Month: November 2022

In 2022,Kim, Yong-Guy; Lee, Jin-Hyung; Park, Sunyoung; Lee, Jintae published an article in Microbiology Spectrum. The title of the article was 《The anticancer agent 3,3′-diindolylmethane inhibits multispecies biofilm formation by acne-causing bacteria and Candida albicans》.HPLC of Formula: 7748-36-9 The author mentioned the following in the article:

The Gram-pos. anaerobic bacterium Cutibacterium acnes is a major inhabitant of human skin and has been implicated in acne vulgaris formation and in the formation of multispecies biofilms with other skin-inhabiting organisms like Staphylococcus aureus and Candida albicans. Indoles are widespread in nature (even in human skin) and function as important signaling mols. in diverse prokaryotes and eukaryotes. In the present study, we investigated the antibacterial and antibiofilm activities of 20 indoles against C. acnes. Of the indoles tested, indole-3-carbinol at 0.1 mM significantly inhibited biofilm formation by C. acnes without affecting planktonic cell growth, and the anticancer drug 3,3′-diindolylmethane (DIM) at 0.1 mM (32μg/mL) also significantly inhibited planktonic cell growth and biofilm formation by C. acnes, whereas the other indoles and indole itself were less effective. Also, DIM at 0.1 mM successfully inhibited multispecies biofilm formation by C. acnes, S. aureus, and C. albicans. Transcriptional analyses showed that DIM inhibited the expressions of several biofilm-related genes in C. acnes, and at 0.05 mM, DIM inhibited hyphal formation and cell aggregation by C. albicans. These results suggest that DIM and other indoles inhibit biofilm formation by C. acnes and have potential use for treating C. acnes associated diseases. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Ding, Pin; Han, Lingbo; Bai, Jiaxing; Liu, Jingjing; Luan, Xinjun published an article in Science China: Chemistry. The title of the article was 《Fine-tuning hydroxylamines as single-nitrogen sources for Pd(0)-catalyzed diamination of o-bromo(or chloro)-biaryls》.Recommanded Product: 89466-08-0 The author mentioned the following in the article:

An efficient Pd(0)-catalyzed inter-mol. [4+1] annulation of o-bromo(or chloro)-biaryls with bifunctional secondary hydroxylamines for the one-step assembly of synthetically useful carbazoles was reported. Noteworthily, a linchpin for this domino reaction was the judicious selection of both the amino-sources and Pd(0)-catalysts for enabling the prerequisite oxidative addition of aryl halides to Pd(0)-species in the presence of hydroxylamines with a labile N-O bond. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 3-Aminopropan-1-olIn 2021 ,《High-Contrast CXCR4-Targeted 18F-PET Imaging Using a Potent and Selective Antagonist》 appeared in Molecular Pharmaceutics. The author of the article were Kwon, Daniel; Lozada, Jerome; Zhang, Zhengxing; Zeisler, Jutta; Poon, Richel; Zhang, Chengcheng; Roxin, Aron; Lin, Kuo-Shyan; Perrin, David; Benard, Francois. The article conveys some information:

C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancers, contributing to proliferation, metastasis, and a poor prognosis. The noninvasive imaging of CXCR4 can enable the detection and characterization of aggressive cancers with poor outcomes. Currently, no 18F-labeled CXCR4 positron emission tomog. (PET) radiotracer has demonstrated imaging contrast comparable to [68Ga]Ga-Pentixafor, a CXCR4-targeting radioligand. We, therefore, aimed to develop a high-contrast CXCR4-targeting radiotracer by incorporating a hydrophilic linker and trifluoroborate radioprosthesis to LY2510924, a known CXCR4 antagonist. A carboxy-ammoniomethyl-trifluoroborate (PepBF3) moiety was conjugated to the LY2510924-derived peptide possessing a triglutamate linker via amide bond formation to obtain BL08, whereas an alkyne ammoniomethyl-trifluoroborate (AMBF3) moiety was conjugated using the copper-catalyzed [3+2] cycloaddition click reaction to obtain BL09. BL08 and BL09 were radiolabeled with [18F]fluoride ion using 18F-19F isotope exchange. Pentixafor was radiolabeled with [68Ga]GaCl3. Side-by-side PET imaging and biodistribution studies were performed on immunocompromised mice bearing Daudi Burkitt lymphoma xenografts. The biodistribution of [18F]BL08 and [18F]BL09 showed tumor uptake at 2 h postinjection (p.i.) (5.67 ± 1.25%ID/g and 5.83 ± 0.92%ID/g, resp.), which were concordant with the results of PET imaging. [18F]BL08 had low background activity, providing tumor-to-blood, -muscle, and -liver ratios of 72 ± 20, 339 ± 81, and 14 ± 3 (2 h p.i.), resp. [18F]BL09 behaved similarly, with ratios of 64 ± 20, 239 ± 72, and 17 ± 3 (2 h p.i.), resp. This resulted in high-contrast visualization of tumors on PET imaging for both radiotracers. [18F]BL08 exhibited lower kidney uptake (2.2 ± 0.5%ID/g) compared to [18F]BL09 (7.6 ± 1.0%ID/g) at 2 h p.i. [18F]BL08 and [18F]BL09 demonstrated higher tumor-to-blood, -muscle, and -liver ratios compared to [68Ga]Ga-Pentixafor (18.9 ± 2.7, 95.4 ± 36.7, and 5.9 ± 0.7 at 2 h p.i., resp.). In conclusion, [18F]BL08 and [18F]BL09 enable high-contrast visualization of CXCR4 expression in Daudi xenografts. Based on high tumor-to-organ ratios, [18F]BL08 may prove a valuable new tool for CXCR4-targeted PET imaging with potential for translation. The use of a PepBF3 moiety is a new approach for the orthogonal conjugation of organotrifluoroborates for 18F-labeling of peptides.3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 1195-59-1In 2019 ,《Regulation of magnetic relaxation behavior by replacing 3d transition metal ions in [M2Dy2] complexes containing two different organic chelating ligands》 appeared in Dalton Transactions. The author of the article were Wang, Hui-Sheng; Yin, Cheng-Ling; Hu, Zhao-Bo; Chen, Yong; Pan, Zhi-Quan; Song, You; Zhang, Yi-Quan; Zhang, Zai-Chao. The article conveys some information:

Four tetranuclear 3d-4f complexes, namely [Fe2Ln2(L)2(teaH)2(Cl)2](NO3)2·4CH3CN (H2L = N1,N3-bis(3-methoxysalicylidene)diethylenetriamine, teaH3 = triethanolamine, Ln = Dy for 1 and Ln = Gd for 1′) and [Co2Ln2(L)2(pdm)2(CH3COO)2(CH3OH)2](NO3)2·xCH3OH·yH2O (pdmH2 = 2,6-pyridinedimethanol, Ln = Dy, x = 5 and y = 2.5 for 2 and Ln = Gd, x = 6 and y = 1.5 for 2′), are reported. Two FeIII and two DyIII in 1 formed a zigzag Fe1-Dy1-Dy1a-Fe1a arrangement with a Fe1-Dy1-Dy1a angle of 105.328(3)°. However, in contrast to 1, two CoIII and two DyIII ions in 2 formed a more linear Co1-Dy1-Dy1a-Co1a arrangement with a Co1-Dy1-Dy1a angle of 141.86(2)°. Addnl., two DyIII ions in 1 are eight-coordinated with a triangular dodecahedron geometry, while two DyIII ions in 2 adopt nine-coordination with a muffin geometry. Magnetic studies revealed slow magnetic relaxation behavior for 1, with an energy barrier Ea of 6.9 K. For 2, single mol. magnet behavior was presented under a zero d.c. field with an effective energy barrier Ueff of 64.0(9) K. Ab initio calculations for 1 and 2 indicate that compared to 2, complex 1 has a larger transversal magnetic moment of its ground Kramers doublets (KD) and a larger value of the tunneling parameter (Δt) for the exchanged coupled ground state, which may result in poor single mol. magnet behavior for 1.2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 3,5-DihydroxybenzaldehydeIn 2021 ,《Design and microwave synthesis of new (5Z) 5-arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-amino-5-arylidene-1,3-thiazol-4(5H)-one as new inhibitors of protein kinase DYRK1A》 appeared in Pharmaceuticals. The author of the article were Bourahla, Khadidja; Guiheneuf, Solene; Limanton, Emmanuelle; Paquin, Ludovic; Le Guevel, Remy; Charlier, Thierry; Rahmouni, Mustapha; Durieu, Emilie; Lozach, Olivier; Carreaux, Francois; Meijer, Laurent; Bazureau, Jean-Pierre. The article conveys some information:

Here, we report on the synthesis of libraries of new 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones 3 (twenty-two compounds) and new 2-amino-5-arylidene-1,3-thiazol-4(5H)-ones 5 (twenty-four compounds) with stereo controlled Z-geometry under microwave irradiation The 46 designed final compounds were tested in order to determine their activity against four representative protein kinases (DYR1A, CK1, CDK5/p25, and GSK3α/β). Among these 1,3-thiazolidin-4-ones, the mols. (5Z) 5-(4-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one 3e (IC50 0.028 μM) and (5Z)-5-benzo[1,3]dioxol-5-ylmethylene-2-(pyridin-2-yl)amino-1,3-thiazol-4(5H)-one 5s (IC50 0.033 μM) were identified as lead compounds and as new nanomolar DYRK1A inhibitors. Some of these compounds in the two libraries have been also evaluated for their in vitro inhibition of cell proliferation (Huh7 D12, Caco2, MDA-MB 231, HCT 116, PC3, and NCI-H2 tumor cell lines). These results will enable us to use the 1,3-thiazolidin-4-one core as pharmacophores to develop potent treatment for neurol. or oncol. disorders in which DYRK1A is fully involved. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Safety of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Safety of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C7H6O2In 2019 ,《Multicomponent synthesis of pyrano[2,3-d]pyrimidine derivatives via a direct one-pot strategy executed by novel designed copperated Fe3O4@polyvinyl alcohol magnetic nanoparticles》 appeared in Materials Today Chemistry. The author of the article were Maleki, A.; Niksefat, M.; Rahimi, J.; Taheri-Ledari, R.. The article conveys some information:

A magnetic nanocatalyst system was designed and used for facilitating one-pot synthesis of pyrano[2,3-d]pyrimidine derivatives I (R = Ph, 2,4-dichlorophenyl, 2-thienyl, etc.). This product takes advantages of copper(II) ions chelated with oxygen atoms of polyvinyl alc. (PVA) strands, which were well composited with iron oxide magnetic nanoparticles during an in situ process. High reaction yields were obtained by using this efficient nanocatalyst in the short times and under mild conditions. High hydrophilicity, convenient separation, and acceptable recyclability have been investigated and introduced as the features of this nanocatalyst. Structural studies related to the nanoscale materials have also been carried out and well interpreted in this report. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4COA of Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.COA of Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 3,5-DihydroxybenzaldehydeIn 2022 ,《Preparation of a resveratrol-ascorbic acid mem conjugate》 appeared in Heterocyclic Letters. The author of the article were Amin, Rasidul; Hunt, David A.. The article conveys some information:

The preparation of a resveratrol-ascorbic acid conjugate in support of pharmacodynamic and pharmacokinetic studies has been achieved through a seven-step convergent synthesis. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C6H7BO3In 2020 ,《A Bi-functional Second Coordination Sphere for Electrocatalytic CO2 Reduction: The Concerted Improvement by a Local Proton Source and Local Coulombic Interactions》 appeared in Chemistry Letters. The author of the article were Matsubara, Yasuo; Shimojima, Miho; Takagi, Shohei. The article conveys some information:

A homogeneous rhenium(I) electrocatalyst possessing hydroxy and ammonio groups in the second coordination sphere is reported for the reduction of carbon dioxide (CO2) to carbon monoxide, wherein the former and latter groups induce a high local concentration of protons and local coulombic interactions with a metallocarboxylate reaction intermediate, resp. In a comparison with precedent catalysts possessing single functional groups in the spheres, we found that the catalyst exhibits a concerted improvement over these single functional groups in the efficiencies of catalysis, based on exptl. standard electrode potentials for the reduction in aqueous N,N-dimethylformamide or acetonitrile solutions and the equilibrium potentials depending on the catalytic systems.2-Hydroxyphenylboronic acid(cas: 89466-08-0Synthetic Route of C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Synthetic Route of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 156-87-6In 2020 ,《Secondary Structure-Governed Polypeptide Cross-Linked Polymeric Hydrogels》 was published in Chemistry of Materials. The article was written by Chen, Chongyi; Lan, Jun; Li, Yuanchao; Liang, Dongran; Ni, Xiuquan; Liu, Qiao. The article contains the following contents:

Modulation of the secondary structures of peptides gives rise to a range of natural peptide-based soft materials with outstanding mech. properties. Here, we discuss detailed insights on how the secondary structure of tailor-made polypeptides governs the mech. properties of polymeric hydrogels. To this end, we developed a series of polymeric hydrogels crosslinked by poly(3-propyl-acrylate-glutamine) with tailorable secondary structures-α-helixes and random coils. Interestingly, the hydrogels crosslinked by the α-helical crosslinker exhibit a high tensile strength and toughness because of the cooperative intramol. hydrogen bonding along the polypeptide backbone. Furthermore, the α-helixes endow the hydrogels with high resilience and rapid recovery because of their reversible cooperative hydrogen bonding. In contrast, the hydrogels crosslinked by the random coil crosslinker show inferior tensile strength and toughness. Our study establishes quant. nanoscale/macroscale structure-property relationships in polymeric hydrogels and has important implications for the rational design of soft materials using polypeptides with a specific secondary structure. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C7H6O2In 2020 ,《Preparation of a trihydrazinotriazine-functionalized core-shell nanocatalyst as an extremely efficient catalyst for the synthesis of benzoxanthenes》 was published in Materials Today Chemistry. The article was written by Rahimi, J.; Maleki, A.. The article contains the following contents:

Herein, trihydrazinotriazine (THDT)-coated Fe3O4@SiO2 as a novel amino-functionalized magnetic nanocompostie was introduced. The nanocatalyst was fully characterized and proved the morphol. and magnetic property of the nanoparticles by using essential analyses. The basic attributed of the amino-rich porous surface of the nanocomposite provided a desirable environment for enhancing various reaction conditions. Several benzoxanthenes were synthesized using Fe3O4@SiO2-THDT nanocatalysts, to examine the applicability of the nanocatalyst in organic reactions. The nanocomposite successfully improved the reaction conditions and provided the benzoxanthenes in an environmentally friendly procedure, which afforded product in excellent yields (80-96%) and reduced time. The nanomagnetic catalyst was easily recovered after each trial by using an external magnet. After six successive runs, the loss of catalytic activity of the nanocomposite was negligible. Finally, a plausible mechanism for the preparation of the benzoxanthenes derivatives using the THDT-functionalized core-shell magnetic nanocatalyst was propounded . In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Electric Literature of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Electric Literature of C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts