Month: November 2022

《Non-viral gene delivery of HIF-1α promotes angiogenesis in human adipose-derived stem cells》 was written by Est-Witte, Savannah E.; Farris, Ashley L.; Tzeng, Stephany Y.; Hutton, Daphne L.; Gong, Dennis H.; Calabresi, Kaitlyn G.; Grayson, Warren L.; Green, Jordan J.. Name: 3-Aminopropan-1-ol And the article was included in Acta Biomaterialia in 2020. The article conveys some information:

Stable and mature vascular formation is a current challenge in engineering functional tissues. Transient, non-viral gene delivery presents a unique platform for delivering genetic information to cells for tissue engineering purposes and to restore blood flow to ischemic tissue. The formation of new blood vessels can be induced by upregulation of hypoxia-inducible factor-1α (HIF-1α), among other factors. We hypothesized that biodegradable polymers could be used to efficiently deliver the HIF-1α gene to human adipose-derived stromal/stem cells (hASCs) and that this treatment could recruit an existing endogenous endothelial cell population to induce angiogenesis in a 3D cell construct in vitro. In this study, end-modified poly(β-amino ester) (PBAE) nanocomplexes were first optimized for transfection of hASCs and a new biodegradable polymer with increased hydrophobicity and secondary amine structures, N’-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine end-modified poly(1,4-butanediol diacrylate-co-4-amino-1-butanol), was found to be most effective. Optimal PBAE nanocomplexes had a hydrodynamic diameter of approx. 140 nm and had a zeta potential of 30 mV. The PBAE polymer self-assembled with HIF-1α plasmid DNA and treatment of hASCs with these nanocomplexes induced 3D vascularization. Cells transfected with this polymer-DNA complex were found to have 106-fold upregulation HIF-1α expression, an approx. 2-fold increase in secreted VEGF, and caused the formation of vessel tubules compared to an untransfected control. These gene therapy biomaterials may be useful for regenerative medicine. Not only is the formation of stable vasculature a challenge for engineering human tissues in vitro, but it is also of valuable interest to clin. applications such as peripheral artery disease. Previous studies using HIF-1α to induce vascular formation have been limited by the necessity of hypoxic chambers. It would be advantageous to simulate endogenous responses to hypoxia without the need for phys. hypoxia. In this study, 3D vascular formation was shown to be inducible through non-viral gene delivery of HIF-1α with new polymeric nanocomplexes. A biodegradable polymer N’-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine end-modified poly(1,4-butanediol diacrylate-co-4-amino-1-butanol) demonstrates improved transfection of human adipose-derived stem cells. This nanobiotechnol. could be a promising strategy for the creation of vasculature for tissue engineering and clin. applications. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Name: 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Aerobic oxidative dehydrogenation of N-heterocycles over OMS-2-based nanocomposite catalysts: preparation, characterization and kinetic study》 was written by Bi, Xiuru; Tang, Tao; Meng, Xu; Gou, Mingxia; Liu, Xiang; Zhao, Peiqing. Application of 7748-36-9 And the article was included in Catalysis Science & Technology in 2020. The article conveys some information:

Sodium phosphotungstate-containing OMS-2-based nanocomposites were prepared and characterized and used as recyclable catalysts for aerobic dehydrogenation/aromatization of nitrogen heterocycles, such as tetrahydroquinolines, tetrahydroquinazolines, indolines, and dihydroquinolines to aromatic nitrogen heterocycles. The mixed crystal phases, increased surface areas, and lattice oxygen atoms of the OMS-2-based nanocomposite catalysts are proposed to explain the activity of the catalysts. The kinetics of dehydrogenation of 1,2,3,4-tetrahydroquinoline and the substrate and catalyst order were determined, and the energy of activation for the aromatization was 29.66 kJ mol-1.Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Cayo; Lai, Joey; Epifanov, Maxim; Wang, Cindy Xinyun; Sammis, Glenn M. published their research in Journal of Fluorine Chemistry in 2021. The article was titled 《Efficient protocol for the SO2F2-mediated deoxyfluorination of aliphatic alcohols》.Product Details of 13325-10-5 The article contains the following contents:

Herein the sulfuryl fluoride-mediated deoxyfluorination of alcs. using room temperature reaction conditions in only an hour is reported. A wide range of primary aliphatic alcs. were efficiently converted to the corresponding fluoride in 46-70% isolated yields. Secondary alcs. were also effectively deoxyfluorinated in 50-92% yields. Chiral secondary alcs. were cleanly converted to the corresponding alkyl fluoride with only a minor deterioration of the enantioenrichment. A steroid derivative also underwent deoxyfluorination in 50% yield and 5.9:1 dr, with the major product resulting from net inversion of the stereocenter.4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Dongyue; Yang, Peng; Yu, Chuanman; Zhao, Fengkai; Wang, Yilei; Peng, Zhihua published their research in Journal of Organic Chemistry in 2021. The article was titled 《N-Alkylation of Amines with Alcohols Catalyzed by Manganese(II) Chloride or Bromopentacarbonylmanganese(I)》.Product Details of 100-55-0 The article contains the following contents:

A manganese-catalyzed N-alkylation reaction of amines with alcs. via hydrogen autotransfer strategy was demonstrated. The developed practical catalytic system included an inexpensive, nontoxic, com. available MnCl2 or MnBr(CO)5 as the metal salt and triphenylphosphine as a ligand provided access to diverse aromatic, heteroaromatic, and aliphatic secondary amines in moderate-to-high yields. In addition, this operationally simple protocol was scalable to the gram level and suitable for synthesizing heterocycles such as indole and resveratrol-derived amines known to be active for Alzheimer’s disease. In the experiment, the researchers used 3-Pyridinemethanol(cas: 100-55-0Product Details of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sanchez-Portillo, Paola; Hernandez-Sirio, Aime; Godoy-Alcantar, Carolina; Lacroix, Pascal G.; Agarwal, Vivechana; Santillan, Rosa; Barba, Victor published their research in Dyes and Pigments in 2021. The article was titled 《Colorimetric metal ion (II) Sensors Based on imine boronic esters functionalized with pyridine》.Related Products of 534-03-2 The article contains the following contents:

The one-step synthesis of three imine boronic esters functionalized with pyridyl groups is described (1a-1c). The presence or absence of a Me group affects the whole conformation, being bent “”L”” or linear as determined by X-ray crystal diffraction. C-H···O, C-H···N, C-H···F and C-H … π hydrogen bond interactions support 2D supramol. arrangements. Ligands were tested as metal ion (M2+) sensors in solution The addition of metal cations (Fe2+, Co2+ and Cu2+) to 1a using methanol as solvent, showed significant color changes (purple, orange and green, resp.), while for metal cations Ni2+, Zn2+, Cd2+ cations no color changes were observed The sensitivity of compound 1a towards Fe2+, Co2+ and Cu2+ was monitored by UV-Vis spectroscopy, where the presence of Fe2+ produces new bands at 360 and 566 nm. For Co2+ and Cu2+ a remarkable intensity increase was observed at 290 nm band and new bands appear at 340 and 462 nm, resp. The stoichiometry of the complexes 1a-Fe2+, 1a-Co2+ and 1a-Cu2+ was determined by Job′s plots being 1:3 (metal:ligand, complex [Fe (1a)3]2+), in contrast with the stoichiometry 1:1 observed for 1b-Fe2+. In fact, the computed ΔG formation associated value showed a strong stabilization for the complex [Fe (1a)3]2+ (-65.5 kcal/mol) in comparison with the possible complex [Fe (1b)3]2+ (-29.7 kcal/mol). Detection limits are in the mM range (determined by UV-Vis) and μM range (determined by Fluorescence). An analogous bis-bidentate derivative (2a) also shows similar behavior but stoichiometric interaction changes to 2:3 (metal:ligand) and detection limits are in the mM range obtained by UV-Vis and Fluorescence techniques. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Related Products of 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Young Woong; Yeop, Jiwoo; Kim, Jin Young; Woo, Han Young published an article in 2021. The article was titled 《Fullerene-Based Photoactive A-D-A Triads for Single-Component Organic Solar Cells: Incorporation of Non-Fused Planar Conjugated Core》, and you may find the article in Macromolecular Research.Electric Literature of C6H15NO The information in the text is summarized as follows:

Two acceptor-donor-acceptor (A-D-A) single-component (SC) photovoltaic triad mols., P3T4Rh-C6-PC61BM and P3T4Rh-C10-PC61BM, were synthesized. A conformation-locked planar conjugated core, 1,4-bis(thiophenylphenylthiophene)-2,5-difluorophenylene (P3T4), with intrachain noncovalent coulombic interactions was coupled with two fullerene derivatives, [6,6]-phenyl-C61 butyric acid propargyl ester, via copper (I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition The D-A separation was varied by modulating the spacer alkyl chain length (C6 and C10). Both SC triads exhibited maximum absorption by the P3T4 core at λabs = 507-510 nm, as well as absorption by PC61BM at ∼300 nm. Because of the broken conjugation between the P3T4 core and PC61BM termini, the HOMO (-5.58 to -5.59 eV) was determined by the P3T4 moiety, and the LUMO (-3.89 to -3.92 eV) was determined by PC61BM in the SC structures. In diluted solution, both SC triads showed significant photoluminescence quenching, indicating efficient intramol. charge transfer between the P3T4 and PC61BM moieties. However, the semicrystalline packing of the P3T4 core was severely disrupted by the incorporation of a bulky PC61BM moiety at each terminus, which degraded the carrier transport and diode characteristics of SC organic solar cells (SCOSCs) based on P3T4Rh-C6-PC61BM and P3T4Rh-C10-PC61BM, as indicated by poor power conversion efficiency (∼0.4%). No clear spacer length effect was observed To improve the performance of SCOSCs, a design strategy is needed that enhances the intermol. packing and ordering of the D and A moieties, which are important prerequisites for the development of optimal SC photoactive mols. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Milic, Mira; Targos, Karina; Tellez Chavez, Magda; Thompson, Madison A. M.; Jennings, Julia J.; Franz, Annaliese K. published an article in 2021. The article was titled 《NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules》, and you may find the article in Journal of Organic Chemistry.Name: Oxetan-3-ol The information in the text is summarized as follows:

The hydrogen-bond-accepting abilities for more than 100 organic mols. are quantified using 19F and 31P NMR spectroscopy with pentafluorobenzoic acid (PFBA) and phenylphosphinic acid (PPA) as com. available, inexpensive probes. Anal. of pyridines and anilines with a variety of electronic modifications demonstrates that changes in NMR shifts can predict the secondary effects that contribute to H-bond-accepting ability, establishing the ability of PFBA and PPA binding to predict electronic trends. The H-bond-accepting abilities of various metal-chelating ligands and organocatalysts are also quantified. The measured Δδ(31P) and Δδp(19F) values correlate strongly with Hammett parameters, pKa of the protonated HBA, and proton-transfer basicity (pKBH+). The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shen, Wenbo; Du, Bin; Liu, Jiaoshi; Zhuo, Haitao; Yang, Chuluo; Chen, Shaojun published an article in 2021. The article was titled 《A facile approach for the preparation of liquid crystalline polyurethane for light-responsive actuator films with self-healing performance》, and you may find the article in Materials Chemistry Frontiers.HPLC of Formula: 627-18-9 The information in the text is summarized as follows:

In this study, liquid crystalline polyurethane was prepared by quaternization between ordinary polyurethane and mesogenic monomers. Meanwhile, a fast light-responsive actuator film with self-healing performance based on liquid crystalline polyurethane was successfully fabricated. In the film, the mesogenic units of the nematic compound were grafted on the polyurethane main chain, leading to liquid crystal phase of the polymer. The photoresponsive units of the liquid crystalline azobenzene were utilized as photosensitive components, and polyurethane was employed as the polymer matrix to endow the material with good film-forming and mech. properties. The as-obtained actuator film not only showed a quick response and large shape deformation upon UV-irradiation but also exhibited temperature-induced self-healing performance. Moreover, the as-prepared light-responsive actuator film exhibited excellent properties coupled with easy fabrication, low cost, and good film-forming and relevant mech. properties, showing promise for future practical applications in photo-driven and optomech. devices.3-Bromopropan-1-ol(cas: 627-18-9HPLC of Formula: 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.HPLC of Formula: 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattiassi, Sabrina; Rizwan, Muhammad; Grigsby, Christopher L.; Zaw, Aung Moe; Leong, Kam W.; Yim, Evelyn K. F. published an article in 2021. The article was titled 《Enhanced efficiency of nonviral direct neuronal reprogramming on topographical patterns》, and you may find the article in Biomaterials Science.Name: 4-Aminobutan-1-ol The information in the text is summarized as follows:

Nonviral direct neuronal reprogramming holds significant potential in the fields of tissue engineering and regenerative medicine. However, the issue of low reprogramming efficiency poses a major barrier to its application. We propose that topog. cues, which have been applied successfully to enhance lineage-directed differentiation and multipotent stem cell transdifferentiation, could improve nonviral direct neuronal reprogramming efficiency. To investigate, we used a polymer-BAM (Brn2, Ascl1, Myt1l) factor transfection polypex to reprogram primary mouse embryonic fibroblasts. Using a multiarchitecture chip, we screened for patterns that may improve transfection and/or subsequent induced neuron reprogramming efficiency. Selected patterns were then investigated further by analyzing β-tubulin III (TUJ1) and microtubule-associated protein 2 (MAP2) protein expression, cell morphol. and electrophysiol. function of induced neurons. Certain hierarchical topogs., with nanopatterns imprinted on micropatterns, significantly improved the percentage of TUJ1+ and MAP2+ cells. It is postulated that the microscale base pattern enhances initial BAM expression while the nanoscale sub-pattern promotes subsequent maturation. This is because the base pattern alone increased expression of TUJ1 and MAP2, while the nanoscale pattern was the only pattern yielding induced neurons capable of firing multiple action potentials. Nanoscale patterns also produced the highest fraction of cells showing spontaneous synaptic activity. Overall, reprogramming efficiency with one dose of polyplex on hierarchical patterns was comparable to that of five doses without topog. Thus, topog. can enhance nonviral direct reprogramming of fibroblasts into induced neurons. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Lin, Shizhuo; Sheng, Xing; Zhang, Xiangyu; Liu, Haibo; Luo, Chujun; Hou, Shuaishuai; Li, Bin; Chen, Xiuwen; Li, Yibiao; Xie, Feng published an article in Journal of Organic Chemistry. The title of the article was 《Layered Double Hydroxides as Reusable Catalysts for Cyclocondensation of Amidines and Aminoalcohols: Access to Multi-functionalized Oxazolines》.Name: 2-Aminopropane-1,3-diol The author mentioned the following in the article:

An efficient catalytic protocol based on reusable MgAl-layered double hydroxides has been developed for the synthesis of multi-functionalized oxazolines via the cyclocondensation of amidines and aminoalcs. The developed method has a broad substrate scope and excellent functional group tolerance and uses a reusable catalyst. The catalyst can be conveniently recycled by filtration and reused for at least five times without obvious deactivation. Addnl., the selective ortho C-H silylation of oxazolines was performed using Ru(II) as the catalyst and tri-Et silane as the silylating reagent, which proved to be a convenient and practical method for the synthesis of versatile organosilyl-functionalized oxazolines with advantageous biol. and phys. properties. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Name: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts