Month: November 2022

《Erbium anchored iminodiacetic acid (IDA) functionalized CoFe2O4 nano particles: an efficient magnetically isolable nanocomposite for the facile synthesis of 1,8-naphthyridines》 was written by Tamoradi, Taiebeh; Daraie, Mansoureh; Heravi, Majid M.; Karmakar, Bikash. Formula: C7H6O2 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

A novel functional material was developed by immobilizing an iminodiacetic acid-erbium (Er) complex onto the surface of magnetic spinel CoFe2O4 nanoparticles. The obtained nanocomposite was fully characterized using different anal. techniques such as FT-IR, XRD, SEM, BET, EDX and X-ray at. mapping anal. The catalytic activity of this novel material was investigated in the successful synthesis of 1,8-naphthyridine derivatives via a three component reaction involving 2-aminopyridine, malononitrile and various aryl aldehydes. The reactions ended up with excellent yields in short reaction times. The catalyst was reused seven times in the proposed reaction without appreciable loss of activity. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Design, Synthesis, and Biological Evaluation of Linear Aliphatic Amine-Linked Triaryl Derivatives as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction with Promising Antitumor Effects In Vivo》 was written by Guo, Jialin; Luo, Longlong; Wang, Zhihong; Hu, Naijing; Wang, Wei; Xie, Fei; Liang, Erguang; Yan, Xinlin; Xiao, Junhai; Li, Song. Name: 2-Aminopropane-1,3-diol And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

A series of novel linear aliphatic amine-linked triaryl derivatives as inhibitors of PD-1/PD-L1 were designed, synthesized, and evaluated in vitro and in vivo. In this chem. series, compound I showed the most potent inhibitory activity and binding affinity with hPD-L1, with an IC50 value of 12 nM and a KD value of 16.2 pM, showing a binding potency approx. 2000-fold that of hPD-1. Compound I could bind with hPD-L1 on the cellular surface and competitively block the interaction of hPD-1 with hPD-L1. In a T cell function assay, I restored the T cell function, leading to increased IFN-γ secretion. Moreover, in a humanized mouse model, compound I significantly inhibited tumor growth without obvious toxicity and showed moderate PK properties after i.v. injection. These results indicated that I is a promising lead for further development of small-mol. PD-1/PD-L1 inhibitors for cancer therapy. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Name: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Consecutive C1-Homologation / Displacement Strategy for Converting Thiosulfonates into O,S-Oxothioacetals》 was written by Ielo, Laura; Pillari, Veronica; Miele, Margherita; Holzer, Wolfgang; Pace, Vittorio. Formula: C6H7NO And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

A conceptually intuitive synthesis of oxothioacetals RSCH2OR1 [R = Me, Ph, 4-FC6H4, 2-F3CC6H4, (4,6-dimethylpyrimidin-2-yl); R1 = Me, 2-BrC6H4, 1-naphthyl, etc.] was reported starting from thiosulfonates as electrophilic sulfur donors. The installation of a reactive CH2Cl motif with a homologating carbenoid reagent, followed by the immediate nucleophilic displacement with alc. groups [(hetero)-aromatic, aliphatic] offered a convenient access to the title compounds RSCH2OR1. Genuine chemoselectivity was uniformly observed in the case of multi-functionalized systems. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression》 was written by Wang, Mao-Ze; Niu, Jie; Ma, Hui-Jian; Dad, Haseeb Anwar; Shao, Hai-Tao; Yuan, Tie-Jun; Peng, Li-Hua. Recommanded Product: 156-87-6 And the article was included in Journal of Controlled Release in 2020. The article conveys some information:

Melanoma is an aggressive disease with rapid progression and fast relapse, representing one of the formidable challenges in clinic. Current systemic therapies for melanoma exhibit limited anticancer potential due to the lack of specificity and limited efficacy. Herein, we design a cationic polymer (SCP-HA-PAE) by conjugating skin/cell penetrating peptide (SCP) and hyaluronic acid (HA) to the amphipathic polymer (poly β-amino esters, PAE), then fabricate the nanocarriers (SHP) composed by SCP-HA-PAE for delivering siRNA to skin melanoma by transdermal application. SHP not only manifests the excellent ability in penetrating through skin stratum corneum (SC), targeting melanoma and being sensitive to pH, but also expresses the advantages in compacting the vector/siRNAs nanocomplexes and stimulating their endosome escape inside cells, which ensure the enhanced siRNA delivery efficiency. SHP/siRNA induce the strong efficacy in retarding the progression and relapse of skin melanoma through the enhanced apoptosis effect both in vitro & in vivo. This study provides a proof-of-concept design of pH-switchable cationic micelles as transdermal gene delivery nanoplatforms with targeting effect for melanoma therapy, which may be adapted widely in the treatment of various superficial tumors and skin genetic diseases. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Recommanded Product: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis of Enaminone-Pd(II) Complexes and Their Application in Catalyzing Aqueous Suzuki-Miyaura Cross Coupling Reaction》 was written by Fu, Leiqing; Cao, Xiaoji; Wan, Jie-Ping; Liu, Yunyun. SDS of cas: 89466-08-0 And the article was included in Chinese Journal of Chemistry in 2020. The article conveys some information:

A series of Pd(II)-enaminone complexes I (R1 = H, 4-MeO, 3,4-di-Cl; R2 = Me, Ph), termed Pd(eao)2, have been synthesized and characterized. The investigation on the catalytic activities of these new Pd(II)-reagents has proved that Pd(II)-complex I (R1 = H; R2 = Me) possesses excellent catalytic activity for the Suzuki-Miyaura cross coupling reactions of aryl bromides/chlorides with aryl/vinyl boronic acids in the environmentally benign media of aqueous PEG400 at low loading (5 mol%.). The superiority of this Pd(II)-reagent to those com. Pd(II) and Pd(0) catalysts in catalyzing the reactions has been confirmed by parallel experiments What’s more, Pd(II)-complex I (R1 = H; R2 = Ph) has been found as a practical catalyst for the homo-coupling reactions of aryl boronic acids. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0SDS of cas: 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. SDS of cas: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An, Ju Hyeon; Kim, Kyu Dong; Lee, Jun Hee published their research in Journal of Organic Chemistry in 2021. The article was titled 《Highly Chemoselective Deoxygenation Of N-Heterocyclic N-Oxides Using Hantzsch Esters As Mild Reducing Agents》.COA of Formula: C3H6O2 The article contains the following contents:

A highly chemoselective room-temperature deoxygenation method applicable to various functionalized N-heterocyclic N-oxides via visible light-mediated metallaphotoredox catalysis using Hantzsch esters as the sole stoichiometric reductant to afford deoxygenated N-heterocycles I [R = 6-OMe, 6-Cl, 2-Ph, etc.], II [R1 = H, 5-Br; X = CH, N] and III [R2 = 3-Ph, 2,6-Cl2, pyridin-2-yl, etc.] were reported. Despite the feasibility of catalyst-free conditions, most of these deoxygenations could be completed within a few minutes using only a tiny amount of a catalyst. This technol. also allowed for multigram-scale reactions even with an extremely low catalyst loading of 0.01 mol %. The scope of this scalable and operationally convenient protocol encompassed a wide range of functional groups, such as amides, carbamates, esters, ketones, nitrile groups, nitro groups and halogens, which provided access to the corresponding compounds I, II and III in good to excellent yields (an average of an 86.8% yield for a total of 45 examples). In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kalola, Anirudhdha G.; Prasad, Pratibha; Patel, Manish P. published an article in 2022. The article was titled 《Reduction of aliphatic, aromatic and heteroaromatic carboxylic acid derivatives to alcohol promoted by trityl resin under presence of copper sulphate and sodium borohydride catalytic system》, and you may find the article in Heterocyclic Letters.Recommanded Product: 100-55-0 The information in the text is summarized as follows:

An efficient, eco-friendly, mild protocol for the acid-alc. transformation is developed. Varied aliphatic, aromatic and heteroaromatic carboxylic acid derivatives RC(O)OH [R = n-heptadecan-1-yl, 1-naphthyl, furan-2-yl, etc.] loaded on to the 2-chloro trityl chloride resin under perseverance of DIPEA base followed by subsequent reduction into corresponding alcs. ROH using CuSO4-NaBH4 catalytic system have been achieved in excellent yield with easy product isolation technique. Facile recycling of the recovered resin is also associated to this methodol. In the experiment, the researchers used 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Mingqin; Li, Xinyan; Zhang, Xiaoyu; Shao, Zhihui published an article in 2022. The article was titled 《Efficient Synthesis of C3-Alkylated and Alkenylated Indoles via Manganese-Catalyzed Dehydrogenation》, and you may find the article in Chemistry – An Asian Journal.Quality Control of 3-Pyridinemethanol The information in the text is summarized as follows:

Herein, a manganese-based catalytic system that enables the efficient synthesis of C3-alkylated indoles I [R = Bn, 2-MeC6H4CH2, 4-ClC6H4CH2, etc.] was described from benzyl alcs. and indoles via the borrowing hydrogen process. Furthermore, dehydrogenative coupling of 2-arylethanols and indoles yields C3-alkenylated indoles I [R = CH=CHPh, 4-MeC6H4CH=CH, 4-BrC6H4CH=CH, etc.]. Meanwhile, reacting 2-aminophenethanol instead of indoles could also obtain the corresponding indole products with high selectivity under the same conditions. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Quality Control of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dai, Li; Lou, Jiangfei; Baek, Na-won; Zhang, Xun; Yuan, Jiugang; Xu, Jin; Fan, Xuerong published an article in 2022. The article was titled 《A rapid way of preparing switchable bacteria-killing and bacteria-releasing cellulosic material with anti-bacteria adhesion capability》, and you may find the article in Cellulose (Dordrecht, Netherlands).Application In Synthesis of 3-Bromopropan-1-ol The information in the text is summarized as follows:

At present, some multifunctional and smart materials equipped with both “”bacteria-killing”” and “”bacteria-defending”” functions have been created to meet the demands of some particular application areas. However, most of these materials were either biol. incompatible or required intricate crafting. In this paper, a finishing agent containing quaternary ammonium lactone ring and NCO groups was developed. Particularly, the quaternary ammonium lactone ring can transfer to zwitterionic form in alk. conditions, providing possibilities for switching of different functions. As a result, this agent was demonstrated to be quickly and covalently grafted to cellulosic materials. Moreover, the finished fabrics can kill more than 99.90% of bacteria (both E. coli and S. aureus) when they are in the form of quaternary ammonium lactone ring structure, and it can release almost 99.00% of the bacteria after being transferred to the zwitterionic form. Simultaneously, the zwitterionic state has a 99.90% efficiency of anti-bacteria adhesion. Hence, this is an easy and rapid way to realize the multifunction of “”bacteria-killing””, “”bacteria-releasing”” and “”anti-bacteria adhesion”” on cellulosic material. It has a great application prospect in inner single-use medical materials to kill the attached bacteria, further release them before using and prevent the materials from being attached by bacteria again. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Application In Synthesis of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Application In Synthesis of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Gutierrez-Bonet, Alvaro; Popov, Stasik; Emmert, Marion H.; Hughes, Jonathan M. E.; Nolting, Andrew F.; Ruccolo, Serge; Wang, Yunyi published an article in Organic Letters. The title of the article was 《Asymmetric Synthesis of Tertiary and Secondary Cyclopropyl Boronates via Cyclopropanation of Enantioenriched Alkenyl Boronic Esters》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

The cyclopropanation of alkenyl boronates and subsequent derivatization of the boronate handle are a convenient strategy to quickly build mol. complexity and access diverse compounds with a high sp3 fraction. Herein, the authors describe the asym. cyclopropanation of enantioenriched hydrobenzoin-derived alkenyl boronic esters toward the synthesis of tertiary and secondary cyclopropyl boronates.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts