Month: November 2022

On January 10, 2013, Liu, Xingjin; Zhang, Xuke published a patent.Safety of (2-Fluorophenyl)methanethiol The title of the patent was Preparation of C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives for treating bacteria and protozoan infection. And the patent contained the following:

The title C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives I [wherein wherein R1 = H, OH, or OMe; R2 = OH; R3 = organic substituent with optional heteroatom(s); R4 = H, Cbz, Bz, or Ac] or pharmaceutically acceptable salts thereof were prepared for treating bacteria and protozoan infections. For example, II was prepared in a multi-step synthesis. Some title compounds showed antibacterial activity with MIC of 0.125 pg/mL, which is 32 times better than Azithromycin and Clarithromycin. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Safety of (2-Fluorophenyl)methanethiol

The Article related to preparation erythromycin a antibacterial agent human, Carbohydrates: Amines and other aspects.Safety of (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 30, 1997, Bazylak, Grzegorz; Aboul-Enein, Hassan Y. published an article.Product Details of 2160-93-2 The title of the article was Chemometric account for retention of lysosomotropic alkanolamines in planar chromatography systems. And the article contained the following:

Planar chromatog. retention data (in form of thermodynamically meaningful RM coefficients) for twelve model alkanolamines, indicating lysosomotropic activity, were determined in eighty chromatog. systems using eight different silica gel layers with varied chem. bonded stationary phases. In performed TLC experiments, aqueous binary mobile phases containing methanol or acetonitrile as organic modifier, in five different proportions, were applied. Addnl., nine quantum chem. descriptors were calculated for test solutes by a semi-empirical mol. modeling procedure (AM1) to describe their structural properties. Chemometric technique by the multivariate method of principal components anal. (PCA) was applied to the all completed chromatog. retention and computational chem. data for identification of the most selective and useful planar chromatog. systems as well as mol. interactions of solutes which affect their retention phenomena in the particular separation mode. The statistically significant relationship was revealed between quant. measure of antimicrobial activity of alkanolamines and values of calculated scores of principal components. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Product Details of 2160-93-2

The Article related to alkanol amine lysosomotropic chemometry planar chromatog, Pharmacology: Methods and other aspects.Product Details of 2160-93-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 2013, Schrauwen, Patrick; Timmers, Silvie; Hesselink, Matthijs K. C. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was Blocking the entrance to open the gate. And the article contained the following:

A review. The research of Keung et al. (2013) entitled ‘Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice’ is reviewed with commentary and references The article by these authors revisits the Randle hypothesis of a reciprocal relationship between fat and glucose oxidation Inhibition of mitochondrial entry of fatty acids by oxfenicine resulted in improved glucose tolerance and insulin sensitivity in high-fat diet-fed mice, while body mass was maintained. The authors confirmed that oxfenicine was indeed able to reduce fat oxidation with a concomitant increase in glucose oxidation facilitated by increased pyruvate dehydrogenase activity. GLUT4 translocation was improved. The results of Keung et al. may provide insight into new targets for diabetes treatment. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to review etomoxir cpt1 inhibitor antidiabetic agent type 2 diabetes, Pharmacology: Reviews and other aspects.Quality Control of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zahara, Kulsoom; Bibi, Yamin; Masood, Saadia; Nisa, Sobia; Sher, Ahmad; Ali, Naushad; Kumar, Sunjeet; Qayyum, Abdul; Ahmed, Waseem; Sami, Rokayya; Al-Mushhin, Amina A. M.; Aljahani, Amani H. published an article in 2022, the title of the article was Isolation and Identification of Bioactive Compounds from Bidens spp. Using HPLC-DAD and GC-MS Analysis and Their Biological Activity as Anticancer Molecules.Quality Control of 2,4-Di-tert-butylphenol And the article contains the following content:

The genus Bidens a member of family Compositae, is widely documented as an ethno-medicinally important genus of plants. In the present study, anticancer potential of three ethno-medicinally important species i.e., B. bipinnata, B. biternata and B. pilosa were tested. For in-vitro evaluation, an MTT (Thiazolyl blue tetrazolium bromide) assay was performed against cervical cancer cells (HeLa), hepatocellular carcinoma (HepG), and adenocarcinoma human alveolar basal epithelial cells (A549). For in vivo evaluation, Artemia salina, Danio rerio, and Caenorhabditis elegans were used. Among all the tested extracts, the ethanol extract of B. biternata appeared to have highest anticancer activity, and the compounds responsible for this activity were identified to be Tris (2,4-di-tert-butylphenyl), 4-hydroxy-2,4-dimethoxychalcone, and 2,4-di-tert-butylphenol. This is the first report of the isolation of Tris (2,4-di-tert-butylphenyl) phosphate from the genus Bidens and the first report of 4-hydroxy-2,4-dimethoxychalcone and 2,4-di-tert-butylphenol from B. biternata. Among the isolated compounds, 4-hydroxy-2,4-dimethoxychalcone showed the highest anticancer activity with an LD50 value of 236.7渭g/mL. Therefore, this compound carries promising potential for being established as a pharmaceutical for chemoprevention and chemotherapy. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Quality Control of 2,4-Di-tert-butylphenol

The Article related to bidens anticancer isolation identification hplc dad gc ms analysis, bidens, anticancer, brine shrimp, zebrafish, Pharmacology: Methods and other aspects.Quality Control of 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 31, 2021, Vlckova, Hana Kocova; Catapano, Maria Carmen; Mitasik, Lucia; Kotland, Ondrej; Nejmanova, Iveta; Pourova, Jana; Mladenka, Premysl; Novakova, Lucie published an article.HPLC of Formula: 621-37-4 The title of the article was Featuring ultimate sensitivity of high-resolution LC-MS analysis of phenolics in rat plasma. And the article contained the following:

Sensitive anal. of very low-mol. weight metabolites using liquid chromatog. with quadrupole-time-of-flight mass spectrometry is challenging due to the high losses of ions in a time-of-flight analyzer. Improvement in sensitivity for these analytes via the optimization of advanced parameters, including quadrupole profile, ion guide parameters, and duty cycle, has been achieved. The optimization of the method was carried out using a large spectrum of structurally different compounds including (iso)flavonoids and their known metabolites. These compounds can be categorized into two major groups, i.e., compounds with (iso)flavonoid core and low-mol. weight phenolics. The optimization of the duty cycle enabled up to a 15-fold increase in analyte responses while the contribution of tuning ion optics and quadrupole profile was negligible. The limits of quantifications of our new method were assessed using both standard solutions and rat plasma. They were decreased at least 10 times for several low-mol. weight phenolics enabling measurement of their concentrations in a range of 1-50 ng/mL in rat plasma after protein precipitation Concurrently, the limits of quantifications for compounds with (iso)flavonoid core did not increase distinctly allowing their detection in a range of 0.5-10 ng/mL. The new method was used for the targeting of phenolics in biol. samples from pharmacokinetics experiments The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to plasma isoflavonoid phenolics lc ms pharmacokinetics, high-resolution mass spectrometry, low-molecular weight analytes, metabolites, phenolics, quadrupole-time-of-flight, Pharmacology: Methods and other aspects.HPLC of Formula: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 15, 2020, Simon, Nina; Sperber, Christine; Voigtlaender, Cornelia; Born, Julia; Gilbert, Daniel F.; Seyferth, Stefan; Lee, Geoffrey; Kappes, Barbara; Friedrich, Oliver published an article.Synthetic Route of 585-88-6 The title of the article was Improved stability of polyclonal antibodies: A case study with lyophilization-conserved antibodies raised against epitopes from the malaria parasite Plasmodium falciparum. And the article contained the following:

Antibodies can be produced as polyclonal (pAb) or monoclonal (mAb) liquid formulations with limited shelf-life. For pAbs, unlike mAbs, only little is known about excipients and lyophilization affecting antibody stability upon reconstitution. We used a model pAb directed against Plasmodium falciparum (Pf) pyridoxal 5′-phosphate synthase 2 (Pdx2) to systemically study effects of bulking agents (amino acids, phosphate buffers, salt solutions), sugar(alcs.), surfactants and protein additions (bovine serum albumin, BSA) in liquid pAb formulations (isolated or in combinations) on the activity to detect the antigen in Pf extracts by Western blots. Repeated freeze-thaw cycles (20x) and extended room temperature storage markedly compromised pAb stability, the former being ameliorated by addition of cryoprotectants (glycerol, sucrose). Lyophilization of pure liquid pAb formulation markedly decreased antibody reactivity upon reconstitution which was not preserved by most bulking agents tested (e.g., histidine, arginine, acetate). Among the tested salt solutions (NaCl, Ringer, PBS), phosphate buffered saline had the largest lyoprotective potential, alongside sucrose, but not trehalose or maltitol. Among combinations of excipients, PBS, sucrose, low concentration BSA and Tween potently preserved PfPdx2 stability. Results for PBS were transferable to PfEnolase pAb, indicating that some of the formulations investigated here might be a low-cost solution for more general applicability to pAbs. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Synthetic Route of 585-88-6

The Article related to plasmodium polyclonal antibody lyophilization epitope, Pharmaceuticals: Other and other aspects.Synthetic Route of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kemung, Hefa Mangzira; Tan, Loh Teng-Hern; Chan, Kok-Gan; Ser, Hooi-Leng; Law, Jodi Woan-Fei; Lee, Learn-Han; Goh, Bey-Hing published an article in 2020, the title of the article was Antioxidant activities of Streptomyces sp. strain MUSC 14 from mangrove forest soil in Malaysia.Recommanded Product: 2,4-Di-tert-butylphenol And the article contains the following content:

Mangrove ecosystem of Malaysia remains yet to be fully explored for potential microbes that produce biol. active metabolites. In the present study, a mangrove-derived Streptomycessp.strain MUSC14 previously isolated from the state of Pahang, Malaysia Peninsula, was studied for its potential in producing antioxidant metabolites. The identity of Streptomyces sp. strain MUSC14 was consistent with the genotypic and phenotypic characteristics of the Streptomyces genus. The antioxidant potential of Streptomyces sp. strain MUSC 14 was determined through screening of its methanolic extract against sets of antioxidant assays. The results were indicative of Streptomyces sp. strain MUSC 14 displaying strong antioxidant activity against ABTS, DPPH free radicals and metal chelating activity of 62.71卤3.30%, 24.71卤2.22%, and 55.82卤2.35%, resp. The result of ferric reducing activity measured in terms of dose was equivalent to 2.35-2.45渭g of pos. control ascorbic acid. Furthermore, there was a high correlation between the total phenolic content and the antioxidant activities with r=0.979, r=0.858, and r=0.983 representing ABTS, DPPH, and metal chelation, resp. Overall, the present study suggests that Streptomycessp.strain MUSC14 from mangrove forest soil. has potential to produce antioxidant metabolites that can be further exploited for therapeutic application. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 2,4-Di-tert-butylphenol

The Article related to streptomyces sp strain musc mangrove forest soil antioxidant activity, Pharmaceuticals: Other and other aspects.Recommanded Product: 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 20, 2020, Hermabessiere, Ludovic; Receveur, Justine; Himber, Charlotte; Mazurais, David; Huvet, Arnaud; Lagarde, Fabienne; Lambert, Christophe; Paul-Pont, Ika; Dehaut, Alexandre; Jezequel, Ronan; Soudant, Philippe; Duflos, Guillaume published an article.Name: 2,4-Di-tert-butylphenol The title of the article was An Irgafos 168 story: When the ubiquity of an additive prevents studying its leaching from plastics. And the article contained the following:

Plastic pollution is a source of chem. to the environment and wildlife. Despite the ubiquity of plastic pollution and thus plastic additive in the environment, plastic additives have been studied to a limited extend. As a prerequisite to a study aiming to evaluate the leaching of a common additive used as an antioxidant (Irgafos 168) from polyethylene microparticles, an inventory of the potential background contamination of the laboratory workplace was done. In this study, Irgafos 168 (tris(2,4-ditert-butylphenyl) phosphite) and its oxidized form (tris (2,4-ditert-butylphenyl) phosphate) were quantified in different laboratory reagents, including the plastic packaging and the powders, using Pyrolysis-GC/MS. At least one form of Irgafos 168 was detected in all tested laboratory reagents with higher concentrations in caps and bottles as compared to the powders. Addnl., oxidized Irgafos 168 was also found in the reverse osmosed and deionized water container used in the laboratory The same profile of contamination, i.e. higher concentration of the oxidized form and higher concentrations in acidic reagents, was observed when comparing the reagent and their resp. containers suggesting that the additive is leaching from the container into the powder. Overall, this study demonstrates that the antioxidant additive Irgafos 168 is ubiquitous in the laboratory workplace. Plastic additives such as Irgafos 168 can therefore largely interfere and biased ecotoxicol. and toxicol. studies especially using environmentally relevant concentrations of microplastics. The source, fate and effects of plastic additive from plastic debris should be carefully considered in future studies that require setting up methods to overcome these contaminations. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Name: 2,4-Di-tert-butylphenol

The Article related to irgafos168 additive leaching plastics, additive, contamination, irgafos 168庐, leaching, microplastic, pyrolysis, Water: Water Pollution and other aspects.Name: 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Yousi; Wang, Yali; Wang, Xingguo; Sun, Yidan; Ren, Jianlin; Fang, Baishan published an article in 2022, the title of the article was Responses of human gut microbiota abundance and amino acid metabolism in vitro to berberine.Computed Properties of 473-81-4 And the article contains the following content:

The intestine is a potential location for berberine (BBR) to exert its therapeutic effects, but the understanding of the influences of BBR on the gut microbiota is limited. Through in vitro fermentation of human intestinal microbiota, author investigated the effects of BBR on microbiota composition and metabolism The result indicated that BBR reduced the production of acetic acid and propionic acid and had no effect on the content of butyric acid. Anal. of the 16S rRNA gene-based community revealed that BBR increased the abundance of Faecalibacterium and decreased the abundance of Bifidobacterium, Streptococcus and Enterococcus. Through metabolomics anal., BBR treatment regulated various amino acid metabolism pathways of intestinal microbiota, especially tyrosine, serine and L-glutamate. Author study presented direct impacts of BBR on the intestinal microbiota, which provided the probable targets of the therapies by BBR and supported further exploration of the underlying mechanisms. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to berberine amino acid metabolism gut microbiota, Animal Nutrition: Other and other aspects.Computed Properties of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2022, Xie, Fei; Jiang, Xue; Yi, Yang; Liu, Zi-Jia; Ma, Chen; He, Jin; Xun, Zhi-ming; Wang, Meng; Liu, Meng-yu; Yao, Mawulikplimi Adzavon; Zhao, Peng-xiang; Ma, Xue-mei published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status. And the article contained the following:

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochem. parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen consumption, the plasma metabolome and gut microbiota were investigated in this study. Compared with the control group, 14 and 10 differential metabolites (DMs) were identified in hydrogen-rich water (HRW) and hydrogen inhalation (HI) group, resp. Pathway enrichment anal. showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. 16S rRNA gene sequencing showed that HRW intake induced significant changes in the structure of gut microbiota, while no marked bacterial community differences was observed in HI group. HRW intake mainly induced significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and decrease in Bacteroides. HI mainly induced decreased abundances of Blautia and Paraprevotella. The metabolic function was determined by metabolic cage anal. and showed that HI decreased the voluntary intake and excretions of rats, while HRW intake did not. The results of this study provide basic data for further research on hydrogen medicine. Determination of the effects of hydrogen intervention on microbiota profiles could also shed light on identification of mechanism underlying the biol. effects of mol. hydrogen. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to lactobacillus ruminococcus clostridium hydrogen rich water intake gas inhalation, Animal Nutrition: Other and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts