prophylaxis from uterine inertia postpartum hemorrhage by hemabate, Related Products of alcohols-buliding-blocks, the publication is Zhongguo Xueye Liubianxue Zazhi (2011), 21(4), 693-694, 769, database is CAplus.

The objective was to evaluate the effect of prophylaxis from uterine inertia postpartum hemorrhage by hemabate. 90 Cases of puerperal with the postpartum hemorrhage volume â‰?50mL, were divided randomly into the observation groups who were injected with hemabate 250μg in the uterus body immediately, and the control groups who were injected with oxytocin 20U in the uterus body and buccal sublingually misoprostol 400μ g, and the rate of postpartum hemorrhage and the hemorrhage volume of 2h postpartum or 2 to 24h postpartum were compared. Comparing with the control groups, the observation groups had a lower rate of postpartum hemorrhage, and the less hemorrhage volume of 2h postpartum and 2 to 24h postpartum, and the difference had a statistical significance. Hemabate is more effective than misoprostol to prevent postpartum hemorrhage, with the characteristics of high performance, quick effect, safety and convenience.

Zhongguo Xueye Liubianxue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Li-na published the artcileEffect of metallic ions on the esterifying conversion of vitamin C, SDS of cas: 526-98-7, the publication is Liaoning Huagong (2014), 43(6), 713-714, database is CAplus.

The machines and pipes in chem. production industry are mainly made of metal. The corrosion can normally cause metallic ions to be separated from the equipments to diffuse into the product, which will lead to the deviation of the quality and productivity. In this paper, effect of iron ions coming from vitamin C production equipments on the esterifying conversion of vitamin C was investigated.

Liaoning Huagong published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C12H17NS2, SDS of cas: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts