Month: December 2022

Lu, Yan published the artcileStructural characteristics and anticancer/antioxidant activities of a novel polysaccharide from Trichoderma kanganensis, Formula: C6H12O6, the main research area is Trichoderma kanganensis anticancer antioxidant polysaccharide structure; Anticancer activity; Antioxidant activity; Polysaccharide; Structural characteristics; Trichoderma kanganensis.

A novel water-soluble polysaccharide designated as TPS was isolated from the fermentation mycelia of Trichoderma kanganensis. TPS had a weight-average mol. mass of 3.074 × 105 Da, and the monosaccharide composition was consisted of Man (45.5%), GlcA (5.5%), Glc (10%), and Gal (39%). The major backbone of TPS was →6-α-D-Galp-1→5-β-D-Manf-1→5,6-β-D-Manf-1→5,6-β-D-Manf-1→, and the side chains are α-D-Glcp-1→4-α-D-Glcp-1→, β-D-Galf-1→, and α-D-Glcp-1→. In addition, we demonstrated that TPS was non-toxic in normal cells (LO2 cells) and inhibited the proliferation of mouse colon cells (CT26 cells). TPS also showed free radical scavenging activity against hydrogen peroxide. Overall, these results suggested that TPS from Trichoderma kanganensis may have potential application in biomedical fields.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Chiyu published the artcileSynthesis and Evaluation of Aminothiazole Derivatives as Hedgehog Pathway Inhibitors, HPLC of Formula: 22483-09-6, the main research area is aminothiazole Hedgehog inhibitor antitumor neoplasm; Gli1, hedgehog signaling; Smo; aminothiazole; benzimidazole; cytotoxicity; synthesis.

A series of aminothiazole derivatives bearing the benzimidazole moiety were synthesized and evaluated in Gli luciferase reporter assays. Lead optimization led to the discovery of potent hedgehog pathway antagonist (I) (2-[3-(1H-benzimidazol-2-yl)-4-chloroanilino]-N-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxamide), with IC50 values in nanomolar range. The mol. basis ascribed to hindering sonic hedgehog-driven Smoothened (Smo) localization within the primary cilium (PC). Moreover, compound I inhibited Gli1 mRNA expression in mutant Smo cell line and displayed moderate cytotoxicity against DAOY cancer cell.

Chemistry & Biodiversity published new progress about Antitumor agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murthy, Sushma S. published the artcileMolecular docking studies of phytocompounds with transcriptional factors in hepatocellular carcinoma, Category: alcohols-buliding-blocks, the main research area is mol docking anticancer agent hepatocellular carcinoma.

Hepatocellular carcinoma is one of the majorly categorized forms of human malignancy and is the prime cause of cancer-related mortality. Transcription factors and co-factors play an important role in the cellular process performing as key regulators in the normal cell and in the cancerous cell. The present study investigates the potential interaction between the potent phytocompounds and key transcriptional factors involved in hepatocellular carcinoma (HCC) by using mol. docking studies. In the area of drug designing and development, computational modeling and simulation play a significant role. Screening of potent phytocompounds against targets by means of conventional methods is tedious and requires more time when compared to computational modeling and simulation studies. In the present study, the application of computational screening of phytocompounds against transcriptional factors was effectively used to determine their binding strength with the pythocompounds. Ten potential phytocompounds linalool, p-cymene, pelargonidin, harpagoside, 1, 8-cineole, afzelin, ginkgolide B, theophylline, bromelain and isoborneol and five transcription factors p53, AP-1, c-Myc, β-catenin and HIF-1α were selected for docking studies. The 3D structures of both phytocompounds and transcription factors were obtained from Pubchem and PDB databases resp. Docking studies were carried out by using AutoDockVina. On evaluating the docking results, it was found that phytocompounds Harpagoside, Bromelain and Afzelin showed strong binding affinity against their targets. These phytocompounds showed the binding free energy more than 6 kcal/mol and RMSD value between 4-7 A0 with targets and can be potential ligands against the selected targets for further mol. investigations.

Rasayan Journal of Chemistry published new progress about Antitumor agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hisama, Masayoshi published the artcileSuppression of mutagens-induced SOS response by phytoncide solution using Salmonella typhimurium TA1535/pSK1002 umu test, Computed Properties of 42822-86-6, the main research area is antimutagen phytoncide solution SOS response Salmonella umu gene.

Four types of phytoncide solution (A-Type, AB-Type, D-Type and G-Type) were evaluated as anti-mutagenic agents with suppressive effects on the SOS-inducing activity of the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (furylfuramide) using Salmonella typhimurium TA1535/pSK1002 umu test. The A-Type, AB-Type, D-Type and G-Type of phytoncide solution suppressed the SOS-inducing activity on furylfuramide at a concentration of 100 μg/mL by 86.1%, 74.7%, 69.5% and 55.4%, resp., and the ID50 (50% ID) values were 9.0 μg/mL, 22.5 μg/mL, 36.0 μg/mL and 72.8 μg/mL. They also showed the suppression of SOS-inducing activity against other chem. mutagens, such as 4-nitroquinoline 1-oxide (4NQO) and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), which do not require liver metabolizing enzymes, and against 2-aminoanthracene (2AA) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which require these enzymes, and against UV irradiation, which is a well known phys. mutagen. In the search for the component-activity relationship, the A-Type of phytoncide solution suppressed the SOS-inducing activity greater than the other types of phytoncide solution for furylfuramide, 4NQO and MNNG. However, in case of 2AA and Trp-P-1, the D-Type of phytoncide solution was most effective in suppressing the SOS-inducing activity in the umu test. From these results, the four types of phytoncide solutions showed the suppressive effect of SOS-inducing activity against chem. and phys. mutagens.

Journal of Oleo Science published new progress about Antitumor agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Computed Properties of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Delcros, Jean-Guy published the artcileEffect of Spermine Conjugation on the Cytotoxicity and Cellular Transport of Acridine, Computed Properties of 87905-98-4, the main research area is acridine spermidine conjugate preparation transport antitumor.

Polyamines are believed to be potent vectors for the selective delivery of chemotherapeutic agents into cancer cells. In this paper, we report the effect of spermine conjugation on the cytotoxic and transport properties of acridine. Six derivatives, composed of a spermine chain attached at its N1 position to an acridine via an aliphatic chain, were synthesized. The aliphatic linker, comprised of 3-5 methylene units, was connected to the position-9 of the heterocycle through either an amide or an amine linkage. Independently of their architecture, all ligands showed a high affinity for DNA binding but a limited DNA sequence selectivity. In a whole cell assay with L1210 and Chinese hamster ovary (CHO) cells, the aminoacridines (IC50 values around 2 μM) were more potent than the amidoacridines (IC50 values between 20 and 40 μM). This was related to a less efficient transport for the latter. As determined from competitive uptake studies with [14C]spermidine, all conjugates had a high affinity for the polyamine transport system (PTS). However, on the basis of competitive studies with an excess of spermidine and on the differential effect on cell growth and accumulation in CHO and in the mutant PTS deficient CHO-MG cells, the accumulation of the conjugates through the PTS was poor but still more efficient for the aminoacridines. α-Difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, which induces an up-regulation of the activity of the PTS, enhanced accumulation of all acridine conjugates through the PTS and had a synergistic effect on the potency of the acridine conjugates to inhibit cell growth. Despite their high affinity for the PTS, the low amount of derivatives transiting through the PTS is likely to be related to their ability to repress rapidly and efficiently the activity of the PTS and, consequently, to inhibit their own uptake via this system.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Computed Properties of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qian, Yuyi published the artcileHighly Tumor-Specific and Long-Acting Iodine-131 Microbeads for Enhanced Treatment of Hepatocellular Carcinoma with Low-Dose Radio-Chemoembolization, Synthetic Route of 22483-09-6, the main research area is iodine 131 microbead transarterial radioembolization liver carcinoma; doxorubicin; hepatocellular carcinoma; iodine-131; transarterial radioembolization; tumor retention.

Transarterial radioembolization (TARE) is considered the standard treatment for intermediate-stage hepatocellular carcinoma (HCC). Iodine-131 (131I)-labeled lipiodol TARE is an effective treatment for HCC but has been withdrawn due to its poor retention in tumor lesions and significant distribution in normal tissues with severe side effects. In this work, a highly tumor-specific 131I-TARE agent with long-time retention is developed by simply introducing tyrosine to poly(vinyl alc.) (PVA) drug-eluting microbeads (Tyr-PVA-DEBs). The labeling efficiency of 131I-labeled microbeads remains above 85% in 50% serum for 31 days. Micro-single-photon emission computed tomog./computed tomog. (μSPECT/CT) evidences that the 131I-labeled microbeads accumulate in the orthotopic N1S1 hepatoma of rats for 31 days following intra-arterial injection. The cumulative radiation dose per cubic centimeter of the tumor is at least 13 678-fold higher than that of normal tissues. The highly tumor-selective radiation of the 131I-labeled microbeads allows localized delivery of 345.04 ± 139.16 Gy to the tumor following a single injection dose as low as 0.2 mCi of 131I. Moreover, the 131I-labeled microbeads are loaded with doxorubicin hydrochloride (DOX) through the carboxy groups on tyrosine of the polymer. The 131I-DOX-loaded microbeads present a synergetic antitumor effect without recurrence in comparison with the microbeads labeled with 131I or loading DOX alone, attributed to the sensitization of DOX to 131I-induced ionizing radiation damage to DNA under the embolization-induced hypoxia. Our results demonstrate a high tumor retention of 131I-labeled embolic agent for low-dose transarterial radio-chemoembolization (TARCE) with a synergetic therapeutic effect on treating HCC, showing potential for clin. application.

ACS Nano published new progress about Antitumor agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Synthetic Route of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gazizov, Almir S. published the artcileThe Highly Regioselective Synthesis of Novel Imidazolidin-2-ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity, Application In Synthesis of 22483-09-6, the main research area is imidazolidinone regioselective preparation anticancer human cytotoxicity quantum chem calculation; urea aromatic nucleophile intramol cyclization electrophilic substitution TFA catalyst; anti-cancer activity; anti-tumor activity; cyclization; cytotoxicity; imidazolidine-2-one; regioselectivity; urea.

A series of novel 4-(het)arylimidazolidin-2-ones I [R = 5-Cl-2,4-di-HO-C6H2, 6-hydroxy-1,3-benzodioxol-5-yl, 4-hydroxy-6-methyl-2-oxo-pyran-3-yl; R1 = H, Me; R2 = Ph, 4-MeC6H4, 3-ClC6H4, etc.] was obtained by the acid-catalyzed reaction of (2,2-dimethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones I benefited from excellent regioselectivity, readily available starting materials and a simple procedure. The regioselectivity of the reaction was rationalized by quantum chem. calculations and control experiments The anti-cancer activity of the obtained compounds was tested in vitro.

Molecules published new progress about Antitumor agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Application In Synthesis of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fuse, Shinichiro published the artcileDesign and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A, Application In Synthesis of 92093-23-7, the main research area is aryldioxaspirodecadienone spiromamakone A analog preparation antitumor activity; Anticancer agent; IXNMJGORXMJZOQ-KGLIPLIRSA-N; Spiroacetal; Spirocycle; Spiromamakone A; Spiropreussione B.

The spirocycle is a key structure found in many bioactive compounds From the cytotoxic and spirocyclic natural product, spiromamakone A (I) and its analogs, a more synthetically accessible spiroacetal template was designed based on structural similarity anal. A total of 50 compounds were rapidly synthesized in only one or two synthetic steps from the starting compound, and their cytotoxicity was evaluated. As a result, (±)-(2R*,5R*)-2-(4-iodophenyl)-7-chloro-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-one (II) was discovered and found to be fifteen-fold more cytotoxic than I. The easily accessible spiroacetal II appeared to act in a manner similar to the highly oxidized natural product, spiromamakone A (I).

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Application In Synthesis of 92093-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Hong published the artcileDiscovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors, Quality Control of 22483-09-6, the main research area is covalent inhibitor PRMT5 hemiaminals cocrystal structure.

Protein arginine methyltransferase 5 (PRMT5) is known to sym. dimethylate numerous cytosolic and nuclear proteins that are involved in a variety of cellular processes. Recent findings have revealed its potential as a cancer therapeutic target. PRMT5 possesses a cysteine (C449) in the active site, unique to PRMT5. Therefore, covalent PRMT5 inhibition is an attractive chem. approach. Herein, we report an exciting discovery of a series of novel hemiaminals that under physiol. conditions can be converted to aldehydes and react with C449 to form covalent adducts, which presumably undergo an unprecedented elimination to form the thiol-vinyl ethers, as indicated by electron d. in the co-crystal structure of the PRMT5/MEP50 complex.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Quality Control of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Usoltseva, Roza V. published the artcileComparison of structure and in vitro anticancer activity of native and modified fucoidans from Sargassum feldmannii and S. duplicatum, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Sargassum colon cancer cell fucoidan cytotoxicity anticancer; Anticancer activity; Fucoidan; Sargassum.

Fucoidans are valuable biol. active polysaccharides of brown algae. The aim of this study was to investigate the structure of fucoidan from Sargassum feldmannii and the anticancer effects of native and modified polysaccharides from S. feldmannii and S. duplicatum. The structure of sulfated (25.3%) galactofucan SfF2 (Fuc/Gal = 72/28 mol%) from S. feldmannii was investigated by NMR spectroscopy of desulfated derivative and mass spectrometry of fucoidan fragments labeled with 18O. SfF2 was shown to contain the main chain from 1,3-linked a-L-fucopyranose and b-D-galactopyranose residues with fucose branches at C4 and C6 of galactose residues and C2 of fucose residues. The following fragments were also identified in SfF2: Fuc-(1,4)-Fuc, Gal-(1,3)-Gal, and Gal-(1,4)-Gal. The sulfate groups occupied positions C2, C3, and C4 of fucose residues and C2, C3, C4, and C6 of galactose residues. The galactofucans from S. feldmannii, S. duplicatum, and their derivatives exhibited no cytotoxicity in vitro. The native and deacetylated fucoidans (200 microg/mL) inhibited colony formation of human colon cancer cells (DLD-1, HT-29, and HCT-116). Both desulfated fucoidans possessed weak anticancer activity.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts