Month: November 2022

In 2022,Shriver, James A.; Kaller, Kaylie S.; Kinsey, Ally L.; Wang, Katelyn R.; Sterrenberg, Summer R.; Van Vors, Madison K.; Cheek, Joshua T.; Horner, John S. published an article in RSC Advances. The title of the article was 《A tunable synthesis of indigoids: targeting indirubin through temperatureã€?Application of 7748-36-9 The author mentioned the following in the article:

The spontaneous conversion of 3-indoxyl to indigo was a well-established process used to produce indigo dyes. It was recently shown that some indoles, when reacted with molybdenum hexacarbonyl and cumyl peroxide, proceed through an indoxyl intermediate to produce significant amounts of indirubin through a competing mechanism. Modulation of this system to lower temperatures allows for careful tuning, leading to selective production of indirubins in a general process. A systematic assay of indoles show that electron deficient indoles work well when substituted at the 5 and 7 positions. In contrast, 6-substituted electron rich indoles give the best results whereas halogeno indoles work well in all cases. This process shows broad functional group tolerance for generally reactive carbonyl-containing compounds such as aldehydes and carboxylic acids. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Wang, Yao; Hou, Mengying; Duan, Shanzhou; Zhao, Ziyin; Wu, Xuejie; Chen, Yongbing; Yin, Lichen published an article in Bioactive Materials. The title of the article was 《Macrophage-targeting gene silencing orchestrates myocardial microenvironment remodeling toward the anti-inflammatory treatment of ischemia-reperfusion (IR) injuryã€?Related Products of 13325-10-5 The author mentioned the following in the article:

Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after infarction and thrombolytic therapy, and it is closely related to the free radical explosion and overwhelming inflammatory responses. Herein, macrophage-targeting nanocomplexes (NCs) are developed to mediate efficient co-delivery of siRNA against MOF (siMOF) and microRNA-21 (miR21) into myocardial macrophages, cooperatively orchestrating the myocardial microenvironment against IR injury. Bioreducible, branched poly(β-amino ester) (BPAE-SS) is designed to co-condense siMOF and miR21 into NCs in a multivalency-reinforced approach, and they are surface-decorated with carboxylated mannan (Man-COOH) to shield the pos. surface charges and enhance the serum stability. The final MBSsm NCs are efficiently internalized by myocardial macrophages after systemic administration, wherein BPAE-SS is degraded into small segments by intracellular glutathione to promote the siMOF/miR21 release, finally provoking efficient gene silencing. Thus, cardiomyocyte protection and macrophage modulation are realized via the combined effects of ROS scavenging, inflammation inhibition, and autophagy attenuation, which ameliorates the myocardial microenvironment and restores the cardiac function via pos. cellular crosstalk. This study renders promising solutions to address the multiple systemic barriers against in vivo nucleic acid delivery, and it also offers new options for IR injury by manipulating multiple reciprocal bio-reactions.4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Li, Xinwei; Bian, Jiqing; Fu, Mingyang; Zhang, Yan; Liu, Hongmei; Gao, Baoxiang published an article in Analytical Methods. The title of the article was 《Photostable fluorescent probes based on multifunctional group substituted naphthalimide dyes for imaging of lipid droplets in live cellsã€?SDS of cas: 18621-18-6 The author mentioned the following in the article:

We designed and synthesized multifunctional group substituted naphthalimide (MFGNI) dyes by introducing glycine Et ester and azetidine on 1,8-naphthalimide. With different azetidine substituents, the emission of the MFGNI dyes was shifted from blue to green. These MFGNI dyes exhibited high photoluminescence quantum yields (61% to 85%) and large Stokes shifts (67 nm). The amides and hydroxyl groups improved the photostability of the MFGNI dyes. Due to the small mol. weight and lipophilic properties, these MFGNI dyes specifically stained lipid droplets in living cells. After reading the article, we found that the author used Azetidin-3-ol hydrochloride(cas: 18621-18-6SDS of cas: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.SDS of cas: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Wang, Zhigang; Lan, Yingjia; Liu, Peng; Li, Xiaohong; Zhao, Youliang published an article in Polymer Chemistry. The title of the article was 《Rational design of a multi-in-one heterofunctional agent for versatile topological transformation of multisite multisegmented polystyrenesã€?Electric Literature of C3H7BrO The author mentioned the following in the article:

Architecture-transformable polymers can expand the family of stimuli-responsive polymers and be utilized to reveal the topol. effect. Despite the tremendous progress, it remains a great challenge to achieve single polymer based on-demand topol. transformations with reduced, similar and enhanced molar masses. To address this challenge, an initiating, coupling and pH/thermo-labile agent is designed to synthesize linker-reactive multisite multisegmented polymers (LMMPs) via tandem ATRP and ATRC, followed by intermol. anthracene dimerization to generate single-chain folding polystyrenes. Meanwhile, bromine and hydroxyl groups are incorporated into each linker to generate graft copolymers comprising poly(tert-Bu acrylate) and poly(ε-caprolactone) side chains. The self-immolative tertiary amine ester linker allows thermo-triggered topol. transformation from multisegmented, intrachain folding and graft polymers to one-segment polymers. The robust one-shot strategy can afford a promising platform to construct heterofunctional multisegmented polymers with tailor-made structures and functions. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Electric Literature of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Electric Literature of C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 534-03-2In 2021 ,《Backbone vs. side-chain: two light-degradable polyurethanes based on 6-nitropiperonalã€?appeared in Polymer Chemistry. The author of the article were Jung, Dimitri; Rust, Tarik; Voellmecke, Katharina; Schoppa, Timo; Langer, Klaus; Kuckling, Dirk. The article conveys some information:

Stimuli-degradable polymers are regarded as interesting materials for various applications like patterning or drug delivery. In particular, light as a trigger received a lot of attention due to the possibility of adjusting wavelength, light intensity and irradiation time, which leads to a precise and controlled application. In this study, we report the synthesis of two novel light-degradable polyurethanes which are based on 6-nitropiperonal and differ in the implementation of the light-cleavable unit. Degradation of these backbone- or side-chain-cleavable polymers was analyzed by UV/Vis spectroscopy and SEC. While both polymers showed rapid decomposition in solution, differences in the degradation rates were observed dependent on the incorporation site of the light-cleavable unit. Furthermore, nanoparticles were fabricated and characterized by photon correlation spectroscopy as well as SEM proving the processability of the polymers for potential application as, e.g., a controlled release system.2-Aminopropane-1,3-diol(cas: 534-03-2Application of 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application of 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 18621-18-6In 2018 ,《Multiheterocyclic Motifs via Three-Component Reactions of Benzynes, Cyclic Amines, and Protic Nucleophilesã€?appeared in Organic Letters. The author of the article were Ross, Sean P.; Hoye, Thomas R.. The article conveys some information:

A broadly general, three-component reaction strategy for the construction of compounds containing multiple heterocycles is described. Thermal benzyne formation (by the hexadehydro-Diels-Alder (HDDA) reaction) in the presence of tertiary cyclic amines and a protic nucleophile (HNu) gives, via ring-opening of intermediate ammonium ion/Nu- ion pairs, heterocyclic products. Many reactions are efficient even when the stoichiometric loading of the three reactants approaches unity. Use of HOSO2CF3 as the HNu gives ammonium triflate intermediates, which can then be ring opened by an even wider variety of nucleophiles. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C6H13NOIn 2018 ,《Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3ã€?appeared in ACS Omega. The author of the article were Ansideri, Francesco; Macedo, Joana T.; Eitel, Michael; El-Gokha, Ahmed; Zinad, Dhafer S.; Scarpellini, Camilla; Kudolo, Mark; Schollmeyer, Dieter; Boeckler, Frank M.; Blaum, Baerbel S.; Laufer, Stefan A.; Koch, Pierre. The article conveys some information:

Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution pattern of the pyridinylimidazole scaffold proved to be effective in shifting the inhibitory activity from the original target p38α MAPK to the closely related JNK3. In particular, a significant improvement for JNK3 selectivity could be achieved by addressing the hydrophobic region I with a small Me group. Furthermore, addnl. structural modifications permitted to explore structure-activity relationships. The most potent inhibitor 4-(4-methyl-2-(methylthio)-1H-imidazol-5-yl)-N-(4-morpholinophenyl)pyridin-2-amine showed an IC50 value for the JNK3 in the low triple digit nanomolar range and its binding mode was confirmed by x-ray crystallog. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Synthetic Route of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Synthetic Route of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 89466-08-0In 2020 ,《Rhodium-Catalyzed ortho-Selective Carbene C-H Insertion of Unprotected Phenols Directed by a Transient Oxonium Ylide Intermediateã€?appeared in Organic Letters. The author of the article were Guo, Rui-Ting; Zhang, Ya-Lin; Tian, Jun-Jie; Zhu, Ke-Yu; Wang, Xiao-Chen. The article conveys some information:

Ortho-Selective carbene C-H insertion of unprotected phenols is achieved with di-Me diazomalonate under the catalysis of [Rh(COD)Cl]2. After the C-H insertion, subsequent cyclization and electrophilic addition of another carbene mol. affords tris-carboxylate-substituted 2-benzofuranones as the final reaction products. The enantioselective variant has been developed with the use of chiral diene ligands. Mechanistic experiments indicate that a transient oxonium ylide directing group might be responsible for the regiocontrol at the C-H activation step.2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2021 ,《Design and synthesis of novel terpyridine-based ligands with one and two terminal aurophilic moieties and their Rh(III) and Ru(II) complexes for the adsorption on metal surfacesã€?was published in Polyhedron. The article was written by Salimova, Irina O.; Berezina, Anna V.; Shikholina, Ilona A.; Zyk, Nikolai V.; Beloglazkina, Elena K.. The article contains the following contents:

Novel terpyridine ligands with one and two terminal aurophilic sulfur containing fragments, (S)-11-(4-([2,2′:6′,2”-terpyridin]-4′-yl)phenoxy)undecyl 5-(1,2-dithiolan-3-yl)pentanoate (7), (S)-((4-([2,2′:6′,2”-terpyridin]-4′-yl)-1,3-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11a), (S)-((4-([2,2′:6′,2”-terpyridin]-4′-yl)-1,2-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11b), (S)-((5-([2,2′:6′,2”-terpyridin]-4′-yl)-1,3-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11c) were synthesized and employed to synthesis of mononuclear ruthenium(II) and rhodium(III) complexes. Electrochem. studies of the obtained ligands and coordination compounds and their ability to chemisorb on gold electrodes surfaces have been carried out. Among the obtained metal complexes, compounds with the min. time of chemisorption with the formation of Au-S bonds were revealed, which are complexes of 3,4- and 3,5-substituted phenylterpyridines. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 6-Aminohexan-1-olIn 2019 ,《Sensitization of Hypoxic Tumor to Photodynamic Therapy via Oxygen Self-Supply of Fluorinated Photosensitizersã€?was published in Biomacromolecules. The article was written by Liu, Zhiyong; Xue, Yudong; Wu, Mengsi; Yang, Guoliang; Lan, Minbo; Zhang, Weian. The article contains the following contents:

Photodynamic therapy (PDT) utilizes photosensitizers to convert innoxious oxygen to cytotoxic reactive oxygen species under an appropriate light thus induce cancer cells necrosis. However, PDT performs in an oxygen-dependent method to destroy cells while hypoxia is a feature for most solid tumors. To effectively improve the PDT effect against solid tumors, an oxygen self-supplying and pH-sensitive therapeutic nanoparticle (PTFC) has been developed by the self-assembly of a tetrakis(pentafluorophenyl) chlorin (TFPC)-conjugated block copolymer (POEGMA-b-P(DEAEMA-co-GMA)). PTFC nanoparticles can transport oxygen to tumor site with their accumulation in tumor on account of the good oxygen solubility, therefore relieving the oxygen deficiency of solid tumor and enhancing the PDT efficacy. It’s worth noting that the oxygen loading was realized by fluorinated photosensitizer itself. In addition, the phototoxicity of PTFC nanoparticles is greatly improved in an acidic aqueous environment due to the DEAEMA unit protonation, which not only enhanced the cellular uptake of nanoparticles but also weakened the aggregation of photosensitizers. Taking the hypoxia and acidic microenvironment of solid tumors, PTFC nanoparticles could be efficiently taken up and disassembled to release oxygen upon accumulated at tumor sites, thus significantly improving the PDT efficacy against solid tumors.6-Aminohexan-1-ol(cas: 4048-33-3Reference of 6-Aminohexan-1-ol) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Reference of 6-Aminohexan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts