Month: November 2022

On June 30, 2022, Indrati, Niken; Sumpavapol, Punnanee; Samakradhamrongthai, Rajnibhas Sukeaw; Phonsatta, Natthaporn; Poungsombat, Patcha; Khoomrung, Sakda; Panya, Atikorn published an article.Application In Synthesis of 2,3-Dihydroxypropanoic acid The title of the article was Volatile and non-volatile compound profiles of commercial sweet pickled mango and its correlation with consumer preference. And the article contained the following:

Summary : Sweet pickled mango named Ma-Muang Bao Chae-Im is a traditional preserved mango from Hat Yai, Thailand. This study investigated (I) volatile and non-volatile compound profiles of com. Ma-Muang Bao Chae-Im and (II) their relationship to consumer preference. Untargeted metabolomics profiling was performed by gas chromatog.-mass quadrupole-time of flight anal. There were 117 volatile and 44 non-volatile compounds annotated in six com. brands of Ma-Muang Bao Chae-Im. Furthermore, 46 volatile and 19 non-volatile compounds discriminant markers were found by Partial least square discriminant anal. Among those markers, sorbic and benzoic acid were observed in several brands; moreover, the combination of both compounds altered the volatile profile, especially the ester group. Partial least square regression revealed that overall consumer liking is correlated to 1-heptanol; 1-octanol; acetoin; acetic acid, 2-phenylethyl ester; D-manitol; terpenes and terpenoids, while firmness to sucrose and L-(-)-sorbofuranose. On the other hand, most ester compounds were not related to consumer preference. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to sweet pickled mango 1heptanol 1octanol acetoin acetic acid, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 18, 2014, Desroy, Nicolas; Heckmann, Bertrand; Brys, Reginald Christophe Xavier; Joncour, Agnes; Peixoto, Christophe; Bock, Xavier published a patent.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of imidazo[1,2-a]pyridine derivatives for treatment of inflammatory disorders. And the patent contained the following:

Disclosed are the title imidazo[1,2-a]pyridine derivatives I [R1a = H, halo, C1-C4 alkyl; R1b = halo, halo-(un)substituted C1-C4 alkyl, halo-(un)substituted C1-C4 alkoxy; X = S, O, N:CH, CH:CH; W = N, CR3; R4 = C1-C4 alkyl; R5 = (un)substituted C1-C4 alkyl with CN, OH, halo, C(:O)NH2; one of R6a or R6b = H, Me, halo, and the other is H; Cy = C4-C10 cycloalkyl, 41̃0 membered mono.bicyclic heterocycloalkyl, 47̃ membered heterocycloalkenyl; R7 = independently OH, oxo, halo, etc.; subscript a = 0, 1, 2; R8 = (L1-W1)m-L2-G1 wherein L1 = absent, O, C(:O), SO2, etc.; W1 = C1-C4 alkylene; subscript m = 0, 1; L2 = absent, O, C(:O), OC(:O), etc.; G1 = H, CN, (un)substituted C1-C4 alkyl, etc.; a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof; or a biol. active metabolite thereof] for treatment of inflammatory disorders. For example, II was prepared in a multistep synthesis. The present invention relates to compounds I inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions, and methods of treatment using I, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatol. disorders, and/or abnormal angiogenesis associated diseases by administering I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to preparation imidazopyridine treatment inflammatory disorder, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 16, 2022, Li, Zhi; Sundara Sekar, Balaji; Lukito, Benedict Ryan published a patent.SDS of cas: 926292-63-9 The title of the patent was Bioproduction of enantiopure (R)- and (S)-2-phenylglycinol from styrene and renewable feedstocks via artificial enzyme cascade. And the patent contained the following:

The present invention relates to methods of bioprodn. of enantiomerically pure or enantiomerically enriched 2- phenylglycinol or a derivative thereof by multiple enzyme-catalyzed chem. transformations in a one-pot reaction system. In a specific embodiment, at least one multiple enzyme is located on one or more plasmids or integrated in the chromosome of each of the one or more recombinant microbial cells. In a further embodiment, one or more recombinant microbial cells are genetically engineered to overexpress multiple enzymes, including styrene monooxygenase, epoxide hydrolase, alc. dehydrogenase, transaminase, phenylalanine ammonia lyase, and phenylacrylic acid decarboxylase. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).SDS of cas: 926292-63-9

The Article related to styrene artificial enzyme cascade phenylglycinol enantiopure, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.SDS of cas: 926292-63-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khuenpet, K.; Truong, N. D. P.; Polpued, R. published an article in 2020, the title of the article was Inulin extraction from Jerusalem artichoke (Helianthus tuberosus L.) tuber powder and its application to yoghurt snack.SDS of cas: 585-88-6 And the article contains the following content:

A ratio of Jerusalem artichoke tuber powder (JATP) and water at 1:20 (weight/weight), the concentrated Jerusalem artichoke extract contained the highest inulin content of 33.14 mg/mL and 2.06 mg/mL of reducing sugar. For yoghurt mixture formulation, the concentrated JA extract was used as an ingredient. Yoghurt was mixed with sugar, concentrated JA extract and juice, namely tomato juice 20% (T), lemon juice 20% (L), passion fruit juice 20% (P), the combination of T 10% with L 10% (TL), T 10% with P 10% (TP) or L 10% with P 10% (LP). The sensorial evaluation demonstrated that the treatment added with P 20% got significantly higher scores than other treatments (p<0.05), which were between 7.03 to 7.93 in aspects of color, flavor, sweetness, sourness and overall acceptability indicating that the panelists like sample very much. The sugar in P-JA yoghurt mixture formula was substituted by four sweeteners including maltitol, xylitol, prebiotic syrup and JA syrup. It appeared that the sugar substitution with JA syrup in P-JA yoghurt mixture caused insignificantly different in flavor, sweetness, sourness and overall acceptability from control (sugar). Yoghurt fortified with concentrated JA inulin, PJ and JA syrup was foamed and dried by foam-mat drying technique. The addition of 35% foaming agent solution (2% methocel and 1.5% carboxymelthyl cellulose) produced stable foam. The obtained foam was squeezed into circle shape and dried at 70μC for 2 h to form JA inulin yoghurt snack. The moisture content, aw and pH of dried snack were 5.73%wb, 0.39 and 4.24 resp. JA yoghurt snack contained inulin 129.78 mg/g and reducing sugar 146.44 mg/g. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).SDS of cas: 585-88-6

The Article related to helianthus tuberosus inulin extraction tuber powder yoghurt snack, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.SDS of cas: 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 15, 2020, Zhong, Wenge; Guo, Wei published a patent.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Benzimidazole derivatives as Glp-1R agonists and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

Provided herein are benzimidazole compounds of formula I and pharmaceutical compositions thereof, for use in, e.g. treating type 2 diabetes mellitus, pre-diabetes, obesity, non-alc. fatty liver disease, non-alc. steatohepatitis, and cardiovascular disease. Compounds of formula I wherein dashed double bond is either as single bond or a double bond; EE is COOH, -COCF3, -CH(OH)CF3, -CO-NH-CN, -CO-NH-OH, etc.; X1-X5 are independently N, CH; W is O, S, (un)substituted CH, NH and derivatives; ring B is 6-membered heteroaryl, 6-membered monocyclic ring, Ph; Y1 and Y3-Y4 are independently N, CH; T6-T8 are independently N, (un)substituted VH; ring C is cyclohexyl, Ph, pyridinyl; L is (un)substituted CH2, S, O, NH and derivatives; ring D is bicyclic heteroaryl; EE is COOH, -COCF3, -CH(OH)CF3, -CONH-CN, -CONH-OH, -CO-NH-OMe, etc.; Rb is H, C1-6 alkyl, C1-6 alkoxy, etc.; R1 is H, halo, CN, OH, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is H, D, halo, CN, OH, oxo, C1-6 alkyl, etc.; R3 is H, D, CN, OH, oxo, C1-6 alkyl, C1-6 alkoxy, etc.; and their pharmaceutically acceptable salts, stereoisomers, solvates, hydrates as Glp-1R agonists in the treatment of diseases thereof, are claimed. Example compound II was prepared starting from 4-bromo-3-fluorobenzeneacetonitrile by using alcoholysis, heterocyclization, cross-coupling, and hydrolysis as the key steps. All the invention compounds were evaluated for their Glp-1R agonistic activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to benzimidazole derivative preparation glp1r agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 15, 2020, Zhong, Wenge; Guo, Wei published a patent.Application of 386704-04-7 The title of the patent was Benzimidazole derivatives as Glp-1R agonists and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

Provided herein are benzimidazole compounds of formula I and pharmaceutical compositions thereof, for use in, e.g. treating type 2 diabetes mellitus, pre-diabetes, obesity, non-alc. fatty liver disease, non-alc. steatohepatitis, and cardiovascular disease. Compounds of formula I wherein dashed double bond is either as single bond or a double bond; X1-X5 are independently N, CH; W is O, S, (un)substituted CH, NH and derivatives; ring B is 6-membered heteroaryl, 6-membered monocyclic ring, Ph; Y1 is N, NH, CH, CH2; ring C is cyclohexyl, Ph, pyridinyl; L is (un)substituted CH2, S, O, NH and derivatives; ring D is bicyclic heteroaryl; EE is COOH, -COCF3, -CH(OH)CF3, -CONH-CN, -CONH-OH, -CO-NH-OMe, etc.; T is -CH(RbRc); Ra, Rb and Rc are independently H, D, halo, CN, C1-6 alkyl, C1-6 alkoxy, etc.; R1 is H, D, halo, CN, OH, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is H, D, halo, CN, OH, oxo, C1-6 alkyl, etc.; R3 is H, D, CN, OH, oxo, C1-6 alkyl, C1-6 alkoxy, etc.; R4 is H, D, halo, OH, CN, C1-6 alkyl, C1-6 alkoxy, etc.; and their pharmaceutically acceptable salts, stereoisomers, solvates, hydrates as Glp-1R agonists in the treatment of diseases thereof, are claimed. Example compound II was prepared starting from 4-bromo-3-fluorobenzeneacetonitrile by using alcoholysis, heterocyclization, cross-coupling, and hydrolysis as the key steps. All the invention compounds were evaluated for their Glp-1R agonistic activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to benzimidazole derivative preparation glp1r agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 1, 2022, Yang, Xiaozhe; Hu, Wenzhong; Xiu, Zhilong; Ji, Yaru; Guan, Yuge published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Interactions between Leu. mesenteroides and L. plantarum in Chinese northeast sauerkraut. And the article contained the following:

LAB are mostly used microorganisms for traditional fermented foods, e.g. Chinese northeast sauerkraut. However, the interactions between these strains are little known in mixed culture. This study aimed to explore the interaction between Leu. mesenteroides and L. plantarum based on metabolomics and transcriptomics during single- and mix-cultured fermentation of Chinese northeast sauerkraut. Metabolomics anal. revealed that the mixed culture showed different metabolite profiles in comparison with single culture. Higher levels of 4-vinylphenol (4.51%), 2,6-diaminopimelic acid (4.47%), Et dodecanoate (5.53%) were observed in mix-cultured samples than that with Leu. mesenteroides. In addition, the levels of 4-isopropylbenzoic acid (3.54%), 2,3-butanediol (7.23%), 1-octadecene (5.15%), Et dodecanoate (5.53%) were higher than that with L. plantarum. The most influenced pathway was carbohydrate metabolism, which was mostly related to 116 genes considered as DEGs in C_30 vs. D_30 groups (CD), according to transcriptomics anal. Addnl., 69 genes were considered as significantly DEGs in C_30 vs. A_30 groups (CA) which were considerably mapped to amino acid metabolism These results provided integrated views into the adaptive responses of the two strains to mix-cultured fermentation, which was useful for the rational development of mixed cultures in sauerkraut industry. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to sauerkraut leuconostoc mesenteroides lactobacillus plantarum interaction, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, Macedo, Leandro Levate; Correa, Jefferson Luiz Gomes; da Silva Araujo, Cintia; Vimercati, Wallaf Costa published an article.Name: SweetPearlR P300 DC Maltitol The title of the article was Effect of osmotic agent and vacuum application on mass exchange and qualitative parameters of osmotically dehydrated strawberries. And the article contained the following:

Sucrose is the most commonly used solute in the osmotic dehydration (OD) of fruits. However, there is increasing interest in replacing it with other alternative sugars. Polyols are carbohydrates with low glycemic, insulinemic, and cariogenic indexes. Therefore, this work aimed to study the influence of the type of osmotic agent (sucrose, erythritol, or maltitol) and vacuum application on mass transfer and phys. and nutritional changes in 10-mm edge strawberry cubes. OD was performed with or without vacuum application during the first 20 min in a total process time of 300 min. Higher solid gain, water loss and weight reduction, and lower water activity and moisture content were observed by using erythritol solution The vacuum application strengthened this behavior. The color of the samples was affected by factors. Osmotic processes reduced the total anthocyanin content (TAC), showing that leaching is an important qual. flow during osmotic processes. Novelty impact statement : Polyols showed good potential as an osmotic agent in the osmotic dehydration of strawberries and are a good alternative to the use of sucrose. Osmotic dehydration promoted a satisfactory impregnation of polyols in the strawberry, mainly with the application of vacuum, in which the mass exchange rates were increased. However, leaching was an important flow of anthocyanin loss from strawberries to the osmotic solution The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Name: SweetPearlR P300 DC Maltitol

The Article related to strawberry sucrose erythritol maltitol vacuum mass exchange osmotic dehydration, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Name: SweetPearlR P300 DC Maltitol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 14, 2020, Zhang, Jiandong; Yang, Xiaoxiao; Dong, Rui; Gao, Lili; Li, Jing; Li, Xing; Huang, Shuangping; Zhang, Chaofeng; Chang, Honghong published an article.Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol The title of the article was Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols. And the article contained the following:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol

The Article related to cascade reaction stereoselective aminohydroxylation styrenyl olefin arylglycinol, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 14, 2020, Zhang, Jiandong; Yang, Xiaoxiao; Dong, Rui; Gao, Lili; Li, Jing; Li, Xing; Huang, Shuangping; Zhang, Chaofeng; Chang, Honghong published an article.COA of Formula: C9H10F3NO The title of the article was Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols. And the article contained the following:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).COA of Formula: C9H10F3NO

The Article related to cascade reaction stereoselective aminohydroxylation styrenyl olefin arylglycinol, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.COA of Formula: C9H10F3NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts