Month: November 2022

Name: 2-Aminopropane-1,3-diolIn 2022 ,《A robust and self-healing elastomer achieved by a thio-β-diketone-Cu(II) coordination and H-bonding dual crosslinked system》 was published in Materials Chemistry Frontiers. The article was written by An, Xiaoming; Liu, Jie; Zhang, Jia-Han; Huang, Xinxin; Zhu, Tangsong; Yan, Hongping; Jia, Xudong; Zhang, Qiuhong. The article contains the following contents:

Elastomers possessing good mech. strength and self-healing capability are showing great importance in stretchable electronics, since they can play the role of robust substrates for devices, and prolong the service life of devices. However, it is hard to balance the trade-off between the high mech. strength and self-healing ability. Here we propose the synergetic strategy via combining thio-β-diketone-Cu2+ metal-ligand (M-L) coordination with hydrogen bonds in one system, through which high mech. strength, good elasticity and self-healing ability are achieved. The elastomer displays excellent mech. performances (with a fracture strength of 4.35 MPa and a fracture strain of 3400%). Meanwhile, the elastomer can realize a high self-healing efficiency (94%) within only 3 h at 80 °C. X-ray absorption fine structure (XAFS) anal. demonstrates the reconfiguration of M-L coordination at the mol. level, and small angle X-ray scattering (SAXS) during stretching demonstrates the microphase structure change of the polymer at the nanoscale level. Based on the elastomer, a self-healable pressure sensor and a self-healable strain sensor are fabricated.2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: 2-Aminopropane-1,3-diol

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Alcohol – Wikipedia,
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《(S)-2-[(N-arylamino)methyl]pyrrolidines-Based Phosphoramidite P,N-Ligand Library for Asymmetric Metal-Catalyzed Allylic Substitution and Conjugate 1,4-Addition》 was published in ChemistrySelect in 2016. These research results belong to Gavrilov, Konstantin N.; Mikhel, Igor S.; Chuchelkin, Ilya V.; Zheglov, Sergey V.; Gavrilov, Vladislav K.; Birin, Kirill P.; Tafeenko, Victor A.; Chernyshev, Vladimir V.; Goulioukina, Nataliya S.; Beletskaya, Irina P.. SDS of cas: 329735-68-4 The article mentions the following:

A library of easy-to-prepare and modular chiral P,N-phosphoramidites based on [1,1′-biaryl]-2,2′-diols and C1-sym. 1,2-diamines was designed and developed. The structures of the novel ligands were elucidated by 2-dimensional-NMR and confirmed in the solid state by x-ray diffraction anal. Stereoselectors of this type exhibited high enantioselectivities in Pd-catalyzed allylic substitution reactions of (E)-1,3-diphenylallyl acetate with NaSO2-p-Tol (up to 91% ee), CH2(CO2Me)2 (up to 89% ee), Pr2NH (up to 94% ee) and (EtO)2P(O)CH2NH2 as a novel nucleophile (up to 98% ee). Ee values of up to 88% and 72% were obtained in the Pd-catalyzed desymmetrization of N,N’-ditosyl-meso-cyclopent-4-ene-1,3-diol biscarbamate and in the Cu-catalyzed 1,4-conjugate addition of diethylzinc to chalcone, resp. The reactions of P,N-bidentate ligands with [Pd(Cod)Cl2] at molar ratios of L/M = 1 and 2 were studied using 1H, 13C, 13C-1H HSQC, 13C-1H HMBC, 1H-1H COSY, 1H-1H ROESY, DOSY and 31P NMR spectroscopy as well as HR ESI mass spectrometry. The results came from multiple reactions, including the reaction of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4SDS of cas: 329735-68-4)

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols.SDS of cas: 329735-68-4 The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).

Referemce:
Alcohol – Wikipedia,
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《Asymmetric hydrogenation of α-hydroxy ketones with an iridium/f-amphox catalyst: efficient access to chiral 1,2-diols》 was published in Organic Chemistry Frontiers in 2017. These research results belong to Wu, Weilong; Xie, Yun; Li, Pan; Li, Xiuxiu; Liu, Yuanhua; Dong, Xiu-Qin; Zhang, Xumu. Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol The article mentions the following:

The tridentate f-amphox ligands has been successfully applied to the iridium-catalytic asym. hydrogenation of various α-hydroxy ketones RC(O)CH2OH (R = CH3CH2, 3-BrC6H4, furan-2-yl, naphthalen-2-yl, etc.) to afford the corresponding chiral 1,2-diols (S)/(R)-RCH(OH)CH2OH with excellent results (almost all products up to 99% yield and >99%ee). This catalytic system displayed extremely high activity, achieving up to 1000000 turnover number (TON). The great performance of this asym. hydrogenation procedure makes the preparation of various chiral 1,2-diols highly practical with great potential. In the part of experimental materials, we found many familiar compounds, such as (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol

Referemce:
Alcohol – Wikipedia,
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《Inhibition of the autoxidation of fats and oils. IX. Antioxidant activity of some 4-alkylcatechols》 was published in Nippon Nogei Kagaku Kaishi in 1954. These research results belong to Tamura, Saburo; Okubo, Hide; Kaneta, Hiroshi. Computed Properties of C10H14O2 The article mentions the following:

cf. C.A. 50, 6403b. 4-Alkylcatechols, 1,2,4-(HO)2C6H3R (I), were synthesized and studied for the relationship between the antioxidant property and chem. structure. Veratrole (20 g.) and 13 g. Ac2O in PhNO2 with 26 g. AlCl3 below 0° gave 19 g. 4-acetylveratrole, b15 170-5°, 13 g. of which was hydrogenated with 40 g. Zn amalgam to 6 g. 4-ethylveratrole, b55 150°, which was demethylated with HI to 60% I (R = Et) (II), b9 130-2°. Similar processes gave: I (R = Bu) (III), b5 143-8°, m. 42-3°, from 4-butylveratrole, b8 128-35° (prepared from 4-butyroylveratrole, b9 175°, m. 52-3°); I (R = hexyl) (IV), b5 164-70°, from 4-hexylveratrole, b11 155-60° (prepared from 4-hexanoylveratrole, b17 176-8°); I (R = decyl) (V), m. 73-4°, from 4-decylveratrole, m. 25-6° (prepared from 4-decanoylveratrole, m. 60-1°); and I (R = dodecyl) (VI), m. 75-6°, from 4-dodecylveratrole, m. 39-40° (prepared from 4-dodecanoylveratrole, m. 57°). Guaiacol propionate, b8 115-18°, prepared from guaiacol and propionic acid in the presence of SOCl2, was treated with AlCl3 and CS2 to obtain 4-propionylguaiacol, b15 182-7°, which was converted to 4-propylguaiacol, b15 130-6°, and then to I (R = Pr) (VII), b12 155-7°. Other I were prepared from catechol esters: 4-valeroylcatechol, b10 245-55°, gave I (R = pentyl) (VIII), b7 155-60°; and 4-octanoylcatechol, b4 210-20°, gave I (R = octyl) (IX), b5 175-80°. The relative antioxidant activity was expressed as in Part V (C.A. 50, 6402b). At 0.01% on a molar basis, the results by the active O method (hrs.) and the inhibitor ratio, resp., were: lard (no antioxidant), 4.5, -; dihydronorguaiaretic acid (IXa), 28.0, 0.53; catechol, 26.0, 0.48; II, 61.0, 1.25 (the most active); VII, 52.0, 1.07; III, 51.0, 1.05; VIII, 48.0, 0.98; IV, 47.0, 0.96; IX, 40.5, 0.81; V, 50.0, 1.00; VI, 42.0, 0.84; propionylcatechol, 8.0, 0.05; and dodecanoylcatechol, 8.0, 0.08. However, most of these alkylcatechols were apt to produce eczema on human skin and discolored the product. In the experiment, the researchers used many compounds, for example, 4-Butylbenzene-1,2-diol(cas: 2525-05-5Computed Properties of C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Computed Properties of C10H14O2

Referemce:
Alcohol – Wikipedia,
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《Metal-free and recyclable route to synthesize polysubstituted olefins via C-C bond construction from direct dehydrative coupling of alcohols or alkenes with alcohols catalyzed by sulfonic acid-functionalized ionic liquids》 was published in Advanced Synthesis & Catalysis in 2014. These research results belong to Han, Feng; Yang, Lei; Li, Zhen; Zhao, Yingwei; Xia, Chungu. HPLC of Formula: 63012-03-3 The article mentions the following:

A direct synthesis of polysubstituted olefins via construction of C-C bonds, which involves the direct dehydrative coupling of alcs. or alkenes with alcs., was realized using a series of alkanesulfonic acid group-functionalized ionic liquids (SO3H-functionalized ILs) without additives. The metal-free and recyclable catalyst system avoided the disposal and neutralization of acidic catalysts after reaction and tolerated a broad range of substrates, including benzylic, allyl, propargylic, aliphatic and aromatic or aliphatic olefins. Addnl., the catalytic system was suitable for a gram-scale preparation Preliminary mechanistic studies indicated that the C-H bond cleavage in this reaction might be involved in the rate-determining step. After reading the article, we found that the author used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3HPLC of Formula: 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.HPLC of Formula: 63012-03-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 329735-68-4On November 15, 2001 ,《Phosphonites Based on the Paracyclophane Backbone: New Ligands for Highly Selective Rhodium-Catalyzed Asymmetric Hydrogenation》 appeared in Organic Letters. The author of the article were Zanotti-Gerosa, Antonio; Malan, Christophe; Herzberg, Daniela. The article conveys some information:

The synthesis of new phosphonites with a chiral paracyclophane backbone is described. The Rh complexes derived from the phosphonites (e.g. I) bearing biphenoxy and binaphthoxy substituents are highly active and highly selective catalysts for the asym. hydrogenation of dehydroamino acids and esters. For example, >99% N-acetylalanine Me ester with 99 %ee was obtained in 1/2 h using the Rh complex of I.(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4SDS of cas: 329735-68-4) was used in this study.

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols.SDS of cas: 329735-68-4 The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneOn March 16, 2015, Gonzalez, Miguel I.; Bloch, Eric D.; Mason, Jarad A.; Teat, Simon J.; Long, Jeffrey R. published an article in Inorganic Chemistry. The article was 《Single-Crystal-to-Single-Crystal Metalation of a Metal-Organic Framework: A Route toward Structurally Well-Defined Catalysts》. The article mentions the following:

Metal-organic frameworks featuring ligands with open chelating groups are versatile platforms for the preparation of a diverse set of heterogeneous catalysts through postsynthetic metalation. The crystalline nature of these materials allows them to be characterized via x-ray diffraction, which provides valuable insight into the structure of the metal sites that facilitate catalysis. A highly porous and thermally robust zirconium-based metal-organic framework, Zr6O4(OH)4(bpydc)6 (bpydc2- = 2,2′-bipyridne-5,5′-dicarboxylate), bears open bipyridine sites that readily react with a variety of solution- and gas-phase metal sources to form the corresponding metalated frameworks. Remarkably, Zr6O4(OH)4(bpydc)6 undergoes a single-crystal-to-single-crystal transformation upon metalation that involves a change in space group from Fm3-m to Pa3-. This structural transformation leads to an ordering of the metalated linkers within the framework, allowing structural characterization of the resulting metal complexes. Also, Zr6O4(OH)4(bpydc)6 yields an active heterogeneous catalyst for arene C-H borylation when metalated with [Ir(COD)2]BF4 (COD = 1,5-cyclooctadiene). These results highlight the unique potential of metal-organic frameworks as a class of heterogeneous catalysts that allow unparalleled structural characterization and control over their active sites. The results came from multiple reactions, including the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 54-17-1On March 31, 2019, Gabr, S. K.; Bakr, R. O.; Mostafa, E. S.; El-Fishawy, A. M.; El-Alfy, T. S. published an article in South African Journal of Botany. The article was 《Antioxidant activity and molecular docking study of Erythrina neillii polyphenolics》. The article mentions the following:

Species of genus Erythrina have a great contribution in folk medicine; various species are utilized as a tranquilizer, to treat insomnia, inflammation and colic. Besides, Erythrina species have reported antioxidant, hepatoprotective and anxiolytic activities. Erythrina × neillii is a hybrid obtained through a cross between E. herbacea L. and E. humeana Spreng. It has not been well-studied for its chem. or biol. profile; therefore it represents an interesting field of study. In this study, seven phenolic compounds; two hydrolysable tannins (1,3), one phenolic acid (2) and four known flavonoids (4-7) were isolated and characterized for the first time in E × neillii and Erythrina genus except for vitexin (7). Isolated compounds were assessed for their antioxidant activities using ORAC assay. 2″”-O-galloyl orientin (6) exhibited the highest activity followed by 2″”-O-galloyl vitexin (5). Flexible mol. docking on heme oxygenase, an important stress protein that is involved in cellular protection, antioxidant and anti-inflammatory activities, justified the antioxidant activity of the isolated compounds The best scoring was observed with 2″”-O-galloyl orientin forming four binding interactions with residues, Arg 136 (two interactions), Met34 and Gly139. Erythrina × neillii offered powerful and available antioxidant beside significantly active phytoconstituents. After reading the article, we found that the author used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Related Products of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Related Products of 54-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 591-70-8On September 21, 2007 ,《1-Phenylethyl isocyanate is a powerful reagent for the chiral analysis of secondary alcohols and hydroxy fatty acids with remote stereogenic centres》 was published in Journal of Chromatography A. The article was written by Habel, Andreas; Spiteller, Dieter; Boland, Wilhelm. The article contains the following contents:

1-Phenylethyl isocyanate (1-PEIC), a chiral derivatization reagent for the resolution of secondary alcs. is a powerful tool to determine the configuration and enantiomeric excess of medium- to long-chain secondary alcs. by capillary gas chromatog. The separation of 1-phenylethylcarbamates (1-PECs) of secondary alcs. was systematically evaluated depending on the position of the stereogenic center in the mol., in alkanols (C15-18), alkenols (C15-18) and hydroxy fatty acids (C14-18). The successful separation of the diastereomeric carbamates of (±)-heptadecan-7-ol or (±)-12-hydroxyoctadecanoic acid Me ester by gas liquid chromatog. demonstrates the unique separation power for 1-PECs for analytes with remote stereogenic centers. Saturated derivatives showed consistently higher resolution factors than the corresponding unsaturated derivatives In the experimental materials used by the author, we found Octadecan-9-ol(cas: 591-70-8Application of 591-70-8)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Application of 591-70-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 6346-09-4On May 3, 2019 ,《Synthesis of Multisubstituted Pyrroles from Enolizable Aldehydes and Primary Amines Promoted by Iodine》 appeared in Journal of Organic Chemistry. The author of the article were Huang, Wenbo; Chen, Shaomin; Chen, Zhiyan; Yue, Meie; Li, Minghao; Gu, Yanlong. The article conveys some information:

1,2,4-Trisubstituted pyrroles were synthesized from enolizable aliphatic aldehydes and primary aliphatic amines by using iodine as the dual Lewis acid/mild oxidant. In the presence of 3.0 equiv of TBHP, enolizable α,β-unsaturated aldehyde, for example, cocal reacted with aromatic primary amines to form C2-iodized N-arylpyrroles. An acetal-containing pyrrole was successfully prepared from 4-aminobutyraldehyde di-Et acetal, which can be converted easily to 5,6,7,8-tetrahydroindolizine derivatives In the experiment, the researchers used many compounds, for example, 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Recommanded Product: 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 6346-09-4

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Alcohol – Wikipedia,
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