Month: December 2022

Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors was written by Aronov, Alex M.;Baker, Christopher;Bemis, Guy W.;Cao, Jingrong;Chen, Guanjing;Ford, Pamella J.;Germann, Ursula A.;Green, Jeremy;Hale, Michael R.;Jacobs, Marc;Janetka, James W.;Maltais, Francois;Martinez-Botella, Gabriel;Namchuk, Mark N.;Straub, Judy;Tang, Qing;Xie, Xiaoling. And the article was included in Journal of Medicinal Chemistry in 2007.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol The following contents are mentioned in the article:

The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p(I), a potent and selective inhibitor of ERK. This study involved multiple reactions and reactants, such as (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol).

(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rh(III)-Catalyzed three-component C-H functionalization reaction with vinylene carbonate: Late-stage C-H esterification of indole derivatives was written by Li, Bin-Shi;Guo, Huai-Xuan;Sun, Wei;Sun, Meng. And the article was included in Tetrahedron Letters in 2022.Name: 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

An efficient and robust Rh(III)-catalyzed three-component C-H esterification reaction of indole derivatives with vinylene carbonate to access indolyl acetates was developed. This protocol exhibited high efficiency, good yields and excellent functional group tolerance. Significantly, this method provided a powerful approach for the late-stage modification of indole-based substrates and natural alcs. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Name: 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Silver-catalyzed remote Csp³-H functionalization of aliphatic alcohols was written by Zhu, Yuchao;Huang, Kaimeng;Pan, Jun;Qiu, Xu;Luo, Xiao;Qin, Qixue;Wei, Jialiang;Wen, Xiaojin;Zhang, Lizhi;Jiao, Ning. And the article was included in Nature Communications in 2018.HPLC of Formula: 106-21-8 The following contents are mentioned in the article:

Herein, a silver-catalyzed δ-selective Csp³-H bond functionalization of abundant and inexpensive aliphatic alcs is reported. Valuable oximonitrile substituted alcs. I (R = Et, n-Bu, Bn, etc.) are easily obtained by using well-designed sulfonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C-C bond formation of simple alkanols. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8HPLC of Formula: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Publication was written by Anonymous. And the article was included in Research Disclosure in 1999.Recommanded Product: 115-84-4 The following contents are mentioned in the article:

Environmental concerns have resulted in reduced sulfur content in diesel fuels. As a consequence of hydrotreating processes also the amount of lubricating compounds has decreased. Poor lubricity can lead to wear problems especially in rotary pumps. The wear can be prevented by providing lubricity additives in the fuel. Reformulated diesel fuel of the winter grade characteristics was used in this study. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Recommanded Product: 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study on boiling water resistance of polyester resin for TGIC powder coating was written by Luo, Yi;Xie, Jing;Li, Yong;Liu, Liang;Shi, Yuan-tang;Chen, Li. And the article was included in Xiandai Tuliao Yu Tuzhuang in 2017.Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

The effect of different amount of 2-butyl-2-ethyl-1,3-propanediol (BEPD), isophthalic acid (PIA) and additives on the boiling water resistance, mech. behavior of powder coatings were discussed. The boiling water resistance was analyzed with contact angle and scanning electron microscope. The results showed that the increasing BEPD and PIA was helpful to improve the water boiling resistance performance. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gas chromatography of insect repellents was written by Acree, Fred Jr.;Beroza, C. Morton. And the article was included in Journal of Economic Entomology in 1962.HPLC of Formula: 115-84-4 The following contents are mentioned in the article:

Thirteen insect repellents (aromatic amides, esters, and branched chain diols) were separated on either Carbowax 20 M, Silicone 550, or Tide. A column of 15% Carbowax 20 M on acid-washed Columpak at a temperature of 246° was most satisfactory. Approx. 0.2 mg. of each repellent was sufficient for an analysis in an instrument using a thermal conductivity detector and a recorder having a 2.5-my. full span. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4HPLC of Formula: 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metal-Free, Visible-Light-Induced Selective C-C Bond Cleavage of Cycloalkanones with Molecular Oxygen was written by Xin, Hong;Duan, Xin-Hua;Liu, Le;Guo, Li-Na. And the article was included in Chemistry – A European Journal in 2020.COA of Formula: C10H22O The following contents are mentioned in the article:

A metal-free, visible-light-induced oxidative C-C bond cleavage of cycloketones with mol. oxygen is described. Cooperative Bronsted-acid catalysis and photocatalysis enabled selective C-C bond cleavage of cycloketones to generate an array of γ, δ- and ε-keto esters under very mild conditions. Mechanistic studies indicate that singlet mol. oxygen (¹O₂) is responsible for this transformation. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8COA of Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A comparison of different herbicides applied at planting, emergence, and post-emergence on field corn was written by Marshall, E. R.;Loeffler, G.. And the article was included in Proceedings of the Northeastern Weed Control Conference in 1954.Product Details of 115-84-4 The following contents are mentioned in the article:

The low volatile esters of 2,4-D, Sinox PE (alkanolamine salt of dinitro-ο-sec-butylphenol), Crag Herbicide I (2,4-dichlorophenoxy Et sulfate), and Bu ester of MCP were most effective when applied at the time of emergence of the field corn. Amino triazole and Dalapon (CH₃CCl₂COOH) gave grass control but caused injury to the corn when used as directional sprays in post-emergence applications. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Product Details of 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

N,N-Dimethylformamide-stabilized ruthenium nanoparticle catalyst for β-alkylated dimer alcohol formation via Guerbet reaction of primary alcohols was written by Nagata, Tatsuki;Okada, Kanji;Kondo, Ryota;Toyao, Takashi;Shimizu, Ken-ichi;Suzuki, Takeyuki;Obora, Yasushi. And the article was included in RSC Advances in 2022.Formula: C10H22O The following contents are mentioned in the article:

N,N-Dimethylformamide-stabilized Ru nanoparticles (NPs) provided a highly efficient catalyst for the Guerbet reaction of primary alcs. DMF-modified Ru NPs were synthesized, and characterized by transition electron microscopy, and X-ray absorption spectroscopy, XPS, and Fourier-transform IR spectroscopy. The Ru NP catalyst was highly durable during catalytic reactions under external additive/solvent-free conditions. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Transdermal Delivery of Anionic Phospholipid Nanoparticles Containing Fullerene was written by Uchida, Noriyuki;Yanagi, Masayoshi;Hamada, Hiroki. And the article was included in Natural Product Communications in 2022.HPLC of Formula: 923-61-5 The following contents are mentioned in the article:

In this work, we prepared a transparent dispersion of fullerene nanoparticles by sonication with anionic phospholipids of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) with fluorescently NBD-labeled 1,2-dipalmitoyl-sn-glycero-3-phosphorylethanolamine (DPPE). Upon incubation of the fullerene nanoparticles with a rat skin, the nanoparticles successfully penetrated the stratum corneum and reached the epidermis. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5HPLC of Formula: 923-61-5).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 923-61-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts