Month: December 2022

Wang, Qiuyue published the artcileLow-Temperature Catalytic Hydrogenolysis of Guaiacol to Phenol over Al-Doped SBA-15 Supported Ni Catalysts, Computed Properties of 645-56-7, the publication is ChemCatChem (2020), 12(19), 4930-4938, database is CAplus.

Selective hydrogenolysis of aromatic carbon-oxygen (C_aryl-O) bonds is a key strategy for the generation of aromatic chems. from lignin. However, this process is usually operated at high temperatures and pressures over hydrogenation catalysts, resulting in a low selectivity for aromatics and an extra consumption of hydrogen. Here, a series of Al-doped SBA-15 mesoporous materials with different Si/Al molar ratios (Al-SBA-15) were prepared via a post-synthesis method using NaAlO₂ as the Al source, and then Al-SBA-15 supported Ni catalysts (Ni/Al-SBA-15) were prepared by a deposition-precipitation method using urea as the hydrolysis reagent. The prepared supports and catalysts were extensively characterized using various techniques such as XRD, N₂ adsorption/desorption, TEM, ²⁷Al NMR, NH₃-TPD, XPS, H₂-TPR, and pyridine-FT-IR, and the catalysts were evaluated in the hydrogenolysis of the C_aryl-O bond in guaiacol and lignin derived compounds under mild conditions. The effects of the Si/Al ratio in catalyst and reaction parameters on guaiacol conversion and product distribution were investigated in detail, associated with solvent effect. The incorporation of Al into the framework of SBA-15 can improve the Lewis acidity and the dispersion of the supported Ni particles and yet modulate the metal-support interactions, which are propitious to the hydrogenolysis of the C_aryl-O bond in guaiacol. The catalyst Ni/Al-SBA-15 with a Si/Al molar ratio of 10 shows the best performance with a guaiacol conversion of 87.4% and a phenol selectivity of 76.9% under the mild conditions conducted, because of its proper acidity, suitable metal-support interactions, and high dispersion of the active species. The present study would stimulate research and development in multi-functional catalysts for the generation of valuable chems. from biomass.

ChemCatChem published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C10H10O2, Computed Properties of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yuhuan published the artcileTailoring diameters of carbon nanofibers with optimal mesopores to remarkably promote hemin adsorption toward ultrasensitive detection of bisphenol A, Application of 4,4′-Sulfonyldiphenol, the publication is Food Chemistry (2022), 132628, database is CAplus and MEDLINE.

Bisphenol A (BPA) is a worldwide used endocrine disrupting chem. that can migration from food containers and packaging, resulting in bioaccumulation of BPA in humans and causing adverse health effects. Porous electrodes have been proved with large surface areas and high sensing abilities in electrochem. detection of BPA. However, how to tailor the pore sizes to further improve the sensing performance is still a great challenge. Here, we delicately tailored the diameters of carbon nanofibers (CNFs) by adjusting electrospinning parameters to have optimal mesopore structure for strong adsorption of hemin that has been demonstrated with high electrocatalytic activity for BPA sensing. Benefiting from the optimal mesopores structure of CNFs and the synergistic effect of hemin and CNFs, this hemin@CNFs based sensor achieves an ultrahigh sensitivity of 40.97μA cm-2μM-1, a low detection limit of 3.1 nM and satisfactory recoveries from 90.2% to 104.2% in the direct detection of BPA in liquors. This work offers a promising sensing platform for ultrasensitive monitoring of BPA.

Food Chemistry published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C5H7NO, Application of 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chu, Weiwei published the artcileEffects of Xuebijing injection combined with ambroxol hydrochloride in the treatment of elderly patients with severe pneumonia on serum DAO, D-Lac, ET levels and arterial blood gas, Application In Synthesis of 23828-92-4, the publication is Guizhou Yiyao (2021), 45(10), 1525-1527, database is CAplus.

Objective To investigate the effect of Xuebijing injection combined with ambroxol hydrochloride in the treatment of elderly patients with severe pneumonia on serum DAO, D-Lac, ET levels and arterial blood gas. Methods A total of 118 elderly patients with severe pneumonia admitted to the department of respiratory medicine of our hospital were selected and divided into the control group and the observation group by random numbers table method, with 59 cases in each group. Both groups were treated with conventional treatment, the control group was given ambroxol hydrochloride on the basis of conventional treatment, and the observation group was given Xuebijing injection on the basis of the control group. Both groups were treated for 14 d. Arterial blood gas, T lymphocyte subsets, intestinal mucosal barrier function and respiratory mechanics indexes were compared between the two groups before and after treatment. Results After treatment, the levels of SaO₂, PaO₂, CD₃⁺, CD₄⁺, CD₄⁺/CD₈⁺ in whole blood of the observation group were higher than before treatment, and the observation group were higher than the control group (P<0.05); Pplat, PIP, mRaw, Paw, PaCO₂, whole blood CD8⁺, serum DAO, D-Lac and ET levels were lower than before treatment, the observation group were lower than the control group (P<0.05). Conclusion Xuebijing injection combined with ambroxol hydrochloride in the treatment of elderly patients with severe pneumonia can reduce serum DAO, D-Lac, ET levels, improve intestinal mucosal barrier function and arterial blood gas, respiratory mechanics indexes, with accurately effect.

Guizhou Yiyao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Mingfeng published the artcileDexmedetomidine prevented Hemabate adverse reactions in cesarean section, Related Products of alcohols-buliding-blocks, the publication is Jiangsu Yiyao (2015), 41(21), 2597-2598, database is CAplus.

Dexmedetomidine prevented Hemabate adverse reactions in cesarean section was studied. After Hemabate in cesarean section, D group treated dexmedetomidine and C group was control group. BP, HR, RR, SpO2 were recoreded at room (T0), before Hemabeta (T1), after drug 10 min (T2). At T2, BP and HR were higher than T0, SpO2 of group D change was small, SpO2 of group C decreased. Adverse reaction of group D was lower than group C. Dexmedetomidine reduced Hemabate adverse reactions in cesarean section.

Jiangsu Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C9H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xia, Xi published the artcileSynthesis of diosgenyl quaternary ammonium derivatives and their antitumor activity, Computed Properties of 622-40-2, the publication is Steroids (2021), 108774, database is CAplus and MEDLINE.

Giosgenin is a naturally steroidal saponin exhibiting a variety of biol. activities including antitumor ones. A series of novel diosgenyl quaternary ammonium derivatives were designed and synthesized to develop potential anti-tumor agents in our research. All novel derivatives were characterized by ¹H NMR, ¹³C NMR and HR-MS, and evaluated for their in vitro anti-proliferative activities using MTT assay. The human cancer cell lines were A549 (human lung cancer cell), H1975 (human lung adenocarcinoma cell), A431 (human skin squamous cell carcinoma), HCT-116 (human colorectal adenocarcinoma cell), Aspc-1 (human metastatic pancreatic cancer cell), Ramos (human B lymphoma cell), HBE (human bronchial epithelioid cell) and LO2 (human normal hepatocyte).

Steroids published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H13NO3, Computed Properties of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Yuan-hui published the artcileMethods for synthesis of trifluoromethylsalicylic acid and its intermediate, HPLC of Formula: 328-90-5, the publication is Zhejiang Huagong (2014), 45(1), 7-10, database is CAplus.

A review. 4-(Trifluoromethyl) salicylic acid and m-trifluoromethylphenol are critical intermediate and raw material in the field of pesticide, medicine and others. This article summarizes the methods for synthesis of 4-(trifluoromethyl) salicylic acid, also mainly introduces the synthetic methods of m-trifluoromethylphenol, the synthetic material of 4-(trifluoromethyl) salicylic acid, including the diazotization and hydrolysis of trifluoromethylaniline, the hydroxylation, the trifluoromethylation, the catalytic hydrogenation, the oxidation of benzotrifluoride with hydrogen peroxide, and so on.

Zhejiang Huagong published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C12H25Br, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cen, Xufeng published the artcilePharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model, Formula: C18H14BrNO5S2, the publication is Nature Communications (2020), 11(1), 5731, database is CAplus and MEDLINE.

There is increasing evidence that inducing neuronal mitophagy can be used as a therapeutic intervention for Alzheimer’s disease. Here, we screen a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy activator. UMI-77 is an established BH3-mimetic for MCL-1 and was developed to induce apoptosis in cancer cells. We found that at sub-LDs, UMI-77 potently induces mitophagy, independent of apoptosis. Our mechanistic studies discovered that MCL-1 is a mitophagy receptor and directly binds to LC3A. Finally, we found that UMI-77 can induce mitophagy in vivo and that it effectively reverses mol. and behavioral phenotypes in the APP/PS1 mouse model of Alzheimer’s disease. Our findings shed light on the mechanisms of mitophagy, reveal that MCL-1 is a mitophagy receptor that can be targeted to induce mitophagy, and identify MCL-1 as a drug target for therapeutic intervention in Alzheimer’s disease.

Nature Communications published new progress about 518303-20-3. 518303-20-3 belongs to alcohols-buliding-blocks, auxiliary class Apoptosis,Bcl-2, name is 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, and the molecular formula is C18H14BrNO5S2, Formula: C18H14BrNO5S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Yugang published the artcileSynthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase, Application In Synthesis of 57044-25-4, the publication is Bioorganic & Medicinal Chemistry (2015), 23(20), 6632-6640, database is CAplus and MEDLINE.

Compounds I.HCl (ND-322) and II (ND-364) are potent selective inhibitors for gelatinases, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9). However, both of them are racemates. Herein the authors report facile synthesis of optically active (R)- and (S)-enantiomers of compounds I.HCl and II. And the sulfonyl of II was transformed to sulfinyl to obtain four epimeric mixtures All synthesized thiirane-based compounds were evaluated in MMP2 and MMP9 inhibitory assays. The results indicated that the configuration of thiirane moiety had little effects on gelatinase inhibition, but the substitution of sulfinyl for sulfonyl was detrimental to gelatinase inhibition. Besides, all target compounds exhibited no inhibition against other two Zn²⁺ dependent metalloproteases, aminopeptidase N (APN) and histone deacetylases (HDACs), which confirmed the unique Zn²⁺ chelation mechanism of thiirane moiety against gelatinases.

Bioorganic & Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C18H24N6O6S4, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Tianhui published the artcileSynthesis of a phenylboronic ester-linked PEG-lipid conjugate for ROS-responsive drug delivery, Computed Properties of 25240-59-9, the publication is Polymer Chemistry (2017), 8(40), 6209-6216, database is CAplus.

Stimuli-responsive drug delivery systems (DDSs) offering spatial-temporal and dosage controlled transport of drugs in vivo have attracted much attention for anticancer drug delivery. In the present work, a kind of phenylboronic ester-linked PEG-lipid conjugate was designed and synthesized for H₂O₂-responsive drug delivery. Firstly, a chain-end alkynyl functionalized methoxy poly(ethylene glycol) with a phenylboronic pinacol ester linker was synthesized via a classical Passerini reaction of carboxyl functionalized methoxy poly(ethylene glycol)₂₀₀₀ (mPEG_2k-COOH), 4-formylphenylboronic pinacol ester and propargyl isocyanoacetamide. The obtained polymer was denoted as mPEG_2k-PBPE-alkynyl. Then, the oxidation-responsive cleavage of the phenylboronic pinacol ester linker between the mPEG_2k-COOH and alkynyl chain-end was verified by in situ¹H NMR and mass spectra characterization. Furthermore, the amphiphilic PEG-lipid conjugate was synthesized by the Cu(I)-catalyzed click reaction of mPEG_2k-PBPE-alkynyl and 3-azido-1,2-propanediol distearate (N₃-DSA). The resultant mPEG_2k-PBPE-DSA could self-assemble into stable micelles in aqueous media. Nile red was used as the model drug and was loaded into the micelles. The obtained drug loaded micelles exhibited a typical H₂O₂-responsive drug release behavior and could be effectively internalized by MCF-7 cells. In addition, the synthesized mPEG_2k-PBPE-DSA was tested to be nontoxic towards RAW264.7 cells. Therefore, this biocompatible mPEG_2k-PBPE-DSA conjugate would be promising for applications in ROS-responsive drug delivery.

Polymer Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C10H10O2, Computed Properties of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Dawei published the artcileAn efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO₂ under microwave irradiation, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Monatshefte fuer Chemie (2016), 147(9), 1605-1614, database is CAplus.

An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, Et acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86-96 %), and were characterized by HRMS, FTIR, ¹H NMR, and ¹³C NMR spectroscopy. Solid support SiO₂ possesses favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO₂. Moreover, the crystal structure of compound di-Et 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented.

Monatshefte fuer Chemie published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C6H6N2O, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts