Month: November 2022

Symmetry and dynamics of molecular rotors in amphidynamic molecular crystals was written by Karlen, Steven D.; Reyes, Horacio; Taylor, R. E.; Khan, Saeed I.; Hawthorne, M. Frederick; Garcia-Garibay, Miguel A.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America on August 24,2010.Application In Synthesis of Cubane-1,4-diyldimethanol The following contents are mentioned in the article:

Rotary biomol. machines rely on highly sym. supramol. structures with rotating units that operate within a densely packed frame of reference, stator, embedded within relatively rigid membranes. The most notable examples are the enzyme FoF1 ATP synthase and the bacterial flagellum, which undergo rotation in steps determined by the symmetries of their rotators and rotating units. Speculating that a precise control of rotational dynamics in rigid environments will be essential for the development of artificial mol. machines, we analyzed the relation between rotational symmetry order and equilibrium rotational dynamics in a set of crystalline mol. gyroscopes with rotators having axial symmetry that ranges from two- to fivefold. The site exchange frequency for these mols. in their closely related crystals at ambient temperature varies by several orders of magnitude, up to ca. 4.46 × 108 s-1. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Application In Synthesis of Cubane-1,4-diyldimethanol).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of Cubane-1,4-diyldimethanol

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Synthesis of isoxazolo[60]fullerenes with dumb-bell-type structure and atropisomeric properties was written by Irngartinger, Hermann; Weber, Anton; Escher, Thomas; Fettel, Peter Walter; Gassner, Franz. And the article was included in European Journal of Organic Chemistry on September 30,1999.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Dumb-bell-type fullerene adducts were synthesized via bifunctional nitrile oxides. A cubane-bridged [60]fullerene of this type was synthesized by 2-fold esterification of cubanedimethanol with an isoxazolo[60]fullerene-carboxylate. When a bulky spacer between the fullerene units was used, atropisomers occurred. A fullerene derivative with an anthracene moiety exhibited axial chirality. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Category: alcohols-buliding-blocks).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Category: alcohols-buliding-blocks

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

The preparation and fate of cubylcarbinyl radicals was written by Eaton, Philip E.; Yip, Yu Chi. And the article was included in Journal of the American Chemical Society on September 25,1991.Application of 60462-27-3 The following contents are mentioned in the article:

The cubylcarbinyl radical was generated from cubylcarbinyl bromide and from the N-hydroxy-2-pyridinethione ester of cubylacetic acid under various conditions favoring hydrogen-atom transfer to the radical. Only when selenophenol in high concentration is used as the hydrogen donor is any methylcubane formed. Otherwise the cubylcarbinyl radical rearranges. A mechanistic scheme accounting for their formation is presented; sequential σ-bond breaking occurs regioselectively, favoring processes in which there is good overlap between the radical orbital and that of the breaking bond. The rate constant for ring cleavage of cubylcarbinyl radical was calculated to be >2 × 1010 s-1, substantially greater than that of any radical derived to date from a saturated hydrocarbon system. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Application of 60462-27-3).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 60462-27-3

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Approaches to 1,4-Disubstituted Cubane Derivatives as Energetic Materials: Design, Theoretical Studies and Synthesis was written by Lal, Sohan; Bhattacharjee, Argha; Chowdhury, Arindrajit; Kumbhakarna, Neeraj; Namboothiri, Irishi N. N.. And the article was included in Chemistry – An Asian Journal on September 1,2022.Computed Properties of C10H12O2 The following contents are mentioned in the article:

Novel 1,4-disubstituted cubane derivatives have been designed and selected ones have been successfully synthesized and characterized by various anal. and spectroscopic techniques, including single-crystal X-ray anal. A detailed computational study at B3LYP/6-311++G(d,p) level of theory revealed that all newly designed 1,4-disubstituted cubane derivatives possess higher densities, higher d.-specific impulse and superior ballistic properties when compared to conventional fuels, for example, RP-1. These compounds also exhibit acceptable kinetic and thermodn. stabilities which were evaluated in terms of their HOMO-LUMO energy gap and bond dissociation energies, resp., and are superior to TEX and many other compounds containing explosophoric groups. These results provide novel insights into the possible application of cubane-based energetic materials. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Computed Properties of C10H12O2).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C10H12O2

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Cubane, bicyclo[1.1.1]pentane and bicyclo[2.2.2]octane: Impact and thermal sensitiveness of carboxyl-, hydroxymethyl- and iodo-substituents was written by Dallaston, Madeleine A.; Houston, Sevan D.; Williams, Craig M.. And the article was included in Chemistry – A European Journal on September 21,2020.Recommanded Product: Cubane-1,4-diyldimethanol The following contents are mentioned in the article:

With the burgeoning interest in cage motifs for bioactive mol. discovery, and the recent disclosure of 1,4-cubane-dicarboxylic acid impact sensitivity, more research into the safety profiles of cage scaffolds is required. Therefore, the impact sensitivity and thermal decomposition behavior of judiciously selected starting materials and synthetic intermediates of cubane, bicyclo[1.1.1]pentane (BCP), and bicyclo[2.2.2]octane (BCO) were evaluated via hammer test and sealed cell differential scanning calorimetry, resp. Iodo-substituted systems were found to be more impact sensitive, whereas hydroxymethyl substitution led to more rapid thermo-decomposition Cubane was more likely to be impact sensitive with these substituents, followed by BCP, whereas all BCOs were unresponsive. The majority of derivatives were placed substantially above Yoshida thresholds-a computational indicator of sensitivity. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Recommanded Product: Cubane-1,4-diyldimethanol).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: Cubane-1,4-diyldimethanol

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

New Type of an Adsorption Layer of Organic Molecules with a Cage Structure Condensed at the Electrode/Solution Interface: The Adsorption of Cubane Derivatives on a Mercury Electrode was written by Stenina, E. V.; Sviridova, L. N.; Krivenko, A. G.; Romanova, L. B.; Eremenko, L. T.. And the article was included in Russian Journal of Electrochemistry (Translation of Elektrokhimiya) on October 31,2003.Electric Literature of C10H12O2 The following contents are mentioned in the article:

A synthesis and a study by method of measuring the differential capacitance on a stationary Hg drop of the adsorption of a number of cubane derivatives in a surface-inactive electrolyte were performed. The compounds studied exhibit a high surface activity. For Br derivatives of cubane (4-bromomethoxycarbonylcubane, 4-bromohydroxymethylcubane) the formation of two-dimensional adsorption layers is discovered. Values of adsorption parameters for these compounds are evaluated with use made of the Frumkin isotherm. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Electric Literature of C10H12O2).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C10H12O2

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Building siRNAs with Cubes: Synthesis and Evaluation of Cubane-Modified siRNAs was written by Hammill, Matthew L.; Salim, Lidya; Tsubaki, Kouta; Varley, Andrew J.; Kitamura, Mitsuru; Okauchi, Tatsuo; Desaulniers, Jean-Paul. And the article was included in ChemBioChem on October 13,2021.Safety of Cubane-1,4-diyldimethanol The following contents are mentioned in the article:

Cubane mols. hold great potential for medicinal chem. applications due to their inherent stability and low toxicity. In this study, we report the synthesis of a cubane derivative phosphoramidite for the incorporation of cubane into small interfering RNAs (siRNAs). Synthetic siRNAs rely on chem. modifications to improve their pharmacokinetic profiles. However, they are still able to mediate sequence-specific gene silencing via the endogenous RNA interference pathway. We designed a library of siRNAs bearing cubane at different positions within the sense and antisense strands. All siRNAs showed excellent gene-silencing activity, with IC50 values ranging from 45.4 to 305 pM. Incorporating the cubane modification in both the sense and antisense strand led to viable duplexes with good biol. activity. To the best of our knowledge, this is the first report of siRNAs bearing a cubane derivative within the backbone. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Safety of Cubane-1,4-diyldimethanol).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of Cubane-1,4-diyldimethanol

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

《A PANI-Fe3O4@ZnO nanocomposite: a magnetically separable and applicable catalyst for the synthesis of chromeno-pyrido[d]pyrimidine derivatives》 was published in RSC Advances in 2020. These research results belong to Chaghari-Farahani, Fatemeh; Abdolmohammadi, Shahrzad; Kia-Kojoori, Reza. Name: 3-Hydroxybenzaldehyde The article mentions the following:

Herein green, practical, PANI-Fe3O4@ZnO-nanocomposite-catalyzed cyclocondensation reactions involving 4-aminocoumarin, 1,3-dimethylbarbituric acid, and aromatic aldehydes in an aqueous medium at room temperature to synthesize 9,11-dimethyl-7-aryl-6H-chromeno[3′,4′:5,6]pyrido[2,3-d]pyrimidine-6,8,10(9H,11H)triones I (Ar = C6H5, 3-HOC6H4, 4-BrC6H4, etc.) is reported. This research aims to provide an applicable and high-yield protocol that follows the principles of green chem., with the use of water as an environmentally benign medium and the PANI-Fe3O4@ZnO nanocomposite as a magnetically recoverable catalyst. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Adaptive Se-Te Metathesis Controlled by Cucurbituril-Based Host-Guest Interaction》 was published in Chemistry – An Asian Journal in 2020. These research results belong to Liu, Cheng; Zhang, Zhiheng; Fan, Zhiyuan; He, Chaowei; Tan, Yizheng; Xu, Huaping. Electric Literature of C3H9NO The article mentions the following:

Regulating the reactivity and equilibrium of a dynamic reaction is essential for adaptive chem. and functional materials. Herein, cucurbituril-based host-guest interaction was embedded into the dynamic metathesis between diselenide and ditelluride to establish an equilibrium-adaptive system. In this system, cucurbit[6]uril (CB[6]) selectively bound with diselenide while cucurbit[7]uril (CB[7]) bound with not only diselenide but also ditelluride and exchange product. The dynamic nature of diselenide bond was locked after forming the inclusion complex with CB[6]. Based on this selective locking effect, the Se-Te products were reversed back to diselenide and ditelluride reactants, which was an equilibrium regulating process. Therefore, by combining CB[6]-based host-guest interaction and dynamic diselenide chem., the reactivity of diselenide bond and the equilibrium of Se-Te metathesis was successfully regulated. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Electric Literature of C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Diphenyl cyclopropenone-centered polymers for site-specific CO-releasing and chain dissociation》 was published in Chinese Chemical Letters in 2020. These research results belong to Shao, Chenchen; Duan, Hanyi; Min, Yuqin; Zhang, Xinghong. Reference of 3-Bromopropan-1-ol The article mentions the following:

The synthesis and stimuli-responsiveness of a di-Ph cyclopropenone (DPCP)-centered poly(Me acrylate) (PMA) are presented. DPCP-centered PMA could release carbon monoxide (CO) upon UV light in a switched on-and-off manner. The CO-releasing process can be reported by the variations in photoluminescence spectra. In addition, DPCP moiety covalently embedded in the crosslinked polyurethane could also release CO under UV light. Of special, DPCP-centered PMA in solution was selectively dissociated at the phenol ester bond under the ultrasound, and a force-induced hydrolyzation reaction was revealed by D2O exchanging 1H NMR spectra. The kinetic study reveals that small quantity of water could enhance the chain scission rate. This work provides a DPCP-centered polymer for site-specific CO-releasing and chain dissociation In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts