Month: November 2022

On September 30, 2022, Mori, Nagisa; Murphy, Neil; Sawada, Norie; Achaintre, David; Yamaji, Taiki; Scalbert, Augustin; Iwasaki, Motoki; Inoue, Manami; Gunter, Marc J.; Tsugane, Shoichiro published an article.Category: alcohols-buliding-blocks The title of the article was Prediagnostic plasma polyphenol concentrations and colon cancer risk: The JPHC nested case-control study. And the article contained the following:

Epidemiol. studies that assessed the associations between dietary polyphenol intakes and colon cancer risk have reported largely null results, possibly due to measurement error associated with dietary assessment. We adopted an objective approach by measuring prediagnostic plasma concentrations of 35 polyphenols and assessing associations with colon cancer risk.We conducted a nested-case control study within the Japan Public Health Center-based prospective study (JPHC Study) utilizing plasma samples collected at the time of a five-year follow-up survey between 1995 and 1999. We identified colon cancer cases who developed cancer during the follow-up from the time of blood collection. Controls were matched by age, sex, area code, population size of the area, season of blood collection, year of blood collection, and duration of fasting time before the blood collection. Prediagnostic concentrations of 35 polyphenols from 375 incident colon cancer cases (followed until 2012) and 710 matched controls were measured by tandem mass spectrometry coupled with ultra-high-pressure liquid chromatog. We used multivariable conditional logistic regression models adjusted for established colon cancer risk factors to estimate odds ratios (ORs) and 95% confidence intervals (CIs).In sexes combined log2-transformed multivariable models, circulating levels of 3,4-dihydroxyphenylpropionic acid (P = 0.02), ferulic acid (P = 0.02), and caffeic acid (P = 0.03) were inversely, and 3-hydroxybenzoic acid (P = 0.03) was pos., associated with colon cancer risk. For men only, circulating levels of 3,4-dihydroxyphenylpropionic acid was inversely, and 3,5-dihydroxyphenylpropionic acid, gallic acid, (+)-epigallocatechin, 3-hydroxybenzoic acid, and epicatechin were pos., associated with colon cancer risk. In women, plasma caffeic acid and ferulic acid concentration were inversely associated with colon cancer risk. However, all these associations were nonsignificant after adjustment for multiple comparisons. The remaining polyphenols were not associated with colon cancer risk. Coffee-derived 3,4-dihydroxyphenylpropionic acid, ferulic acid, and caffeic acid concentrations were inversely associated with colon cancer risk although the association were nonsignificant after adjustment for multiple comparisons. These results support a possible role of coffee polyphenols in preventing colorectal cancer. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to colon cancer risk prediagnosis blood plasma polyphenol japan, colon cancer, japanese, phytochemicals, plasma, polyphenols, Animal Nutrition: Other and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2021, Barfoot, Katie Louise; Istas, Geoffrey; Feliciano, Rodrigo Pedro; Lamport, Daniel Joseph; Riddell, Patricia; Rodriguez-Mateos, Ana; Williams, Claire Michelle published an article.Related Products of 621-37-4 The title of the article was Effects of daily consumption of wild blueberry on cognition and urinary metabolites in school-aged children: a pilot study. And the article contained the following:

Acute intervention with wild blueberry (WBB) has previously revealed pos. cognitive and mood effects in typically developing children; however, it is unclear whether effects persist after daily supplementation. In addition, no data have been published exploring the metabolite profiles of children following berry consumption, to our knowledge. A study of this kind could provide insight into a mechanism of action for the cognitive and mood improvements observed previously in children. The aim of this pilot study was to assess cognitive performance and urinary metabolite concentrations in healthy 7-10-yr-old children across a 4 wk daily WBB drink intervention. This pilot study examined the effects of daily WBB consumption for 4 wk (766 mg total polyphenols; 253 mg anthocyanins; equivalent to 240 g fresh blueberries per day) on cognition and mood in 15 healthy 7-10-yr-old children. Polyphenol metabolites were measured in 24 h urine before and after the 4 wk intervention. Chronic WBB-related benefits were seen on cognitively demanding trials on the modified attention network task, a task measuring executive functioning. Specifically, the WBB group maintained significantly higher accuracy on incongruent trials (96%; SE 0.03) compared with placebo participants (85%; SE 0.03; p = 0.038) after the 4 wk intervention, suggesting WBB was of most benefit on the more difficult aspects of the task. No significant WBB-related effects were observed on the auditory verbal learning task or the childs version of the pos. and neg. affect schedule. Urinary metabolite analyses indicated significant increases in different metabolites in WBB and placebo groups after 4 wk consumption. The research demonstrates 24 h WBB bioavailability in a child cohort for the first time with increases in urinary hippuric acid excretion during 2 wk daily WBB consumption. This study highlights the importance of conducting a larger study in children investigating the mechanism of action behind cognitive effects using bioavailability data. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to blueberry cognition metabolites urine anthocyanins, blueberries, children, cognition, executive function, flavonoids, metabolite, Animal Nutrition: Other and other aspects.Related Products of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Piccini, Ilaria; Sousa, Marta; Altendorf, Sabrina; Jimenez, Francisco; Rossi, Alfredo; Funk, Wolfgang; Biro, Tamas; Paus, Ralf; Seibel, Jens; Jakobs, Mira; Yesilkaya, Tanju; Edelkamp, Janin; Bertolini, Marta published an article in 2022, the title of the article was Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype.Formula: C3H6O4 And the article contains the following content:

Female pattern hair loss (FPHL) is a non-scarring alopecia resulting from the progressive conversion of the terminal (t) scalp hair follicles (HFs) into intermediate/miniaturized (i/m) HFs. Although data supporting nutrient deficiency in FPHL HFs are lacking, therapeutic strategies are often associated with nutritional supplementation. Here, we show by metabolic anal. that selected nutrients important for hair growth such as essential amino acids and vitamins are indeed decreased in affected iHFs compared to tHFs in FPHL scalp skin, confirming nutrient insufficiency. IHFs also displayed a more quiescent metabolic phenotype, as indicated by altered metabolite abundance in freshly collected HFs and release/consumption during organ culture of products/substrates of TCA cycle, aerobic glycolysis, and glutaminolysis. Yet, as assessed by exogenous nutrient supplementation ex vivo, nutrient uptake mechanisms are not impaired in affected FPHL iHFs. Moreover, blood vessel d. is not diminished in iHFs vs. tHFs, despite differences in tHFs from different FPHL scalp locations or vs. healthy scalp or changes in the expression of angiogenesis-associated growth factors. Thus, our data reveal that affected iHFs in FPHL display a relative nutrient insufficiency and dormant metabolism, but are still capable of absorbing nutrients, supporting the potential of nutritional supplementation as an adjunct therapy for FPHL. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Formula: C3H6O4

The Article related to hair follicle human nutrient insufficiency dormant metabolism, female pattern hair loss, hair follicle, metabolism, nutrient supplementation, Animal Nutrition: Other and other aspects.Formula: C3H6O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vaillant, Fabrice; Corrales-Agudelo, Vanesa; Moreno-Castellanos, Natalia; Angel-Martin, Alberto; Henao-Rojas, Juan Camilo; Munoz-Durango, Katalina; Poucheret, Patrick published an article in 2021, the title of the article was Plasma Metabolome Profiling by High-Performance Chemical Isotope-Labelling LC-MS after Acute and Medium-Term Intervention with Golden Berry Fruit (Physalis peruviana L.), Confirming Its Impact on Insulin-Associated Signaling Pathways.Electric Literature of 621-37-4 And the article contains the following content:

Golden berry (Physalis peruviana L.) is an exotic fruit exported from Colombia to different countries around the world. A review of the literature tends to demonstrate a hypoglycemic effect with an improvement in insulin sensitivity after oral ingestion of fruit extracts in animal models. However, little is known about their potential effects in humans, and very little is known about the mechanisms involved. This study aimed at identifying discriminant metabolites after acute and chronic intake of golden berry. An untargeted metabolomics strategy using high-performance chem. isotope-labeling LC-MS was applied. The blood samples of eighteen healthy adults were analyzed at baseline, at 6 h after the intake of 250 g of golden berry (acute intervention), and after 19 days of daily consumption of 150 g (medium-term intervention). Forty-nine and 36 discriminant metabolites were identified with high confidence, resp., after the acute and medium-term interventions. Taking into account up- and downregulated metabolites, three biol. networks mainly involving insulin, epidermal growth factor receptor (EGFR), and the phosphatidylinositol 3-kinase pathway (PI3K/Akt/mTOR) were identified. The biol. intracellular networks identified are highly interconnected with the insulin signalling pathway, showing that berry intake may be associated with insulin signalling, which could reduce some risk factors related to metabolic syndrome. Primary registry of WHO. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Electric Literature of 621-37-4

The Article related to diet supplement physalis plasma metabolome insulin egfr putrescine vitamina, physalis peruviana, insulin, metabolomic, nutritional intervention, Animal Nutrition: Other and other aspects.Electric Literature of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Immobilization of manganese dioxide nanoparticles on modified poly 2,4-dichlorostyrene microspheres: a highly efficient and recyclable catalyst for borrowing hydrogen reactions》 were Qiu, Ye; Zhang, Yilin; Jin, Lu; Pan, Le; Du, Guangming; Ye, Dongdong; Wang, Dawei. And the article was published in Organic Chemistry Frontiers in 2019. SDS of cas: 873-75-6 The author mentioned the following in the article:

Manganese dioxide nanoparticles have been fabricated using a facile approach and immobilized onto the surface of modified poly 2,4-dichlorostyrene microspheres. The resulting multifunctional hybrid materials were characterized by SEM, transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray power diffraction and X-ray photoelectron spectrometry. This cheap heterogeneous manganese catalyst revealed excellent reactivity and stability for the direct alkylation of primary alcs. with ketones via a hydrogen borrowing pathway. In addition, this catalytic system could be readily recycled more than five times with high reactivity retained, which provided a practical atom-economical approach for C-C bond formation and 1-benzyl-2-aryl-1H-benzo[d]imidazole synthesis. Mechanism investigations were conducted to better understand this catalyst system and these transformations. In the experiment, the researchers used (4-Bromophenyl)methanol(cas: 873-75-6SDS of cas: 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.SDS of cas: 873-75-6 It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Ligand-promoted cobalt-catalyzed radical hydroamination of alkenes》 was published in Nature Communications in 2020. These research results belong to Shen, Xuzhong; Chen, Xu; Chen, Jieping; Sun, Yufeng; Cheng, Zhaoyang; Lu, Zhan. Synthetic Route of C6H12O The article mentions the following:

Here, a ligand-promoted cobalt-catalyzed Markovnikov-type selective radical hydroamination of alkenes with diazo compounds was reported. This operationally simple protocol uses unsym. NNN-tridentate (UNT) ligand, readily available alkenes and hydrosilanes to construct hydrazones I (R = C6H5, 4-FC6H4, 3-pyridyl, etc.; R1 = Et, t-Bu, 4-MeOC6H4) with good functional group tolerance. The hydrazones can underwent nitrogen-nitrogen bond cleavage smoothly to deliver valuable amine derivatives Addnl., asym. intermol. hydroamination of unactivated aliphatic terminal alkenes using chiral N-imidazolinylphenyl 8-aminoquinoline (IPAQ) ligands has also been achieved to afford chiral amine derivatives II (R = Et, 4-FC6H4, C6H5CH2CH2, etc.; PG = Boc, Bz, (CH2)2CH(Ph)2, etc.) with good enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0Synthetic Route of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Synthetic Route of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Studies toward the Synthesis of Amphidinolide C1: Stereoselective Construction of the C(1)-C(15) Segment》 was published in Organic Letters in 2020. These research results belong to Namirembe, Sheila; Yan, Lu; Morken, James P.. Recommanded Product: 78782-17-9 The article mentions the following:

An enantioselective synthesis of the C(1)-C(15) segment (I) of the marine natural product amphidinolide C has been accomplished by a route that includes a stereoselective boron-Wittig reaction to furnish a trisubstituted alkenylboronate. In addition, the route employs enantioselective alkene diboration to install the C(6) hydroxyl group which undergoes intramol. conjugate addition to establish a THF ring. Lastly, a catalytic Suzuki-Miyaura cross-coupling is accomplished to construct the C(9)-C(10) bond. In the experiment, the researchers used many compounds, for example, Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Recommanded Product: 78782-17-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Visible-Light-Promoted Iododifluoromethylation of Alkenes via (Phosphonio)difluoromethyl Radical Cation》 was published in Organic Letters in 2020. These research results belong to Trifonov, Alexey L.; Panferova, Liubov I.; Levin, Vitalij V.; Kokorekin, Vladimir A.; Dilman, Alexander D.. Computed Properties of C6H12O The article mentions the following:

A reaction of an iododifluoromethylphosphonium salt with unactivated alkenes mediated by peri-xanthenoxanthene under blue-light irradiation is described. The reaction proceeds via activation of the carbon-iodine bond to generate (phosphonio)difluoromethyl radical cation, which attacks the double bond with subsequent quenching by the iodine. The intermediate phosphonium salts are easily hydrolyzed, furnishing products of iododifluoromethylation of alkenes. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0Computed Properties of C6H12O) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Computed Properties of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Imidodiphosphorimidate (IDPi) as an efficient organocatalyst for controlled/living ring-opening polymerization of lactones》 was written by Zhang, Xun; Jiang, Yu; Ma, Qiang; Hu, Siping; Wang, Qinggang; Liao, Saihu. SDS of cas: 821-41-0 And the article was included in European Polymer Journal in 2020. The article conveys some information:

Imidodiphosphorimidate (IDPi) is demonsatreted as a novel and efficient acid/base bifunctional organocatalyst for controlled/living ring-opening polymerization of lactones, which delivered the metal-free poly(δ-valerolactone) and poly(ε-caprolactone) with excellent control over the mol. weight and narrow dispersity at a low catalyst loading under mild conditions. NMR and MALDI-TOF characterizations, kinetic study, and chain extension experiment suggest a well-controlled/living nature of the current ROP of lactones catalyzed by the IDPi catalyst. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0SDS of cas: 821-41-0) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.SDS of cas: 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis of indole-based acetohydrazide analogs: their in vitro and in silico thymidine phosphorylase studies》 was written by Taha, Muhammad; Aldhamin, Ebaa Ahmed Jassim; Almandil, Noor Barak; Anouar, El Hassane; Uddin, Nizam; Alomari, Munther; Rahim, Fazal; Adalat, Bushra; Ibrahim, Mohamad; Nawaz, Fasial; Iqbal, Naveed; Alghanem, Bandar; Altolayyan, Abdulelah; Khan, Khalid Mohammed. Category: alcohols-buliding-blocks And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this study, a series of indole-based acetohydrazides I [R = 4-HOC6H4, 2-MeOC6H4 2,3-(HO)2C6H3, 2,4-(MeO)2C6H3, etc.] were synthesized and characterized. The products I were tested for their thymidine phosphorylase inhibitory potential. These derivatives inhibited thymidine phosphorylase at different concentration ranging from 1.10 ± 0.10 to 41.10 ± 1.10μM when compared with the standard 7-deazaxanthine (IC50 value 38.68 ± 1.12μM). The compound I [R = 2,4,6-(HO)3C6H2] was found to be the most potent among the series with IC50 1.10 ± 0.10μM. The structure activity relationships have been established for all compounds keeping in the view the role of substitution and the effect of functional group which significantly affect thymidine phosphorylase activity. The nature of binding interactions of the most potent compounds and active sites of the enzymes was confirmed through mol. docking study. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts