Month: December 2022

Fernández de Arriba, A published the artcileInhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid., Synthetic Route of 328-90-5, the publication is Molecular pharmacology (1999), 55(4), 753-60, database is MEDLINE.

The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells. This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression. This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate. Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis. Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.

Molecular pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Minero, Claudio published the artcileRole of adsorption in photocatalyzed reactions of organic molecules in aqueous titania suspensions, Formula: C22H38O2, the publication is Langmuir (1992), 8(2), 481-6, database is CAplus.

The photocatalyzed transformation of chem. compounds strongly adsorbed on a particle surface was investigated in the presence of different photoactive and “inert” supports. For several compounds, such as dioctylquinol and chrysene, the rate of degradation is only slightly affected by the initial adsorption onto nonphotocatalytic materials (SiO₂, Al₂O₃) when irradiated in a slurry with added micrometer size TiO₂ particles. A rapid exchange of the substrate between the different inorganic supports was exptl. observed and explains the photocatalytic results. Decafluorobiphenyl (DFBP), which adsorbs tenaciously on Al₂O₃, degrades slowly when irradiated in the presence of TiO₂ particles. Measurements confirm that DFPB is poorly exchanged from alumina to TiO₂. Comparison with the results obtained using colloidal TiO₂ or silica particles, and with the behavior of pentafluorophenol, under otherwise identical conditions, suggests that the photogenerated oxidizing species does not migrate far from the photogenerated active centers and that the degradation process occurs at the surface or within a few monolayers around the photocatalytic particles.

Langmuir published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vlckova, Hana Kocova published the artcileFeaturing ultimate sensitivity of high-resolution LC-MS analysis of phenolics in rat plasma, Product Details of C8H8O3, the publication is Journal of Separation Science (2021), 44(9), 1893-1903, database is CAplus and MEDLINE.

Sensitive anal. of very low-mol. weight metabolites using liquid chromatog. with quadrupole-time-of-flight mass spectrometry is challenging due to the high losses of ions in a time-of-flight analyzer. Improvement in sensitivity for these analytes via the optimization of advanced parameters, including quadrupole profile, ion guide parameters, and duty cycle, has been achieved. The optimization of the method was carried out using a large spectrum of structurally different compounds including (iso)flavonoids and their known metabolites. These compounds can be categorized into two major groups, i.e., compounds with (iso)flavonoid core and low-mol. weight phenolics. The optimization of the duty cycle enabled up to a 15-fold increase in analyte responses while the contribution of tuning ion optics and quadrupole profile was negligible. The limits of quantifications of our new method were assessed using both standard solutions and rat plasma. They were decreased at least 10 times for several low-mol. weight phenolics enabling measurement of their concentrations in a range of 1-50 ng/mL in rat plasma after protein precipitation Concurrently, the limits of quantifications for compounds with (iso)flavonoid core did not increase distinctly allowing their detection in a range of 0.5-10 ng/mL. The new method was used for the targeting of phenolics in biol. samples from pharmacokinetics experiments

Journal of Separation Science published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C13H26N2, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Dominguez, Raul published the artcileFood and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study, Related Products of alcohols-buliding-blocks, the publication is Molecular Nutrition & Food Research (2021), 65(23), 2100606, database is CAplus and MEDLINE.

Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. The article studies the long-term prospective Three-City Cohort, which consists of two sep. nested case-control sample sets from different geog. regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychol. tests (Mini-Mental State Examination, Benton Visual Retention Test, Isaac’s Set Test, Trail-Making Test part A, and Trail-Making Test part B). The food-related and microbiota-derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large-scale quant. metabolomics anal. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol-rich foods, and cognitive decline, as well as a neg. association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alc. These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.

Molecular Nutrition & Food Research published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Botero, David published the artcileComparative study of pyrantel pamoate, bephenium hydroxynaphthoate, and tetrachloroethylene in the treatment of Necator americanus infections, HPLC of Formula: 3818-50-6, the publication is American Journal of Tropical Medicine and Hygiene (1972), 22(1), 45-52, database is CAplus and MEDLINE.

A study of 105 patients with the hookworm N. americanus infections was undertaken to compare the new anthelmintic pyrantel pamoate (I-pamoate) [22204-24-6] and 2 commonly used drugs bephenium hydroxynaphthoate [3818-50-6] and tetrachloroethylene [127-18-4]. I, in a dose of 10 mg/day, orally, for 3 days, had action comparable or superior to the other drugs against the hookworm. In addition, I caused an almost 100% cure rate in patients infected with Ascaris lumbricoides, and caused a slight decrease in egg count in patients infected with Trichuris trichiura. I was tolerated well and no toxic effects were observed by hematol. and biochem. examination

American Journal of Tropical Medicine and Hygiene published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, HPLC of Formula: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yasin Tabatabaei Dakhili, S. published the artcileRecombinant silicateins as model biocatalysts in organosiloxane chemistry, Category: alcohols-buliding-blocks, the publication is Proceedings of the National Academy of Sciences of the United States of America (2017), 114(27), E5285-E5291, database is CAplus and MEDLINE.

The family of silicatein enzymes from marine sponges (phylum Porifera) is unique in nature for catalyzing the formation of inorganic silica structures, which the organisms incorporate into their skeleton. However, the synthesis of organosiloxanes catalyzed by these enzymes has thus far remained largely unexplored. To investigate the reactivity of these enzymes in relation to this important class of compounds, their catalysis of Si-O bond hydrolysis and condensation was investigated with a range of model organosilanols and silyl ethers. The enzymes’ kinetic parameters were obtained by a high-throughput colorimetric assay based on the hydrolysis of 4-nitrophenyl silyl ethers. These assays showed unambiguous catalysis with k_cat/K_m values on the order of 2-50 min^-1 μM^-1. Condensation reactions were also demonstrated by the generation of silyl ethers from their corresponding silanols and alcs. Notably, when presented with a substrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the latter group, in clear contrast to nonenzymic silylations. Furthermore, the silicateins are able to catalyze transetherifications, where the silyl group from one silyl ether may be transferred to a recipient alc. Despite close sequence homol. to the protease cathepsin L, the silicateins seem to exhibit no significant protease or esterase activity when tested against analogous substrates. Overall, these results suggest the silicateins are promising candidates for future elaboration into efficient and selective biocatalysts for organosiloxane chem.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C4H6N2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yasin Tabatabaei Dakhili, S. published the artcileRecombinant silicateins as model biocatalysts in organosiloxane chemistry, Computed Properties of 17877-23-5, the publication is Proceedings of the National Academy of Sciences of the United States of America (2017), 114(27), E5285-E5291, database is CAplus and MEDLINE.

The family of silicatein enzymes from marine sponges (phylum Porifera) is unique in nature for catalyzing the formation of inorganic silica structures, which the organisms incorporate into their skeleton. However, the synthesis of organosiloxanes catalyzed by these enzymes has thus far remained largely unexplored. To investigate the reactivity of these enzymes in relation to this important class of compounds, their catalysis of Si-O bond hydrolysis and condensation was investigated with a range of model organosilanols and silyl ethers. The enzymes’ kinetic parameters were obtained by a high-throughput colorimetric assay based on the hydrolysis of 4-nitrophenyl silyl ethers. These assays showed unambiguous catalysis with k_cat/K_m values on the order of 2-50 min^-1 μM^-1. Condensation reactions were also demonstrated by the generation of silyl ethers from their corresponding silanols and alcs. Notably, when presented with a substrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the latter group, in clear contrast to nonenzymic silylations. Furthermore, the silicateins are able to catalyze transetherifications, where the silyl group from one silyl ether may be transferred to a recipient alc. Despite close sequence homol. to the protease cathepsin L, the silicateins seem to exhibit no significant protease or esterase activity when tested against analogous substrates. Overall, these results suggest the silicateins are promising candidates for future elaboration into efficient and selective biocatalysts for organosiloxane chem.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C7H8BBrO3, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cox, Eugene F. published the artcileSmall-ring compounds. XXXIV. Carbonium ion reactions of 1-methylcyclobutyl-, (1-methylcyclopropyl)carbinyl, and (β-methylallyl)carbinyl derivatives, Name: 1-Methylcyclobutan-1-ol, the publication is Journal of the American Chemical Society (1961), 2719-24, database is CAplus.

cf. CA 46, 1453a, 55, 22160d. (1-Methylcyclopropyl)carbinyl chloride (I) solvolyzed in 50% aqueous EtOH about 10 times faster than 1-methylcyclobutyl chloride (II) and as fast as Me₃CCl. Treatment of (1-methylcyclopropyl)carbinylamine (III) and 1-methylcyclobutylamine (IV) with HNO₂ gave only 1-methylcyclobutanol (V). CH₂:CMeCH₂CH₂NH₂ (VI) gave V as the only cyclic product. About 3% of the C¹⁴ content of V from the deamination of III-α-C¹⁴ (VII) was found at the 3-position. These results were interpretable in terms of classical carbonium ions and(or) substituted bicyclobutonium ion intermediates with fairly localized pos. charges. CH₂: CMeCO₂Me added to CH₂N₂-Et₂O at 0°, the resulting pyrazoline (90%) pyrolyzed in small quantities, and the combined crude product distilled yielded 316 g. crude Me ester (VIII) of 1-methylcyclopropanecarboxylic acid (IX), containing some unsaturated material, which treated in petr. ether with slightly alk. 0.25M KMnO₄ at 0° and worked up gave pure VIII, b_60.4-65.6 55.9-7.1°, n²⁵_D 1.4192-1.4193. The VIII hydrolyzed gave 90% IX, m. 32.4-4.3° (all m.ps. corrected); p-bromophenacyl ester m. 64.1-5.0° (50% aqueous EtOH); anilide m. 100.5-1.6° (50% aqueous EtOH), 100.6-1.3° (hexane). The Ag salt of IX in Freon-12 treated with Br gave 71% 1-methylcyclopropyl bromide (X), b₇₄₀ 77.2-8.0°, n²⁵_D 1.44711.4474. A small amount of X converted to the Grignard reagent and treated with PhNCO gave 1-methylcyclopropanecarboxanilide, m. 99.2-100.1°. IX was converted into 72% amide, m. 145.7-6.9°. CH₂:CMeCN with CH₂N₂ in Et₂O yielded 1-methylcyclopropanecarbonitrile (XI), b₇₆₅ 127.7-8.5°, n²⁵_D 1.4128. VIII reduced with LiAlH₄ gave (1-methylcyclopropyl)carbinol, b₇₃₉ 125.8-6.3°, n²⁵_D 1.42901.4292; 3,5-dinitrobenzoate m. 88.9-90.7° (C₆H₆-cyclohexane). XI reduced with Na-EtOH gave 56% III, b₇₆₄ 95.0-6.8°, n²⁵_D 1.4269. XI reduced with LiAlH₄ in Et₂O gave 70% III, b₇₆₁ 94.3-6.1°, n²⁵_D 1.4207-1.4273; N-phenyl-N’-(1-methylcyclopropylcarbinyl)thiourea m. 112.7-13.5° (95% EtOH). Me₂C(CH₂OH)₂ treated with PBr₃ and the dibromide cyclized gave 1,1-dimethylcyclopropane (XII), b₇₃₈ 19.0-20.0°. XII (74.5 g.) chlorinated by the method of Robert and Mazur (loc. cit.) gave 102 g. mixture of 49% I, 16% II, 14% CH₂: CHMeCH₂Cl, and 32% unreactive chloride, which carefully refractionated gave pure I, b₇₃₅, 83.0-3.9°, n²⁵_D 1.4045-1.4052. The H₂SO₄-catalyzed addition of H₂O to methylenecyclobutane (XIII), b₇₃₉ 41.0-2.0°, yielded 68% V, b₇₄₆ 117.8-18.3°, n²⁵_D 1.4332-1.4336. The hydrolysis of II yielded 40% V, b₇₅₆ 117.1-18.9°, n²⁵_D 1.4329. Cyclobutanone with MeMgBr gave 67% V, b₇₆₅ 118.3°, n²⁵_D 1.4332. HCl added to XIII yielded 81% II, b₇₄₂ 90.8-1.3°, n²⁵_D 1.4283-1.4287. MeCN (9.0 g.), 100 cc. glacial AcOH, and 20 cc. concentrated H₂SO₄ treated with stirring with 13.6 g. XIII, stirred 1 hr. at 20°, cooled, diluted with 300 cc. H₂O, basified with Na₂CO₃, and extracted with Et₂O, and the extract worked up yielded 17.7 g. N-(1-methylcyclobutyl)acetamide (XIV). XIV (10.0 g.) and 400 cc. 4N KOH in (CH₂OH)₂ refluxed 48 hrs. and continuously extracted with Et₂O yielded 3.1 g. IV, b₇₆₄ 85.5-6.0°, n²⁵_D 1.4200. XIII (13.6 g.), 11.0 g. 90% NaCN, and 25 cc. glacial AcOH treated at 0° with 25 cc. AcOH and 50 g. concentrated H₂SO₄ during 25 min., stirred 3 hrs. at 0°, 1 hr. at room temperature, and 45 min. at 55°, kept overnight at room temperature, treated slowly with stirring with 120 g. NaOH in 250 cc. H₂O, refluxed 8 hrs., and steam distilled, and the distillate (250 cc.) extracted 18 hrs. with Et₂O yielded 8.03 g. IV, b₇₄₅ 84.0-4.7°, n²⁵_D 1.4292-1.4293; N-phenyl-N’-(1-methylcyclobutyl)thiourea, m. 135.3-5.8° (aqueous EtOH). CH₂:CMeCH₂CH₂Cl was converted by the method of Kharasch and Fuchs (CA 38, 6281⁹) in 35% yield to CH₂:CMeCH₂CH₂OH (XV), b₇₄₁ 127.9-30.4°, n²⁵_D 1.43051.4312; 1-naphthylurethan m. 66.7-7.3° (petr. ether). XV (8.61 g.), 25 cc. dry Et₂O, 18.5 g. Bu₃N treated with stirring at 0° with 11.9 g. SOCl₂ during 3 hrs. gave CH₂:CMeCH₂CH₂Cl (XVI), b₇₃₉, 101.0-2.7°, n²⁵_D 1.4301-4305. XVI with K phthalimide in HCONMe₂ yielded 85% N-I-(3-methyl-3-butenyl)phthalimide (XVII), m. 51.2-2.8°. Hydrazinolysis of XVII in HClO₄ gave 26% VI, b₁₀₁ 47.6-8.5°, n²⁵_D 1.4288. CH₂:CMeCHO with MeMgBr yielded CH₂:CMeCH(OH)Me, b_59.9-60.4 54.6-6.8°, n²⁵_D 1.4241-1.4242. 3-Methyl-3-carbomethoxy-l-pyrazoline pyrolyzed and the high-boiling fractions of the product redistilled gave Me tiglate, b₇₄₀ 136.9-7.1°, n²⁵_D 1.4338, which reduced with LiAlH₄ yielded about 40% MeCH:CMeCH₂OH, b. 137.6-7.9°, n²⁵_D 1.4386-1.4401. III (12.8 g.) in 50 cc. H₂O and 180 cc. 1.0N HClO₄ treated during 0.5 hr. with stirring with 30 g. NaNO₂ in 100 cc. H₂O, heated 1 hr. at 50-65 mm., and steam-distilled, the aqueous phase of the distillate saturated with K₂CO₃ and extracted with Et₂O, and the combined organic layer and extract distilled gave 0.72 g. V. The Grignard reagent from X carbonated in vacuo with C¹⁴O₂, diluted with inactive IX, and distilled gave IX-α-C¹⁴, b_19.2-19.4 96.6-7.4° (radioactive yield 88%), which was converted to the amide and further by reduction with LiAlH₄ to 51% VII. VII treated in AcOH with NaNO₂ in portions, poured into 20% aqueous NaOH, and extracted with Et₂O, and the resulting mixture of labeled alc. and acetate reduced with LiAlH₄ gave V. VII.HCl oxidized with alk. KMnO₄ and a portion of the resulting acid converted to the amide gave a material containing 0.128 microcuries/millimole; another portion of the acid was subjected to a Schmidt degradation and the resulting amine converted to the benzamide, m. 161.7-3.0°, containing 0.000-37 microcuries/millimoles, corresponding to 0.29% of the original activity. The rates of the solvolysis in 50% EtOH were determined for the following compds (reaction temperature, and k₁ × 10⁵/sec. given): cyclopropyl bromide, 130°, 0.26; X, 130°, 10.5; II, 50°, 61.7; II, 30°, 7.15; I, 30°, 69; XVI, 90°, 0.17.

Journal of the American Chemical Society published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Name: 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sanchez de Miguel, Lourdes published the artcileComparison of in vitro effects of triflusal and acetylsalicylic acid on nitric oxide synthesis by human neutrophils, HPLC of Formula: 328-90-5, the publication is European Journal of Pharmacology (1998), 343(1), 57-65, database is CAplus and MEDLINE.

Recent studies have suggested that the protective anti-ischemic effects of acetylsalicylic acid are stronger than the inhibition of platelet thromboxane A₂ synthesis. Since ischemic events still occur in acetylsalicylic acid-treated patients, the development of new drugs with more powerful protective effects is needed. The authors compared the effects of a new platelet antiaggregating drug, 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal) and of acetylsalicylic acid on the interaction between human neutrophils and platelets, examining the capability of neutrophils to generate nitric oxide (NO). Triflusal, in the presence of neutrophils, showed a greater antiplatelet potency than acetylsalicylic acid to inhibit thrombin-induced platelet activation. Significant stimulation of NO-mediated mechanisms in the presence of acetylsalicylic acid or triflusal was demonstrated by the following findings: (1) increased metabolism of arginine to citrulline, (2) increase of cGMP in the platelet/neutrophil system and (3) the inhibitory action of the L-arginine (L-Arg) competitive analog, N^G-nitro-L-arginine-Me ester (L-NAME), which was reversed by L-Arg. Triflusal increased the stimulation of NO synthesis by neutrophils more than did of acetylsalicylic acid. The main metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), alone or in combination with acetylsalicylic acid, did not modify NO production by neutrophils. Therefore, the whole mol. of triflusal is needed to stimulate NO production by neutrophils. The results show that, in the presence of neutrophils, triflusal exerts an antiplatelet effect greater than that of acetylsalicylic acid, demonstrating a more powerful stimulation of the NO/cGMP system. The present results indicate that it is possible to develop new and more potent acetylsalicylic acid-related antiplatelet drugs for the prevention of the myocardial ischemic/reperfusion processes.

European Journal of Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cabrera-Afonso, Maria J. published the artcileSite-selective Oxidative Dearomatization of Phenols and Naphthols into ortho-Quinols or Epoxy ortho-Quinols using Oxone as the Source of Dimethyldioxirane, Computed Properties of 86-48-6, the publication is Advanced Synthesis & Catalysis (2019), 361(19), 4468-4473, database is CAplus.

A novel reactivity of dimethyldioxirane generated in-situ from oxone and acetone, with substituted phenols and naphthols was reported. This methodol. allowed the synthesis of ortho-quinols or epoxy ortho-quinols from a site-selective oxidative dearomatization process with good yields under very mild conditions. A short total synthesis of natural product lacinilene C Me ether was also described using this process as the key step.

Advanced Synthesis & Catalysis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts