Month: November 2022

In 2019,Polymers (Basel, Switzerland) included an article by Li, Botian; Shao, Wei; Wang, Yanzan; Xiao, Da; Xiong, Yi; Ye, Haimu; Zhou, Qiong; Jin, Qingjun. Reference of 2-Aminopropane-1,3-diol. The article was titled 《Synthesis and morphological control of biocompatible fluorescent/magnetic janus nanoparticles based on the self-assembly of fluorescent polyurethane and Fe3O4 nanoparticles》. The information in the text is summarized as follows:

Functionalized Janus nanoparticles have received increasing interest due to their anisotropic shape and the particular utility in biomedicine areas. In this work, a simple and efficient method was developed to prepare fluorescent/magnetic composite Janus nanoparticles constituted of fluorescent polyurethane and hydrophobic nano Fe3O4. Two kinds of fluorescent polyurethane prepolymers were synthesized by the copolymerization of fluorescent dye monomers, and the fluorescent/magnetic nanoparticles were fabricated in one-pot via the process of mini-emulsification and self-assembly. The nanostructures of the resulting composite nanoparticles, including core/shell and Janus structure, could be controlled by the phase separation in assembly process according to the result of transmission electron microscopy, whereas the amount of the nonpolar segments of polyurethane played an important role in the particle morphol. The prominent magnetic and fluorescent properties of the Janus nanoparticles were also confirmed by vibrating magnetometer and confocal laser scanning microscope. Furthermore, the Janus nanoparticles featured excellent dispersity, storage stability, and cytocompatibility, which might benefit their potential application in biomedical areas. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Reference of 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Biomaterials Science included an article by Vasey, Catherine E.; Pearce, Amanda K.; Sodano, Federica; Cavanagh, Robert; Abelha, Thais; Cuzzucoli Crucitti, Valentina; Anane-Adjei, Akosua B.; Ashford, Marianne; Gellert, Paul; Taresco, Vincenzo; Alexander, Cameron. Reference of 2-Aminopropane-1,3-diol. The article was titled 《Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles》. The information in the text is summarized as follows:

Here we describe the syntheses of amphiphilic tri- and tetra-block copolymers, using diazabicyclo[5.4.0]undec-5-ene (DBU) as a metal-free catalyst for ring-opening polymerizations of the widely-utilized monomer lactide combined with a functionalised protected cyclic carbonate. These syntheses employed PEGylated macroinitiators with varying chain lengths and architectures, as well as a labile-ester methacrylate initiator, and produced block copolymers with good control over monomer incorporation, molar masses, side-chain and terminal functionality and physico-chem. properties. Regardless of the nature of the initiators, the fidelity of the hydroxyl end group was maintained as confirmed by a second ROP chain extension step, and polymers with acryloyl/methacryloyl termini were able to undergo a second tandem reaction step, in particular thiol-ene click and RAFT polymerizations for the production of hyperbranched materials. Furthermore, the polymer side-chain functionalities could be easily deprotected to yield an active amine which could be subsequently coupled to a drug mol. in good yields. The resultant amphiphilic copolymers formed a range of unimol. or kinetically-trapped micellar-like nanoparticles in aqueous environments, and the non-cationic polymers were all well-tolerated by MCF-7 breast cancer cells. The rapid and facile route to such highly adaptable polymers, as demonstrated here, offers promise for a range of bio materials applications. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,New Journal of Chemistry included an article by Ahamad, M. Naqi; Shahid, M.; Ansari, Azaj; Kumar, Manjeet; Khan, Ishaat M.; Ahmad, Musheer; Rahisuddin; Arif, Rizwan. Quality Control of 3-Aminopropan-1-ol. The article was titled 《A combined experimental and theoretical approach to investigate the structure, magnetic properties and DNA binding affinity of a homodinuclear Cu(II) complex》. The information in the text is summarized as follows:

Herein, an antiferromagnetic homodinuclear Cu(II) complex of propanolamine, [Cu2(pa)2(OAc)2] (1), containing an acetate auxiliary was crystallized out. The complex was characterized by spectral, x-ray crystallog., magnetic and DFT/TD-DFT studies. Single crystal x-ray data reveal that 1 crystallizes in the triclinic system with the P1̅ space group, and each Cu(II) ion adopts a four-coordinated square planar geometry with the [N,O,O,O] donor set. The two [Cu(CH3COO)(pa)]+ units are connected through two alkoxy groups of the pa- ligand belonging to each unit; this gave a binuclear Cu(II) system with the bridging Cu1-O1-Cu2 angle = 103.81° and the intradimer Cu···Cu distance = 3.022 Å. The exptl. results obtained via the binding experiments of the present complex with DNA are in line with the theor. results. The auxiliary acetate group and the bridged pa- ligand facilitate the binding tendency of the complex to DNA in the minor groove region (as confirmed by docking anal.), thereby forming stronger H-bonding interactions. The easy transfer of an electron from the HOMO of DNA to the LUMO of the complex further supports the existence of a stronger binding interaction, as confirmed by the DFT anal. Temperature variable magnetic studies (SQUID measurements) revealed strong antiferromagnetic interactions (J = -222.4(2) cm-1) between two Cu(II) nuclei in a mol., and the presence of these interactions was further supported by theor. studies. The larger Cu···Cu distance and Cu-O-Cu angle are the factors behind the antiferromagnetic exchange between two Cu(II) centers. Thus, the present study establishes that the fine tuning of structures in transition metal complexes can gave magnetically and biol. important mols. for future applications. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Quality Control of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Biomedicine & Pharmacotherapy included an article by Pham, Lyna; Dang, Le Hang; Truong, Minh Dung; Nguyen, Thi Hiep; Le, Ly; Le, Van Thu; Nam, Nguyen Dang; Bach, Long Giang; Nguyen, Van Toan; Tran, Ngoc Quyen. Formula: C3H9NO. The article was titled 《A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application》. The information in the text is summarized as follows:

This study aimed to fabricate the potential therapeutic scaffold to efficiently and safely fastening skin wound healing. A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regeneration. A detailed in the rheol. study found that the encapsulated agents induced the change in the stiffness of the hydrogel from the hard to the soft. Especial, the thermally induced phase transition of CP hydrogel was governed by the participant of gelatin rather than curcumin. For example, at 25 wt% gelatin, CP hydrogel exhibited a unique gel-sol-gel transition following the function of temperature Moreover, in vitro investigation revealed that the hybrid hydrogel provides the capacity of especially induced curcumin release with a sustainable rate as well as the excellent biocompatibility scaffold. Altogether with in vivo study, the hybrid hydrogel highlighted the advance of the dual synergistic of curcumin and gelatin in development of smart scaffold system, which promoted the efficacy in the regeneration of the structure and the barrier’s function of damaged skin such as wound or skin cancer. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR》 were Tombari, Robert J.; Saunders, Carla M.; Wu, Chun-Yi; Dunlap, Lee E.; Tantillo, Dean J.; Olson, David E.. And the article was published in ACS Chemical Biology in 2019. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:

Tryptophan, an essential amino acid, is metabolized into a variety of small mols. capable of impacting human physiol., and aberrant tryptophan metabolism has been linked to a number of diseases. There are three principal routes by which tryptophan is degraded, and thus methods for measuring metabolic flux through these pathways can be used to understand the factors that perturb tryptophan metabolism and potentially to measure disease biomarkers. Here, we describe a method utilizing 6-fluorotryptophan as a probe for detecting tryptophan metabolites in ex vivo tissue samples via 19F NMR. As a proof of concept, we demonstrate that 6-fluorotryptophan can be used to measure changes in tryptophan metabolism resulting from antibiotic-induced changes in gut microbiota composition Taken together, we describe a general strategy for monitoring amino acid metabolism using 19F NMR that is operationally simple and does not require chromatog. separation of metabolites. In the part of experimental materials, we found many familiar compounds, such as Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Preparation of golf ball-shaped microspheres with fluorinated polycaprolactone via single-solvent electrospraying for superhydrophobic coatings》 were Li, Wulong; Wang, Haipeng; Li, Zhanxiong. And the article was published in Progress in Organic Coatings in 2019. Recommanded Product: 6-Aminohexan-1-ol The author mentioned the following in the article:

1H,1H,2H,2H-Perfluorooctyl polyacrylate (PTFOA) with a controllable mol. weight was successfully synthesized via atom-transfer radical polymerization (ATRP) followed by condensation with polycaprolactone (PCL) to obtain a new fluorinated block copolymer. Then, the copolymer PCL-b-PTFOA was processed via single-solvent electrospraying in chloroform to fabricate hierarchically porous microspheres. The microsphere size could be controlled from 5.13 ± 0.51 μm to 8.61 ± 0.90 μm, and the pore size on the microsphere surface could be controlled from 282.5 ± 42.0 nm to 603.3 ± 99.6 nm. Solvent evaporation-induced phase separation and fluorinated segment migration are the major reasons for the formation of the golf ball-shaped microspheres. In this study, the influence of electro-spraying parameters on the size and morphol. of the porous microspheres was systemically studied. The golf ball-shaped microspheres significantly improved the surface roughness and the CA of their coatings reached 167.3 ± 1.7°. Furthermore, a superhydrophobic fabric was produced by pretreating cotton fabric with adhesive followed by coating with PCL-b-PTFOA via electrospraying. The robust superhydrophobicity can be obtained by the stable binding of PCL-b-PTFOA microspheres onto the fibers, with the CA reaching 155.3 ± 1.1°. Electrospraying of the fluoropolymer microsphere coating was proven to be a very promising technique to produce superhydrophobic coatings on textiles through a simple procedure. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Recommanded Product: 6-Aminohexan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives》 were Gokmen, Zeliha; Onan, Mehmet Erdi; Deniz, Nahide Gulsah; Karakas, Didem; Ulukaya, Engin. And the article was published in Synthetic Communications in 2019. Electric Literature of C6H15NO The author mentioned the following in the article:

New N- and S,S-substituted-1,4-naphthoquinone (1,4 NQ) derivatives such as I [R = 2-furoyl, 4-FC6H4CH2, 2-pyridinyl, etc.] and II resp. were synthesized in excellent yields and were completely characterized by spectroscopic anal. IR, NMR (1H and 13C), MS and microanal. The cytotoxic activities of 1,4-NQ derivatives I and II were examined against A-549, DU145, HCT-116 and MDA-MB-231 cancer cells. Among these compounds, I [R = 2-furoyl] and II were identified as the most potent anticancer agents with cytotoxic activity against three cell lines (breast (MDA-MB-231), prostate (DU145), colorectal (HCT-116)). The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Electric Literature of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Phosphonium-based porous ionic polymer with hydroxyl groups: a bifunctional and robust catalyst for cycloaddition of CO2 into cyclic carbonates》 was published in Polymers (Basel, Switzerland) in 2020. These research results belong to Lei, Yizhu; Wan, Yali; Zhong, Wei; Liu, Dingfu; Yang, Zhou. Computed Properties of C3H7BrO The article mentions the following:

The integration of synergic hydrogen bond donors and nucleophilic anions that facilitates the ring-opening of epoxide is an effective way to develop an active catalyst for the cycloaddition of CO2 with epoxides. In this work, a new heterogeneous catalyst for the cycloaddition of epoxides and CO2 into cyclic carbonates based on dual hydroxyls-functionalized polymeric phosphonium bromide (PQPBr-2OH) was presented. Physicochem. characterizations suggested that PQPBr- 2OH possessed large surface area, hierarchical pore structure, functional hydroxyl groups, and high d. of active sites. Consequently, it behaved as an efficient, recyclable, and metal-free catalyst for the additive and solventfree cycloaddition of epoxides with CO2. Comparing the activity of PQPBr-2OH with that of the reference catalysts based on mono and non-hydroxyl functionalized polymeric phosphonium bromides suggested that hydroxyl functionalities in PQPBr-2OH showed a critical promotion effect on its catalytic activity for CO2 conversion. Moreover, PQPBr-2OH proved to be quite robust and recyclable. It could be reused at least ten times with only a slight decrease of its initial activity. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Computed Properties of C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis, characterization, and antimicrobial evaluation of random poly(ester-carbonate)s bearing pendant primary amine in the main chain》 was written by Dong, Peng; Feng, Jing; Li, Sujuan; Sun, Tingli; Shi, Qingshan; Xie, Xiaobao. HPLC of Formula: 534-03-2 And the article was included in Polymers (Basel, Switzerland) in 2020. The article conveys some information:

Starting from primary amine bearing cyclic carbonate tert-butyl-(2-oxo-1,3-dioxan-5-yl) carbamate (TBODC) and caprolactone (CL), amphiphilic poly(caprolactone-ran-amino tri-Me carbonate)s (P(CL-ran-ATC)s) random copolymers with controlled mol. weight and composition were synthesized via ring opening polymerization (ROP) and deprotection, using stannous octoate (Sn(Oct)2) as catalyst and benzyl alc. (BnOH) as initiator. Therefore, hydrophilic/lipophilic ratio (HLR) of the P(CL-ran-ATC)s copolymers can be finely adjusted by the feed ratio of TBODC and CL. The antimicrobial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) of P(CL-ran-ATC)s were proportional to HLR, and P(CL-ran-ATC)s presented more vigorous bactericidal activity towards S. aureus. The min. inhibitory concentration (MIC) values of P(CL-ran-ATC 50.9%) are 2000μg mL-1 and 3000μg mL-1 for S. aureus and E. coli. While P(CL-ran-ATC 50.9%) exhibited deficient hemolytic activity as 1.41%. In addition, the P(CL-ran-ATC)s showed extremely low cytotoxicity towards fibroblast L929 cells. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ingale, Ajit P.; Shinde, Sandeep V.; Thorat, Nitin M. published their research in Synthetic Communications in 2021. The article was titled 《Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions》.Name: 3-Aminopropan-1-ol The article contains the following contents:

Sulfated tungstate catalyzed an efficient and ecofriendly protocol was described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently underwent the N-tert-butyloxycarbonylation under the developed protocol. The aminoalc., aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability were the advantages of this protocol. This made the protocol feasible, economical and environmentally benign. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Name: 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts