Month: November 2022

Shahrivari, Saba published the artcileA comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species, Quality Control of 106-25-2, the publication is Scientific Reports (2022), 12(1), 7234, database is CAplus and MEDLINE.

Artemisia is one of the most diverse genera in the Asteraceae family. The genus is wildly distributed in Irano-Turanian habitats and includes 34 species in Iran. Here, for the first time the essential oil variability, antioxidants and anti-cholinesterase and anti-tyrosinase activities of extracts of three Artemisia species (A. tournefortiana, A. khorassanica, A. haussknechtii), from different regions of Iran were evaluated. Based on GC-MS analyses, 81.84% to 98.70% of the total oils were identified. Cluster anal. grouped the studied populations in three different chemotypes. The highest and the lowest essential oil contents were observed in A. khorassanica and A. haussknechtii species, resp. Camphor, en-in-dicycloether, 1,8-cineole and (Z)-β-farnesene were the dominant components of essential oil in investigated ecotypes. The results revealed that the total phenol content was higher in A. tournefortiana collected from Kerman and A. haussknechtii collected from Chaharmahal and Bakhtiari. However, the lowest phenol content was recorded for A. haussknechtii collected from Isfahan province. The highest flavonoids content was found in A. tournefortiana collected from West Azerbaijan and A. khorassanica collected from North Khorasan. The highest FRAP antioxidant activity was observed in A. tournefortiana (Kerman) and the lower amount was in A. haussknechtii collected from Kohgiluyeh and Boyer-Ahmad. The highest antioxidant activity by DPPH method was in A. khorassanica collected from South Khorasan and the lowest activity was in Isfahan’s A. haussknechtii. The acetycholine esterase inhibitory activity was higher in A. tournefortiana collected from West Azerbaijan; and the lowest activity was in A. haussknechtii collected from Chaharmahal and Bakhtiari province. The highest tyrosinase inhibitory activity was in A. khorassanica collected from North Khorasan; and the lowest was in A. haussknechtii collected from Chaharmahal and Bakhtiari.

Scientific Reports published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C40H35N7O8, Quality Control of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bansal, Kuldeep Kumar published the artcileEvaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers, Category: alcohols-buliding-blocks, the publication is International Journal of Polymeric Materials and Polymeric Biomaterials, database is CAplus.

Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus and poly(lactide) copolymer. The presence of “ene” groups on PJL′s backbone offers a unique opportunity to insert functional groups. We introduced -COOH and Ph groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM.

International Journal of Polymeric Materials and Polymeric Biomaterials published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alam, Shoaib published the artcileInvestigation utilizing the HLB concept for the development of moisturizing cream and lotion: in-vitro characterization and stability evaluation, SDS of cas: 70445-33-9, the publication is Cosmetics (2020), 7(2), 43, database is CAplus.

The current study aims to utilize the concept of the hydrophilic-lipophilic balance (HLB) value of ingredients for the development of a stable emulsion-based moisturizing cream and lotion for cosmetic application. The combination of a hydrophilic and lipophilic emulsifier such as glyceryl stearate (HLB value 3.8) and PEG-100 stearate (HLB value 18.8) were found to be effective to emulsify the chosen oil phase system at a specific concentration to achieve the required HLB for the development of the stable emulsion-based system. The developed formulation was characterized for pH, viscosity, spreadability, rheol., and droplet morphol. The influence of carbopol ETD 2020 and the concentration of the oil phase on the rheol. of the product was investigated and found to be significant to achieve the required thickening to convert the lotion into a cream. The formulation system developed through utilizing the concept of HLB was compared to a product developed through the conventional approach. It was observed that the utilization of the HLB method for the development of an emulsion-based product is a promising strategy compared to the conventional method. The phys. stability and thermodn. stability tests were carried out under different storage conditions. It was observed that the developed formulation was able to retain its integrity without showing any signs of instability during storage.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chandra, Girish published the artcileImproved synthesis of a DNA-dependent protein kinase inhibitor IC86621, Synthetic Route of 27292-49-5, the publication is Archives of Pharmacal Research (2012), 35(4), 639-645, database is CAplus and MEDLINE.

An improved synthesis of DNA-dependent protein kinase inhibitor IC86621 is described. This developed method provides an easy access to this simple mol. by using amination, acetylation and Fries rearrangement reactions.

Archives of Pharmacal Research published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Synthetic Route of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pouchain, Laurent published the artcileQuaterthiophenes with Terminal Indeno[1,2-b]thiophene Units as p-Type Organic Semiconductors, Synthetic Route of 239075-02-6, the publication is Journal of Organic Chemistry (2009), 74(3), 1054-1064, database is CAplus and MEDLINE.

Quaterthiophenes 4T, Oct-4T, and Tol-4T based on a central 2,2′-bithiophene core α,ω-terminated with 4,4-unsubstituted and 4,4-disubstituted n-octyl or p-tolyl indeno[1,2-b]thiophene were synthesized by Stille or Miyaura-Suzuki couplings. Compound 4T was also synthesized by an alternative route involving a soluble precursor bearing solubilizing trimethylsilyl groups which were eliminated in the last step. The electronic properties of the compounds were analyzed by cyclic voltammetry, UV-visible absorption and fluorescence emission spectroscopy. Thermal evaporation of 4T and Oct-4T leads to crystalline thin films and UV-visible absorption and x-ray diffraction data for these films suggest that the mols. adopt a quasi-vertical orientation onto the substrate. Strong π-π intermol. interactions were observed for 4T but not for mols. Oct-4T due to the presence of n-octyl chains. Sublimed thin films of Tol-4T show an amorphous character. The characterization of field-effect transistors fabricated from these three materials gave a hole-mobility of 2.2 × 10^-2 cm² V^-1 s^-1 with an on/off ratio of 2.2 × 10⁴ for 4T while no field-effect was observed for Oct-4T and Tol-4T.

Journal of Organic Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Synthetic Route of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhebentyaev, A. I. published the artcileIon-pair thin-layer chromatography of drugs which are quaternary ammonium compound derivatives, Name: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Farmatsiya (Moscow) (1998), 47(1), 21-22, 27, database is CAplus.

The influence of mobile phase composition on chromatog. development of 12 drugs which are quaternary ammonium compound derivatives (QAD) was studied. Chromatog. development optimal conditions of some QAD using organic solvent and aqueous counter-ion solution mixture were established. Distribution coefficients of investigated GAD in system with different counter-ions was calculated

Farmatsiya (Moscow) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C5H6BNO2, Name: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Yu-Hsun published the artcileDirect Transformation of Nitroalkanes to Nitriles Enabled by Visible-Light Photoredox Catalysis and a Domino Reaction Process, Name: 2-Methoxy-4-(2-nitroethyl)phenol, the publication is Organic Letters (2019), 21(19), 7750-7754, database is CAplus and MEDLINE.

A mild and convenient process for direct transformation of nitroalkanes to the corresponding nitriles was developed using a visible-light photoredox catalysis strategy with household decorative blue LEDs and the additives of Et₃N and DIPIBA (or DIPEA). Application of the process in secondary nitroalkanes bearing a β-alc. resulted in a domino process of the retro-Henry reaction and the subsequent acetalization, aldol, cyanohydrin, and ring-contraction reactions with stereoselectivities. The photocatalytic reaction was demonstrated by a continuous flow method.

Organic Letters published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Name: 2-Methoxy-4-(2-nitroethyl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Samav, Yasemin published the artcilePreparation of Responsive Zwitterionic Diblock Copolymers Containing Phosphate and Phosphonate Groups, Application In Synthesis of 622-40-2, the publication is Macromolecular Research (2020), 28(12), 1134-1141, database is CAplus.

In this study, novel zwitterionic diblock copolymers, namely poly(2-(N-morpholino)ethyl methacrylate)-block-poly(2-(methacryloyloxy)ethyl phosphate) (PMEMA-b-PMOEP) and poly-2-(N-morpholino)ethyl methacrylate-block-poly ((methacryloyloxy)methyl phosphonic acid) (PMEMA-b-PMOMP), were synthesized via reversible addition-fragmentation chain transfer controlled radical polymerization Solution properties of these phosphorus-based diblock copolymers were investigated using dynamic light scattering, transmission electron microscopy and proton NMR spectroscopy. Since the PMEMA block has both salt- and thermo-responsive properties, PMEMA-b-PMOEP and PMEMA-b-PMOMP diblock copolymers formed core-shell micelles in basic aqueous media as the PMEMA block formed insoluble micelle core with the addition of Na₂SO₄ or an increase in temperature in basic solution Addnl., PMEMA-b-PMOMP diblock copolymers interacted strongly with calcium cations and yielded reverse micellar structures via complexation of phosphate with metal cation in aqueous media.

Macromolecular Research published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application In Synthesis of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pickel, Thomas C. published the artcileEsterification by Redox Dehydration Using Diselenides as Catalytic Organooxidants, Computed Properties of 20880-92-6, the publication is Journal of Organic Chemistry (2019), 84(9), 4954-4960, database is CAplus and MEDLINE.

Ortho-functionalized aryl diselenides are catalytic (5.0 mol %) oxidants for the construction of esters from carboxylic acids and alcs. in the presence of stoichiometric tri-Et phosphite and dioxygen in air as the terminal redox reagents (redox dehydration conditions). The reaction proceeds through the intermediacy of the anhydride and requires the presence of 10% DMAP to drive the esterification.

Journal of Organic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kojima, Ryoto published the artcileA Copper(I)-Catalyzed Enantioselective γ-Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched γ,γ-gem-Difluoroallylboronates, Synthetic Route of 83706-94-9, the publication is Angewandte Chemie, International Edition (2018), 57(24), 7196-7199, database is CAplus and MEDLINE.

The first catalytic enantioselective γ-boryl substitution of CF₃-substituted alkenes is reported. A series of CF₃-substituted alkenes was treated with a diboron reagent in the presence of a copper(I)/Josiphos catalyst to afford the corresponding optically active γ,γ-gem-difluoroallylboronates in high enantioselectivity. The thus obtained products could be readily converted into the corresponding difluoromethylene-containing homoallylic alcs. using highly stereospecific allylation reactions.

Angewandte Chemie, International Edition published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Synthetic Route of 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts