Month: December 2022

Ma, Guobin published the artcileMetal catalyst-free photo-induced alkyl C-O bond borylation, Synthetic Route of 608534-44-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(70), 10219-10222, database is CAplus and MEDLINE.

Metal catalyst free, blue visible light-induced C-O bond borylation of unactivated tertiary alkyl Me oxalates was developed to furnish tertiary alkyl boronates. From the secondary alcs. activated with imidazolylthionyl, moderate yields of boronates were attained under standard photo-induced conditions. Preliminary mechanistic studies confirmed the involvement of a (DMF)₂-B₂cat₂ adduct that weakly absorbs light at 437 nm so as to initiate a Bcat radical. A radical-chain process is proposed wherein the alkyl radical is engaged.

Chemical Communications (Cambridge, United Kingdom) published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Synthetic Route of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Le-Cheng published the artcileCobalt-Catalyzed Direct Aminocarbonylation of Ethers: Efficient Access to α-Amide Substituted Ether Derivatives, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(23), e202203797, database is CAplus and MEDLINE.

Herein, a novel cobalt-catalyzed carbonylative coupling of ethers with amines to construct α-carbonylated ethers R¹C(O)NR²R³ [R¹ = tetrahydrofuran-2-yl, cyclopentyl, tetrahydropyran-2-yl, etc.; R² = Ph, 4-MeC₆H₄, 3-pyridyl, etc.; R³ = H, Me, Et] was repored. Remarkably, Alfuzosin, a medicine for treatment of benign prostatic hyperplasia (BPH), could be synthesized by this process straightforwardly. Notably, this protocol presented the first example on the direct carbonylative reaction of ethers.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C38H24F4O4P2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Le-Cheng published the artcileNickel-Catalyzed Four-Component Carbonylation of Ethers and Olefins: Direct Access to γ-Oxy Esters and Amides, Product Details of C12H20O6, the publication is Angewandte Chemie, International Edition (2022), 61(33), e202207970, database is CAplus and MEDLINE.

Multi-component carbonylation of olefins, a reaction that installs both a carbon-carbon(heteroatom) bond and a carbonyl group across the double bond, is an attractive strategy for alkene functionalization. Herein, a novel nickel-catalyzed four-component carbonylation of olefins with ethers under low CO gas pressure is developed. Using alcs. and amines as the reaction partner, diverse γ-oxy-substituted esters and amides were produced in good yields with excellent functional group tolerance. Notably, Naftidrofuryl, a medicine for the treatment of cerebrovascular disease (CVD), can be synthesized by this process straightforwardly.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C13H9FO, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Peng, Huige published the artcileReprogramming Tumor-Associated Macrophages To Reverse EGFR^T790M Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat, Synthetic Route of 96345-79-8, the publication is Nano Letters (2017), 17(12), 7684-7690, database is CAplus and MEDLINE.

Gefitinib is a first-line therapy in the EGFR-mutated nonsmall cell lung cancer (NSCLC). However, the development of drug resistance is almost unavoidable, thus leading to an unsustainable regimen. EGFR^T790M mutation is the major cause responsible for the mol.-targeting therapy failure in NSCLC. Although the recently approved osimertinib is effective for the EGFR^T790M-pos. NSCLC, the osimertinib-resistant EGFR mutation is rapidly developed, too. In this study, we proposed a tumor-associated macrophage (TAM) reprogramming strategy for overcoming the EGFR^T790M-associated drug resistance via a dual-targeting codelivery system of gefitinib/vorinostat that acted on both TAM with overexpression of mannose receptors and the HER-2 pos. NSCLC cells. The trastuzumab-modified, mannosylated liposomal system was able to repolarize the protumor M2 phenotype to the antitumor M1 and cause the elevating ROS in the cancer cells, consequently modulating the intracellular redox balance via ROS/NOX3/MsrA axis. The suppressed MsrA facilitated the EGFR^T790M degradation through 790M oxidation by ROS, thus resensitizing the EGFR^T790M-pos. cells to gefitinib. The dual-targeting codelivery and TAM-reprogramming strategies provided a potential method for rescuing the EGFR^T790M-caused resistance to tyrosine kinase inhibitor treatment.

Nano Letters published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Synthetic Route of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jadhav, Sandip B. published the artcileDiastereoselective Desymmetrization of p-Quinamines through Regioselective Ring Opening of Epoxides and Aziridines, SDS of cas: 57044-25-4, the publication is Organic Letters (2019), 21(24), 10115-10119, database is CAplus and MEDLINE.

A highly diastereoselective desymmetrization of p-quinamines via regioselective ring opening of epoxides and aziridines under mild conditions has been developed. A chairlike six-membered transition state with minimized 1,3-diaxial interactions explains the relative stereoselectivity of the cyclization reaction. This transition-metal free [3 + 3] annulation reaction provides rapid access to fused bicyclic morpholines and piperazines with a tetrasubstituted carbon center in high yields. In addition, it also allows the synthesis of enantioenriched products by using easily accessible chiral nonracemic epoxides and aziridines.

Organic Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, SDS of cas: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arnett, Edward M. published the artcileMaster equations for calculating heterolysis energies in solution, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Energy & Fuels (1987), 1(1), 17-23, database is CAplus.

The title LFER, in which carbocation stability is represented by the π-delocalization energy instead of k_R⁺, correlates. The reactions of six carbocations with twenty-one carbanions and five phenoxides with excellent statistical accuracy and self-consisting. This equation can be used to predict the bond heterolysise enthalpies when resonance stabilized ions are formed.

Energy & Fuels published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Youenou, Benjamin published the artcileIn vitro study to evaluate the antimicrobial activity of various multifunctional cosmetic ingredients and chlorphenesin on bacterial species at risk in the cosmetic industry, Computed Properties of 70445-33-9, the publication is Journal of Applied Microbiology (2022), 132(2), 933-948, database is CAplus and MEDLINE.

We evaluated the activity of the preservative chlorphenesin and of four antimicrobial cosmetic multifunctional ingredients against various strains of gram-neg. and gram-pos. human opportunistic pathogens. Growth kinetics, modeling growth parameters and statistical analyses enabled comparing bacterial behavior in the presence and in the absence of the compound Whatever compound tested (i.e. chlorphenesin, phenylpropanol, hexanediol, ethylhexylglycerin, hydroxyacetophenone) and strain origin (i.e. clin. vs. industrial), the growth of 42 strains belonging to Acinetobacter spp., Burkholderia cepacia complex and Stenotrophomonas maltophilia, was totally inhibited. On the opposite all of the P. aeruginosa strains (n = 13) as well as 4 and 6 out of 10 strains of Pluralibacter gergoviae grew in the presence of chlorphenesin and ethylhexylglycerin, resp. Some P. gergoviae and Staphylococcus hominis strains withstand hydroxyacetophenone. Within a species, the different strains show variable latency phase, growth rate (r) and carrying capacity (K). They can be similar, lower or higher than those measured in control conditions. Data showed differences in the antimicrobial activity of compounds Upon exposure, strains differed in their behavior between and within species. Whatever species and strains, compound sensitivity could not be related to antibiotic resistance. Most multifunctional ingredients showed significant antimicrobial properties against the wide panel of species and strains evaluated. This will help adjusting preservation strategies in the cosmetic industry.

Journal of Applied Microbiology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C13H18BFO3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rout, Kanhu Charan published the artcileA copper(II) complex as selective turn-on fluorosensor for nitric oxide and its intracellular application, Category: alcohols-buliding-blocks, the publication is Inorganica Chimica Acta (2015), 201-206, database is CAplus.

A highly water soluble copper(II) complex, 1 of a fluorophore ligand 4-(2-hydroxybenzylamino)-5-hydroxynaphthalene-2,7-disulfonic acid (FL₁) was synthesized and characterized. In the complex, the fluorescence intensity of the ligand was found to quench due to the presence of paramagnetic Cu(II) center. In degassed methanol solution of complex 1, the Cu(II) center was found to undergo reduction in presence of nitric oxide. This resulted in the simultaneous formation of N-nitrosated ligand. In the process, the quenched fluorescence intensity of the ligand restored. The selective turn on fluorogenic nature of the complex 1 was used to study the endogenously produced NO in living cells.

Inorganica Chimica Acta published new progress about 5941-07-1. 5941-07-1 belongs to alcohols-buliding-blocks, auxiliary class Salt,Benzene,Naphthalene,Phenol,Inhibitor, name is 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, and the molecular formula is C17H12NNaO8S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatterjee, Maya published the artcileProduction of lactic acid mediated by compressed carbon dioxide on heterogeneous Ni(II) catalysts: a facile approach, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Green Chemistry (2022), 24(16), 6145-6155, database is CAplus.

Lactic acid is one of the appealing platform mols. in organic synthesis, currently in high demand after the innovation of bio-plastics. The limitations of traditional manufacturing routes (microbial process and chem. synthesis using petroleum resources) directed us to develop economically and environmentally viable catalytic strategies exploring renewable resources to meet the expected demand. In this study, we demonstrated a method of lactic acid synthesis by fixing CO₂ as a waste gas into acetaldehyde used as a biobased feedstock on a highly active, recyclable heterogeneous Ni catalyst. The significance of the developed process lies in the transformation of easily available low-cost starting materials to a high-value product without harsh reaction conditions, extra sensitive reagents, and addnl. steps to derive the right starting material or to remove impurities, which is advantageous in terms of sustainability. Moreover, the optimization of different reaction parameters ensures achieving high yields (>80%) and an excellent production rate of 6700μmol g^-1 h^-1. In addition, the characterization of the catalyst by different spectroscopic techniques suggested an interaction between the substrate and the catalyst, which provides an indication of the possible reaction path, thus a mechanism would be outlined. The successful extension of this process to various aldehydes was possible to produce their corresponding hydroxycarboxylic acid with broad functional group tolerance. Altogether, this methodol. opens up a promising avenue for the production of biochems. from renewable resources, which is a key to develop a sustainable society.

Green Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rej, Supriya published the artcileTransient Imine as a Directing Group for the Metal-Free o-C-H Borylation of Benzaldehydes, Safety of 4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde, the publication is Journal of the American Chemical Society (2021), 143(7), 2920-2929, database is CAplus and MEDLINE.

Organoboron reagents are important synthetic intermediates and have wide applications in synthetic organic chem. The selective borylation strategies that are currently in use largely rely on the use of transition-metal catalysts. Hence, identifying much milder conditions for transition-metal-free borylation would be highly desirable. The authors herein present a unified strategy for the selective C-H borylation of electron-deficient benzaldehyde derivatives using a simple metal-free approach, using an imine transient directing group. The strategy covers a wide spectrum of reactions and (i) even highly sterically hindered C-H bonds can be borylated smoothly, (ii) despite the presence of other potential directing groups, the reaction selectively occurs at the o-C-H bond of the benzaldehyde moiety, and (iii) natural products appended to benzaldehyde derivatives can also give the appropriate borylated products. Also, the efficacy of the protocol was confirmed by the fact that the reaction proceeds even in the presence of external impurities.

Journal of the American Chemical Society published new progress about 1883607-86-0. 1883607-86-0 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester, name is 4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde, and the molecular formula is C13H17BO4, Safety of 4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts