Month: November 2022

On September 18, 2018, Wang, Xiaoting; Zheng, Yajun; Shi, Jun; Gong, Xiaoyun; Ji, Yue; Han, Weiwei; Jiang, You; Austin, Daniel E.; Fang, Xiang; Zhang, Zhiping published an article.Computed Properties of 4719-04-4 The title of the article was Elucidating the Reaction Mechanisms between Triazine and Hydrogen Sulfide with pH Variation Using Mass Spectrometry. And the article contained the following:

Triazine is one of the most economical and effective scavengers for hydrogen sulfide (H2S) removal, but the reaction mechanisms between triazine and H2S with pH variation in solution are still poorly understood. Herein, we show that the reaction process can be directly probed by means of paper spray mass spectrometry, in which an aprotic solvent (e.g., acetonitrile) is more favorable to the observation of reaction intermediates than a protic solvent (e.g., methanol), because of hydrogen bond interaction. Varying the pH of the reaction leads to completely different reaction pathways. With the pH in the range of 5.58 to 7.73, the major product was thiadiazine. With a pH of 3.02-3.69, thiadiazine is converted to 2-(5-(2-hydroxyethyl)-1,3,5-thiadiazinan-3-yl)acetaldehyde, which differs from the traditional pathway of analogous reactions. However, as ammonia was added into the reaction and the pH was adjusted to the range 8.45-9.43, triazine readily undergoes hydrolysis, and the formed intermediate reacts with ammonia and formaldehyde generated in situ from triazine to produce 1-(2-hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo [3.3.1.13,7]decane (HTAD). Further increasing the pH up to 10.27-11.21 leads to the decomposition of HTAD. Based on the exptl. observation and evidence from high-resolution and tandem mass spectrometry, we propose the plausible reaction mechanisms between triazine and H2S, as well as the derived reaction from triazine under different pH conditions. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Computed Properties of 4719-04-4

The Article related to triazinetriethanol hydrogen sulfide reaction ph paper spray mass spectrometry, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Computed Properties of 4719-04-4

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Alcohol – Wikipedia,
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On February 29, 2020, Hamidi, Armita; Tadesse, Yonas published an article.Quality Control of SweetPearlR P300 DC Maltitol The title of the article was 3D printing of very soft elastomer and sacrificial carbohydrate glass/elastomer structures for robotic applications. And the article contained the following:

Recently, soft materials such as silicone elastomers are widely used in soft robotics due to their high flexibility and safe phys. interaction with humans. Focusing on three aspects-highly elastic materials, sacrificial materials, and actuation units, we aim to develop an additive manufacturing strategy that allows the fabrication of highly elastic soft structures more efficiently. First, silicone thinner is used to tailor the mech. properties of the soft silicone elastomer. The authors found out that adding 20% volume thinner to the silicone improved the ultimate tensile elongation of 3D printed silicone samples up to 1260%, which is the highest among all the 3D printed soft materials previously reported. However, in a cyclic tensile test, this strain is not achieved; instead, the maximum strain was 600%. Second, carbohydrate glasses are introduced as sacrificial materials for 3D printing silicone with hollow channels. Few configurations of pneumatic and hydraulic actuators are developed by forming channels in the silicone elastomer via 3D printed sacrificial carbohydrate structures and subsequently dissolving. The 3D printed structures actuated successfully to get morphed shapes, which showed that our method is effective for manufacturing of functional soft robotic structures. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Quality Control of SweetPearlR P300 DC Maltitol

The Article related to carbohydrate glass silicone elastomer 3d printing actuator robotic application, Synthetic Elastomers and Natural Rubber: Compounding and Processing and other aspects.Quality Control of SweetPearlR P300 DC Maltitol

Referemce:
Alcohol – Wikipedia,
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On September 12, 2012, Taylor, Grahame N.; Prince, Philippe; Matherly, Ron; Ponnapati, Ramakrishna; Tompkins, Rose; Vaithilingam, Panchalingam published an article.Application In Synthesis of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol The title of the article was Identification of the Molecular Species Responsible for the Initiation of Amorphous Dithiazine Formation in Laboratory Studies of 1,3,5-Tris (hydroxyethyl)-hexahydro-s-triazine as a Hydrogen Sulfide Scavenger. And the article contained the following:

Amorphous dithiazine is produced from a solution of tris-(2-hydroxyethyl)-hexahydro-s-triazine (I) that is heavily consumed by hydrogen sulfide (H2S). Previously, it has been reported that the chem. structure of amorphous dithiazine is a polymeric structure which involves opening of the dithiazine ring. Evidence is presented here that the first step in this polymerization reaction is conversion of the terminal hydroxyl functionality into a terminal thiol. Thereafter, the thiol initiates the ring opening of the dithiazine to yield a polymeric, highly insoluble material. It has been observed that the critical chem. species in the initiation of this chain reaction is the bisulfide anion. This bisulfide anion is produced from the reaction of H2S with ethanolamine liberated in the sulfur insertion reaction undergone by tris-(2-hyroxyethyl)-hexahydro-s-triazine (I). This process has been artificially induced by the reaction of monomeric or crystalline 5-hydroxyethyldithiazine (II) and ethanolammonium hydrosulfide. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Application In Synthesis of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to identification mol species responsible initiation amorphous dithiazine formation, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Application In Synthesis of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

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On December 10, 2015, Behnam, Mira A. M.; Graf, Dominik; Bartenschlager, Ralf; Zlotos, Darius P.; Klein, Christian D. published an article.Name: H-Phg(4-OH)-OH The title of the article was Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue. And the article contained the following:

The dengue virus (DENV) and West Nile Virus (WNV) NS2B-NS3 proteases are attractive targets for the development of dual-acting therapeutics against these arboviral pathogens. We present the synthesis and extensive biol. evaluation of inhibitors that contain benzyl ethers of 4-hydroxyphenylglycine as non-natural peptidic building blocks synthesized via a copper-complex intermediate. A three-step optimization strategy, beginning with fragment growth of the C-terminal 4-hydroxyphenylglycine to the benzyloxy ether, followed by C- and N-terminal optimization, and finally fragment merging generated compounds with in vitro affinities in the low nanomolar range. The most promising derivative reached Ki values of 12 nM at the DENV-2 and 39 nM at the WNV proteases. Several of the newly discovered protease inhibitors yielded a significant reduction of dengue and West Nile virus titers in cell-based assays of virus replication, with an EC50 value of 3.4 μM at DENV-2 and 15.5 μM at WNV for the most active analog. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Name: H-Phg(4-OH)-OH

The Article related to hydroxyphenylglycine peptide preparation protease inhibitor dengue west nile virus, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Name: H-Phg(4-OH)-OH

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On January 19, 2011, Taylor, Grahame N.; Matherly, Ron published an article.HPLC of Formula: 4719-04-4 The title of the article was Structural Elucidation of the Solid Byproduct from the use of 1,3,5-Tris(hydroxyalkyl)hexahydro-s-triazine Based Hydrogen Sulfide Scavengers. And the article contained the following:

Two forms of the solid byproduct from the use of hydroxyalkyl hexahydrotriazine as a hydrogen sulfide scavenger were investigated. The crystalline monomeric dithiazine and the intractable solid, known formerly as amorphous dithiazine. It was implied that the latter was simply another solid form of the same chem. species. The exact chem. structure and derivation of amorphous dithiazine were investigated in this study and the anal. data suggest that the material is polymeric in nature. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).HPLC of Formula: 4719-04-4

The Article related to solid byproduct structure trishydroxyalkylhexahydrotriazine hydrogen sulfide scavenger, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.HPLC of Formula: 4719-04-4

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Alcohol – Wikipedia,
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On July 5, 2013, Gaudelli, Nicole M.; Townsend, Craig A. published an article.Safety of H-Phg(4-OH)-OH The title of the article was Stereocontrolled Syntheses of Peptide Thioesters Containing Modified Seryl Residues as Probes of Antibiotic Biosynthesis. And the article contained the following:

Methods have been developed to synthesize tri- and pentapeptide thioesters containing one or more p-(hydroxyphenyl)glycine (pHPG) residues and L-serine, some where the latter is O-phosphorylated, O-acetylated, or exists as a β-lactam. Selection of orthogonal protection strategies and development of conditions to achieve seryl O-phosphorylation without β-elimination and to maintain stereochem. control, especially simultaneously at exceptionally base-labile pHPG α-carbons, are described. Intramol. closure of a seryl peptide to a β-lactam-containing peptide and the syntheses of corresponding thioester analogs are also reported. Modification of classical Mitsunobu conditions is described in the synthesis of the β-lactam-containing products, and in a broadly useful observation, it was found that simple exclusion of light from the P(OEt)3-mediated Mitsunobu ring closure afforded yields of >95%, presumably owing to reduced photodegradation of the azodicarboxylate used. These sensitive potential substrates and products will be used in mechanistic studies of the two nonribosomal peptide synthetases NocA and NocB that lie at the heart of nocardicin biosynthesis, a family of monocyclic β-lactam antibiotics. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to serine phosphoserine beta lactam peptide thioester preparation nocardicin epimerization, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Safety of H-Phg(4-OH)-OH

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On September 30, 2000, Hirose, Keiji; Ogasahara, Kazuko; Nishioka, Kazuyuki; Tobe, Yoshito; Naemura, Koichiro published an article.Name: (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol The title of the article was Enantioselective complexation of phenolic crown ethers with chiral aminoethanol derivatives: effects of substituents of aromatic rings of hosts and guests on complexation. And the article contained the following:

Optically active azophenolic crown ethers having Ph groups substituted at the resp. para-position were prepared and their association constants with chiral aminoethanol derivatives, including 2-amino-2-phenylethanols having an electron-donating or an electron-withdrawing group, were determined in chloroform by means of UV-vis titration methods. The enantioselectivities of these crown ethers are estimated from the ratio of the association constants KR/KS and the effect of aromatic substituents of both hosts and guests on the binding abilities and enantioselectivities is discussed. The structures of the complexes were investigated on the basis of the 1H NMR and UV-vis spectra. The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).Name: (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol

The Article related to enantioselective complexation phenolic crown ether chiral aminoethanol substituent effect, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Name: (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol

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Alcohol – Wikipedia,
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On November 1, 2013, Gaudelli, Nicole M.; Townsend, Craig A. published an article.Synthetic Route of 32462-30-9 The title of the article was Stereocontrolled Syntheses of Peptide Thioesters Containing Modified Seryl Residues as Probes of Antibiotic Biosynthesis [Erratum to document cited in CA159:134091]. And the article contained the following:

The Supporting Information contained incorrectly placed NMR spectra for six figures; the corrected files are now included online. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to erratum serine phosphoserine beta lactam peptide thioester preparation, nocardicin epimerization erratum, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Synthetic Route of 32462-30-9

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On November 3, 2021, Romero, Iveth; Kucheryavskiy, Sergey; Maschietti, Marco published an article.COA of Formula: C9H21N3O3 The title of the article was Experimental Study of the Aqueous Phase Reaction of Hydrogen Sulfide with MEA-Triazine Using In Situ Raman Spectroscopy. And the article contained the following:

A method for quantitation of bisulfide in the aqueous phase reactions of H2S scavenging with MEA-triazine is proposed. The method is based on time-resolved in situ Raman spectroscopy, thus allowing in situ monitoring of the reactions. The method is applied to obtain the kinetic data of the reactions in batch configuration at room temperature for initial pH values of 9, 10, and 11 and MEA-triazine/bisulfide initial concentration ratios in the range of 0.5-10. The pH increases remarkably during the reactions, causing a substantial decrease in the rate of disappearance of bisulfide. If the system is reacidified, complete depletion of bisulfide can be achieved, evidencing the irreversibility of the scavenging reactions. The results are also supported by a qual. anal. of the trends of the characteristic Raman peaks of MEA-triazine, dithiazine, and monoethanolamine. These trends are in line with the currently accepted reaction scheme, consisting of two scavenging reactions in series. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).COA of Formula: C9H21N3O3

The Article related to hydrogen sulfide trishydroxyethylhexahydrotriazine mea triazine aqueous reaction kinetics, in situ raman spectroscopy, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.COA of Formula: C9H21N3O3

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On October 8, 2015, Weigel, Lena F.; Nitsche, Christoph; Graf, Dominik; Bartenschlager, Ralf; Klein, Christian D. published an article.Safety of H-Phg(4-OH)-OH The title of the article was Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors. And the article contained the following:

Dengue virus is an increasingly global pathogen. One of the promising targets for antiviral drug discovery against dengue and related flaviviruses such as West Nile virus is the viral serine protease NS2B-NS3. We here report the synthesis and in vitro characterization of potent peptidic inhibitors of dengue virus protease that incorporate phenylalanine and phenylglycine derivatives as arginine-mimicking groups with modulated basicity. The most promising compounds were (4-amidino)-L-phenylalanine-containing inhibitors, which reached nanomolar affinities against dengue virus protease. The type and position of the substituents on the phenylglycine and phenylalanine side chains has a significant effect on the inhibitory activity against dengue virus protease and selectivity against other proteases. In addition, the non-natural, basic amino acids described here may have relevance for the development of other peptidic and peptidomimetic drugs such as inhibitors of the blood clotting cascade. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to phenylalanine phenylglycine based arginine mimetic tripeptide preparation antiviral, dengue protease inhibitor tripeptide arginine mimetic, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Safety of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts