Month: November 2022

In 2019,Tetrahedron Letters included an article by Fonte, Melanie; Fagundes, Natalia; Gomes, Ana; Ferraz, Ricardo; Prudencio, Cristina; Araujo, Maria Joao; Gomes, Paula; Teixeira, Catia. HPLC of Formula: 13325-10-5. The article was titled 《Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials》. The information in the text is summarized as follows:

This is the first multi-step synthetic route, which has been developed towards N4,N9-disubstituted 4,9-diaminoacridines I. The target structures I are likely to reveal interesting biol. activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Fluorous hydrophobic fluorescent (E)-Stilbene derivatives for application on security paper》 were Granados, Albert; Vallribera, Adelina. And the article was published in Dyes and Pigments in 2019. Name: 3,5-Dihydroxybenzaldehyde The author mentioned the following in the article:

(E)-Stilbene hydrophobic fluorophores (e.g., I) possessing long perfluorinated or hydrocarbonated chains have been prepared through a stereoselective Wittig-Schlosser reaction. When covalently grafted upon paper, they give rise to a fluorescent-labeled paper upon irradiation with UV light. The hydrophobicity and oleophobicity of the fluorous (E)-stilbene derivative furnish self-cleaning properties. Application in the detection of money counterfeiting is envisioned. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Name: 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Rheo-Optical Near-Infrared (NIR) Characterization of Hydroxyl-Functionalized Polypropylene (PPOH)-Mesoporous Silica Nanocomposites Using Two-Trace Two-Dimensional (2T2D) Correlation Analysis》 were Watanabe, Ryota; Hagihara, Hideaki; Sato, Hiroaki; Mizukado, Junji; Shinzawa, Hideyuki. And the article was published in Applied Spectroscopy in 2019. Synthetic Route of C6H12O The author mentioned the following in the article:

A rheo-optical characterization technique based on the combination of near-IR (NIR) spectroscopy and mech. anal. was applied to the nanocomposite consisting of hydroxyl-functionalized polypropylene (PPOH) and mesoporous silica (MPS) to probe the deformation behavior. Substantial levels of spectral changes of NIR spectral features were captured when the polymer samples underwent tensile deformation. Sets of spectra were subjected to projection treatment to remove the effect of baseline fluctuations and thickness change inevitably caused by the tensile deformation of the sample. Then, two-trace two-dimensional (2T2D) correlation spectroscopy was applied to the pretreated spectra to elucidate spectroscopic signature associated with the difference between the initial and deformed samples. An asynchronous correlation peak appears between the bands at 1720 and 1700 nm resp. reflecting the contributions of predominantly amorphous and crystalline component of the PPOH, indicating the predominant variation of amorphous structure followed by that of crystalline structure. In addition, the predominant spectral change related to the amorphous band becomes even more acute by including the MPS with large pores. It is hence likely that the larger pore size of the MPS confines the more amorphous structure, which, in turn, causes simultaneous reorientation of the polymer chains in the amorphous region during the elastic deformation. Consequently, the incorporation of the MPS selectively restricts the deformation of the amorphous structure which eventually provides the obvious increase in the mech. property of the PPOH polymer. In the part of experimental materials, we found many familiar compounds, such as 5-Hexen-1-ol(cas: 821-41-0Synthetic Route of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Synthetic Route of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo》 were Kozielski, Kristen L.; Ruiz-Valls, Alejandro; Tzeng, Stephany Y.; Guerrero-Cazares, Hugo; Rui, Yuan; Li, Yuxin; Vaughan, Hannah J.; Gionet-Gonzales, Marissa; Vantucci, Casey; Kim, Jayoung; Schiapparelli, Paula; Al-Kharboosh, Rawan; Quinones-Hinojosa, Alfredo; Green, Jordan J.. And the article was published in Biomaterials in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:

Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can simultaneously target GBM cells’ ability to grow and migrate. Herein, we describe a synthetic, bioreducible, biodegradable polymer that can package and deliver hundreds of siRNA mols. into a single nanoparticle, facilitating combination therapy against multiple GBM-promoting targets. We demonstrate that siRNA delivery with these polymeric nanoparticles is cancer-selective, thereby avoiding potential side effects in healthy cells. We show that we can deliver siRNAs targeting several anti-GBM genes (Robo1, YAP1, NKCC1, EGFR, and survivin) simultaneously and within the same nanoparticles. Robo1 (roundabout homolog 1) siRNA delivery by biodegradable particles was found to trigger GBM cell death, as did non-viral delivery of NKCC1, EGFR, and survivin siRNA. Most importantly, combining several anti-GBM siRNAs into a nanoparticle formulation leads to high GBM cell death, reduces GBM migration in vitro, and reduces tumor burden over time following intratumoral administration. We show that certain genes, like survivin and EGFR, are important for GBM survival, while NKCC1, is more crucial for cancer cell migration. This represents a powerful platform technol. with the potential to serve as a multimodal therapeutic for cancer. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《A novel hydroxy-bisphosphonic acid prodrug as a candidate for the delivery of ibuprofen to bone》 were Aoun, Sameh; Bennour, Haythem. And the article was published in Synthetic Communications in 2019. Recommanded Product: 100-83-4 The author mentioned the following in the article:

Active targeting with controlled delivery of anti-inflammatory drugs to the bone is not sufficiently explored. In this study, concise and novel synthesis of a hydroxy-bisphosphonic acid (HBPA) prodrug containing ibuprofen is described. The key step consisted of preparing the HBPA function from a carboxylic acid precursor, in mild conditions and using appropriate Arbuzov reactions with tris(trimethylsilyl)phosphite. This prodrug would be an excellent candidate for the treatment of bone inflammation diseases such as rheumatoid arthritis. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Recommanded Product: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《The α-alkylation of ketones with alcohols in pure water catalyzed by a water-soluble Cp*Ir complex bearing a functional ligand》 were Meng, Chong; Xu, Jing; Tang, Yawen; Ai, Yao; Li, Feng. And the article was published in New Journal of Chemistry in 2019. Synthetic Route of C7H7BrO The author mentioned the following in the article:

A water-soluble dinuclear Cp*Ir complex bearing 4,4′,6,6′-tetrahydroxy-2,2′-bipyrimidine as a bridging ligand was found to be a highly effective catalyst for the α-alkylation of ketones with alcs. in pure water. In the presence of catalyst (0.5 mol%), a series of desirable products were obtained with high reaction economy under environmentally benign conditions. The importance of the hydroxy group in the ligand for catalytic hydrogen transfer was confirmed by mechanism experiments Furthermore, the application of this catalytic system for the synthesis of a biol. active mol. donepezil in pure water was accomplished. Notably, this research would facilitate the progress of C-C bond-forming reactions in water catalyzed by water-soluble metal-ligand bifunctional catalysts. After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Synthetic Route of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Synthetic Route of C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Scalable Synthesis of Sequence-Defined Oligomers via Photoflow Chemistry》 were Van De Walle, Matthias; De Bruycker, Kevin; Junkers, Tanja; Blinco, James P.; Barner-Kowollik, Christopher. And the article was published in ChemPhotoChem in 2019. Application of 156-87-6 The author mentioned the following in the article:

The development of practical routes that enable the synthesis of unimol. non-natural macromols. on multi-gram scales remains a key challenge in polymer chem. Herein, we present a continuous flow setup employing the light-induced chem. based on photocaged dienes as a controlled ligation system to establish a new platform for scalable monodisperse macromol. synthesis. 800 Mg of sequence-defined linear chains with 8 repeating units were obtained in a sequential protecting group based 2-step process. The current study demonstrates that photoflow synthesis is a viable approach to generate large quantities of monodisperse oligomers. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application of 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Synthesis and Aggregation of a Porphyrin-Cored Hyperbranched Polyglycidol and Its Application as a Macromolecular Photosensitizer for Photodynamic Therapy》 were Kadhim, Alaa; McKenzie, Luke K.; Bryant, Helen E.; Twyman, Lance James. And the article was published in Molecular Pharmaceutics in 2019. COA of Formula: C3H7BrO The author mentioned the following in the article:

Macromols. are potentially useful delivery systems for cancer drugs, as their size allows them to utilize the enhanced permeability and retention effect (EPR), which facilitates selective delivery to (and retention within) tumors. In addition, macromol. delivery systems can prolong circulation times as well as protect and solubilize toxic and hydrophobic drug moieties. Overall, these properties and abilities can result in an enhanced therapeutic effect. Photodynamic therapy (PDT) combines the use of oxygen and a photosensitizer (PS), which become toxic upon light irradiation We proposed that a PS encapsulated within a water-soluble macromol. could exploit the EPR effect and safely and selectively deliver the PS to a tumor. In this paper, we describe the synthesis of a porphyrin-cored hyperbranched polymer that aggregated into larger micellar structures. DLS and TEM indicated that these aggregated structures had diameters of 45 and 20 nm for the solvated and nonsolvated species, resp. The porphyrin-cored HBP (PC-HBP), along with the nonencapsulated porphyrin (THPP), were screened against EJ bladder carcinoma cells in the dark and light. Both THPP and PC-HBP displayed good toxicity in the light, with LD50 concentrations of 0.5 and 1.7μM, resp. However, in the dark, the nonincorporated porphyrin (THPP) displayed significant toxicity, generating an LD50 of 4μM. On the other hand, no dark toxicity was observed for the polymer system (PC-HBP) at concentrations of 100μM or less. As such, incorporation within the large polymer aggregate serves to eliminate dark toxicity while maintaining excellent toxicity when irradiated. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9COA of Formula: C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.COA of Formula: C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Enthalpies of dilution of amino alcohols in aqueous solutions at 298.15 K》 was published in Thermochimica Acta in 2020. These research results belong to Romero, Carmen M.; Cruz, Yadhi P.; Perez-Casas, Silvia. Quality Control of 3-Aminopropan-1-ol The article mentions the following:

The enthalpies of dilution of aqueous solutions of the amino alcs.: 3-amino-1-propanol, (RS)-1-amino-2-propanol, (RS)-3-amino-1,2-propanediol, and 1,3-diamino-2-propanol were measured as a function of concentration at 298.15 K using a thermal activity monitor (TAM). The results of the exptl. measurements were treated according to the McMillan-Mayer theory, to obtain the enthalpic homogeneous interaction coefficients The pair interaction coefficient hxx shows a clear dependence on the position and number of polar groups. The enthalpic coefficients are discussed in terms of the mol. interaction between solvated solute mols. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Quality Control of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides》 was published in Chemical Science in 2020. These research results belong to Pagire, Santosh K.; Kumagai, Naoya; Shibasaki, Masakatsu. Recommanded Product: 7748-36-9 The article mentions the following:

A cooperative catalytic system comprising a chiral Cu(I) complex and an Ir(III) photocatalyst fueled by visible-light irradiation that allows for seamless integration of the catalytic formation of a-amino alkyl radicals and subsequent enantioselective addition to α,β-unsaturated amides I [R = H, OMe; R1 = Me, Ph, pyridin-2-yl, etc.; R2 = H, Me; R3 = H, OMe, Cl; X = CH2, C(CH3)2] was reported. A 7-aza-6-MeO-indoline attachment on the amide substrates plays a pivotal role in suppressing the undesired pathways, resulting in excellent enantioselectivity and enabling expedited access to valuable γ-aminobutyramides II (R4 = Ph, 2-fluorophenyl; R5 = H, Me, i-Pr, Bn). The indoline amide was readily diversified with full recovery of the azaindoline attachment, highlighting the synthetic utility of this cooperative catalytic system. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts