Month: November 2022

《Glucose- and pH-Responsive Supramolecular Polymer Vesicles Based on Host-Guest Interaction for Transcutaneous Delivery of Insulin》 was written by Lin, Yonghui; Hu, Wei; Bai, Xiaowen; Ju, Yanshan; Cao, Cong; Zou, Shufen; Tong, Zaizai; Cen, Chao; Jiang, Guohua; Kong, Xiangdong. Related Products of 627-18-9 And the article was included in ACS Applied Bio Materials in 2020. The article conveys some information:

Smart insulin delivery platforms having the ability of mimicking pancreatic cells are highly expected for diabetes treatment. Herein, a smart glucose-sensitive insulin delivery platform on the basis of transcutaneous microneedles has been designed. The as-prepared microneedles are composed of glucose- and pH-responsive supramol. polymer vesicles (PVs) as the drug storage and water soluble polymers as the matrix. The well-defined PVs are constructed from the host-guest inclusion complex between water-soluble pillar[5]arene (WP5) with pH-responsiveness and paraquat-ended poly(phenylboronic acid) (PPBA-G) with glucose-sensitivity. The drug-loaded PVs, including insulin and glucose oxidase (GOx) can quickly respond to elevated glucose level, accompanied by the disassocn. of PVs and fast release of encapsulated insulin. Moreover, the insulin release rate is further accelerated by GOx, which generates gluconic acid at high glucose levels, thus decreasing the local pH. Therefore, the host-guest interaction between WP5 and PPBA-G is destroyed and a total structure disassocn. of PVs takes place, contributing to a fast release of encapsulated insulin. The in vivo insulin delivery to diabetic rats displays a quick response to hyperglycemic levels and then can fast regulate the blood glucose concentrations to normal levels, which demonstrates that the obtained smart insulin device has a highly potential application in the treatment of diabetes. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Selective Covalent Modification of Layered Double Hydroxide Nanoparticles with Tripodal Ligands on Outer and Interlayer Surfaces》 was written by Muramatsu, Keisuke; Hayashi, Shiori; Kuroda, Yoshiyuki; Oka, Yuya; Wada, Hiroaki; Shimojima, Atsushi; Kuroda, Kazuyuki. Computed Properties of C3H9NO2 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Layered double hydroxides (LDHs) have occupied an important place in the fields of catalysts, electrocatalysts, and fillers, and their applicability can be greatly enhanced by interlayer organic modifications. In contrast to general organic modification based on noncovalent modification using ionic organic species, this study has clarified in situ interlayer covalent modification of LDH nanoparticles (LDHNPs) with the tripodal ligand tris(hydroxymethyl)aminomethane (Tris-NH2). Interlayer-modified CoAl LDHNPs were obtained by a one-pot hydrothermal treatment of an aqueous solution containing metal salts and Tris-NH2 at 180°C for 24 h. Tris-NH2 was covalently bonded on the interlayer surface of LDHNPs. Interlayer-modified NiAl LDHNPs were also similarly synthesized. Some comparative experiments under different conditions indicate that the important parameters for interlayer modification are the number of bonding sites per a modifier, the electronegativity of a constituent divalent metal element, and the concentration of a modifier; this is because these parameters affect the hydrolytic stability of alkoxy-metal bonds between a modifier and a layer of LDHNPs. The synthesis of interlayer-modified MgAl LDHNPs was achieved by adjusting these parameters. This achievement will enable new potential applications because modification of only the outer surface has been achieved until now. Interlayer-modified LDHNPs possessing CO32- in the interlayer space were delaminated into monolayers under ultrasonication in water. The proposed method provides a rational approach for interlayer modification and facile delamination of LDHNPs. Layered double hydroxide nanoparticles (LDHNPs), whose interlayer surfaces were organically modified with tripodal ligands, were prepared, and they showed improved delamination behavior in water under ambient conditions. Factors affecting the interlayer modification of LDHNPs were discussed on the basis of the stability of alkoxy bonds between the LDH layers and the ligands. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Computed Properties of C3H9NO2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Computed Properties of C3H9NO2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Exploring solvent dependent catecholase activity in transition metal complexes: an experimental and theoretical approach》 was written by I., Mantasha; Shahid, M.; Kumar, Manjeet; Ansari, Azaj; Akhtar, Muhammad Nadeem; AlDamen, Murad A.; Song, You; Ahmad, Musheer; Khan, Ishaat M.. Application of 1195-59-1 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

In contrast to polynuclear complex models for biomimetic activity, a series of mononuclear complexes are designed in this work in order to assess their catecholase activity and kinetics. Four new complexes, namely, [Mn(pdmH2)(Phen)Cl]Cl·H2O (1), [Mn(pmmH)2(SCN)2] (2), [Ni(pmmH)2(SCN)2] (3) and [Zn(phen)3][(pdm)]·11H2O (4) utilizing an amino alc. ligand, pyridine-2,6-dimethanol (pdmH2) or 2-pyridinemonomethanol (pmmH), and an auxiliary ligand, 1,10-phenanthroline (phen) or thiocyanate (SCN-), are synthesized. The complexes are characterized by elemental anal., FTIR, UV-visible, EPR, fluorescence (solution and solid state), Hirshfeld surface anal., magnetic, single crystal X-ray and DFT/TD-DFT studies. X-ray structures confirm the geometry around the M(II) ions to be octahedral in all the complexes. In 1-3, the primary aminoalc. ligand binds to a metal ion in a neutral (pdmH2 or pmmH) mode while 4 exists as a cation-anion type complex where a deprotonated ligand (pdm2-) is present in the outer sphere having no coordination to the metal. The Zn(II) complex also shows remarkable luminescence in the solid state photoluminescence spectrum. Variable temperature magnetic studies show the presence of antiferromagnetic exchange in 1-3 (θ = -2.8, -1.7 and -5.2, resp.) with the observation of anisotropy (D = 4.0 and E = 3.4) in 3. DFT/TD-DFT results provide ample information regarding the structures, spin densities, charge distribution, and electronic spectra along with the transitions. The spin d. values, ρ = 4.793, 4.792 and 1.676, confirm the presence of five, five and two unpaired electrons on the metal d-orbitals of 1, 2 and 3, resp. Interestingly, solvent dependent catecholase activity has been observed for the first time in mononuclear Mn(II) complexes (1 and 2) with Kcat = 2602.8 h-1 (acetonitrile), 1490.4 h-1 (methanol) for 1, and 1083.6 h-1 (acetonitrile), 806.4 h-1 (methanol) for 2. This can be rationalized in terms of the coordinating powers of the solvent, i.e., DMSO > MeOH > MeCN. Further, the order of activity in 1 and 2 (i.e., 1 > 2) and inactivity of 3 and 4 are very well corroborated by DFT which ascertains the highest charge contribution on the metal in 1 [33% on HOMO and 2% on LUMO of Mn(II)] resulting in the formation of the most stable metal-substrate adduct, thus enhancing the activity. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cations》 was written by Zhang, Xiaoping; Ren, Xiang; Chingin, Konstantin; Xu, Jiaquan; Yan, Xin; Chen, Huanwen. Computed Properties of C6H12O And the article was included in Analytica Chimica Acta in 2020. The article conveys some information:

We present an approach for the elucidation of C=C bond position and cis/trans isomers, which is achieved by the reaction of ambient water radical cations and double bonds, followed by the fragmentation of epoxide radical cations to generate diagnostic ions in tandem mass spectrometry. Hexenol double bond positional isomers and cis/trans isomers which exhibit different properties and biol. functions are characterized as a proof of concept. The merits of the approach include the simplicity of exptl. setup, rapid derivatization (within seconds), the obviation of organic solvents, as well as easy spectral interpretation. In the experimental materials used by the author, we found 5-Hexen-1-ol(cas: 821-41-0Computed Properties of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Computed Properties of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis and characterization of light-degradable bromocoumarin functionalized polycarbonates》 was written by Mueller, Ann-Kathrin; Jung, Dimitri; Sun, Jingjiang; Kuckling, Dirk. Name: 2-Aminopropane-1,3-diol And the article was included in Polymer Chemistry in 2020. The article conveys some information:

Biocompatible polymeric materials that can degrade in response to external irradiation with high spatial and temporal control show enormous potential in the field of biomedical applications. Herein, two six-membered cyclic carbonate monomers with a light-cleavable bromocoumarin functional pendent moiety attached via a carbamate linkage were prepared from 2-amino-1,3-propanediol (serinol) and 2-(aminomethyl)-2-methylpropane-1,3-diol, resp. A series of light-degradable polycarbonates were synthesized by organo-catalyzed ring opening polymerization (ROP) of both monomers, and meanwhile their polymerization kinetics were investigated. Upon light-induced deprotection, both types of polycarbonates degraded rapidly into low mol.-weight compounds The results of size exclusion chromatog. (SEC), NMR (NMR) spectroscopy and UV/visible (UV/VIS) spectroscopy confirmed the polymer structures and the light-induced degradation behavior. The photo-cleavage rates of bromocoumarin pendent groups and the degradation rates of the polymers were strongly dependent on polymer structures and used solvents. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Name: 2-Aminopropane-1,3-diol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ritmaleni; Hastutitama, A. N. A.; Persitamaia, I.; Restiwardani, T.; Eksakta, A.; Munandar, R. F.; Abdullah, M. S.; Purwanto, A. E.; Astuti, P.; Sardjiman published their research in Rasayan Journal of Chemistry in 2021. The article was titled 《Synthesis and antibacterial activity of dibenzylidene-cyclohexanone》.Safety of 3-Hydroxybenzaldehyde The article contains the following contents:

Dibenzylidene-cyclohexanones I (R = 3-O2NC6H4, 2-CH3OC6H4, 4-OH-3-CH3OC6H3, etc.) were synthesized by reacting aromatic aldehydes RCHO with cyclohexanone in the acidic condition through the carbonyl condensation reaction. The antibacterial activity was tested by using microdilution method against K. pneumonia, E. coli, S. aureus, B. subtilis and E. faecalis. The isolated products were obtained as pure curcumin analogs with moderate to high yield. The antibacterial assay showed that I (R = 3-OHC6H4) gave MIC and MBC at 50μg/mL in E. coli, S. aureus, and E. faecalis. Moreover, it showed that the percentage inhibition of B. subtilis was around 54% at a concentration of 25μg/mL. Among all the tested compounds, I (R = 3-OHC6H4) showed better activity against all those bacteria while none showed activity against K. pneumonia. A I (R = 2,5-CH3OC6H3) was obtained as the compound with the highest yield and I (R = 3-OHC6H4) was the most potent compound While I (R = 2-OH-3-C2H5OC6H3) was the most potent compound according to the docking study. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Jianfeng; Liu, Dan; Yang, Qianqian; Ge, Yan; Tang, Jinkui; Qi, Zhenhui published their research in New Journal of Chemistry in 2021. The article was titled 《Magnetic investigation in di- and tetranuclear lanthanide complexes》.Computed Properties of C7H9NO2 The article contains the following contents:

By using a crab-like hydrazone ligand, dinuclear and tetranuclear dysprosium-based complexes Dy2 and Dy4 have been isolated. Magnetic investigation reveals that complex Dy2 shows typical single-mol. magnet behavior under a zero field, benefiting from the ferromagnetic coupling between the DyIII ions, while Dy4 possesses a diamagnetic ground state with the anisotropy axes of DyIII ions in centripetal arrangement. The magnetic anisotropies and couplings were confirmed by ab initio calculations In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H9NO2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Du, Xin; Zhao, Huan; Li, Xinling; Zhang, Lizhi; Dong, Yunhui; Wang, Ping; Zhang, Daopeng; Liu, Qing; Liu, Hui published an article in 2021. The article was titled 《Ligand-Regulated Palladium-Catalyzed Regiodivergent Hydroarylation of the Distal Double Bond of Allenamides with Aryl Boronic Acid》, and you may find the article in Journal of Organic Chemistry.Related Products of 89466-08-0 The information in the text is summarized as follows:

The ligand-regulated regiodivergent hydroarylation of the distal double bond of allenamides with aryl boronic acid was achieved in the presence of Pd(II) catalysts, delivering a variety of functionalized enamide with excellent E selectivity and Markovnikov/anti-Markovnikov selectivity. Two possible coordination intermediates probably are responsible for the regiodivergent hydroarylation: (1) The coordination Intermediate I, which probably is formed through the coordination of MeCN, distal double bond, Ph to Pd, led to the aryl group away from the Intermediate I, inducing excellent E selectivity and anti-Markovnikov selectivity. (2) A switch of regioselectivity to 1,2-Markovnikov hydroarylation was obtained using bidentate phosphine ligand (dppf or Xantphos). The formed coordination Intermediate II led to the N-tether away from the Intermediate II and at the trans position of aryl, resulting in excellent E selectivity and Markovnikov selectivity. Meanwhile, tentative study on the mechanism proved that the hydron source of this hydroarylation is more likely to be boronic acid. The transmetalation between aryl boronic acid and Pd catalyst was the initial step of this transformation. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Robinson, Donovan J.; Ortiz, Kacey G.; O’Hare, Nathan P.; Karimov, Rashad R. published an article in Organic Letters. The title of the article was 《Dearomatization of Heteroarenium Salts with ArBpin Reagents. Application to the Total Synthesis of a Nuphar Alkaloid》.Recommanded Product: 24388-23-6 The author mentioned the following in the article:

Rhodium-catalyzed enantioselective addition of aryl and heteroaryl boron pinacol esters to pyridinium and quinolinium salts were developed for the synthesis of enantioenriched dihydroheteroarenes. The methodol. was enabled the synthesis of 2-heteroaryl-substituted dihydropyridines in high yield and ee, which provided efficient synthetic access to a nuphar alkaloid.4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 24388-23-6) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 24388-23-6

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In 2022,Hu, Chunyang; Chen, Fangming; Lu, Guo-Ping; Yi, Wen-Bin published an article in Chinese Chemical Letters. The title of the article was 《Deuterated N-difluoromethylthiophthalimide: A stable, scalable reagent for radical and electrophilic deuteriodifluoromethylthiolations》.Related Products of 7748-36-9 The author mentioned the following in the article:

A new, stable and scalable reagent for deuteriodifluoromethylthiolation (deuterated N-difluoromethylthiophthalimide, PhthSCF2D) has been developed. This reagent can be applied for the photocatalytic radical deuteriodifluoromethylthiolation of various olefins and aldehydes (30 examples). Meanwhile, it can achieve the electrophilic deuteriodifluoromethylthiolation of a series of electrophilic substrates including electron-rich arenes, aryl/vinylboronicacids, alkynes, amines, thiols and β-ketoesters (22 examples). Some complex mols. can also be applied in both radical and electrophilic deuteriodifluoromethylthiolation using PhthSCF2D as the reagent. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts