Month: December 2022

Barton, Lisa M. published the artcileElectrochemical borylation of carboxylic acids, HPLC of Formula: 608534-44-7, the publication is Proceedings of the National Academy of Sciences of the United States of America (2021), 118(34), e2109408118, database is CAplus and MEDLINE.

A simple electrochem. mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, HPLC of Formula: 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bandarage, Upul K. published the artcileNitrosothiol esters of diclofenac: synthesis and pharmacological characterization as gastrointestinal-sparing prodrugs, Application of 2-Methyl-2-sulfanylpropan-1-ol, the publication is Journal of Medicinal Chemistry (2000), 43(21), 4005-4016, database is CAplus and MEDLINE.

Despite its widespread use, diclofenac has gastrointestinal liabilities common to nonsteroidal antiinflammatory drugs (NSAIDs) that might be reduced by concomitant administration of a gastrointestinal cytoprotectant such as nitric oxide (NO). A series of novel diclofenac esters containing a nitrosothiol (-S-NO) moiety as a NO donor functionality has been synthesized and evaluated in vivo for bioavailability, pharmacol. activity, and gastric irritation. All S-NO-diclofenac derivatives acted as orally bioavailable prodrugs, producing significant levels of diclofenac in plasma within 15 min after oral administration to mice. At equimolar oral doses, S-NO-diclofenac derivatives I [R = R’ = Me, Et, RR’ = (CH₂)₅] and II (n = 2, 3) displayed rat antiinflammatory and analgesic activities comparable to those of diclofenac in the carrageenan-induced paw edema test and the mouse phenylbenzoquinone-induced writhing test, resp. All tested S-NO-diclofenac derivatives I and II were gastric-sparing in that they elicited markedly fewer stomach lesions as compared to the stomach lesions caused by a high equimolar dose of diclofenac in the rat. Nitrosothiol esters of diclofenac comprise a novel class of NO-donating compounds having therapeutic potential as nonsteroidal antiinflammatory agents with an enhanced gastric safety profile.

Journal of Medicinal Chemistry published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Application of 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Qiumei published the artcileMorpholinyl dendrimer phthalocyanine: synthesis, photophysical properties and photoinduced intramolecular electron transfer, Quality Control of 622-40-2, the publication is Dalton Transactions (2018), 47(37), 13164-13170, database is CAplus and MEDLINE.

A novel series of morpholinyl dendrimer phthalocyanines were synthesized. Their structures were characterized by ¹H NMR, IR, elemental anal., ESI-MS as well as MALDI-TOF MS. The photophys. properties of these phthalocyanines were studied by UV/visible and fluorescence spectroscopic methods. The photophys. properties of these dendrimer phthalocyanines exhibited dependence on the number of morpholinyl groups and the central ion. The photoinduced intramol. electron transfer from the morpholinyl groups to the phthalocyanine ring was evidenced by the remarkably quenched fluorescence intensity and shortened lifetime of the silicon phthalocyanine. This difference in photoinduced intramol. electron transfer effect for axially and peripherally substituted morpholinyl dendrimer phthalocyanines was also studied. Besides, introduction of morpholinyl groups on the dendrimer structure could enhance water solubility as well as increase the singlet oxygen quantum yield.

Dalton Transactions published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xiubing published the artcileSynthesis and surface properties of alkyl β-D-thioglucopyranoside, Related Products of alcohols-buliding-blocks, the publication is Journal of Molecular Liquids (2019), 282-289, database is CAplus.

Alkyl thioglycosides are a class of nonionic sugar-based sulfur-containing surfactants and bioreagents. The surfactants 1,2-trans alkyl β-D-thioglucopyranosides with different alkyl chain length (n = 6-12) were stereoselectively prepared by the Helferich method. Their properties including HLB number, logP value, water solubility, foam property, emulsifying property, surface property and thermotropic liquid crystal property were mainly investigated. The results showed that their HLB numbers and water-solubility decreased as the related logP values increased with increasing the alkyl chain length. Alkyl β-D-thioglucosides were already insoluble in water with n = 10. Both β-D-thioglucopyranosides (n = 8, 9) reduced the surface tension of the related aqueous solution to nearly 29 mN.m^-1 at the critical micelle concentration (CMC), they also had excellent foaming ability and foam stability. Nonyl β-D-thioglucopyranoside had good emulsifying properties for both n-octane/water system and toluene/water system. Alkyl β-D-thioglucopyranosides (n = 6-12) were observed to have the thermotropic liquid crystal properties.

Journal of Molecular Liquids published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C22H18O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Wei published the artcileRemote Stereocenter through Amide-Directed, Rhodium-Catalyzed Enantioselective Hydroboration of Unactivated Internal Alkenes, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of the American Chemical Society (2022), 144(29), 13071-13078, database is CAplus and MEDLINE.

Despite the frequent occurrence of γ-branched amines in bioactive mols., the direct catalytic asym. synthesis of this structural motif containing a remote stereocenter remains an important synthetic challenge. Here, authors report an amide-directed, rhodium-catalyzed highly diastereo- and enantioselective hydroboration of unactivated internal alkenes. This method provided facile access to enantioenriched amines containing β,γ-vicinal stereocenters. The application of this strategy to the synthesis of bioactive mols. was demonstrated. Computational studies indicated that migratory insertion of the alkene into rhodium hydride controls the enantioselectivity.

Journal of the American Chemical Society published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C15H21BO2, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Liming published the artcileGelatin enhances 2-keto-L-gulonic acid production based on Ketogulonigenium vulgare genome annotation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Biotechnology (2011), 156(3), 182-187, database is CAplus and MEDLINE.

In the two-step fermentative production of vitamin C, its precursor 2-keto-L-gulonic acid (2-KLG) was synthesized by Ketogulonicigenium vulgare through co-culture with Bacillus megaterium. The reconstruction of the amino acid metabolic pathway through completed genome sequence annotation demonstrated that K. vulgare was deficient in one or more key enzymes in the de novo biosynthesis pathways of eight different amino acids (L-histidine, L-glycine, L-lysine, L-proline, L-threonine, L-methionine, L-leucine, and L-isoleucine). Among them, L-glycine, L-proline, L-threonine, and L-isoleucine play vital roles in K. vulgare growth and 2-KLG production The addition of those amino acids increased the 2-KLG productivity by 20.4%, 17.2%, 17.2%, and 11.8%, resp. Furthermore, food grade gelatin was developed as a substitute for the amino acids to increase the cell concentration, 2-KLG productivity, and L-sorbose consumption rate by 10.2%, 23.4%, and 20.9%, resp. As a result, the fermentation period decreased to 43 h in a 7-L fermentor.

Journal of Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gallaher, Joseph K. published the artcileEvolution of Nonmirror Image Fluorescence Spectra in Conjugated Polymers and Oligomers, Quality Control of 239075-02-6, the publication is Journal of Physical Chemistry Letters (2016), 7(17), 3307-3312, database is CAplus and MEDLINE.

The nonmirror image relation between absorption and fluorescence spectra of conjugated polymers contrasts with most organic chromophores and is widely considered a signature of interchromopohore energy funneling. The authors apply broad-band ultrafast fluorescence spectroscopy to resolve the evolution of fluorescence spectra for dilute solutions of conjugated oligothiophenes, where no energy transfer is possible. Fluorescence spectra evolve from a mirror image of absorption, which lacks vibronic structure, toward a spectrally narrower and vibronically structured species on the hundreds of femtosecond to early picosecond time scale. The authors’ anal. of this fluorescence spectral evolution shows that a broad distribution of torsional conformers is driven to rapidly planarize in the excited state, including in solid films, which is supported by Raman spectroscopy and quantum chem. modeling. The authors’ data have important implications for understanding different energy-transfer regimes that are delineated by structural relaxation.

Journal of Physical Chemistry Letters published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Pin-jian published the artcileEstablishment and optimization of the two-dimensional gel electrophoresis for total protein in Bacillus cereus, Category: alcohols-buliding-blocks, the publication is Junshi Yixue (2012), 36(12), 942-945, 953, database is CAplus.

Objective: To establish a two-dimensional gel electrophoresis (2-DE) of proteome in Bacillus cereus and to explore how B. cereus stimulates the growth of Gluconobacter oxydans to produce 2-keto-L-gulonic acid (2-KLG) after entering the stationary phase. Methods: Different parameters, including protein preparation by different ultrasonic broken time, new type lysis, pH gradient and different sample of B. cereus protein, were used to evaluate the effect of 2-DE of proteins in B. cereus. Results and Conclusion: The clear background and reproducibility of 2-DE are established under conditions of 15 min of ultrasonic broken extraction, selection of protein cleavage I, pH 4-7, 24 cm IPG strips, 80 μg loading volume, and isoelec. focus at 60 V 15 min, and 120 V 6 h.

Junshi Yixue published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Baoyi published the artcileIdentification of aroma-active components in black teas produced by six Chinese tea cultivars in high-latitude region by GC-MS and GC-O analysis, COA of Formula: C10H18O, the publication is European Food Research and Technology (2022), 248(3), 647-657, database is CAplus.

In this study, gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O) anal. was performed to figure out the characteristic aroma compounds of high-latitude black teas and select the suitable cultivar for producing high-aroma black tea. Sensory evaluation revealed that Jinxuan presented an obviously floral aroma and got the highest score, followed by Longjing Changye, Zhongcha 302, Yingshuang, Baihaozao and Huangshan Quntizhong. Furthermore, a total of 135 volatiles were identified in all black teas and 12 components can be used to distinguish different latitude black teas by principal component anal. (PCA). Cluster anal. (CA) showed six samples were divided into two clusters and Jinxuan was classified sep. of cluster B. Based on GC-O anal., 41 volatile organic compounds (VOCs) were found to promote the aroma of high-latitude black teas. Among them, phenylethyl alc., geraniol, linalool, α-ionone, cis-3-hexenyl hexanoate and Me salicylate were the major contributors to the floral fragrance of black tea and accounted for a relative high proportion in Jinxuan, Longjing Changye and Baihaozao. In summary, Jinxuan and Longjing Changye were suitable for producing high-quality black tea in high-latitude area.

European Food Research and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C13H17BrO3, COA of Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Palmer, Ian Arthur published the artcileNovel salicylic acid analogs induce a potent defense response in Arabidopsis, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is International Journal of Molecular Sciences (2019), 20(13), 3356, database is CAplus and MEDLINE.

The master regulator of salicylic acid (SA)-mediated plant defense, NPR1 (NONEXPRESSER OF PR GENES 1) and its paralogs NPR3 and NPR4, act as SA receptors. After the perception of a pathogen, plant cells produce SA in the chloroplast. In the presence of SA, NPR1 protein is reduced from oligomers to monomers, and translocated into the nucleus. Several of these analogs can induce SA-mediated defense and inhibit growth of Pseudomonas syringae in Arabidopsis. These analogs, when sprayed on Arabidopsis, can induce the accumulation of the master regulator of plant defense NPR1. In a yeast two-hybrid system, these analogs can strengthen the interactions among NPR proteins. We demonstrated that these analogs can induce the expression of the defense marker gene PR1. Furthermore, we hypothesized that these SA analogs could be potent tools against the citrus greening pathogen Candidatus liberibacter spp. In fact, our results suggest that the SA analogs we tested using Arabidopsis may also be effective for inducing a defense response in citrus. Several SA analogs consistently strengthened the interactions between citrus NPR1 and NPR3 proteins in a yeast two-hybrid system. In future assays, we plan to test whether these analogs avoid degradation by SA hydroxylases from plant pathogens. In future assays, we plan to test whether these analogs avoid degradation by SA hydroxylases from plant pathogens.

International Journal of Molecular Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts