Month: November 2022

《Laminated self-standing covalent organic framework membrane with uniformly distributed subnanopores for ionic and molecular sieving》 was published in Nature Communications in 2020. These research results belong to Li, Yang; Wu, Qianxun; Guo, Xinghua; Zhang, Meicheng; Chen, Bin; Wei, Guanyi; Li, Xing; Li, Xiaofeng; Li, Shoujian; Ma, Lijian. Recommanded Product: 34374-88-4 The article mentions the following:

The preparation of subnanoporous covalent-organic-framework (COF) membranes with high performance for ion/mol. sieving still remains a great challenge. In addition to the difficulties in fabricating large-area COF membranes, the main reason is that the pore size of 2D COFs is much larger than that of most gas mols. and/or ions. It is urgently required to further narrow their pore sizes to meet different separation demands. Herein, we report a simple and scalable way to grow large-area, pliable, free-standing COF membranes via a one-step route at organic-organic interface. The pore sizes of the membranes can be adjusted from >1 nm to sub-nm scale by changing the stacking mode of COF layers from AA to AB stacking. The obtained AB stacking COF membrane composed of highly-ordered nanoflakes is demonstrated to have narrow aperture (∼0.6 nm), uniform pore distribution and shows good potential in organic solvent nanofiltration, water treatment and gas separation After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Recommanded Product: 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Table-salt enabled interface-confined synthesis of covalent organic framework (COF) nanosheets》 was published in Chemical Science in 2020. These research results belong to Shi, Xiansong; Ma, Dongwei; Xu, Fang; Zhang, Zhe; Wang, Yong. Category: alcohols-buliding-blocks The article mentions the following:

Two-dimensional covalent organic frameworks (COFs) are gaining tremendous interest for their potential applications in a diversity of fields. However, synthesis of COF nanosheets (CONs) usually suffers from tedious exfoliation processes and low yields. Herein, we present an exfoliation-free and scalable strategy to prepare few-layered CONs based on interface-confined synthesis, in which cheap and recyclable table salt (NaCl) is used as the sacrificial substrate. Salt particles are introduced into the reaction system, creating billions of solid-liquid interfaces. Oligomers formed upon the reaction between monomers are immediately adsorbed on salt surfaces, and the following polymerization leading to crystalline CONs is exclusively confined to salt surfaces. Salts can be easily removed by water washing, producing CONs with the thickness down to a few nanometers and lateral sizes up to hundreds of micrometers depending on the size of salt particles and the concentration of monomers. Four different kinds of CONs, both imine-linked and boron-containing, are synthesized from this generic method. As a demonstration, we prepare highly permeable and selective membranes using resultant CONs as building blocks. Thanks to the defect-free stacking of CONs with thin thicknesses and large lateral sizes on porous substrates, the membranes precisely sep. similarly sized dyes while allowing ultrafast water permeation. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Category: alcohols-buliding-blocks) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Category: alcohols-buliding-blocksFor acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Eco-Friendly Sustainable Poly(benzoxazine-co-urethane) with Room-Temperature-Assisted Self-Healing Based on Supramolecular Interactions》 was published in ACS Omega in 2020. These research results belong to Sriharshitha, Salendra; Krishnadevi, Krishnamoorthy; Devaraju, Subramani; Srinivasadesikan, Venkatesan; Lee, Shyi-Long. Application of 156-87-6 The article mentions the following:

This work is an attempt to develop bio-based eco-friendly poly(benzoxazine-co-urethane) [poly(U-co-CDL-aee)] materials using cardanol-based benzoxazines (CDL) and hexamethylene diisocyanate (HMDI) to check their self-healing ability and thermal properties. CDL monomers were synthesized using cardanol, amino ethoxyethanol (aee) or 3-aminopropanol (3-ap), and paraformaldehyde through the Mannich reaction. Later, CDL-aee or CDL-3-ap monomers were copolymerized with a urethane precursor (HMDI), followed by ring-opening polymerization through thermal curing. The thermal properties of poly(U-co-CDL) were evaluated by differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA). The self-healing behavior of the bio-based poly(U-co-CDL) was checked by applying a mild external pressure. The results revealed that the developed poly(U-co-CDL) showed repeatable self-healing ability due to supramol. hydrogen-bonding interactions. Further, the self-healing ability of poly(U-co-CDL) was studied using d. functional theory (DFT). From the above results, the developed material with superior self-healing ability can be used in the form of self-healing coatings and composites for various applications with extended shelf-life and reliability. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application of 156-87-6

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Alcohol – Wikipedia,
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《Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77》 was written by Fang, Hua; Zhang, Jianyu; Ao, Mingtao; He, Fengming; Chen, Weizhu; Qian, Yuqing; Zhang, Yuxiang; Xu, Yang; Fang, Meijuan. Related Products of 13325-10-5 And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this work, three series of ω-3 polyunsaturated fatty acid-alkanolamine derivatives (PUFA-AAs) were synthesized, characterized and their anti-inflammatory activity in vivo was evaluated. Three compounds exhibited marked anti-inflammatory activity in LPS-stimulated RAW 264.7 cells. The most promising compound cis-7,10,13,16,19-docosapentaenoic acid 2-hydroxyethyl amide (I) dose-dependently suppressed the cytokines with IC50 values in the low micromolar range. Further, I exhibited potential in vitro Nur77-binding affinity (Kd = 6.99 x 10-6 M) which is consistent with the result of docking studies. Next, the anti-inflammatory mechanism of I was found to be through NF-κB signal pathway in a Nur77-dependent manner. Moreover, we also observed I significantly inhibited LPS-induced expression of cytokines (IL-6, TNF-α, and IL-1β) through suppressing NF-κB activation and attenuated LPS-induced inflammation in mouse acute lung injury (ALI) model. In conclusion, the study strongly suggests that the PUFA-AA derivatives can be particularly as new Nur77 mediators for further treatment in inflammatory diseases. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis and photophysical studies of an indigo derivative: N-octyl-7,7′-diazaindigo》 was written by de Miguel, Gustavo; Garzon-Ruiz, Andres; Navarro, Amparo; Garcia-Frutos, Eva M.. Recommanded Product: Oxetan-3-ol And the article was included in RSC Advances in 2020. The article conveys some information:

In this paper, we explore the synthesis, characterization, and photophys. properties of a novel indigo derivative, N-octyl-7,7′-diazaindigo, being the first time that diazaindigos have been studied as photophys.-active chem. entities. Reduction of the neutral “”keto-form”” to the so-called “”leuco-form”” changes the global spectroscopic and photophys. behaviors. Both species have been investigated by different photophys. studies, such as anal. of absorption and emission spectra, fluorescence quantum yields (ϕF) and lifetimes. Finally, to appraise in depth the deactivation of the excited state of the keto form, femtosecond transient absorption (TA) experiments and D. Functional Theory (DFT) and Time Dependent (TD)-DFT calculations were performed. In an organic aprotic solvent (N,N-dimethylformamide), TA experiments showed a fast deactivation channel (τ1 = 2.9 ps), which was ascribed to solvent reorganization, and a longer decay component (τ2 = 86 ps) associated with an internal conversion (IC) process to the ground-state, in opposition to the excited state proton transfer (ESPT) mechanism that takes place in the indigo mols. but in protic solvents. A comparative study was also carried out on the parent mol., 7,7′-diazaindigo, corroborating the previous conclusions obtained for the alkyl derivative In agreement with exptl. observations, DFT and TD-DFT calculations revealed that the deactivation of the S1 state of the keto form takes place through an internal conversion process. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A visible-light Paterno-Buchi dearomatisation process towards the construction of oxeto-indolinic polycycles》 was written by Mateos, Javier; Vega-Penaloza, Alberto; Franceschi, Pietro; Rigodanza, Francesco; Andreetta, Philip; Companyo, Xavier; Pelosi, Giorgio; Bonchio, Marcella; Dell’Amico, Luca. Computed Properties of C4H12KNaO10 And the article was included in Chemical Science in 2020. The article conveys some information:

A variety of highly functionalized N-containing polycycles such as I [R = H, 6-F, 5-Br, 5-MeO; R1 = Me, CH2OH, Ph, etc.; R2 = Ph, 4-ClC6H4, C(O)C6H5, etc.; R3 = H, Me, Ph; R4 = Me, Boc; Ar = Ph, 4-ClC6H4, 4-FC6H4, etc.] were synthesized from simple indoles and aromatic ketones through a mild visible-light Paterno-Buchi process. Tetrahydrooxeto[2,3-b]indole scaffolds, with up to three contiguous all-substituted stereocenters, were generated in high yield (up to >98%) and excellent site- regio- and diastereocontrol (>20:1). The use of visible light (405 or 465 nm) ensures enhanced performances by switching off undesired photodimerization side reactions. The reaction could be easily implemented using a microfluidic photoreactor with improved productivity (up to 0.176 mmol h-1) and generality. Mechanistic investigations revealed that two alternative reaction mechanisms could account for the excellent regio- and diastereocontrol observed The results came from multiple reactions, including the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Computed Properties of C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Computed Properties of C4H12KNaO10 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《225Ac-H4py4pa for Targeted Alpha Therapy》 was written by Li, Lily; Rousseau, Julie; Jaraquemada-Pelaez, Maria de Guadalupe; Wang, Xiaozhu; Robertson, Andrew; Radchenko, Valery; Schaffer, Paul; Lin, Kuo-Shyan; Benard, Francois; Orvig, Chris. Product Details of 1195-59-1 And the article was included in Bioconjugate Chemistry in 2021. The article conveys some information:

Herein, we present the syntheses and characterization of a new undecadendate chelator, H4py4pa, and its bifunctional analog H4py4pa-phenyl-NCS, conjugated to the monoclonal antibody, Trastuzumab, which targets the HER2+ cancer. H4py4pa possesses excellent affinity for 225Ac (α, t1/2 = 9.92 d) for targeted alpha therapy (TAT), where quant. radiolabeling yield was achieved at ambient temperature, pH = 7, in 30 min at 10-6 M chelator concentration, leading to a complex highly stable in mouse serum for at least 9 d. To investigate the chelation of H4py4pa with large metal ions, lanthanum (La3+), which is the largest nonradioactive metal of the lanthanide series, was adopted as a surrogate for 225Ac to enable a series of nonradioactive chem. studies. In line with the 1H NMR spectrum, the DFT (d. functional theory)-calculated structure of the [La(py4pa)]- anion possessed a high degree of symmetry, and the La3+ ion was secured by two distinct pairs of picolinate arms. Furthermore, the [La(py4pa)]- complex also demonstrated a superb thermodn. stability (log K[La(py4pa)]- ~20.33, pLa = 21.0) compared to those of DOTA (log K[La(DOTA)]- ~24.25, pLa = 19.2) or H2macropa (log K[La(macropa)]- = 14.99, pLa ~8.5). Moreover, the functional versatility offered by the bifunctional py4pa precursor permits facile incorporation of various linkers for bioconjugation through direct nucleophilic substitution. In this work, a short phenyl-NCS linker was incorporated to tether H4py4pa to Trastuzumab. Radiolabeling studies, in vitro serum stability, and animal studies were performed in parallel with the DOTA-benzyl-Trastuzumab. Both displayed excellent in vivo stability and tumor specificity. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Product Details of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maji, Milan; Borthakur, Ishani; Guria, Saikat; Singha, Suman; Kundu, Sabuj published their research in Journal of Catalysis in 2021. The article was titled 《Direct access to 2-(N-alkylamino)pyrimidines via ruthenium catalyzed tandem multicomponent annulation/N-alkylation》.Recommanded Product: 100-55-0 The article contains the following contents:

A new cooperative ruthenium complex catalyzed tandem multicomponent synthesis of 2-(N-alkylamino)pyrimidines I [R = Ph, 4-MeOC6H4; R1 = 4-MeC6H4, 4-BrC6H4, 2-thienyl, etc.; R2 = H, Me; R3 = Ph, 4-FC6H4, cyclohexyl, etc.; R2R3 = (CH2)5] directly from guanidine salt and alcs. was developed. The reactions proceeded through the dehydrogenation of alcs., followed by C-C coupling and sequential C-N coupling with guanidine and primary alc., with the elimination of three equivalent of hydrogen gas. In this work, application of both the acceptorless dehydrogenative coupling (ADC) and borrowing hydrogen (BH) strategies were accomplished in a single reaction. This catalytic method tolerated a wide range of substrates. The viability of the current method was demonstrated by preparative scale synthesis of a few products. A plausible catalytic cycle was proposed based on various control experiments, mechanistic studies and DFT calculations Remarkably, 42 new 2-(N-alkylamino)pyrimidines were synthesized following this catalytic protocol. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 100-55-0

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Alcohol – Wikipedia,
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Mudasani, Gopal; Paidikondala, Kalyani; Gundla, Rambabu; Joseph Maddirala, Shambabu; Das, Viswanath published their research in ChemistrySelect in 2021. The article was titled 《Synthesis and Biological Evaluation of 5′-Arylspiro[piperidine-4,3′-pyrrolo-[2,3-b]pyridin] Analogues》.Related Products of 7748-36-9 The article contains the following contents:

The synthesis of a novel series of spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one analogs I [R = H, CONH2; Ar = pyrimidin-5-yl, 4-fluorophenyl, 1,3-benzodioxol-5-yl, etc.] and in-vitro antiproliferative activity of these compounds against four human cancer cell lines were reported. Synthesis of analogs I were done using a rational designing approach in a seven-step sequence and the characterization of compounds was performed using 1H-NMR, LC-MS, and 13C-NMR. Thirteen novel compounds I were synthesized in moderate to good yields. The anti-proliferation activity of the compounds I against human breast MCF-7 and MDA-MB-231, leukemic K-562 and lung A549 cancer cells were determined by a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Two compounds among all the synthesized compounds I had moderate IC50 values in MCF-7 cells and thus were identified to have better antiproliferative activity against estrogen-receptor-pos. cancer cells. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sampson, Jessica; Bruening, Meaghan; Akhtar, Muhammed Naseem; Jaseer, E. A.; Theravalappil, Rajesh; Garcia, Nestor; Agapie, Theodor published their research in Organometallics in 2021. The article was titled 《Copolymerization of Ethylene and Long-Chain Functional α-Olefins by Dinuclear Zirconium Catalysts》.HPLC of Formula: 821-41-0 The article contains the following contents:

Bimetallic catalysts have shown promise for improving polar comonomer incorporation by late transition metals, but such effects are underexplored using early transition metal catalysts. Herein, the copolymerization of ethylene and α-olefins bearing alc. groups was performed using mono- and dizirconium bisamine bisphenolate catalysts in the presence of MAO and AliBu3. Under these conditions, catalyst activity was retained with comonomer incorporation trends mirroring those observed with unfunctionalized α-olefins, i.e., lower incorporation by bimetallic catalysts. Although incorporation levels are low, these data provide mechanistic insight for polar comonomer incorporation. These results are consistent with our earlier proposal that larger comonomers sterically clash with the distal metal center of the bimetallic catalysts, leading to lower incorporation. Addnl., a bimetallic mechanism for polar comonomer coordination and incorporation is not supported by the current data.5-Hexen-1-ol(cas: 821-41-0HPLC of Formula: 821-41-0) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.HPLC of Formula: 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts