Month: December 2022

Chong, Curtis R. published the artcileA clinical drug library screen identifies astemizole as an antimalarial agent, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Nature Chemical Biology (2006), 2(8), 415-416, database is CAplus and MEDLINE.

The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery the authors created a library of 2687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.

Nature Chemical Biology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guan, Weixiang published the artcileHighly Dispersed Rh/NbO_x Invoking High Catalytic Performances for the Valorization of Lignin Monophenols and Lignin Oil into Aromatics, HPLC of Formula: 645-56-7, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(9), 3529-3541, database is CAplus.

As fossil fuels are constantly depleted, valorization of lignocellulosic biomass into valuable aromatic compounds is of great significance but exceedingly challenging. In this work, the structure and catalytic performance of various Rh/Nb₂O₅ catalysts were studied in detail via the catalytic hydrodeoxygenation of a representative lignin monophenol compound 2-methoxy-4-propylphenol. The best catalytic performance was obtained over Rh/Nb₂O₅-400 (Nb₂O₅ calcined at 400°C) with an exceptional 98% yield of propylbenzene under 0.5 MPa H₂, which was mainly due to the cooperation between highly dispersed Rh metals and NbO_x species, in which Rh was responsible for dissociation of H₂ and NbO_x for breaking of C-O bonds at the metal-support interface. Besides, the lignin oil obtained in depolymerization of raw pine wood was directly used as the substrate in the catalytic hydrodeoxygenation reaction over the Rh/Nb₂O₅-400 catalyst under 0.5 MPa H₂. Encouragingly, the liquid products were identified and found that lignin oil was completely converted into C₆-C₁₀ hydrocarbons (>99% selectivity) with an 80.1 mol % yield of aromatics The results achieved in this work highlighted that high-value utilization of lignocellulosic biomass feedstocks to produce aromatic chems. and liquid fuels could be achieved over Rh/Nb₂O₅ under a low hydrogen pressure.

ACS Sustainable Chemistry & Engineering published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, HPLC of Formula: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zema, Zelalem Anja published the artcileTuning the CO₂ absorption and physicochemical properties of K⁺ chelated dual functional ionic liquids by changing the structure of primary alkanolamine ligands, Application of 2-Aminobutan-1-ol, the publication is Journal of Molecular Liquids (2021), 117983, database is CAplus.

To reveal the effects of the alkyl substitutions at alpha (α) or beta (β) position adjacent to amino group of primary alkanolamine ligands on CO₂ absorption and physicochem. properties of metal chelated dual functional ionic liquids (DFILs), four DFILs were prepared by reacting potassium imidazole salt (KIm) with alkanolamine ligands, including 2-amino-2-methyl-1-propanol (AMP), 2-amino-1-butanol (AMB), DL-1-amino-2-propanol (DLAMP), and monoethanolamine (MEA). CO₂ absorption behavior and mechanism of DFILs were studied, and d. (ρ), speed of sound (u), and viscosity (η) of DFILs were measured to correlate with the CO₂ absorption performance. DFT calculations were employed to explore the influence of the interactions between K⁺ and alkanolamine on the CO₂ absorption and physicochem. properties of DFILs. The results show that CO₂ capacity at 333.2 K is as follows: [K(AMP)₂][Im] > [K(AMB)₂][Im] > [K(DLAMP)₂][Im] > [K(MEA)₂][Im], indicating that the introduction of alkyl group at α or β position of alkanolamines can enhance CO₂ capacity, and the effect of the α position is more significant than the β position. Both ρ and u follow the order: [K(AMP)₂][Im] < [K(AMB)₂][Im] < [K(DLAMP)₂][Im] < [K(MEA)₂][Im], while η is in the reverse order. Moreover, the saturated CO₂ capacity of DFILs has an approx. linear relation with the thermal expansion coefficient DFT calculations show that the presence of the alkyl group at α or β position of alkanolamines reduces the Mulliken charge of N and O atom, thereby weakening the cation coordination interaction between K⁺ with ligand, resulting in the decrease in ρ and u of DFILs. Moreover, the decrease in the Mulliken charge of N and O atom in alkanolamine leads to the increase of chelated cation-[Im]^– interaction, thereby increasing η of DFILs. Consequently, [K(AMP)₂][Im] exhibits higher CO₂ capacity and good reversibility, due to the fact that CO₂ can react with the chelated cation and [Im]^– simultaneously. The present study provides a new method for effectively regulating the performance of DFILs.

Journal of Molecular Liquids published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C13H15NO6S, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Wenbo published the artcileSynthesis of Multisubstituted Pyrroles from Enolizable Aldehydes and Primary Amines Promoted by Iodine, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Journal of Organic Chemistry (2019), 84(9), 5655-5666, database is CAplus and MEDLINE.

1,2,4-Trisubstituted pyrroles were synthesized from enolizable aliphatic aldehydes and primary aliphatic amines by using iodine as the dual Lewis acid/mild oxidant. In the presence of 3.0 equiv of TBHP, enolizable α,β-unsaturated aldehyde, for example, cocal reacted with aromatic primary amines to form C2-iodized N-arylpyrroles. An acetal-containing pyrrole was successfully prepared from 4-aminobutyraldehyde di-Et acetal, which can be converted easily to 5,6,7,8-tetrahydroindolizine derivatives

Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tu, Ya-lin published the artcileDiscovery of lipoic acid-4-phenyl-1H-pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is RSC Advances (2016), 6(63), 58516-58520, database is CAplus.

A series of lipoic acid (LA) and 4-phenyl-1H-pyrazole hybrids as bifunctional Rho-associated kinase (ROCK) inhibitors were designed, synthesized and evaluated. Compound 15 is identified to be a novel potent bifunctional ROCK inhibitor with antioxidant activity and neuroprotection.

RSC Advances published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C11H12O4, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Xiushang published the artcileSynthesis and characterization of dibenzo[hi,st]ovalene as a highly fluorescent polycyclic aromatic hydrocarbon and its π-extension to circumpyrene, Formula: C8H5F3O3, the publication is Yuki Gosei Kagaku Kyokaishi (2020), 78(11), 1094-1104, database is CAplus.

This account described the synthetic approaches to dibenzo[hi,st]ovalene (DBOV) as a novel PAH with a combination of armchair and zigzag edges and the elucidation of its unique optoelectronic and photophys. properties, such as strong red emission with a fluorescence quantum yield of up to 0.89 and stimulated emission. Furthermore, DBOV demonstrated the so-called fluorescence blinking that enables its application as a fluorophore in single-mol. localization microscopy, which is one of the modern superresoln. fluorescence microscopy methods. The self-assembly of a DBOV derivative bearing two 3,4,5-tris(dodecyloxy)phenyl groups was also investigated, showing the formation of helical columnar stacks. On the other hand, the regioselective bromination of DBOV was achieved, allowing the postsynthetic functionalization and modulation of the optoelectronic properties. Moreover, π-extension of the DBOV at the bay regions led to circumpyrene, the largest circumarene synthesized to date.

Yuki Gosei Kagaku Kyokaishi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C6H5NO, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Jun published the artcileIntestinal toxicity of micro- and nano-particles of foodborne titanium dioxide in juvenile mice: Disorders of gut microbiota-host co-metabolites and intestinal barrier damage, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is Science of the Total Environment (2022), 153279, database is CAplus and MEDLINE.

The wide use of TiO2 particles in food and the high exposure risk to children have prompted research into the health risks of TiO2. We used the microbiome and targeted metabolomics to explore the potential mechanism of intestinal toxicity of foodborne TiO2 micro-/nanoparticles after oral exposure for 28 days in juvenile mice. Results showed that the gut microbiota-including the abundance of Bacteroides, Bifidobacterium, Lactobacillus, and Prevotella-changed dynamically during exposure. The organic inflammatory response was activated, and lipopolysaccharide levels increased. Intestinal toxicity manifested as increased mucosal permeability, impaired intestinal barrier, immune damage, and pathol. changes. The expression of antimicrobial peptides, occludin, and ZO-1 significantly reduced, while that of JNK2 and Src/pSrc increased. Compared with micro-TiO2 particles, the nano-TiO2 particles had strong toxicity. Fecal microbiota transplant confirmed the key role of gut microbiota in intestinal toxicity. The levels of gut microbiota-host co-metabolites, including pyroglutamic acid, L-glutamic acid, phenylacetic acid, and 3-hydroxyphenylacetic acid, changed significantly. Significant changes were observed in the glutathione and propanoate metabolic pathways. There was a significant correlation between the changes in gut microbiota, metabolites, and intestinal cytokine levels. These, together with the intestinal barrier damage signaling pathway, constitute the network mechanism of the intestinal toxicity of TiO2 particles.

Science of the Total Environment published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C11H11NO2, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Haotong published the artcileCharacterization of rheological properties and aging performance of bitumen modified by bio-oil from bamboo charcoal production, COA of Formula: C9H12O, the publication is Journal of Cleaner Production (2022), 130678, database is CAplus.

As a waste stream from charcoal production, the liquid bio-oil has not been properly used, leading to both environmental and economic issues. In this study, this deleterious waste was explored as a promising additive for petroleum-based bitumen. Raw bio-oil was pretreated through distillation under different temperature to remove undesirable components. The resulting medium and heavy bio-oil fractions were blended with petroleum-based bitumen by weight ratios up to 12% to obtain bio-bitumen. The rheol. and aging properties of the bio-bitumen were further evaluated with various test means. The results showed that the addition of bio-oil had softening effect on bitumen. Bio-bitumen performed better brittleness resistance with smaller Glover-Rowe parameters and better fatigue crack resistance at shorter crack length than that of base bitumen. The lower non-recoverable creep compliance of the heavy fraction modified bio-bitumen indicated its better rutting resistance, compared to that of the base bitumen. Characterization of the carbonyl and sulfoxide functional groups in the aged bitumen showed comparative aging performance of the bio-bitumen modified with heavy fraction. The findings of this study indicate that the promising potential of bio-oil heavy fraction to replace petroleum-based bitumen for generating sustainable road paving material.

Journal of Cleaner Production published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Jieming published the artcileNovel Monodisperse PEGtide Dendrons: Design, Fabrication, and Evaluation of Mannose Receptor-Mediated Macrophage Targeting, Category: alcohols-buliding-blocks, the publication is Bioconjugate Chemistry (2013), 24(8), 1332-1344, database is CAplus and MEDLINE.

Novel PEGtide dendrons of generations 1 through 5 (G1.0-5.0) containing alternating discrete poly(ethylene glycol) (dPEG) and amino acid/peptide moieties were designed and developed. To demonstrate their targeting utility as nanocarriers, PEGtide dendrons functionalized with mannose residues were developed and evaluated for macrophage targeting. PEGtide dendrons were synthesized using 9-fluorenylmethyloxycarbonyl (Fmoc) solid-phase peptide synthesis (SPPS) protocols. The N-α-Fmoc-N-ε-(5-carboxyfluorescein)-l-lysine (Fmoc-Lys(5-FAM)-OH) and monodisperse Fmoc-dPEG₆-OH were sequentially coupled to Fmoc-β-Ala-resin to obtain the resin-bound intermediate Fmoc-dPEG₆-Lys(5-FAM)-β-Ala (1). G1.0 dendrons were obtained by sequentially coupling Fmoc-Lys(Fmoc)-OH, Fmoc-β-Ala-OH, and Fmoc-dPEG₆-OH to 1. Dendrons of higher generation, G2.0-5.0, were obtained by repeating the coupling cycles used for the synthesis of G1.0. Dendrons containing eight mannose residues (G3.0-mannose₈) were developed for mannose receptor (MR) mediated macrophage targeting by conjugating α-d-mannopyranosylphenyl isothiocyanate to G3.0 dendrons. In the present study PEGtide dendrons up to G5.0 were synthesized. The mol. weights of the dendrons determined by MALDI-TOF were in agreement with calculated values. The hydrodynamic diameters measured using dynamic light scattering (DLS) ranged from 1 to 8 nm. Cell viability in the presence of G3.0 and G3.0-mannose₈ was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and was found to be statistically indistinguishable from that of untreated cells. G3.0-mannose₈ exhibited 12-fold higher uptake than unmodified G3.0 control dendrons in MR-expressing J774.E murine macrophage-like cells. Uptake was nearly completely inhibited in the presence of 10 mg/mL mannan, a mannose analog and known MR substrate. Confocal microscopy studies demonstrated the presence of significant intracellular punctate fluorescence colocalized with a fluid endocytosis marker with little surface fluorescence in cells incubated with G3.0-mannose₈. No significant cell-associated fluorescence was observed in cells incubated with G3.0 dendrons that did not contain the targeting ligand mannose. The current studies suggest that PEGtide dendrons could be useful as nanocarriers in drug delivery and imaging applications.

Bioconjugate Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Hai-Jun published the artcileChemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols, Product Details of C12H20O6, the publication is Angewandte Chemie, International Edition (2021), 60(38), 20700-20705, database is CAplus and MEDLINE.

Herein a Ni-catalyzed electrochem. driven protocol to afford aryl-alkyl ether bonds through O-arylation of alcs. was depicted. This electrochem. method did not require strong base, exogenous expensive transition metal catalysts (e.g., Ir, Ru), and could easily be scaled up in either a batch or flow setting. Interestingly, e-etherification exhibited an enhanced substrate scope over the mechanistically related photochem. variant as it tolerated tertiary amine functional groups in the alc. nucleophile. with a broad substrate scope in an operationally simple way.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C7H7IN2O, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts