Month: November 2022

In 2022,Chen, Kuang-Yao; Chen, Yi-Ju; Cheng, Chien-Ju; Jhan, Kai-Yuan; Wang, Lian-Chen published an article in Biomolecules. The title of the article was 《Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stressã€?Safety of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

Excretory-secretory products (ESPs) are the main research targets for investigating the hosts and helminths interaction. Parasitic worms can migrate to parasitic sites and avoid the host immune response by secreting this product. Angiostrongylus cantonensis is an important food-borne zoonotic parasite that causes severe neuropathol. damage and symptoms, including eosinophilic meningitis or meningoencephalitis in humans. Benzaldehydes are organic compounds composed of a benzene ring and formyl substituents. This compound has anti-inflammatory and antioxidation properties. Previous studies showed that 3-hydroxybenzaldehyde (3-HBA) and 4-hydroxybenzaldehyde (4-HBA) can reduce apoptosis in A. cantonensis ESP-treated astrocytes. These results on the protective effect underlying benzaldehyde have primarily focused on cell survival. The study was designed to investigate the mol. mechanisms of endoplasmic reticulum stress (ER stress) and oxidative stress in astrocytes in A. cantonensis ESP-treated astrocytes and to evaluate the therapeutic consequent of 3-HBA and 4-HBA. First, we initially established the RNA-seq dataset in each group, including normal, ESPs, ESPs + 3-HBA, and ESPs + 4-HBA. We also found that benzaldehyde (3-HBA and 4-HBA) can stimulate astrocytes to express ER stress-related mols. after ESP treatment. The level of oxidative stress could also be decreased in astrocytes by elevating antioxidant activity and reducing ROS generation. These results suggested that benzaldehyde may be a potential therapeutic compound for human angiostrongyliasis to support brain cell survival by inducing the expression levels of ER stress- and oxidative stress-related pathways. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhou, Yuan; Xiong, Tong; Zhou, Li-Yan; Li, Hong-Yan; Xiao, You-Cai; Chen, Fen-Er published an article in Organic Letters. The title of the article was 《Diastereo- and Enantioselective Synthesis of Borylated 3-Hydroxyoxindoles by Addition of gem-Diborylalkanes to Isatinsã€?Recommanded Product: 78782-17-9 The author mentioned the following in the article:

The catalytic asym. synthesis of borylated 3-hydroxyoxindoles by addition of gem-diborylalkanes to isatins is disclosed. Chiral 3-hydroxyoxindoles bearing two contiguous stereogenic centers were produced in up to >20:1 dr and 99% ee. The synthetic utility of the corresponding products is presented through several transformations of the boryl moiety. This report provides an efficient strategy to incorporate a boryl functional group toward the synthesis of 3-hydroxyoxindoles. In addition to this study using Bis[(pinacolato)boryl]methane, there are many other studies that have used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: 78782-17-9) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Recommanded Product: 78782-17-9 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Kim, Haeun; Jung, Yujin; Cho, Seung Hwan published an article in Organic Letters. The title of the article was 《Defluorinative C-C Bond-Forming Reaction of Trifluoromethyl Alkenes with gem-(Diborylalkyl)lithiumsã€?COA of Formula: C13H26B2O4 The author mentioned the following in the article:

Authors report the transition-metal-free defluorinative C-C bond-forming reaction of trifluoromethyl alkenes with gem-(diborylalkyl)lithiums. This synthetic strategy provides access to a variety of 4,4-difluoro homoallylic diboronate esters, which serve as versatile intermediates in the efficient preparation of valuable gem-difluoroalkene derivatives Further synthetic modifications are conducted to demonstrate the synthetic utility of the obtained 4,4-difluoro homoallylic diboronate esters. In addition to this study using Bis[(pinacolato)boryl]methane, there are many other studies that have used Bis[(pinacolato)boryl]methane(cas: 78782-17-9COA of Formula: C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.COA of Formula: C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Taheri, Maryam; Aslani, Samira; Ghafouri, Hossein; Mohammadi, Asadollah; Akbary Moghaddam, Vaha; Moradi, Nastarn; Naeimi, Hananeh published an article in BMC Chemistry. The title of the article was 《Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors on PC12 cellsã€?Formula: C7H6O2 The author mentioned the following in the article:

The loss of cholinergic neurotransmission in Alzheimer′s disease (AD) patientsâ€?brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic clefts. Thus, the use of acetylcholinesterase inhibitors (AChEIs) to block the cholinergic degradation of ACh is a promising approach for AD treatment. In the present study, a series of 2-chloro-3-hydrazinopyrazine derivatives (CHP1-5) were designed, synthesized, and biol. evaluated as potential multifunctional anti-AD agents. In addition, the chem. structures and purity of the synthesized compounds were elucidated through using IR, 1H and 13C NMR, and elemental analyses. Further, the intended compounds were assessed in vitro for their AChE inhibitory and neuroprotective effects. Furthermore, DPPH, FRAP and ABTS assays were utilized to determine their antioxidant activity. The statistical anal. was performed using one-way ANOVA. Based on the results, CHP4 and CHP5 exhibited strong AChE inhibitory effects with the IC50 values of 3.76 and 4.2 μM compared to the donepezil (0.53 μM), resp. The study examined the effect and mol. mechanism of CHP4 on the Ab1-42-induced cytotoxicity in differentiated PC12 cells. At concentrations of 0-100 μM, CHP4 was non-toxic in PC12. Addnl., Ab1-42 significantly stimulated tau hyperphosphorylation and induced differentiated PC12 cell death. Further, CHP4 resulted in diminishing the Ab1-42-induced toxicity in PC12 cell significantly. CHP4 at 30 μM concentration significantly increased the Ab1-42-induced HSP70 expression and decreased tau hyperphosphorylation. According to the results of our studies CHP4 can be considered as safe and efficient AChEI and employed as a potential multifunctional anti-AD agent. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Mansawat, Woraluk; Yukhet, Phanomsak; Bhanthumnavin, Worawan; Reiser, Oliver; Vilaivan, Tirayut published an article in Synlett. The title of the article was 《Kinetic Resolution of dl-Hydrobenzoins Catalyzed by Copper(II) Complexes of C2-Symmetric Thiophene-Derived Ligandsã€?SDS of cas: 126456-43-7 The author mentioned the following in the article:

C2-Sym. chiral amino alc. ligands with a central thiophene moiety were shown to be effective in combination with CuCl2 for the asym. acylation of dl-hydrobenzoins. In contrast to previously developed chiral ligands, readily available acetyl chloride and acetic anhydride can be used as reagents, in addition to benzoyl chloride, giving rise to the corresponding monoacylated products in up to 99% ee ( S= 532). The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)â€? RS(O)2â€? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ€?; the products are amides of the corresponding acids.SDS of cas: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Pecoraro, Camilla; Parrino, Barbara; Cascioferro, Stella; Puerta, Adrian; Avan, Amir; Peters, Godefridus J.; Diana, Patrizia; Giovannetti, Elisa; Carbone, Daniela published an article in Molecules. The title of the article was 《A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cellsã€?Reference of Oxetan-3-ol The author mentioned the following in the article:

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years, protein kinases have emerged as promising pharmacol. targets for the treatment of several solid and hematol. tumors. Interestingly, cyclin-dependent kinase 1 (CDK1) is overexpressed in PDAC tissues and has been correlated to the aggressive nature of these tumors because of its key role in cell cycle progression and resistance to the induction of apoptosis. For these reasons, CDK1 is one of the main causes of chemoresistance, representing a promising pharmacol. target. In this study, we report the synthesis of new 1,2,4-oxadiazole compounds and evaluate their ability to inhibit the cell growth of PATU-T, Hs766T, and HPAF-II cell lines and a primary PDAC cell culture (PDAC3). Compound 6b was the most active compound, with IC50 values ranging from 5.7 to 10.7 μM. Mol. docking of 6b into the active site of CDK1 showed the ability of the compound to interact effectively with the ATP binding pocket. Therefore, we assessed its ability to induce apoptosis (which increased 1.5- and 2-fold in PATU-T and PDAC3 cells, resp.) and to inhibit CDK1 expression, which was reduced to 45% in Hs766T. Lastly, compound 6b passed the ADME prediction, showing good pharmacokinetic parameters. These data demonstrate that 6b displays cytotoxic activity, induces apoptosis, and targets CDK1, supporting further studies for the development of similar compounds against PDAC. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 100-83-4In 2021 ,《Synthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism in the presence of a novel quinoline-based dendrimer-like ionic liquidã€?appeared in RSC Advances. The author of the article were Torabi, Morteza; Yarie, Meysam; Zolfigol, Mohammad Ali; Rouhani, Shamila; Azizi, Shohreh; Olomola, Temitope O.; Maaza, Malik; Msagati, Titus A. M.. The article conveys some information:

In the present study, the synthesis of a novel quinoline-based dendrimer-like ionic liquid I was reported. After characterization of the mentioned ionic liquid with suitable techniques such as Fourier transform IR spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), elemental mapping, thermogravimetric anal. (TGA) and derivative thermogravimetry (DTG), its catalytic performance was investigated in the synthesis of new pyridines with sulfonamide moiety II (R = Ph, 2-chlorophenyl, thiophen-2-yl, etc.) and III via a cooperative vinylogous anomeric-based oxidation mechanism under mild reaction conditions. All target mols. II ad III were achieved in short reaction times and high yields. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Recommanded Product: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of Oxetan-3-olIn 2020 ,《Reusable, homogeneous water soluble photoredox catalyzed oxidative dehydrogenation of N-heterocycles in a biphasic system: application to the synthesis of biologically active natural productsã€?appeared in Green Chemistry. The author of the article were Srinath, S.; Abinaya, R.; Prasanth, Arun; Mariappan, M.; Sridhar, R.; Baskar, B.. The article conveys some information:

A simple and efficient method for the oxidative dehydrogenation (ODH) of partially saturated N-heterocycles (indolines, tetrahydro-β-carbolines and tetrahydro(iso)quinolines) e.g., I is described using a reusable, homogeneous cobalt-phthalocyanine photoredox catalyst II (R = SO3Na; M = Co) in a biphasic medium. A biphasic system offers an advantage of easy separation of the product and an efficient reusability of the homogeneous photoredox catalyst. Also, the current system significantly helps to overcome the solubility issue of the substrate and catalyst at room temperature Its potential applications to organic transformations are demonstrated by the synthesis of various biol. active N-heterocycles (indoles, β-carbolines, (iso)quinolines) e.g., III and natural products such as eudistomin U, norharmane, and harmane and precursors to perlolyrine and flazin. Without isolation and purification, the catalyst solution can be reused up to 5 times with almost comparable reactivity. Furthermore, the efficiency of the reaction was demonstrated on a gram scale. To the best of our knowledge, this is the first report on ODH reactions using a non noble, reusable and homogeneous cobalt photoredox catalyst under environmentally friendly conditions. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Quality Control of Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Quality Control of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 3-HydroxybenzaldehydeIn 2019 ,《Fe3O4@nano-cellulose/Cu(II): a bio-based and magnetically recoverable nano-catalyst for the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivativesã€?appeared in RSC Advances. The author of the article were Safajoo, Nasrin; Mirjalili, Bi Bi Fatemah; Bamoniri, Abdolhamid. The article conveys some information:

Fe3O4@nano-cellulose/Cu(II) as a green bio-based magnetic catalyst was prepared through in situ co-precipitation of Fe2+ and Fe3+ ions in an aqueous suspension of nano-cellulose. The mentioned magnetically heterogeneous catalyst was characterized by FT-IR, XRD, VSM, FESEM, TEM, XRF, EDS and TGA. In this research, the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives I (R = 4-Cl, 2-NO2, 3,4-(OH)2, etc.) was developed via a three component reaction of aromatic aldehydes RC6H4CHO, 2-aminobenzothiazole and Et acetoacetate using Fe3O4@nano-cellulose/Cu(II) under solvent-free condition at 80 °C. Some advantages of this protocol are good yields, environmentally benign, easy work-up and moderate reusability of the catalyst. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolaneIn 2019 ,《About solid phase vs. Liquid phase in Suzuki-Miyaura reactionã€?appeared in Catalysts. The author of the article were Bourouina, Amine; Meille, Valerie; de Bellefon, Claude. The article conveys some information:

A review. A critical review of conclusions about the putative heterogeneous mechanism in the Suzuki-Miyaura coupling by supported Pd solids is reported. In the first section, the turnover frequencies (TOF) of 20 well-established homogeneous catalysts are shown to be in the range 200 to 1,000,000,000 h-1. The evidences used to prove a heterogeneous mechanism are discussed and another interpretation is proposed, hypothesizing that only the leached species are responsible for the catalytic reaction, even at ppb levels. Considering more than 40 published catalytic systems for which liquid phase Pd content have been reported, activities have been computed based on leached Pd concentrations and are shown to be in the range TOF 150 to 70,000,000 h-1. Such values are compatible with those found for the well-established homogeneous catalysts which questions the validity of the conclusions raised by many papers about the heterogeneous (solid) nature of Suzuki-Miyaura catalysis. Last, a tentative methodol. is proposed which involves the rational use of well-known tests (hot-filtration test, mercury test, …) to help to discriminate between homogeneous and heterogeneous mechanisms. In addition to this study using 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane, there are many other studies that have used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
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