Month: November 2022

In 2013,Biodegradation included an article by Ogata, Yuka; Toyama, Tadashi; Yu, Ning; Wang, Xuan; Sei, Kazunari; Ike, Michihiko. Application In Synthesis of 4-Butylbenzene-1,2-diol. The article was titled 《Occurrence of 4-tert-butylphenol (4-t-BP) biodegradation in an aquatic sample caused by the presence of Spirodela polyrrhiza and isolation of a 4-t-BP-utilizing bacteriumã€? The information in the text is summarized as follows:

Although 4-tert-butylphenol (4-t-BP) is a serious aquatic pollutant, its biodegradation in aquatic environments has not been well documented. In this study, 4-t-BP was obviously and repeatedly removed from water from four different environments in the presence of Spirodela polyrrhiza, giant duckweed, but 4-t-BP persisted in the environmental waters in the absence of S. polyrrhiza. Also, 4-t-BP was not removed from autoclaved pond water with sterilized S. polyrrhiza. These results suggest that the 4-t-BP removal from the environmental waters was caused by biodegradation stimulated by the presence of S. polyrrhiza rather than by uptake by the plant. Moreover, Sphingobium fuliginis OMI capable of utilizing 4-t-BP as a sole carbon and energy source was isolated from the S. polyrrhiza rhizosphere. Strain OMI degraded 4-t-BP via a meta-cleavage pathway, and also degraded a broad range of alkylphenols with linear or branched alkyl side chains containing two to nine carbon atoms. Root exudates of S. polyrrhiza stimulated 4-t-BP degradation and cell growth of strain OMI. Thus, the stimulating effects of S. polyrrhiza root exudates on 4-t-BP-degrading bacteria might have contributed to 4-t-BP removal in the environmental waters with S. polyrrhiza. These results demonstrate that the S. polyrrhiza-bacteria association may be applicable to the removal of highly persistent 4-t-BP from wastewaters or polluted aquatic environments. The experimental process involved the reaction of 4-Butylbenzene-1,2-diol(cas: 2525-05-5Application In Synthesis of 4-Butylbenzene-1,2-diol)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Application In Synthesis of 4-Butylbenzene-1,2-diol Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Bin; Yan, Jiekuan; Huang, Ruoyan; Wang, Weihong; Jin, Zhichao; Zanoni, Giuseppe; Zheng, Pengcheng; Yang, Song; Chi, Yonggui Robin published an article in Organic Letters. The title of the article was 《Kinetic Resolution of 1,2-Diols via NHC-Catalyzed Site-Selective Esterificationã€?Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol The author mentioned the following in the article:

1,2-Diols underwent regioselective acylation and kinetic resolution with benzaldehyde in the presence of a nonracemic triazolooxazinium salt and a diphenoquinone oxidant to yield nonracemic 1,2-diol-1-benzoates and 1,2-diols. In the part of experimental materials, we found many familiar compounds, such as (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol

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Alcohol – Wikipedia,
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Xia, Li-Jun; Tang, Min-Hua; Hu, Jian-Bing; Ding, Zuo-Ding; Jin, Hao; Zhao, Gang published an article on January 31 ,2002. The article was titled 《Enantiomeric resolution of secondary aromatic alcohols and arylethanediols by HPLC on chiral stationary phaseã€? and you may find the article in Youji Huaxue.SDS of cas: 133082-13-0 The information in the text is summarized as follows:

Separation of racemic mixtures of thirty-eight secondary aromatic alcs. and arylethanediols with different substituting group was achieved with HPLC by using Chiralcel OD and Chiralcel OJ as chiral stationary phase and hexane/2-propanol mixtures of different ratios as eluents. The chromatog. parameters of these racemates on OD and OJ columns were examined The results showed enantiomeric resolution ability of the racemic mixtures on these columns was strongly dependent on the site and the property of substituents. The hydrogen bonding and π-π interactions between the chiral stationary phase and the polar group of secondary aromatic alcs. and arylethanediols may be responsible for the chiral resolution This method had been applied to determination of the optical purity of the asym. reduction products of prochiral ketones. In the experiment, the researchers used many compounds, for example, (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0SDS of cas: 133082-13-0)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.SDS of cas: 133082-13-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2013,Li, Zhi-bin; Lu, Wen-shan; Zhang, Zhao published 《Electroplating behavior of Zn-Ni alloys in an alkaline electrolyteã€?Fushi Yu Fanghu published the findings.Computed Properties of C4H12KNaO10 The information in the text is summarized as follows:

The electroplating behavior of Zn-Ni alloys in an alk. electrolyte was investigated using cyclic voltammetry(CV), chronoamperometry(CHR), SEM(SEM) and energy dispersive spectrometer(EDS) techniques. The results showed that a layer of Ni-enriched deposits was preferentially formed on A3 steel substrate during the initial electroplating stage of Zn-Ni alloy. The Zn2+ ions in the solution inhibited the reduction of Ni2+ ions, while Ni2+ ions accelerated the reduction reaction of Ni2+ ions. The initial deposition process of Zn-Ni alloy follows the mechanism of 2D nucleation/growth under mass transfer control. In addition to this study using Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate, there are many other studies that have used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Computed Properties of C4H12KNaO10) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Computed Properties of C4H12KNaO10 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Edelstein, Emma K.; Grote, Andrea C.; Palkowitz, Maximilian D.; Morken, James P. published 《A Protocol for Direct Stereospecific Amination of Primary, Secondary, and Tertiary Alkylboronic Estersã€?Synlett published the findings.Electric Literature of C13H26B2O4 The information in the text is summarized as follows:

Primary, secondary, and (non-benzylic) tertiary alkylboronic acids underwent stereoselective (stereospecific) amination with O-methylhydroxylamine and potassium-tert-butoxide in toluene/THF to yield either Boc-protected primary or secondary amines or Boc-protected or free tertiary amines; nonracemic secondary and tertiary alkylamines were prepared in >98% enantiospecificities from the corresponding boronates.Bis[(pinacolato)boryl]methane(cas: 78782-17-9Electric Literature of C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Electric Literature of C13H26B2O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Meuser, Megan E.; Murphy, Michael B.; Rashad, Adel A.; Cocklin, Simon published 《Kinetic characterization of novel HIV-1 entry inhibitors: discovery of a relationship between off-rate and potencyã€?Molecules published the findings.Safety of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

The entry of HIV-1 into permissible cells remains an extremely attractive and underexploited therapeutic intervention point. We have previously demonstrated the ability to extend the chemotypes available for optimization in the entry inhibitor class using computational means. Here, we continue this effort, designing and testing three novel compounds with the ability to inhibit HIV-1 entry. We demonstrate that alteration of the core moiety of these entry inhibitors directly influences the potency of the compounds, despite common proximal and distal groups. Moreover, by establishing for the first time a surface plasmon resonance (SPR)-based interaction assay with soluble recombinant SOSIP Env trimers, we demonstrate that the off-rate (kd) parameter shows the strongest correlation with potency in an antiviral assay. Finally, we establish an underappreciated relationship between the potency of a ligand and its degree of electrostatic complementarity (EC) with its target, the Env complex. These findings not only broaden the chem. space in this inhibitor class, but also establish a rapid and simple assay to evaluate future HIV-1 entry inhibitors. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Safety of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Safety of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,ACS Catalysis included an article by Ahn, Seihwan; Sorsche, Dieter; Berritt, Simon; Gau, Michael R.; Mindiola, Daniel J.; Baik, Mu-Hyun. HPLC of Formula: 78782-17-9. The article was titled 《Rational Design of a Catalyst for the Selective Monoborylation of Methaneã€? The information in the text is summarized as follows:

Combined computational and exptl. studies elucidate the mechanism and suggest rational design and optimization strategies of a bis(phosphine) supported Ir catalyst for methane monoborylation. The activation of the C-H bond in methane via oxidative addition using an Ir(III)-polypyridyl complex carrying three pinacolboryl ligands is modeled computationally. This model shows that the use of the soft Lewis base ligand such as bis(dimethylphosphino)ethane (dmpe) lowers the activation barrier of the rate determining step as it facilitates polarization of the metal center, lowering the barrier of the oxidative addition to afford a seven-coordinate Ir(V) intermediate. The exptl. optimization of this reaction using high throughput methods show that up to 170 turnovers can be achieved at 150° (500 psi) within 16 h using bis(pinacolato)diboron, a well-defined homogeneous and monomeric catalyst (dmpe)Ir(COD)(Cl) that is readily available from com. precursors, with selectivity for the monoborylation product. High-boiling cyclic aliphatic solvents decalin and cyclooctane also prove suitable for this reaction, while being inert towards borylation. In accordance with the lower calculated activation barrier, catalytic turnover is also observed at 120° with up to 50 turnovers over 4 days in cyclohexane solvent. The borylation of methane is only formed via one catalytic cycle, and buildup of pinacolborane, a side product from methane borylation with bis(pinacolato)diboron, inhibits catalytic activity.Bis[(pinacolato)boryl]methane(cas: 78782-17-9HPLC of Formula: 78782-17-9) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.HPLC of Formula: 78782-17-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Organometallics included an article by Zhang, Chong; Zhao, Jiong-Peng; Hu, Bowen; Shi, Jing; Chen, Dafa. Recommanded Product: (4-Bromophenyl)methanol. The article was titled 《Ruthenium-Catalyzed β-Alkylation of Secondary Alcohols and α-Alkylation of Ketones via Borrowing Hydrogen: Dramatic Influence of the Pendant N-Heterocycleã€? The information in the text is summarized as follows:

Three bidentate ruthenium(II) complexes with a pyridonate fragment I (1-3; R = Ph, 2-thienyl, 2-thiazolyl) were prepared and fully characterized. These complexes are structurally similar, but differ in their pendant substituents. Complex 1 contains a Ph unit, whereas complexes 2 and 3 have uncoordinated thienyl and thiazolyl groups, resp. These complexes were tested as catalysts for β-alkylation of secondary alcs. ArCH(OH)Me (Ar = Ph, 4-ClC6H4, 4-MeOC6H4) with primary alcs. R1CH2OH (R1 = aryl, Cy, Bu), giving benzyl alcs. ArCH(OH)CH2CH2R1 and 3 shows the highest activity, suggesting the thiazolyl ring participates in the catalytic process. Furthermore, 3 is an excellent catalyst for α-alkylation of ketones with primary alcs. Various α-alkylated ketones were synthesized in high yields, by using 0.05 mol % 3 and 0.25 equiv of t-BuOK within 30 min. In the experiment, the researchers used (4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,ChemBioChem included an article by Fang, Xiaofeng; Ju, Bo; Liu, Zhihe; Wang, Fei; Xi, Guan; Sun, Zezhou; Chen, Haobin; Sui, Changxiang; Wang, Mingxue; Wu, Changfeng. Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane. The article was titled 《Compact Conjugated Polymer Dots with Covalently Incorporated Metalloporphyrins for Hypoxia Bioimagingã€? The information in the text is summarized as follows:

Hypoxia is closely related to multiple diseases, especially in tumors, which increases the aggressiveness and drug resistance of cancer cells. Precise hypoxia imaging is of great significance for cancer diagnosis and the evaluation of therapeutic effects. A kind of hydrophobic polymer (i.e., PFPtTFPP) as an imaging probe for hypoxia with fluorene as an energy donor and an oxygen-sensitive PtII porphyrin as an energy acceptor was developed. Compact polymer dots (Pdots) with a small size were prepared by nanopptn. The PFPtTFPP Pdots showed excellent hypoxia sensing in solution with high sensitivity and full reversibility. The emission intensity, quantum yields, lifetime, and single-particle brightness significantly increased under hypoxia conditions. Remarkably, hypoxia imaging in vitro and in vivo was realized, and a clear increase in brightness was observed under hypoxia conditions and in the tumor area. Excellent hypoxia imaging ability is beneficial to potential applications in cancer diagnosis. In the experiment, the researchers used many compounds, for example, 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,ChemCatChem included an article by Sheng, Jing-Li; Dong, Hong; Meng, Xiang-Bin; Tang, Hong-Liang; Yao, Yu-Hao; Liu, Dan-Qing; Bai, Lin-Lu; Zhang, Feng-Ming; Wei, Jin-Zhi; Sun, Xiao-Jun. Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde. The article was titled 《Effect of different functional groups on photocatalytic hydrogen evolution in covalent-organic frameworksã€? The information in the text is summarized as follows:

Covalent-organic frameworks (COFs) have been recognized as a new type of promising photocatalysts for hydrogen evolution. To investigate how different functional groups attached in the backbone of COFs affect the overall photocatalytic H2 evolution, for the first time, we selected and synthesized a series of ketoenamine-based COFs with the same host framework as model system. It includes TpPa-COF-X (X=-H, -(CH3)2, and -NO2) with three different groups attached in the backbone of TpPa-COF. We systematically investigated the differences in morphol., light-absorption intensity and band gap of these 2D COFs. The results of photocatalytic H2 evolution measurements indicate that the TpPa-COF-(CH3)2 shows the best activity, while the activity of TpPa-COF-NO2 is relatively low compared to that of other two COFs in the system. Moreover, the separation ability of photogenerated charge was also followed the order of TpPa-COF-(CH3)2>TpPa-COF>TpPa-COF-NO2. The best photocatalytic H2 production performance of TpPa-COF-(CH3)2 in these systems should be mainly attributed to the better electron-donating ability of -CH3 groups compared to -H or -NO2 group, which result in more efficient charge transferring in the inner of the material. This work demonstrates that reasonably adding electron-donating group in TpPa-COFs can lead to a better photocatalytic H2 evolution activity, and which is meaningful for further design of efficient COF-based photocatalysts for H2 evolution. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeFor acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts