Month: November 2022

Hu, Yongke; Xia, Jiawei; Li, Jin; Li, Huaju; Li, Yanxing; Li, Shaozhong; Duanmu, Chuansong; Li, Bindong; Wang, Xin published an article in 2021. The article was titled 《Direct oxidative esterification of alcohols catalyzed by a nitrogen-doped carbon black-supported PdBi bimetallic catalyst under ambient conditions》, and you may find the article in Journal of Materials Science.Related Products of 100-55-0 The information in the text is summarized as follows:

A highly efficient nitrogen-doped carbon black (NCB)-supported PdBi alloy nanocatalyst has been fabricated via a facile coredn. wet chem. approach. The optimal PdBi/NCB shows outstanding catalytic performance with broad substrate scope, good functional group tolerance towards direct oxidative esterification of alcs. under mild conditions in a heterogeneous catalytic system with air as the sole oxidant. A variety of benzylic and allylic alcs. were smoothly reacted with methanol and even with long-chain aliphatic alcs., providing desired esters in good to excellent yields. Moreover, the as-prepared catalyst is easily recycled and can be reused at least five times without a significant loss of catalytic activity. Superior catalytic activity is mainly attributable to the unique structure of the catalyst, including synergetic electronic effect between Pd and Bi, as well as modulated surface character by acidification and N doping for better active components’ anchoring and dispersion, as well as reactants’ adsorption. This study provides a facial, practical, eco-friendly and efficient catalytic system for oxidative esterification of alcs. and shows promising prospect in industrial production The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Related Products of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Hong, Xianfang; Guo, Jingcheng; Liu, Jinhua; Cao, Wei; Wei, Chenlong; Zhang, Ye; Zhang, Xiaoxiang; Fu, Zhenqian published an article in Science China: Chemistry. The title of the article was 《Organocatalytic dynamic kinetic resolution of N-arylindole lactams: Atroposelective construction of axially chiral amino acids bearing a C-N chiral axis》.HPLC of Formula: 100-55-0 The author mentioned the following in the article:

Organocatalytic dynamic kinetic resolution of configurationally labile cyclic mols. represents one of the most efficient methods for the atroposelective construction of axially chiral mols. bearing a tetra-ortho-substituted chiral axis. Notably, this privileged strategy is limited to constructing a C-C chiral axis. Herin, organocatalytic dynamic kinetic resolution of configurationally labile N-arylindole lactams has been successfully achieved for the first time, allowing for access to a structurally diverse set of axially chiral N-arylindole amino esters with a tetra-ortho-substituted C-N chiral axis in excellent yields and atroposelectivities. In addition to the N-arylindole skeleton, N-aryl thieno[3,2-b]pyrrole, furo[3,2-b]pyrrole, and pyrrolo[2,3-b]pyridine skeletons are also compatible with this transformation. This transition-metal-free facile strategy features a broad substrate scope, mild reaction conditions, easy scale-up and excellent atom economy. Several potentially valuable mols., such as axially chiral peptides, were efficiently generated from the resulting configurationally stable axially-chiral N-arylindole amino esters, demonstrating the power of this strategy. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Yadav, Sushma; Chauhan, Maruf; Jacob, MercyKutty; Malhotra, Priti published an article in New Journal of Chemistry. The title of the article was 《Distinguished performance of biogenically synthesized reduced-graphene-oxide-based mesoporous Au-Cu2O/RGO ternary nanocomposites for sonocatalytic reduction of nitrophenols in water》.Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:

In order to achieve a sustainable environment, the development of eco-friendly protocols for the production of noble metal catalysts has been the primary focus of major research. Ternary nanocomposites (TNCs) comprising Au-Cu2O anchored on reduced graphene oxide (Au-Cu2O/RGO) were synthesized employing a novel one-pot greener approach using sugarcane bagasse (SB) waste and Fehling’s solution without engaging harmful chems. as reagents and surfactants. In addition to the mild reducing capability of the polysaccharides present in SB, it also induces functionalization of RGO, avoiding aggregation of the reduced sheets and thereby providing in situ stabilization of Cu2O. The sonocatalytic performance of biogenically synthesized Au-Cu2O/RGO TNCs for reducing nitrophenols to the corresponding aminophenol in the presence of sodium borohydride (NaBH4) as a reducing agent was estimated TNCs showed high performance in the sonocatalytic reduction of 4-nitrophenols (4-NP), 2-nitrophenol (2-NP), and 3-nitrophenol (3-NP) with 88%, 72%, and 78% conversion within 90, 60, and 40 s, resp. The sonocatalytic activity of Au-Cu2O/RGO was enhanced compared to that of Cu2O and Cu2O/RGO due to the easier electron transfer process. The current work showcases a novel, eco-friendly, and benign protocol for the synthesis of nanocomposites (NCs) and simultaneously emphasizes the exploration of decorated metal oxide as a nanocatalyst with high catalytic potential; compared to unanchored metal oxide nanoparticles (NPs), the supported NCs exhibit greater efficacy and ease of recovery. The experimental part of the paper was very detailed, including the reaction process of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Chen, Su; Van der Eycken, Erik V.; Sharma, Upendra K. published an article in Advanced Synthesis & Catalysis. The title of the article was 《Remote Alkenylation via Carbopalladation/1,4-Palladium Migration/Heck Reaction Sequence with Unactivated Alkenyl Alcohols》.Recommanded Product: 821-41-0 The author mentioned the following in the article:

Intramol. C-H bond activation via 1,4-palladium migration has become a synthetic tool to enable remote functionalization of C-H bonds. In this work, authors report a Pd-catalyzed remote alkenylation with unactivated alkenyl alcs. involving a 1,4-palladium migration step. This method provides a regioselective access to synthesize substituted unsaturated alcs. in a single operational step. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Recommanded Product: 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Balakrishnan, Venkadesh; Ganguly, Anirban; Rasappan, Ramesh published an article in Organic Letters. The title of the article was 《Interception of Nickel Hydride Species and Its Application in Multicomponent Reactions》.Recommanded Product: 100-55-0 The author mentioned the following in the article:

The hydrogen borrowing strategy is an economical method for the α-functionalization of ketones. While this strategy is extremely advantageous, it does not lend itself to the synthesis of β,β-disubstituted ketones. This can be achieved, if the in situ generated metal hydride can be intercepted with a nucleophilic coupling partner. Authors present a multicomponent strategy for the coupling of alcs., ketones, and boronic acids using only 1 mol % nickel catalyst and without the need for added ligands. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Xia, Lei; Tian, Jia; Yue, Tao; Cao, Hongliang; Chu, Ju; Cai, Haibo; Zhang, Weian published an article in Advanced Healthcare Materials. The title of the article was 《Pillar[5]arene-Based Acid-Triggered Supramolecular Porphyrin Photosensitizer for Combating Bacterial Infections and Biofilm Dispersion》.Synthetic Route of C6H15NO The author mentioned the following in the article:

The treatment of pathogenic bacterial infection has long been the most serious threat to human life and attracted widespread attention. Herein, a supramol. photosensitizer platform based on carboxylatopillar[5]arene (CP5) and tetrafluorophenyl porphyrin functionalized with a quaternary ammonium group (TFPP-QA) for combating bacteria and dispersing biofilm via photodynamic treatment is constructed. By introducing the host macrocycle CP5 and host-guest interaction, the supramol. photosensitizer has great biocompatibility and acid responsiveness. On the one hand, the acid-triggered dissociation of TFPP-QA/CP5 could induce the porphyrin photosensitizer to target bacterial cells and disrupt the charge balance of bacterial membranes, enhance the permeability of the bacterial membrane. On the other hand, the TFPP-QA/CP5 antibacterial platform possesses superb reactive oxygen species (ROS) generation capability under light irradiation, leading to enhanced photodynamic antibacterial efficacy. The in vitro and in vivo studies show that the supramol. photosensitizers exhibit high antibacterial efficiency and biofilm dissipation effect under 660 nm light irradiation Therefore, it is anticipated that the rational design and integration of photosensitizers and quaternary ammonium compounds through the supramol. strategy would provide a promising prospect for clin. photodynamic antimicrobial therapy. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Synthetic Route of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of (4-Bromophenyl)methanolIn 2019 ,《Iridium Supported on Phosphorus-Doped Porous Organic Polymers: Active and Recyclable Catalyst for Acceptorless Dehydrogenation and Borrowing Hydrogen Reaction》 appeared in Advanced Synthesis & Catalysis. The author of the article were Yao, Wei; Duan, Zheng-Chao; Zhang, Yilin; Sang, Xinxin; Xia, Xiao-Feng; Wang, Dawei. The article conveys some information:

Iridium-on-phosphorus-doped porous organic polymers (POP-Ir) were developed by anchoring simple iridium onto the skeleton of porous organic polymers through coordination bonds. This POP-Ir catalyst, which was thoroughly characterized by means of EDS, SEM, TEM, XRD, XPS, and FT-IR, revealed excellent catalytic activity for the reaction of di-Ph phosphinamide with benzyl alcs. through borrowing hydrogen strategy and acceptorless dehydrogenation with wide functional group tolerance. Moreover, this POP-Ir catalyst could be simply recovered and reused for at least five times without a significant loss of activity, and revealed considerable application prospects. The mechanism was investigated to further understand this POP-Ir catalytic system and transformations. Overall, the POP-Ir catalytic system has shown high activity and reusability in the borrowing hydrogen reaction between di-Ph phosphinamides and benzyl alcs. In the experiment, the researchers used (4-Bromophenyl)methanol(cas: 873-75-6Application In Synthesis of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Application In Synthesis of (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2022 ,《Crosslinked Protein Delivery Strategy with Precise Activity Regulation Properties for Cancer Therapy and Gene Editing》 appeared in Advanced Healthcare Materials. The author of the article were Liu, Ning; Zhu, Lianghan; Sun, Honghao; Zhou, Zhanwei; Dong, Jingwen; Sun, Minjie. The article conveys some information:

Protein drugs hold tremendous promise for therapeutic applications due to their direct and superior pharmacol. effects. However, protein drugs can be degraded in blood stream and unable to cross many phys. barriers to exert therapeutic effect. Degradable synthetic crosslinking is a versatile strategy to enhance the stability of the nanoparticle in a complex physiol. medium and is helpful to get through phys. barriers. Herein, crosslinked polypeptide (PABP) composed of poly-amino acids including cystine, tyrosine, lysine, ketal bridge, and polyethylene glycol (PEG) is modularly explored and synthesized for protein delivery. Notably, plasma membrane V-ATPase is the particular pathway which induces the macropinocytosis of the inner peptide analogous core (PAB/protein) after the outer PEG shell disassocn. at tumor intercellular sites. In addition, PABP/protein achieves proteins′ activity shielding in systemic circulation and recovery in tumor cytoplasm precisely. In application, PABP/RNase-A shows satisfying tumor accumulation and antineoplastic efficacy. More importantly, PABP/Cas9 + small guide RNA displays obvious gene editing efficiency. The crosslinked protein delivery strategy not only makes the accurate protein transport and activity regulation possible but also is promising in paving the way for clin. translation of protein drugs. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 4-Aminobutan-1-olIn 2019 ,《Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions》 appeared in Green Chemistry. The author of the article were Senadi, Gopal Chandru; Kudale, Vishal Suresh; Wang, Jeh-Jeng. The article conveys some information:

Alcs. and ethers were identified as sustainable methine sources for synthesizing quinazolinones I [R = H, 8-Me, 7-NO2, etc.; R1 = OMe, allyl, Ph, etc,] and benzimidazoles II [R2 = H, 5-Cl, 6,7-di-Me, etc.] using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone I [R = H; R1 = CH2CH2OH, 2-(1H-indol-3-yl)ethyl] (a common precursor of rutaecarpine and (±) evodiamine) and dimedazole II [R2 = 5,6-di-Me]. Notable features of this method included its low toxicity, use of com. feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 1195-59-1In 2019 ,《Metal-ligand cooperativity in a ruthenium(II) complex of bis-azoaromatic ligand for catalytic dehydrogenation of alcohols》 was published in Inorganica Chimica Acta. The article was written by Saha, Tanushri; Pramanick, Rajib; Sengupta, Debabrata; Goswami, Sreebrata. The article contains the following contents:

Herein a new Ru-phosphine complex (1) with mol. formula [RuL(PPh3)Cl2] is reported where L is a redox active pincer ligand 2,6-bis(phenylazo)pyridine. The isolated complex was characterized by usual spectroscopic techniques including single crystal x-ray crystallog. anal. Complex 1 efficiently catalyzes aerobic oxidation of a wide range of primary and secondary benzylic, allylic, heterocyclic, alicyclic alcs. under mild conditions and is superior over several other Ru (0, +2 and +3), Ru-H and Ru-PPh3 catalysts. Mechanistic studies indicate that a transient Ru-H intermediate is formed in the catalytic cycle which gets switched into a Ru-hydrazo intermediate via hydrogen-walking mechanism. The catalyst is regenerated by aerial oxidation producing H2O2 as a byproduct. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 1195-59-1

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Alcohol – Wikipedia,
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