Month: November 2022

Investigations of repellents for protection against mosquitoes in Alaska, 1953 was written by Altman, Robert M.;Smith, Carroll N.. And the article was included in Journal of Economic Entomology in 1955.Electric Literature of C9H20O2 The following contents are mentioned in the article:

Field tests conducted in Alaska against mosquitoes were made with 15 individual repellents and 12 repellent mixtures for application to the skin, and with 44 repellents and 6 mixtures for application to the clothing. The 5 most effective individual repellents for application to the skin were N,N-diethyl-m-toluamide; ο-ethoxy-N,N-diethylbenzamide; ο-chloro-N,N-diethylbenzamide; citral-malonic acid condensate; and Pr N,N-diethylsuccinamate. The 3 most effective mixtures each contained di-Me phthalate 40; 2-ethyl-1,3-hexanediol 30; and N,N-diethyl-m-toluamide or ο-ethoxy-N,N-diethylbenzamide or Pr N,N-diethylsuccinamate 30%. The 3 most effective individual repellents for application to clothing were undecenoic acid, 1-butyl-4-methylcarbostyril, and amyl mandelate. The best mixture contained undecenoic acid 30, N-butyl-4-cyclohexene-1,2-dicarboximide 30, N-butylacetanilide 30, and emulsifier (Tween 80) 10%. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Electric Literature of C9H20O2).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C9H20O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prediction and identification of new type holin protein of Escherichia coli phage ECP26 was written by Park, Do-Won;Lee, Jong Hun;Park, Jong-Hyun. And the article was included in Food Science and Biotechnology in 2022.Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

Bacteriophages (phages) infecting specifically target bacteria utilize a unique lysis module known as the holin-endolysin cassette to release progeny. Studies on the phage lytic proteins could contribute to the development of alternatives to antibiotics. Here, we predicted and identified the holin protein of rV5-like phage ECP26 for increasing lytic activity of the phage endolysin. In silico anal. revealed that open reading frame 151 (ORF151) of ECP26 contained two transmembrane domains. Co-expression of endolysin with ORF151 resulted in the cell lysis of Escherichia coli, suggesting that ORF151 protein functioned as the holin that disrupted the cytoplasmic membrane. The putative holin showed a high amino acid homol. by more than 80% to the predicted holins of rV5-like phages. Therefore, the holin protein would be helpful for developing efficient lysis strategies with endolysin against gram-neg. E. coli. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Structural Modification of Pyridoxal. Synthesis and Evaluation of Anti-Infective Activity of New 4-Chloro- and 4-Alkyl(dialkyl)aminomethyl-2-hetaryl(hetaroyl)furo[2,3-c]pyridines was written by Zubenko, A. A.;Divaeva, L. N.;Morkovnik, A. S.;Fetisov, L. N.;Sochnev, V. S.;Kononenko, K. N.;Bodryakov, A. N.;Klimenko, A. I.. And the article was included in Russian Journal of General Chemistry in 2020.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

4-Hydroxymethyl-2-hetaryl(hetaroyl)furo[2,3-c]pyridines I [R = OH; R¹ = PhCO, 4-BrC₆H₄CO, 2,3-dihydro-1,4-benzodioxine-6-carbonyl, 6-oxo-[1,3]dioxolo[4,5-g]chromen-8-yl], the products of furan cyclization of pyridoxal with Me halides, easily reacted with thionyl chloride in DMF to form new series of 4-chloromethyl-2-heteroaryl[2,3-c]pyridines I [R = Cl]. Further action of primary or secondary amines on these chloromethyl derivatives led to the nucleophilic substitution of chlorine atoms with the formation of 4-aminomethyl-2-heteroaryl[2,3-c]pyridines I [R = NHCH(Me)₂, NHCH₂CH₂OMe, 1-piperidyl, morpholino]. The study of anti-infective activity of the compounds I showed significant protistocidal and moderate antibacterial activity of some of representatives of these compounds This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Category: alcohols-buliding-blocks).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective sensing of nitric oxide by a 9,10-phenanthroquinone-pyridoxal based fluorophore was written by Maiti, Debjani;Islam, Abu Saleh Musha;Sasmal, Mihir;Prodhan, Chandraday;Ali, Mahammad. And the article was included in Photochemical & Photobiological Sciences in 2018.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

In this article, we have designed and synthesized a new, convenient and efficient phenanthroquinone-pyridoxal based fluorogenic probe PQPY, highly suitable for the selective and sensitive detection of nitric oxide in an aerated aqueous (7 : 3/H₂O : MeCN) medium at pH 7.0 (10 mM HEPES buffer). Upon addition of nitric oxide, this probe exhibits emission in the green region (λ_em = 505 nm) which is ascribed to ICT (intramol. charge transfer) from the phenanthroquinone moiety to the imidazole -N-N=O fragment. The apparent formation constant, Kf, of the NO product of the ligand is (1.00 ± 0.2) × 10⁵ M^-1 and the LOD is 78 nM. The substantial enhancement of the life-time of the ligand (τ₀ = 2.68 ns) occurs due to binding with nitric oxide (τ₀ = 3.96 ns). This probe is low cytotoxicity, cell permeable and suitable for living cell imaging application. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A novel diarylethene probe with high selective recognition of CN- and Mg²⁺and its application was written by Yuwen, Zhiyang;Mei, Hongxin;Li, Hui;Pu, Shouzhi. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2020.Related Products of 65-22-5 The following contents are mentioned in the article:

A chem. sensor composed of pyridoxal hydrochloride schiff base based on diarylethene (1O) was synthesized. Its photochem. properties and selectivity to ions were further studied. The chemosensor could detect cyanide effectively and is almost undisturbed by other ions. When titrating CN^–, the reaction aroused a distinct change in the absorption spectrum with the color change from transparent to yellow, and the fluorescence intensity centered at 562 nm was increased 68 folds. It also exhibited a good fluorescence sensing of Mg²⁺ with high selectivity and sensitivity. Upon addition of Mg²⁺, its emission intensity enhanced 110 folds, with the color change from dark to bright blue. Its good spectral response could be applied to mol. logic circuit. Moreover, the chemosensor could be made into test paper strips for the qual. and quant. detection of CN^– and Mg²⁺. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Microwave-assisted pyrolysis of seaweed biomass for aromatics-containing bio-oil production was written by Wang, Xinyun;Li, Chuan;Chen, Mingqiang;Wang, Jun. And the article was included in E3S Web of Conferences in 2021.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Microwave-assisted pyrolysis of seaweed biomass was conducted using a microwave pyrolysis system. The product yields were determined and the components of bio-oil were analyzed by a gas chromatog.-mass spectrometry (GC-MS). Results showed that as the pyrolysis temperature increased from 400°C to 600°C, the gas yield increased and the bio-char yield decreased. However, the bio-oil yield rose firstly and then reduced. The maximal bio-oil yield was 18.4 weight% when pyrolysis temperature was 500°C. The bio-oil obtained is a mixture of very complex organic compounds, mainly consisting of aldehydes, ketones, alcs., esters, phenols, aliphatic hydrocarbons, aromatic hydrocarbons and nitrogencontaining compounds The relative content of aromatics in bio-oil accounted for about 16%. The above results reveal that microwave-assisted pyrolysis of seaweed biomass is a feasible method to produce aromatics-containing bio-oil. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Category: alcohols-buliding-blocks).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Extreme dependence of Chloroflexus aggregans LOV domain thermo- and photostability on the bound flavin species was written by Smolentseva, Anastasia;Goncharov, Ivan M.;Yudenko, Anna;Bogorodskiy, Andrey;Semenov, Oleg;Nazarenko, Vera V.;Borshchevskiy, Valentin;Fonin, Alexander V.;Remeeva, Alina;Jaeger, Karl-Erich;Krauss, Ulrich;Gordeliy, Valentin;Gushchin, Ivan. And the article was included in Photochemical & Photobiological Sciences in 2021.Synthetic Route of C9H18O5S The following contents are mentioned in the article:

Light-oxygen-voltage (LOV) domains are common photosensory modules that found many applications in fluorescence microscopy and optogenetics. Here, we show that the Chloroflexus aggregans LOV domain can bind different flavin species (lumichrome, LC; riboflavin, RF; FMN, FMN; FAD, FAD) during heterologous expression and that its physicochem. properties depend strongly on the nature of the bound flavin. We show that whereas the dissociation constants for different chromophores are similar, the melting temperature of the protein reconstituted with single flavin species varies from ∼ 60°C for LC to ∼ 81°C for FMN, and photobleaching half-times vary almost 100-fold. These observations serve as a caution for future studies of LOV domains in non-native conditions yet raise the possibility of fine-tuning various properties of LOV-based fluorescent probes and optogenetic tools by manipulating the chromophore composition This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Synthetic Route of C9H18O5S).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C9H18O5S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Detection of vapors from overheated PVC cables with modified sea urchin-like ZnO for fire warning was written by Li, Zhou;Han, Jia;Chen, Wenjia;Yi, Jianxin. And the article was included in Sensors and Actuators, B: Chemical in 2022.Recommanded Product: 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

Detecting the emitted vapors from overheated polyvinyl chloride (PVC) cables has proven to be an effective way to monitor early elec. fires. In this work, the vapors generated from both conventional and phthalate-free PVC cables were first examined 2-ethylhexanol (2-EH) was found to be ubiquitously present and can serve as a universal signature gas for the overheated cables. Sea urchin-like ZnO was then prepared via a template-free hydrothermal route for sensing 2-EH. A facile immersion-calcination method was adopted to further modify ZnO, and different CuO/ZnO and Cr₂O₃/ZnO composites were obtained. The surface modification led to significant improvement in the response of the ZnO sensors to 2-EH. Cable fire simulation tests were also conducted to evaluate the response of optimized gas sensors to overheated conventional and phthalate-free cables in comparison with a typical smoke detector. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Recommanded Product: 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rapid and Versatile Cell Aggregate Formation Using Lipid-Conjugated Heparin was written by Kim, Eunsol;Kim, Jong Chul;Min, Kiyoon;Goh, MeeiChyn;Tae, Giyoong. And the article was included in ACS Applied Materials & Interfaces in 2018.Name: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:

Cell aggregates hold significant therapeutic promise for in vitro cell anal., ex vivo tissue models, and in vivo cell therapy and tissue engineering. Traditional methods of making cell aggregates require long incubation times and can only produce three-dimensional-spheroid-shaped aggregates. We propose a novel method of making cell aggregates of diverse sizes and shapes using lipid-conjugated heparin. Shaking the cell suspension containing a small amount of lipid-conjugated heparin for approx. 30 min produced cell aggregates. This approach can be applied to any cell type, including stem cells, fibroblast cells, and T lymphocytes. The shape of biocompatible templates could modulate the shape of cell aggregates. In addition to layered, multicompartmental cell aggregates on template, template-free, tube-shaped cell aggregates could also be made. The cell aggregates formed were alive and maintained biol. activities. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Name: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Method for Predicting Odor Intensity of Perfumery Raw Materials Using Dose-Response Curve Database was written by Wakayama, Hideki;Sakasai, Mitsuyoshi;Yoshikawa, Keiichi;Inoue, Michiaki. And the article was included in Industrial & Engineering Chemistry Research in 2019.Application In Synthesis of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

The main purpose of this study is to facilitate fragrance development on the basis of scientific knowledge. To this end, data on 314 perfumery raw materials (PRMs) showing the relationship between PRM odor intensity and gas concentration were obtained, and a calculation model for the data was then developed with the following features: (1) maximum PRM coverage, (2) calculating values implying odor intensity from only arbitrary gas concentration, and (3) estimating odor intensity from the calculated values directly and easily. To verify the prediction accuracy of this model, the predicted odor intensity was compared with the evaluated value for both single component and a mixture, and the same degree of root mean square error (RMSE) was confirmed. RMSE in the single component was 6.22 while that in the mixture was 6.69. Thus, the odor intensity of a PRM or mixture can be predicted from arbitrary gas concentrations This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Application In Synthesis of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts