Month: November 2022

Nagao, Yukinori published the artcileSyntheses of leuco triphenylmethane derivatives and their UV-VIS spectra, Application of 9-Phenyl-9H-xanthen-9-ol, the publication is Nippon Kagaku Kaishi (1987), 1839-45, database is CAplus.

Leuco triphenylmethane derivatives (I; R = H, Me, OMe, NMe₂; Z = O, S, NMe, NPh) were prepared by the condensation of aromatic ketones with substituted benzenes or by Grignard reactions of aromatic ketones with bromoaryl compounds I turned into colored cations in acidic medium. UV-visible spectra in AcOH and H₂SO₄ were measured and discussed in terms of the effects of substituent R and bridging group Z. A good correlation between λ_max of the xanthene derivatives and the Hammett σ value of the substituents was observed, and the effect of the bridging group on the longest λ_max was that the bathochromic shift increased as the electron-donating ability of the bridging group decreased except for Z = S. The effects of R and Z were very similar to those of substituents on the Y band in triphenylmethane dyes having substituents on 2 rings.

Nippon Kagaku Kaishi published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Application of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beck, R. published the artcileA Novel L₃-Phase from a Ca-Salt of an Anionic Surfactant and a Cosurfactant, COA of Formula: C11H24O3, the publication is Journal of Physical Chemistry B (2002), 106(13), 3335-3338, database is CAplus.

An L₃-phase is observed for the first time in a ternary phase diagram of a Ca-salt of an α-sulfonated alkyl fatty acid Me ester, the cosurfactant (2-ethylhexyl)monoglyceride and water. As for other ternary surfactant/cosurfactant systems, the L₃-phase occurs with increasing cosurfactant/surfactant ratios after the L_α-phase. Some properties of the newly observed L₃-phases are the same as for other known L₃-phases. It is a low viscosity, optically isotropic fluid with a low flow birefringence. The time constants τ of the elec. birefringence results scale with τ ∼ O^-3. Its conductivity is very much higher than that of the neighboring L_α-phase, but there are some marked differences from known L₃-phases. This novel L₃-phase is thermodynamically stable despite ionic structure of the surfactant. We found no two phase region between the L_α and the L₃-phase, and the L₃-phase is stable over a wide cosurfactant/surfactant ratio between one and two. In SANS measurements it shows a broad correlation peak that occurs at about the same position as the sharper peak in the L_α-phase. The structure of the L₃-phase is demonstrated by FF-TEM micrographs.

Journal of Physical Chemistry B published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Md, Shadab published the artcileAmbroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells, Synthetic Route of 23828-92-4, the publication is Gels (2021), 7(4), 243, database is CAplus and MEDLINE.

This study aimed to develop gastro-retentive sustained-release ambroxol (ABX) nanosuspensions utilizing ambroxol-kappa-carrageenan (ABX-CRGK) complexation formulations. The complex was characterized by differential scanning calorimetry, powder x-ray diffractometer, and SEM. The prepared co-precipitate complex was used for the development of the sustained-release formulation to overcome the high metabolic and poor solubility problems associated with ABX. Furthermore, the co-precipitate complex was formulated as a suspension in an aqueous floating gel-forming vehicle of sodium alginate with chitosan, which might be beneficial for targeting the stomach as a good absorption site for ABX. The suspension exhibited rapid floating gel behavior for more than 8 h, thus confirming the gastro-retentive effects. Particle size anal. revealed that the optimum nanosuspension (ABX-NS) had a mean particle size of 332.3 nm. Afterward, the ABX released by the nanoparticles would be distributed to the pulmonary tissue as previously described. Based on extensive pulmonary distribution, the developed nanosuspension-released ABX nanoparticles showed significant cytotoxic enhancement compared to free ABX in A549 lung cancer cells. However, a significant loss of mitochondrial membrane potential (MMP) also occurred. The level of caspase-3 was the highest in the ABX-NS-released particle-treated samples, with a value of 416.6 ± 9.11 pg/mL. Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumor necrosis alpha (NF-kB, IL-6, IL-1β, and TNF-α, resp.) were lower for ABX-NS compared to free ABX (p < 0.05). In caspase-3, Bax, and p53, levels significantly increased in the presence of ABX-NS compared to free ABX. Overall, ABX-NS produced an enhancement of the anticancer effects of ABX on the A549 cells, and the developed sustained-release gel was successful in providing a gastro-retentive effect.

Gels published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Synthetic Route of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vagapova, L. I. published the artcileKabachnik-Fields Reaction in the Synthesis of New Acetal-Containing Aminophosphine Oxides, Quality Control of 6346-09-4, the publication is Russian Journal of General Chemistry (2018), 88(9), 1912-1914, database is CAplus.

The Kabachnik-Fields reaction in a ternary system of 4,4-diethoxybutylamine-dialkyl(tolyl)-phosphine acid-3,5-di-tert-butyl-4-hydroxybenzaldehyde (or paraformaldehyde) afforded new aminophosphine oxides containing 3,5-di-tert-butyl-4-hydroxyphenol moiety and an acetal group.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C11H8O3, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Saeidian, Hamid published the artcileThe first general protocol for N-monoalkylation of sulfamate esters: benign synthesis of N-alkyl Topiramate (anticonvulsant drug) derivatives, COA of Formula: C12H20O6, the publication is Journal of Sulfur Chemistry (2015), 36(5), 463-470, database is CAplus.

A novel protocol for the highly selective N-monoalkylation of the sulfamate ester moiety has been developed. This reaction proceeded efficiently using alkyl halides, benzyl halides and α-halo ketones as the electrophile in the presence of KF-Al₂O₃ as a cost-effective and robust catalyst. This approach provides new access to N-monoalkylated Topiramate (anticonvulsant drug) derivatives I (R = CH₃, C₂H₅, CH₂C₆H₅, Bn, etc.) which are potentially of great importance in medicinal chem.

Journal of Sulfur Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tian, Maoqun published the artcileDiscovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Medicinal Chemistry (2020), 63(11), 6164-6178, database is CAplus and MEDLINE.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity vs. other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC₅₀ 0.0192 μM)(I) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC₅₀ 0.0231 μM)(II), displayed >500-fold selectivity vs. P2X2 and P2X3, and 10-fold selectivity vs. P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as neg. allosteric modulators, and mol. modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H26O2, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Kader, Nora S. published the artcileCombined experimental, DFT theoretical calculations and biological activity of sulfaclozine azo dye with 1-hydroxy-2-naphthoic acid and its complexes with some metal ions, Formula: C11H8O3, the publication is New Journal of Chemistry (2019), 43(44), 17466-17485, database is CAplus.

Sulfaclozine-1-hydroxy-2-naphthoic acid azo dye (Scna) and its metal complexes with Ni(II) Cu(II), Zn(II) and Pd(II) metal ions were prepared and characterized using different techniques. The nonisothermal degradation of Pd(II)-(Scna) was studied using Flynn-Wall-Ozawa and Starink methods at various heating rates (5, 10, 15 and 20° min^-1) from the TG/derivative TG (TG/DrTG) and DTA curves. The values of the activation energy (E) obtained using the two methods are in impeccable harmony. Theor. studies (d. functional theory, DFT) were also carried out to support the corresponding exptl. results. Computational calculations were achieved using a DFT/GEN level of theory. Theor. aspects, in terms of geometrical optimization and mol. charge d. plots are also mentioned using the standard basis set LANL2DZ for metal ions. A suitable distorted square planar for Pd-(Scna), distorted tetrahedral for Cu₂-(Scna), and distorted octahedral with Ni-(Scna) and Zn-(Scna)₂ structures were observed for the complexes. The electronic structure and nonlinear optical parameters (NLO) of the complexes were calculated The nature of the interaction between the metal ions and the ligand, mol. stability and bond strengths were studied using DFT calculations employing natural bond orbital (NBO) anal. The complexes are nonplanar and demonstrate the expected optical properties. The synthesized ligand (Scna) and its complexes were screened for antimicrobial activity against bacteria, Staphylococcus aureus as the Gram-pos. and Escherichia coli as the Gram-neg., using the disk diffusion method. The Zn-(Scna)₂ complex displayed the highest activity against both bacteria.

New Journal of Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Kader, Nora S. published the artcileSpectroscopic studies, density functional theory calculations, non-linear optical properties, biological activity of 1-hydroxy-4-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)diazenyl)-2-naphthoic acid and its chelates with Nickel(II), Copper(II), Zinc(II) and Palladium(II) metal ions, Computed Properties of 86-48-6, the publication is Journal of Molecular Structure (2021), 129203, database is CAplus.

Novel Nickel(II), Copper(II), Zinc(II) and Palladium(II) chelates with 1-hydroxy-4-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)diazenyl)-2-naphthoic acid (H₃L) have been produced and clarified using several physicochem. techniques. Quantum mech. calculations of energies, geometries were achieved by using the d. functional theory with Becke’s three parameter exchange functional, the Lee_Yang_Parr correlation functional (B3LYP/GEN) combined with 6.311 G (d,p) and LANL2DZ basis sets. The analyses of HOMO and LUMO have been used to justify the charge transfer within the ligand and its chelates. The considered small energy gap between Occupied MO (HOMO) and LUMO energies expressions that the charge transfer occurs within the ligand and its chelates. The results show that the azo dye ligand exists in two tautomeric structures, the first structure (H₃L), the sulfonamide (SO₂NH), while the second one, the sulfonamide group in enolic form (H₂L-OH). The H₂L-OH tautomer has energy of 12.93 kcal/mol higher than that of H₃L. The structure of H₃L was the most stable and used as the ligand in this study. The bond lengths of Ni(II) ion with the donating sites of the ligand in Ni-(H₂L)₂ chelate suggest a distorted octahedral geometry, Cu₂-(L) chelate, suggests a highly distorted tetrahedral geometry, Zn-(HL) chelate displays a distorted octahedral geometry, Pd-(H₂L) chelate approves a distorted square planar geometry around its own central metal ion. Geometrical parameters, mol. electrostatic potential maps and total electron densities analyses of the ligand and its chelates have been carried out. Mol. stability, hyper conjugative interactions, intramol. charge transfer and bond strength have been examined by applying of natural bond orbital (NBO) anal. Total static dipole moment, mean polarizability, anisotropy of the polarizability, mean first-order hyperpolarizability have been also achieved. From the mol. hyperpolarizability (<β>), The computed (<β>) values show that for the ligand (H₃L) and its Ni-(H₂L)₂, Cu₂-(L), Zn-(HL) and Pd-(H₂L) are ∼23, ∼70, ∼44, ∼132 and ∼38 times greater than that of Urea, indicating all the studied ligand and its chelates reveal significant polarizability and first-order hyperpolarizability and are predicted to be successful for Non-Linear Optical (NLO) materials. The analyses of the chelates indicate that the Zn(II) and Pd(II) form 1:1, Ni(II) form 1:2 while Cu(II) ion form 2:1 (M:L) and non-electrolytic behavior of chelates indicate the absence of counter ion. Ni-(H₂L)₂ complex had zero antibacterial activity against E. coli while its activity is higher than the azo dye against Staphylococcus aureus. Pd-H₂L complex had almost the same activity as the azo dye against both types of bacteria. The higher activity of Zn-HL and Cu₂-L complexes can be explained by their chelation.

Journal of Molecular Structure published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdelaleem, Eglal A. published the artcileAn Innovative Method, Interference Subtraction, for Determination of Drugs in Syrups in Presence of Potential Interfering Excipients, Product Details of C13H19Br2ClN2O, the publication is Analytical Chemistry Letters (2018), 8(6), 782-793, database is CAplus.

Pharmaceutical dosage forms contain both active ingredients and inactive materials called exipients, most of which cause high interference specially in direct UV-spectrophotometry. This problem is highly obvious in syrups which may contain preservatives, coloring agents, thickening agents and sweetening agents. Thus, there is an urgent need to develop and validate a simple, accurate and selective method named interference subtraction method for determination of drugs in syrups in presence of these excipients without pre-separation by solving this interference. This newly designed method was successfully applied to; Oxybutynin hydrochloride in Detronin syrup, Ambroxol hydrochloride in Muco syrup and Ibuprofen in both Brufen syrup and Megafen N oral suspension. These chosen syrups contain different excipients causing different types of interference. This innovative method was validated according to ICH guidelines. The results obtained by interference subtraction method were statistically compared with those obtained by the official and /or reported methods of the proposed drugs.

Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Product Details of C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lotfy, Hayam Mahmoud published the artcileStability indicating spectrophotometric methods for determination of Nicardipine in the presence of its alkaline induced degradation products, Formula: C10H15NO, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2016), 8(3), 62-66, database is CAplus.

Objective: Derivative, ratio spectra derivative and ratio difference spectrophotometric methods were developed and validated for simultaneous determination of Nicardipine (NIC) in the presence of its alk. induced degradation products. Methods: In these methods the overlapped spectra of NIC and its alk. induced degradation products were well resolved by measuring the amplitudes of first derivative (D1) spectra and the second derivative (D2) at 382.3 and 239 nm, resp. NIC was determined by ratio spectra derivative by measuring the amplitude at 244 nm. The ratio difference spectrophotometric method was developed in which the difference between amplitudes at 237.5 nm and 260 nm of the ratio spectra were recorded. The linearity range for the applied methods was 2-18 μg/mL. Results: All the developed methods were validated according to ICH Guidelines, NIC was determined with acceptable accuracy and precision. Conclusion: These methods were suitable as stability indicating methods for the determination of NIC in the presence of its alk. induced degradation products either in bulk powder or in a pharmaceutical formulation. Statistical anal. of the results with those obtained by applying a reported method has been carried out revealing high accuracy and good precision.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts