Month: December 2022

Ferrit, Monica published the artcileThe study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is European Journal of Pharmaceutical Sciences (2007), 31(3-4), 211-220, database is CAplus and MEDLINE.

In this research, the effects of micellar systems on alk. hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) were found to be dependant upon the surfactant charge within the micelle. In cationic micelles, there is a catalytic effect at low concentrations of surfactant. However, this reaction is inhibited at higher surfactant concentrations In anionic micelles, a catalytic effect occurs, while in zwitterionic and non-ionic micelles there is an inhibitory effect. Such reactions are attributable to changes in reactants on the micellar surface, or to the fact that both reactants are found in different microenvironments. The pseudophase (PS) and ion-exchange (PPIE) models were found to be consistent with the exptl. result. Furthermore, the association constants for both drugs could be determined together with micellar rate constants in heterogeneous media.

European Journal of Pharmaceutical Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ferrit, M. published the artcileEffects of long-chains of zwitterionic micelles on binding constants of triflusal and acetylsalicylic acid, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2009), 345(1-3), 26-30, database is CAplus.

A spectrophotometric study of the reaction of the alk. hydrolysis of triflusal (TFL) and acetylsalicylic acid (ASA) in the presence of zwitterionic micelles was carried out, with the objective of determining the effects of the hydrophobic and electrostatic interactions on the micellar union of both drugs. A series of zwitterionic surfactants of alkyldimethylammonio propanesulfonate (SB3-n) was used: decyldimethylammonio propanesulfonate (SB3-10), tetradecyldimethylammonio propanesulfonate (SB3-14), hexadecyldimethylammonio propanesulfonate (SB3-16). This reaction is inhibited at higher surfactant concentrations The exptl. data has been processed according to the micellar pseudophase model. The values of the binding constants of both drugs in the micelle (K _S) determine the importance of the hydrophobic and electrostatic interactions in the micelle solubilization of both drugs.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paioti, Paulo H. S. published the artcileCatalytic Enantioselective Boryl and Silyl Substitution with Trifluoromethyl Alkenes: Scope, Utility, and Mechanistic Nuances of Cu-F β-Elimination, Application In Synthesis of 83706-94-9, the publication is Journal of the American Chemical Society (2019), 141(50), 19917-19934, database is CAplus and MEDLINE.

Catalytic enantioselective methods are introduced that allow access to a variety of allyl boronates and silanes that contain a difluoroalkene unit; the resulting products may be used for the preparation of organofluorine compounds in high enantiomeric purity. Also, a number of key mechanistic aspects of the transformations were studied and analyzed. Thus, 1st, an NHC-Cu-catalyzed method for boryl substitution with F₃C-substituted alkenes is introduced. These processes, unlike the previously reported strategies, are applicable to alkyl as well as aryl substituted substrates, afford allyl boronates bearing a difluoroalkene moiety (up to 98% yield and 95:5 er). Second, the corresponding silyl substitutions, the 1st reported cases of their kind, are presented (up to 94% yield and 97:3 er). Third, exptl. and computational (DFT) studies are described that shed light on key mechanistic aspects of the catalytic processes. Evidence (x-ray structures of Cu-alkyl intermediates and kinetic studies) is put forth illustrating that the initial Cu-boryl and Cu-silyl addition is significantly faster than the ensuing Cu-F elimination, and that the latter step can be facilitated by either a mild Lewis acid (e.g., a Li or Na cation) or a nucleophilic promoter (e.g., an alkoxide). These findings together with DFT studies demonstrate that Cu-F β-elimination probably proceeds with anti-stereochem. Representative cases of ways through which the new mechanistic understanding may be used to rationalize previously disclosed findings, significantly improve a transformation, or develop new diastereo- and enantioselective catalytic methods are provided. For example, an explanation is provided regarding why bisphosphine-Cu complexes do not efficiently promote boryl substitutions with aryl-substituted substrates, but the corresponding silyl substitutions are facile, and how the size of a ligand can impact regioselectivity and efficiency.

Journal of the American Chemical Society published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Application In Synthesis of 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bagutski, Viktor published the artcileMechanistic studies into amine-mediated electrophilic arene borylation and its application in MIDA boronate synthesis, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Journal of the American Chemical Society (2013), 135(1), 474-487, database is CAplus and MEDLINE.

Direct electrophilic borylation using Y₂BCl (Y₂ = Cl₂ or o-catecholato) with equimolar AlCl₃ and a tertiary amine has been applied to a wide range of arenes and heteroarenes, yielding aryl and heterocyclic boronates in a regioselective way. In situ functionalization of the ArBCl₂ products is possible with Me₃SiOCOCH₂NMeCH₂CO₂SiMe₃ (TMS₂MIDA), to afford bench-stable and easily isolable MIDA-boronates in moderate to good yields; pinacol and neopentylglycol esters were also prepared According to a combined exptl. and computational study, the borylation of activated arenes at 20° proceeds through an S_EAr mechanism with borenium cations, [Y₂B(amine)]⁺, the key electrophiles. For catecholato-borocations, two amine dependent reaction pathways were identified: with [CatB(NEt₃)]⁺, an addnl. base is necessary to accomplish rapid borylation by deprotonation of the borylated arenium cation (σ complex), which otherwise would rather decompose to the starting materials than liberate the free amine to effect deprotonation. Apart from amines, the addnl. base may also be the arene itself when it is sufficiently basic (e.g., N-Me-indole). When the amine component of the borocation is less nucleophilic (e.g., 2,6-lutidine), no addnl. base is required due to more facile amine dissociation from the boron center in the borylated arenium cation intermediate. Borenium cations do not borylate poorly activated arenes (e.g., toluene) even at high temperatures; instead, the key electrophile in this case involves the product from interaction of AlCl₃ with Y₂BCl. When an extremely bulky amine is used, borylation again does not proceed via a borenium cation; instead, a number of mechanisms are feasible including via a boron electrophile generated by coordination of AlCl₃ to Y₂BCl, or by initial (heteroarene)AlCl₃ adduct formation followed by deprotonation and transmetalation.

Journal of the American Chemical Society published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Llama, Emilio F. published the artcileSynthesis and antinociceptive activity of 9-phenyl-9-alkoxy or 9-acyloxy derivatives of xanthene, thioxanthene and acridine, Category: alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (1989), 24(4), 391-6, database is CAplus.

9-Phenyl-9-(alkoxy or acyloxy) derivatives of xanthene, thioxanthene, and acridine I (X = O, S, NH, NMe; R = Me, Et, Ac, COEt) are prepared by PhLi or PhMgBr addition to xanthone, thioxanthone or acridone followed by derivatization of the resultant hydroxy group. I (X = O, S; R = COEt) demonstrated potent antinociceptive activity.

European Journal of Medicinal Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arvand, Majid published the artcileElectrochemical study on the natural and chemical preservatives antibacterial effect against S. aureus PTCC 1112 and its determination at low levels, Computed Properties of 70445-33-9, the publication is Journal of the Iranian Chemical Society (2020), 17(1), 195-203, database is CAplus.

Pathogen microorganisms detection, such as Staphylococcus aureus (S. aureus), is so critical because it can be dangerous for public health. In this research, we have tried to introduce a simple and sensitive modified biosensor by multiwalled carbon nanotubes (MWCNTs) for S. aureus PTCC 1112 detection which was inoculated in PBS (pH 7.4). The pulsed amperometric detection (PAD) method showed that by increasing the concentration of S. aureus suspension, the related current will increase linearly in a dynamic range of 1.88 × 10⁷-3.00 × 10⁸ cfu mL^-1, with a detection limit of 4.85 × 10⁵ cfu mL^-1. The antibacterial effect of three herbal essential oils, tea, bergamot and lemon, and three common chem. cosmetic preservatives, euxyl (phenoxyethanol:ethylhexylglycerin), benzyl alc. and benzalib (alkyl benzyl di-Me ammonium chloride), was compared by electrochem. and biol. methods. The results based on disk diffusion agar method and PAD revealed that this biosensor can be used for comparing the effectiveness of natural and chem. preservatives to inhibit the growth of bacteria. By adding the essential oils into the S. aureus suspension in PBS, the related currents were largely decreased about 65.83% (green tea), 80.49% (bergamot) and 93.30% (lemon) that are in agreement with the inhibition zones of microbial test and comparable to chem. preservatives of euxyl (73.52%), benzyl alc. (90.65%) and benzalib (93.81%). It demonstrates the comparative antibacterial effect of these essential oils vs. chem. preservatives and the ability of MWCNTs/GCE to detect the presence or absence of S. aureus in a few minutes.

Journal of the Iranian Chemical Society published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bozkus, Tugba Nigar published the artcileChemical characterization of water and ethanolic extracts of Turkish propolis by HPLC-DAD and GC-MS, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Journal of Liquid Chromatography & Related Technologies (2021), 44(1-2), 77-86, database is CAplus.

This study aims to determine the qual. and quant. contents of Turkish propolis collected from various regions of Turkey using high-performance liquid chromatog. with the diode-array detector (HPLC-DAD) and gas chromatog.-mass spectrometry (GC-MS) in water and ethanolic extracts In HPLC-DAD analyses, it was determined that water extract of Turkish propolis contains phenolic acids such as caffeic acid (204.00 μg/mL), trans-cinnamic, chlorogenic, and caffeoylquinic acids, responsible for its antioxidant activity; whereas, the ethanolic extract of Turkish propolis contains chrysin (641.33 μg/mL), caffeic acid phenethyl ester (630.67 μg/mL), pinocembrin (572.67 μg/mL), galangin (534.11 μg/mL), naringenin (372.39 μg/mL), and also kaempferol, trans-cinnamic acid, caffeic acid, myricetin, and quercetin. GC-MS analyses showed that ethanolic extract of propolis contains caffeic acid by Rtx-1 column and the water extract of propolis contains quinic acid and ferulic acid by Rtx-5ms column. Various sugar derivatives were detected by both columns in water and ethanolic extracts of Turkish propolis. HPLC-DAD can be considered as a more effective method than GC-MS for the chem. characterization of propolis. Water extract of Turkish propolis can be a good source of raw materials for various sectors, as it is both cheap and has less health risk than ethanolic extract, and is suitable for human use.

Journal of Liquid Chromatography & Related Technologies published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ait Amiri, Sabrina published the artcileIdentification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation, SDS of cas: 86-48-6, the publication is Journal of Medicinal Chemistry (2021), 64(9), 5667-5688, database is CAplus and MEDLINE.

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive impairments. Kallikrein-related peptidase (KLK)6 is the most abundant serine protease secreted in the CNS, mainly by oligodendrocytes, the myelin-producing cells of the CNS, and KLK6 is assumed to be a robust biomarker of MS, since it is highly increased in the cerebrospinal fluid (CSF) of MS patients. Here, we report the design and biol. evaluation of KLK6′s low-mol.-weight inhibitors, para-aminobenzyl derivatives Interestingly, selected hit compounds were selective of the KLK6 proteolytic network encompassing KLK1 and plasmin that also participate in the development of MS physiopathol. Moreover, hits were found noncytotoxic on primary cultures of murine neurons and oligodendrocyte precursor cells (OPCs). Among them, two compounds (32 and 42) were shown to promote the differentiation of OPCs into mature oligodendrocytes in vitro constituting thus emerging leads for the development of regenerative therapies.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pothakos, Vasileios published the artcileFermentation Titer Optimization and Impact on Energy and Water Consumption during Downstream Processing, Product Details of C6H10O7, the publication is Chemical Engineering & Technology (2018), 41(12), 2358-2365, database is CAplus and MEDLINE.

A common focus of fermentation process optimization is the product titer. Different strategies to boost fermentation titer target whole-cell biocatalyst selection, process control, and medium composition Working at higher product concentrations reduces the water that needs to be removed in the case of aqueous systems and, therefore, lowers the cost of downstream separation and purification Different approaches to achieve higher titer in fermentation are examined Energy and water consumption data collected from different Cargill fermentation plants, i.e., ethanol, lactic acid, and 2-keto-L-gulonic acid, confirm that improvements in fermentation titer play a decisive role in downstream economics and environmental footprint.

Chemical Engineering & Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajasekariah, G. R. published the artcileResponse of preadult Necator americanus to some known anthelminthics in hamsters, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Chemotherapy (Basel, Switzerland) (1986), 32(1), 75-82, database is CAplus and MEDLINE.

Hamsters infected with laboratory-adapted preadult N. americanus were dosed with 6 reference anthelmintics; their efficacy was measured in terms of percentage cure of infected animals as well as percentage worm reduction following treatment. Mebendazole and pyrantel were equally effective in this system. Other anthelmintics, including the anti-hookworm compound, bephenium hydroxynaphthoate, were less effective. The comparative results revealed that the N. americanus model is sensitive and reliable for identifying and characterizing new anti-parasite preparations

Chemotherapy (Basel, Switzerland) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts