Month: November 2022

In 2019,Organic Letters included an article by Pezzetta, Cristofer; Bonifazi, Davide; Davidson, Robert W. M.. SDS of cas: 126456-43-7. The article was titled 《Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach》. The information in the text is summarized as follows:

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common com. material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 126456-43-7

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In 2019,Materials Transactions included an article by Mai, Bich Dung; Nguyen, Hoai Thuong; Hoang, Duc-Quang. Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate. The article was titled 《Influence of cellulose nanoparticles on structure and electrophysical properties of ferroelectrics》. The information in the text is summarized as follows:

In present work, a comparative study on electrophys. properties of two ferroelec. nanocomposites based on cellulose nanoparticles (CNP) mixed with Rochelle salt (RS) and sodium nitrite (NaNO2) at different composition mass ratios was conducted to clarify the influence of cellulose on dielec. properties of primitive ferroelecs. The composites were carefully characterized XRD and FTIR techniques. The experiments were carried out in a wide temperature range under a weak elec. field with an amplitude of 2 V/cm at 1 kHz. The obtained results revealed that at relatively high cellulose content, the phase transition temperature of Rochelle salt in the composite increased, while for sodium nitrite – decreased as compared to those of volume ferroelecs. Besides, the higher the cellulose content was, the stronger the shift of phase transition point was observed At small cellulose content, the Curie point characteristic for volume ferroelecs. occurred. The intermol. hydrogen bonds and size effects were supposed to be responsible for the observed anomalies. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

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In 2019,European Polymer Journal included an article by Liu, Jingjing; Zhang, Chan; Li, Zhenjiang; Zhang, Lei; Xu, Jiaxi; Wang, Haixin; Xu, Songquan; Guo, Tianfo; Yang, Kun; Guo, Kai. Related Products of 821-41-0. The article was titled 《Dibutyl phosphate catalyzed commercial relevant ring-opening polymerizations to bio-based polyesters》. The information in the text is summarized as follows:

Organocatalyzed ring-opening polymerization (ROP) of cyclic esters was developed into a stage that demanding translation of the academic success into com. viable production An industrial relevant development of the organocatalysis in ROPs required bulk polymerizations at high temperatures up to 180 °C. Organic phosphoric acid was one of the few organocatalysts workable under these conditions that devoid of otherwise commonly appeared transesterification, epimerization, and decarboxylation in the ROPs. A com. di-Bu phosphate (DBuP), which was inexpensive and available by hundreds of tons as antistatic agent, was firstly evaluated as a catalyst. Well-defined polyesters catalyzed by DBuP were obtained with narrow dispersities (Dm 1.08-1.31) and predicted mol. weights from 2.1 to 55 kg mol-1. Series of homopolymers, diblock copolymers and end-functionalized polymers of ε-caprolactone (CL), δ-valerolactone (VL), trimethylene carbonate (TMC), and L-lactide (LA) were synthesized. 1H NMR, 13C NMR, SEC, and MALDI-ToF MS analyses indicated that the obtained polyesters were exactly the designated ones. NMR titration experiments confirmed that the ROP proceeded a bifunctional activation mechanism. The cytotoxicity test using MTT assay showed biosafety of the polyesters. The exptl. results suggested that di-Bu phosphate is a com. organocatalyst widely useful in all major cyclic ester monomer toward com. relevant ring-opening polymerizations In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Related Products of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Related Products of 821-41-0

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The author of 《Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids》 were Hinkes, Stefan P. A.; Klein, Christian D. P.. And the article was published in Organic Letters in 2019. Recommanded Product: 24388-23-6 The author mentioned the following in the article:

Boronic acids are an increasingly important compound class for many applications, including C-C bond formation reactions, medicinal chem., and diagnostics. The deprotection of boronic ester intermediates is frequently a problematic and inefficient step in boronic acid syntheses. The authors describe an approach that highly facilitates this transformation by leveraging the volatility of methylboronic acid and its diol esters. The method was performed under mild conditions, provides high yields, and eliminates cumbersome and problematic purification steps. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Recommanded Product: 24388-23-6

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The author of 《Assessing structure/property relationships and synthetic protocols in the fabrication of poly(oxanorbornene imide) single-chain nanoparticles》 were Chen, Ruiwen; Benware, Sarah J.; Cawthern, Sawyer D.; Cole, Justin P.; Lessard, Jacob J.; Crawford-Eng, Isabelle M.; Saxena, Riya; Berda, Erik B.. And the article was published in European Polymer Journal in 2019. SDS of cas: 4048-33-3 The author mentioned the following in the article:

We present the synthesis of poly(oxanorbornene imide) single-chain nanoparticles (SCNP) by intrachain radical polymerization of pendant methacryloyl units. Well-defined poly(oxanorbornene imide)s were first prepared via ring-opening metathesis polymerization (ROMP) of methacryloyl-containing monomers. Handling and polymerizing these monomers requires some special care to prevent undesired premature reaction of the methacryloyl groups. Addition of AIBN to dilute solution of the ROMP polymers triggers intrachain radical polymerization of pendant methacryloyl groups, folding the linear polymers into SCNP. Characterization by NMR spectroscopy and SEC confirmed SCNP formation and revealed structure/property relationships related to methacryloyl pendent length and percent incorporation. In addition to this study using 6-Aminohexan-1-ol, there are many other studies that have used 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.SDS of cas: 4048-33-3

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The author of 《Metal free synthesis of ethylene and propylene carbonate from alkylene halohydrin and CO2 at room temperature》 were Khokarale, Santosh Govind; Mikkola, Jyri-Pekka. And the article was published in RSC Advances in 2019. Related Products of 627-18-9 The author mentioned the following in the article:

Herein we describe a metal free and one-pot pathway for the synthesis of industrially important cyclic carbonates such as ethylene carbonate and propylene carbonates from mol. CO2 under mild reaction conditions. In the actual synthesis, the alkylene halohydrins such as alkylene chloro- or bromo or iodohydrin and organic superbase, 1,8-diazabicyclo-[5.4.0]-undec-7-ene (DBU) reacted equivalently with CO2 at room temperature The syntheses of cyclic carbonates were performed in DMSO as a solvent. Both 1,2 and 1,3 halohydrin precursors were converted into cyclic carbonates except 2-bromo- and iodoethanol, which were reacted equivalently with DBU through n-alkylation and formed corresponding n-alkylated DBU salts instead of forming cyclic carbonates. NMR anal. was used to identify the reaction components in the reaction mixture whereas this technique was also helpful in terms of understanding the reaction mechanism of cyclic carbonate formation. The mechanistic study based on the NMR anal. studies confirmed that prior to the formation of cyclic carbonate, a switchable ionic liquid formed in situ from alkylene chlorohydrin, DBU and CO2. As a representative study, the synthesis of cyclic carbonates from 1,2 chlorohydrins was demonstrated where the synthesis was carried out using chlorohydrin as a solvent as well as a reagent. In this case, alkylene chlorohydrin as a solvent not only replaced DMSO in the synthesis but also facilitated an efficient separation of the reaction components from the reaction mixture The EC or PC, [DBUH][Cl] as well as an excess of the alkylene chlorhydrin were separated from each other following solvent extraction and distillation approaches. In this process, with the applied reaction conditions, >90% yields of EC and PC were achieved. Meanwhile, DBU was recovered from in situ formed [DBUH][Cl] by using NaCl saturated alk. solution Most importantly here, we developed a metal free, industrially feasible CO2 capture and utilization approach to obtain EC and PC under mild reaction conditions. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

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《Amino-Acid-Mediated Aerobic Oxidation of Organoborons for the Synthesis of Phenolic Derivatives Using Single Electron Transfer》 was published in ChemistrySelect in 2020. These research results belong to Gujjarappa, Raghuram; Vodnala, Nagaraju; Garg, Aakriti; Hazra, Chinmoy K.; Gupta, Sreya; Malakar, Chandi C.. Computed Properties of C6H7BO3 The article mentions the following:

An efficient amino-acid-mediated ipso-hydroxylation of arylboronic acids, aryl boronate esters and aryl trifluoroborates RX (R = 4-chlorophenyl, naphthalen-1-yl, quinolin-5-yl, etc.; X = BF3K, B(OH)2, Bpin) to aryl alcs. ROH has been described. The current protocol was realized by using sub-stoichiometric amount of L-histidine in presence of triethylamine under aerobic conditions in DMF as solvent. This amino-acid-mediated process provides an alternative route for the hydroxylation of organoborons through in situ generation of hydrogen peroxide. The present protocol explores the synthetic utility of amino acids as organocatalysts for the preparation of aryl alcs. It was observed that L-histidine plays an important role for the conversion of aerial oxygen into hydrogen peroxide via thermal excitation process followed by thermal degradation of Et3N. The developed approach holds good for a wide range of compounds with excellent yields and competent functional group tolerance. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

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《Mesoporous covalent organic framework: An active photocatalyst for formic acid synthesis through carbon dioxide reduction under visible light》 was published in Molecular Catalysis in 2020. These research results belong to Sarkar, Priyanka; Riyajuddin, Sk.; Das, Anjan; Hazra Chowdhury, Arpita; Ghosh, Kaushik; Islam, Sk. Manirul. Safety of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde The article mentions the following:

The photocatalytic reduction is demonstrate of CO2 into HCOOH using mesoporous covalent organic framework (COF) as the active photocatalyst, Co(DMG)2 as co-catalyst with Triethanolamine (TEOA) as sacrificial electron source under atm. pressure. Greater than 125 TON is achieved with 10 mg catalyst. The reaction cycle is dependent on the use of co-catalyst, Co(DMG)2 and sacrificial electron donor (TEOA). The reaction does not occur in the absence of light (445 nm) and can readily be controlled by light intensity alternation. It is also demonstrate that a TON of 36 can be obtained with use of sunlight using the catalytic cycle. These results open the door to an entirely new class of protocol for photocatalytic reduction of CO2 using COF and Co(DMG)2 as co-catalyst under visible light. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Safety of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Safety of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydePhloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

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《Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker》 was published in Molecular Pharmaceutics in 2020. These research results belong to Prag, Hiran A.; Kula-Alwar, Duvaraka; Pala, Laura; Caldwell, Stuart T.; Beach, Timothy E.; James, Andrew M.; Saeb-Parsy, Kourosh; Krieg, Thomas; Hartley, Richard C.; Murphy, Michael P.. Computed Properties of C3H7BrO The article mentions the following:

Many mitochondrial metabolites and bioactive mols. contain two carboxylic acid moieties that make them unable to cross biol. membranes. Hence, there is considerable interest in facilitating the uptake of these mols. into cells and mitochondria to modify or report on their function. Conjugation to the triphenylphosphonium (TPP) lipophilic cation is widely used to deliver mols. selectively to mitochondria in response to the membrane potential. However, permanent attachment to the cation can disrupt the biol. function of small dicarboxylates. Here, we have developed a strategy using TPP to release dicarboxylates selectively within mitochondria. For this, the dicarboxylate is attached to a TPP compound via a single ester bond, which is then cleaved by intramitochondrial esterase activity, releasing the dicarboxylate within the organelle. Leaving the second carboxylic acid free also means mitochondrial uptake is dependent on the pH gradient across the inner membrane. To assess this strategy, we synthesized a range of TPP monoesters of the model dicarboxylate, malonate. We then tested their mitochondrial accumulation and ability to deliver malonate to isolated mitochondria and to cells, in vitro and in vivo. A TPP-malonate monoester compound, TPP11-malonate, in which the dicarboxylate group was attached to the TPP compound via a hydrophobic undecyl link, was most effective at releasing malonate within mitochondria in cells and in vivo. Therefore, we have developed a TPP-monoester platform that enables the selective release of bioactive dicarboxylates within mitochondria. In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Computed Properties of C3H7BrO

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Alcohol – Wikipedia,
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《Hypoxia-Responsive, Polymeric Nanocarriers for Targeted Drug Delivery to Estrogen Receptor-Positive Breast Cancer Cell Spheroids》 was written by Mamnoon, Babak; Feng, Li; Froberg, Jamie; Choi, Yongki; Sathish, Venkatachalem; Mallik, Sanku. Application In Synthesis of 3-Aminopropan-1-ol And the article was included in Molecular Pharmaceutics in 2020. The article conveys some information:

Uncontrolled cell growth, division, and lack of enough blood supply causes low oxygen content or hypoxia in cancerous tumor microenvironments. 17β-Estradiol (E2), an estrogen receptor (ER) ligand, can be incorporated on the surface of nanocarriers for targeted drug delivery to breast cancer cells overexpressing ER. In the present study, we synthesized estradiol-conjugated hypoxia-responsive polymeric nanoparticles (polymersomes) encapsulating the anticancer drug doxorubicin (E2-Dox-HRPs) for targeted delivery into the hypoxic niches of estrogen-receptor-pos. breast cancer microtumors. Estradiol-conjugated polymersomes released over 90% of their encapsulated Dox in a sustained manner within hypoxia (2% oxygen) after 12 h. However, they released about 30% of Dox in normal oxygen partial pressure (21% oxygen, normoxia) during this time. Fluorescence microscopic studies demonstrated higher cytosolic and nuclear internalization of E2-Dox-HRPs (targeted polymersomes) compared to those of Dox-HRPs (nontargeted polymersomes). Monolayer cell viability studies on ER-pos. MCF7 cells showed higher cytotoxicity of targeted polymersomes in hypoxia compared to in normoxia. Cytotoxicity studies with hypoxic three-dimensional spheroid cultures of MCF7 cells treated with targeted polymersomes indicated significant differences compared to those of normoxic spheroids. The novel estradiol-conjugated hypoxia-responsive polymersomes described here have the potential for targeted drug delivery in estrogen-receptor-pos. breast cancer therapy. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application In Synthesis of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application In Synthesis of 3-Aminopropan-1-ol

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