Month: November 2022

Pyridoxal derivatized copper(II) complexes: Evaluation of antioxidant, catecholase, and DNA cleavage activity was written by Pereira, Mateus Brum;Fontana, Liniquer Andre;Siqueira, Josieli Demetrio;Auras, Bruna L.;da Silva, Marcos P.;Neves, Ademir;Gabriel, Philipe;Terenzi, Hernan;Iglesias, Bernardo Almeida;Back, Davi Fernando. And the article was included in Inorganica Chimica Acta in 2018.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

This manuscript describes the synthesis, characterization and structural anal. of Cu(II) complexes with pyridoxal-type bidentate ligands, obtained from the condensation between pyridoxal and ortho-halogenated substituted anilines (C1–C5). Complexes C1, C2 and C5 were measured by x-ray single crystal anal. which showed classic and trifurcated H bonds and interaction as a sigma-hole between the O atoms of the iodine ligand derivative in the C5. All compounds were tested as mimetics of superoxide dismutase (SOD), through NBT photoreduction method in aqueous solution of pH 7.8, but the complex C5 showed an expressive IC₅₀ of 0.4 μM. Catecholase-like activity of C1–C5 in the presence of substrate 3,5-di-tert-butylcatechol and cleavage of plasmid DNA were also evaluated. Again, the best results were associated with the complex C5 containing I in the ortho position. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A ternary system of α-tocopherol with phosphatidylethanolamine and L-ascorbyl palmitate in bulk oils provides antioxidant synergy through stabilization and regeneration of α-tocopherol was written by Doert, Martin;Grebenteuch, Sandra;Kroh, Lothar W.;Rohn, Sascha. And the article was included in Food Chemistry in 2022.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:

The stabilization of fats and oils against oxidative lipid deterioration is still a great challenge. The synergistic interaction between phospholipids, L-ascorbate, and tocopherols have not yet been comprehensively understood. The mechanism of the synergistic antioxidant effect of 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (PE) in mixtures with L-ascorbyl palmitate (AP) and α-tocopherol (α-Toc) was investigated in an Et linoleate model and sunflower oil at 110 °C. The mixture of PE, AP, and α-Toc is stabilized through continuous regeneration of α-Toc from its oxidation product α-tocopherylquinone (α-TQ). This reaction is catalyzed by acids and proceeded through the formation of the α-tocopherone ion (T⁺) as an intermediate product. In addition to the direct reduction of T⁺ by AP, PE can also cause regeneration indirectly by reacting with dehydroascorbyl palmitate (DHAP) or other tricarbonyl compounds to form amino reductones. PE and AP undergo an amino-carbonyl reaction to form the condensate PE(AP)₂. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Determination of the Organics in Trimethylolpropane Wastewater was written by Xing, Xin;Xi, Hong-bo;Zuo, Jiane;Zhou, Yue-xi;Song, Guang-qing. And the article was included in Analytical Letters in 2017.Computed Properties of C9H20O2 The following contents are mentioned in the article:

Organic components play a pivotal role in the treatment of trimethylolpropane wastewater; therefore, research aimed at gaining a better understanding of these components can aid in developing potential treatment methods to remove these pollutants. Thus, the use of liquid-liquid extractions coupled with gas chromatog.-mass spectrometry is reported to examine the semivolatile organic components in trimethylolpropane wastewater, while purge-and-trap coupled with flame ionization detection was used to determine the volatile organic components. Several factors which could affect the precision of the anal. method in pretreatment and detection steps were optimized. These techniques exhibited good linearity (determination coefficients >0.9899), good intraday precision (<4.26%), and good interday precision (<13.09%). The optimized method was used for the determination of 23 organics in trimethylolpropane wastewater. The main components were 2-ethylacrolein, butanoic acid, 1-hexanol, 2-ethyl-, trimethylolpropane, butyraldehyde, and toluene. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Computed Properties of C9H20O2).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C9H20O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diaporthe/Phomopsis longicolla degrades an array of bisphenol analogues with secreted laccase was written by Baluyot, Jobriell C.;Santos, Hanna Keith;Batoctoy, Dessa Camille R.;Torreno, Vicenzo Paolo M.;Ghimire, Leela B.;Joson, Santiago Emil A. IV;Obusan, Marie Christine M.;Yu, Eizadora T.;Bela-ong, Dennis B.;Gerona, Roy R.;Velarde, Michael C.. And the article was included in Microbiological Research in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:

With recent initiatives to ban bisphenol A (BPA) in certain com. products, manufacturers shifted to the production and use of BPA analogs. However, some of these BPA alternatives still possess endocrine disruptive activities. Many fungal enzymes are known to biodegrade phenolic compounds, such as BPA. However, the activity of these enzymes on BPA analogs remains unexplored. This study reports a secreted laccase from the endophytic fungus Diaporthe longicolla capable of degrading an impressive range of bisphenol analogs. The secreted crude enzymes are optimally active at pH 5 from 39°C to 60°C, efficiently degrading BPA as well as BPA analogs BPB, BPC, BPE and BPF. A purified form of laccase was identified from the crude fungal extract using FPLC and peptide sequencing. Furthermore, BPA induced the expression of this D. longicolla laccase gene. Overall, this paper demonstrated that the crude laccase enzyme from D. longicolla metabolizes BPA and select analogs, implicating the potential role of this fungus to remove environmental bisphenols. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

CO₂ + n-dodecane + 3,7-dimethyl-1-octanol: High pressure experimental phase equilibria data and thermodynamic modelling was written by van Niekerk Fourie, Frederick Christiaan;Schwarz, Cara Elsbeth;Knoetze, Johannes Hendrik. And the article was included in Journal of Supercritical Fluids in 2017.Product Details of 106-21-8 The following contents are mentioned in the article:

New high pressure VLE data for the ternary mixture CO₂ + n-dodecane (nC₁₂) + 3,7-dimethyl-1-octanol (37DM1O) are presented. A static apparatus with online anal. was used to measure phase compositions at 35, 55 and 75°C, and pressures between 68 and 157 bar. In the high-nC₁₂ region the mixture displayed enhanced solubility, presenting as a pinched two phase band and s-shaped liquid phase curves. Relative solubility, an indicator of fractionation sharpness, increased with 37DM1O content and the 75:25 nC₁₂:37DM1O mixture cannot be separated using CO₂. RK-ASPEN, SR-POLAR, PR-BM and PC-SAFT models were evaluated for their ability to correlate these data. RK-ASPEN and PC-SAFT models provided the best and worst correlation of equilibrium pressures with resp. percentage average absolute deviations of 3.1% and 8.5%. RK-ASPEN model was impressive in its ability to capture the co-solubility pinch seen for the 75:25 nC₁₂:37DM1O mixture and the resultant s-shaped liquid phase complexity. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Product Details of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Product Details of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel rearrangement of 1,3-glycols was written by Crowdle, James H.;Knipper, Joseph E.;Schmidt, Jerome E.;Conley, Robert T.. And the article was included in Journal of Organic Chemistry in 1960.Quality Control of 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

The glycols, RR’C(CH₂OH)₂ (I, R = Me, Et, Et, R’ = Et, Et, Bu) (II, III, IV) with strong base in the presence of Na₂SO₃, NaAsO₂, or Na₂H₃PO₃ yielded approx. 50% mono alcs., RR’CMeCH₂OH (V), also given by rearrangement of the corresponding cyclic sulfites, RR’C.CH₂.O.SO.O.CH₂ (VI) by strong base alone. H₂O (1 mole), 3 moles NaOH, and 1.0 mole Na₂SO₃ treated slowly at 130-40° with 1.0 mole I, the mixture slowly cooled, and diluted with H₂O gave 46-49% V. Similar treatment of VI with omission of Na₂SO₃ gave similar yields of the same products. The rearrangement was presumed to be an interesting 1-3 hydride shift to an aldehyde, with subsequent Cannizzaro reaction in the strongly basic medium. It was assumed that I formed only monosulfite and that the consequent steric compression of the substituents on the α-C atom facilitated the rearrangement to the aldehyde. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Quality Control of 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Relationship between emergent BPA-substitutes and renal and cardiovascular diseases in adult population was written by Moreno-Gomez-Toledano, Rafael. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

Plastic waste pollution is one of the leading environmental problems of modern society. Its use, disposal, and recycling lead to the release of xenobiotic compounds such as bisphenol A (BPA), a known endocrine disruptor related to numerous pathologies. Due to the new restrictions on its use, it is gradually being replaced by derived mols., such as bisphenol F or S (BPF or BPS), whose health risks have not yet been adequately studied. In the present work, significant relationships between the new BPA substitute mols. and renal and cardiovascular diseases have been detected by performing binomial and multinomial logistic regressions in one of the worlds largest cohorts of urinary phenols. The results have shown a significant relationship between urinary BPF and renal function or heart disease (specifically congestive heart failure). Urinary BPS has shown a pos. relationship with the risk of hypertension and a neg. relationship with kidney disease. Consequently, applying new substitute mols. could imply potential health risks equivalent to BPA. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8COA of Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The ability of deep eutectic solvent systems to extract bioactive compounds from apple pomace was written by Moni Bottu, Heleena;Mero, Angelica;Husanu, Elena;Tavernier, Serge;Pomelli, Christian S.;Dewaele, Annelies;Bernaert, Nathalie;Guazzelli, Lorenzo;Brennan, Lorraine. And the article was included in Food Chemistry in 2022.HPLC of Formula: 29106-49-8 The following contents are mentioned in the article:

The objective of this study was to examine the bioactivity of extracts from apple pomace obtained by non-conventional green extraction methods (DES systems). Bioactivity was antioxidant capacity and ability to stimulate insulin secretion from pancreatic beta-cells. The antioxidant capacity of extracts was examined using the DPPH and the FRAP assay. Impact of the extracts on cell viability and insulin secretion were examined using the BRIN-BD11 cell line. ChCl:EG(1:4) extracts resulted in high antioxidant capacity in the DPPH assay (80.1% inhibition vs. 11.3%). Extracts obtained from the classical systems demonstrated an ability to promote insulin secretion significantly higher than the pos. control, p < 0.05. ChCl:EG(1:4) extracts stimulated insulin secretion to a lesser extent. Overall, the data provides evidence for the potential of DES systems to extract bioactive compounds from apple pomace that have relevance for metabolic health. Further optimization of the extraction procedures should be tailored to the desired bioactive properties. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8HPLC of Formula: 29106-49-8).

(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 29106-49-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Production and characterization of GPC3-N protein and its nanobody was written by Lao, Zhiting;Li, Shuanqi;Liang, Jinhui;Su, Jingyi;Gong, Xin;Cui, Xiping;Zhao, Suqing. And the article was included in Protein Expression and Purification in 2022.Related Products of 367-93-1 The following contents are mentioned in the article:

Glypican-3 (GPC3) has a promise to be the diagnostic biomarker as well as therapeutic target for hepatocellular carcinoma (HCC). Nanobody have the great potential in clin. diagnosis and treatment for their characteristics of small size, high solubility, stability, manipulability, binding advantages, and ease of production In this study, the recombinant glypican-3-N terminal (GPC3-N) protein was expressed as inclusion body in E. coli BL21(DE3)pLysS cells and then purified, which is then used as the immunogen to construct nanobody phage library. The pos. clone (named MF15) was obtained by four rounds of bio-panning, and then transformed into the E. coil TOP10F′ cells to express nanobody protein, with the mol. weight of 19 kDa. Both Western blot and immunofluorescence anal. revealed that bacterially expressed GPC3-N protein is biol. active, and MF15 could specifically recognized native GPC3 expressed in HepG2 cells. The results in this study would provide the tech. support for the development of diagnostic kits and antibody drugs targeting GPC3. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Related Products of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of Starch Primers on the Fine Structure of Enzymatically Synthesized Glycogen-like Glucan was written by Liu, Jialin;Wang, Yanli;Li, Xiaoxiao;Jin, Zhengyu;Svensson, Birte;Bai, Yuxiang. And the article was included in Journal of Agricultural and Food Chemistry in 2022.Product Details of 367-93-1 The following contents are mentioned in the article:

Glycogen-like glucan (GnG) is a unique hyperbranched polysaccharide nanoparticle which is drawing increasing attention due to its biodegradability and abundant short branches that can be functionalized. Because starch and GnG are both composed of glucose residues and have similar glucosidic bonds, GnG could be fabricated by sucrose phosphorylase, α-glucan phosphorylase, and branching enzymes from starch primers and sucrose. In this study, high-amylose starch, normal starch, and waxy corn starch were used as primers to synthesize GnG, and their impact on the fine structure of GnG was investigated. Structural anal. indicated that with increasing content of amylopectin in the starch primer, the proportion of short chains in GnG decreased, and the degree of β-amylolysis and α-amylolysis was enhanced. Amylose in the primer contributed to a compact and homogeneous structure of GnG, while amylopectin triggered the formation of branch points with a more open distribution. These findings provide a new strategy for regulating the fine structure of GnG. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Product Details of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts