Month: November 2022

Wan, Xueting; Jiang, Jian; Tu, Yanyan; Xu, Siyuan; Li, Jing; Lu, Huanjun; Li, Zhikai; Xiong, Lianhu; Li, Xiaohong; Zhao, Youliang; Tu, Yingfeng published an article in 2021. The article was titled 《A cascade strategy towards the direct synthesis of green polyesters with versatile functional groupsã€? and you may find the article in Polymer Chemistry.HPLC of Formula: 1195-59-1 The information in the text is summarized as follows:

The synthesis of polyesters with the desired functional groups without addnl. protection and deprotection steps remains a worthwhile challenge to polymer chemists. Herein, we put forward a solution for the direct preparation of green copolyesters with versatile functionalities via the cascade polycondensation-coupling ring-opening polymerization (PROP) using a biobased cyclic diester ethylene brassylate as the monomer and functional diols/polyether diols as initiators. The combination of two polymerization processes into one system enables the facile synthesis of biodegradable polyesters with versatile functionalities, including alkane, alkene, alkyne, aromatic, halide, ether, and amide functional groups, and poly(ether ester) multiblock copolymers, together with high functional group contents (50% molar ratio to brassylate) and relatively high mol. weights (up to 6 x 104 Da). The cascade strategy provides a feasible method for the synthesis of high functional group content polyesters with tailor-made properties, highly effective for post-modifications that are suitable for a variety of applications. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Hyungi; Lee, Sungmin; Min, Jun Sik; Kim, Eunsu; Choi, Junwon; Ko, JeongGil; Kim, Eunha published an article in 2021. The article was titled 《Fluorescent sensor array for high-precision pH classification with machine learning-supported mobile devicesã€? and you may find the article in Dyes and Pigments.Application of 89466-08-0 The information in the text is summarized as follows:

There is growing research interest from many scientific, healthcare, and industrial applications toward the development of high-precision optical pH sensors that cover a broad pH range. Despite enthusiastic endeavors, however, it remains challenging to develop cost-effective, high-precision, and broadband working paper-strip-type optical pH measurement systems, particularly for on-site or in-the-field pH sensing applications. We develop a fluorescent array based on a KIz system for accurate pH level classification. Based on the indolizine fluorescent core skeleton, a library of 30 different pH-responsive fluorescent probes is rationally designed and efficiently synthesized. Spotting the compounds in a checkered pattern (5 x 6) allows for the development of a disposable compound array on wax-printed cellulose paper. Compounds sharing a single chem. core skeleton result in the interrogation of all the components of a system with a single excitation light, resulting in a simple system design for pH classification. Furthermore, we design a 3D-printed enclosure to capture the fluorescence pattern changes of the array by using an intelligent, smartphone-based, handheld pH detection system. Specifically, by exploiting a random forest-based machine learning algorithm on a smartphone, we can effectively analyze the fluorescence pattern changes. Our results suggest that our proposed system can classify pH levels in fine-grain (0.2 pH) units.2-Hydroxyphenylboronic acid(cas: 89466-08-0Application of 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al Mokhtar Lamsabhi; Mo, Otilia; Yanez, Manuel published an article in 2021. The article was titled 《Perturbating intramolecular hydrogen bonds through substituent effects or non-covalent interactionsã€? and you may find the article in Molecules.Computed Properties of C4H11NO The information in the text is summarized as follows:

An anal. of the effects induced by F, Cl, and Br-substituents at the α-position of both, the hydroxyl or the amino group for a series of amino-alcs., HOCH2(CH2)nCH2NH2 (n = 0-5) on the strength and characteristics of their OH···N or NH···O intramol. hydrogen bonds (IMHBs) was carried out through the use of high-level G4 ab initio calculations For the parent unsubstituted amino-alcs., it is found that the strength of the OH···N IMHB goes through a maximum for n = 2, as revealed by the use of appropriate isodesmic reactions, natural bond orbital (NBO) anal. and atoms in mols. (AIM), and non-covalent interaction (NCI) procedures. The corresponding IR (IR) spectra also reflect the same trends. When the α-position to the hydroxyl group is substituted by halogen atoms, the OH···N IMHB significantly reinforces following the trend H < F < Cl < Br. Conversely, when the substitution takes place at the α-position with respect to the amino group, the result is a weakening of the OH···N IMHB. A totally different scenario is found when the amino-alcs. HOCH2(CH2)nCH2NH2 (n = 0-3) interact with BeF2. Although the presence of the beryllium derivative dramatically increases the strength of the IMHBs, the possibility for the beryllium atom to interact simultaneously with the O and the N atoms of the amino-alc. leads to the global min. of the potential energy surface, with the result that the IMHBs are replaced by two beryllium bonds. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Haowen; Zhou, Cen; Zheng, Ying; Zhang, Xiao published an article in 2021. The article was titled 《Isotruxene-based porous polymers as efficient and recyclable photocatalysts for visible-light induced metal-free oxidative organic transformationsã€? and you may find the article in Green Chemistry.HPLC of Formula: 89466-08-0 The information in the text is summarized as follows:

Two new isotruxene-based porous polymers were prepared and demonstrated to be highly efficient, metal-free heterogeneous photocatalysts for oxidative transformations using air as the mild oxidant under visible-light irradiation Both catalysts show excellent recyclability. In addition, the reactions can be performed in water, further indicating the greenness of this method. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. HPLC of Formula: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jinquan; Zhang, Shuaizhong; Zou, Hongbin published an article in 2021. The article was titled 《Acid- and Base-Switched Palladium-Catalyzed γ-C(sp3)-H Alkylation and Alkenylation of Neopentylamineã€? and you may find the article in Organic Letters.Electric Literature of C3H6O2 The information in the text is summarized as follows:

Reported Pd-catalyzed γ-C(sp3)-H-selective alkylation and alkenylation with removable 7-azaindole as a directing group. Acid and base were found to be the decisive regulators for the selective alkylation and alkenylation, resp., on the same single substrate under otherwise the same reaction conditions. Various acrylates were compatible for the formation of C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds. The alkenylation protocol could be further extended to acrylates with natural product units and α,β-unsaturated ketones. The preliminary synthetic manipulation of the alkylation and alkenylation products demonstrates the potential of this strategy for structurally diverse aliphatic chain extension and functionalization. Mechanistic exptl. studies showed that the acidic and basic catalytic transformations shared the same six-membered dimer palladacycle.Oxetan-3-ol(cas: 7748-36-9Electric Literature of C3H6O2) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Electric Literature of C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zhaobin; Yang, Ze-Peng; Fu, Gregory C. published an article in 2021. The article was titled 《Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halidesã€? and you may find the article in Nature Chemistry.Formula: C4H12KNaO10 The information in the text is summarized as follows:

The development of efficient methods, particularly catalytic and enantioselective processes, for the construction of all-carbon quaternary stereocentres is an important (and difficult) challenge in organic synthesis due to the occurrence of this motif in a range of bioactive mols. One conceptually straightforward and potentially versatile approach is the catalytic enantioconvergent substitution reaction of a readily available racemic tertiary alkyl electrophile by an organometallic nucleophile; however, examples of such processes are rare. Here we demonstrate that a nickel-based chiral catalyst achieves enantioconvergent couplings of a variety of tertiary electrophiles (cyclic and acyclic α-halocarbonyl compounds) with alkenylmetal nucleophiles to form quaternary stereocentres with good yield and enantioselectivity under mild conditions in the presence of a range of functional groups. These couplings, which probably proceed via a radical pathway, provide access to an array of useful families of organic compounds, including intermediates in the total synthesis of two natural products, (-)-eburnamonine and madindoline A. The experimental part of the paper was very detailed, including the reaction process of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Formula: C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Formula: C4H12KNaO10 It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Xin; Li, Yanfei; Li, Dengyu; Zhou, Xiang; Qiao, Haishi; Yang, Lifen; Ji, Yicheng; Zhang, Xuejiao; Huang, Dechun; Chen, Wei published an article in 2021. The article was titled 《Black phosphorus assisted polyionic micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumorsã€? and you may find the article in Biomaterials Science.HPLC of Formula: 534-03-2 The information in the text is summarized as follows:

Nanomedicines have been widely used in the effective delivery of chemotherapeutic drugs due to their advantages such as increasing the half-life of drugs, selectively targeting tumor tissues, and thus reducing systemic toxicity. However, the low drug entrapment rate and the difficulty of real-controlled release at tumor sites hinder their further clin. translations. Here we have developed biodegradable polyionic micelles (PD-M) to facilitate black phosphorus (BP) encapsulation (PD-M@BP) for improved drug loading. With the introduction of BP, PTX-loaded PD-M@BP (PD-M@BP/PTX) with sizes of 124-162 nm exhibited superior encapsulation efficiency over 94% and excellent colloidal stability. Meanwhile, PD-M well protected BP from fast degradation to show the good photothermal performance under near-IR (NIR) irradiation, thus achieving the remotely controlled fast PTX release due to micelle core melting and dissociation, accompanied by the synergistic photothermal tumor therapy. The in vivo results demonstrated that the PD-M@BP/PTX nanosystem not only realized significant inhibition of multi-drug resistant (MDR) cervical tumors (HeLa/PTXR tumor) by remote NIR-regulation, but also reduced the potential damage of chemotherapeutic drugs to the whole body, rendering these hybrid nanosystems as great tools to treat MDR tumors synergistically. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)â€? RS(O)2â€? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ€?; the products are amides of the corresponding acids.HPLC of Formula: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Hansol; Khazi, Mohammed Iqbal; Kim, Jong-Man published an article in 2021. The article was titled 《Preparation and colorimetric response of an aldehyde-functionalized macrocyclic diacetylene-derived polydiacetyleneã€? and you may find the article in Dyes and Pigments.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

Stimulus-responsive colorimetric materials have found great utility in a variety of fields including anticounterfeiting, display and sensor technologies. Herein, the authors describe a colorimetric polydiacetylene (PDA) that is generated by polymerization of the aldehyde-functionalized macrocyclic diacetylene, MCDA-CHO. UV irradiation of self-assembled MCDA-CHO generates a blue-color PDA, which undergoes a sequential blue-purple-brown-orange color change upon heating. Interestingly, the PDA displays a remarkably high temperature reversible thermochromism between 30 (blue) and 180° (reddish-brown). In addition to displaying reversible thermochromism, polymerized MCDA-CHO can be employed for colorimetric differentiation between aromatic and aliphatic primary amines. Accordingly, a blue-to-reddish brown color change takes place when the PDA is exposed to primary aniline derivatives while no color change occurs in the presence of aliphatic primary amines. IR spectroscopic anal. confirms that this colorimetric selectivity is a consequence of the facile formation of imine groups through reactions of the aldehyde moieties in the PDA with anilines. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Sun, Kangkang; Shan, Hongbin; Ma, Rui; Wang, Peng; Neumann, Helfried; Lu, Guo-Ping; Beller, Matthias published an article in Chemical Science. The title of the article was 《Catalytic oxidative dehydrogenation of N-heterocycles with nitrogen/phosphorus co-doped porous carbon materialsã€?Reference of Oxetan-3-ol The author mentioned the following in the article:

A metal-free oxidative dehydrogenation of N-heterocycles e.g., quinoline utilizing a nitrogen/phosphorus co-doped porous carbon (NPCH) catalyst was reported. The optimal material is robust against traditional poisoning agents and shows high antioxidant resistance. It exhibits good catalytic performance for the synthesis of various quinolines I (R1 = H, 5-Br, 6-OMe, 8-OH, etc.; R1 = H, 2-Me, 2-Ph, 3-Me, 4-Me), indoles II (R3 = H, 4-CN, 5-Me, 5-Cl, etc.; R4 = 2-Me, 3-Me, 3-COOMe), isoquinolines III (R5 = H, Me, Ph), and quinoxalins IV (R6 = H, Me, Ph; R7 = H, NO2) ‘on-water’ under air atm. The active sites in the NPCH catalyst are proposed to be phosphorus and nitrogen centers within the porous carbon network. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhong, Shuting; Fang, Xianfu; Wang, Yiting; Zhang, Gong; Li, Yangfeng; Li, Yizhou published an article in Organic Letters. The title of the article was 《DNA-compatible diversification of indole π-activated alcohols via a direct dehydrative coupling strategyã€?Application of 7748-36-9 The author mentioned the following in the article:

Indole-based diversification is highly desired in the DNA-encoded chem. library construction. Herein, we present a general strategy for on-DNA synthesis of diverse C3-functionalized indole derivatives via indole π-activated alc. formation followed by direct dehydrative coupling. Highly efficient bond linkages of C-C, C-N, and C-S were achieved to fuse building blocks that are widely com. available. DNA-encoding compatibility of the method has been further demonstrated to pave an avenue for application in constructing indole-focused three-dimensional libraries. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts