Month: November 2022

《Highly efficient N-heterocyclic carbene/ruthenium catalytic systems for the acceptorless dehydrogenation of alcohols to carboxylic acids: effects of ancillary and additional ligands》 was written by Wang, Wan-Qiang; Cheng, Hua; Yuan, Ye; He, Yu-Qing; Wang, Hua-Jing; Wang, Zhi-Qin; Sang, Wei; Chen, Cheng; Verpoort, Francis. SDS of cas: 4048-33-3 And the article was included in Catalysts in 2020. The article conveys some information:

The transition-metal-catalyzed alc. dehydrogenation to carboxylic acids has been identified as an atom-economical and attractive process. Among various catalytic systems, Ru-based systems have been the most accessed and investigated ones. With our growing interest in the discovery of new Ru catalysts comprising N-heterocyclic carbene (NHC) ligands for the dehydrogenative reactions of alcs., we designed and prepared five NHC/Ru complexes ([Ru]-1-[Ru]-5) bearing different ancillary NHC ligands. Moreover, the effects of ancillary and addnl. ligands on the alc. dehydrogenation with KOH were thoroughly explored, followed by the screening of other parameters. Accordingly, a highly active catalytic system, which is composed of [Ru]-5 combined with an addnl. NHC precursor L5, was discovered, affording a variety of acid products in a highly efficient manner. Gratifyingly, an extremely low Ru loading (125 ppm) and the maximum TOF value until now (4800) were obtained. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.SDS of cas: 4048-33-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Sustainable and Selective Alkylation of Deactivated Secondary Alcohols to Ketones by Non-bifunctional Pincer N-heterocyclic Carbene Manganese》 was written by Lan, Xiao-Bing; Ye, Zongren; Liu, Jiahao; Huang, Ming; Shao, Youxiang; Cai, Xiang; Liu, Yan; Ke, Zhuofeng. Formula: C7H7BrO And the article was included in ChemSusChem in 2020. The article conveys some information:

A sustainable and green route to access diverse functionalized ketones RC(O)CH2CH2R1 (R = Ph, thiophen-2-yl, 4-bromophenyl, etc.; R1 = Ph, naphthalen-2-yl, pyridin-3-yl, etc.) via dehydrogenative-dehydrative cross-coupling of primary R1CH2OH and secondary alcs. RCH(OH)CH3 is demonstrated. This borrowing hydrogen approach employing a pincer N-heterocyclic carbene Mn complex I•Br- (R2 = Me, iPr, Ph) displays high activity and selectivity. A variety of primary and secondary alcs. is well tolerant and results in satisfactory isolated yields. Mechanistic studies suggest that this reaction proceeds via a direct outer-sphere mechanism and the dehydrogenation of the secondary alc. substrates plays a vital role in the rate-limiting step. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Formula: C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A novel sustainable metal organic framework as the ultimate aqueous phase sensor for natural hazards: detection of nitrobenzene and F- at the ppb level and rapid and selective adsorption of methylene blue》 was written by I., Mantasha; Shahid, M.; Saleh, Hatem A. M.; Qasem, Khalil M. A.; Ahmad, Musheer. Category: alcohols-buliding-blocks And the article was included in CrystEngComm in 2020. The article conveys some information:

Herein, a new cationic Cu(II)-based porous and water stable metal organic framework (MOF), [{Cu(bipy)1.5(H2pdm)}βoxO3βox]n (Cu-MOF-1) is designed using pyridine-2,6-dimethanol (H2pdm) and 4,4′-bipyridine (bipy) through slow evaporation process. The MOF is characterized by FTIR, PXRD, TGA, magnetic and single crystal XRD anal. The structural unit of Cu-MOF-1 consists of two Cu(II) ions bridged by bipy and supported by the H2pdm. This material exhibits excellent sensing ability for nitrobenzene (NB) and fluoride ion (F-) in 100% aqueous medium with ultra-low limit of detection (LOD) i.e., 0.093 and 1.203 ppb for NB and F-, resp. The detection of NACs is governed by PET and FRET mechanism while vapor pressure plays major role for NB detection showing highest fluorescent quenching of 96.4%. Moreover, the MOF revealed high water stability, significant recyclability and microporosity. The MOF was also employed for adsorption and separation of methylene blue from the mixture of three dyes (methylene blue, rhodamine-B and methyl orange). At equilibrium, the removal percentage of Cu-MOF-1 for MB is 98.23% and the mechanism of dye adsorption is also explored. Thus, the present MOF comes out as a sustainable multifunctional material for aqueous phase sensing of hazardous nitrobenzene and fluoride ions, as well as an excellent dye adsorbent. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Category: alcohols-buliding-blocks) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Nanosized Organo-Silica Particles with “”Built-In”” Surface-Initiated Atom Transfer Radical Polymerization Capability as a Platform for Brush Particle Synthesis》 was written by Han, Jin; Zhai, Yue; Wang, Zongyu; Bleuel, Markus; Liu, Tong; Yin, Rongguan; Wu, Wenjie; Hakem, Ilhem F.; Karim, Alamgir; Matyjaszewski, Krzysztof; Bockstaller, Michael R.. SDS of cas: 821-41-0 And the article was included in ACS Macro Letters in 2020. The article conveys some information:

A facile synthetic method was developed to prepare sub-5 nm organo-silica (oSiO2) nanoparticles through the self-condensation of atom transfer radical polymerization (ATRP)-initiator-containing silica precursors. The obtained oSiO2 nanoparticles were characterized by a combination of NMR, thermogravimetric anal. (TGA), transmission electron microscopy (TEM), dynamic light scattering (DLS), and small-angle neutron scattering (SANS). The accessibility of the surface-Br initiating sites was evaluated by the polymerization of poly(Me methacrylate) (PMMA) ligands from the surface of the oSiO2 nanoparticles using surface-initiated atom transfer radical polymerization (SI-ATRP). The ultrasmall size, tunable composition, and ease of surface modification may render these organo-silica nanoparticle systems with built-in SI-ATRP capability an interesting alternative to conventional silica nanoparticles for functional material design. The experimental part of the paper was very detailed, including the reaction process of 5-Hexen-1-ol(cas: 821-41-0SDS of cas: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.SDS of cas: 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Huaifeng; Lupp, Daniel; Das, Pradip K.; Yang, Li; Goncalves, Theo P.; Huang, Mei-Hui; El Hajoui, Marwa; Liang, Lan-Chang; Huang, Kuo-Wei published their research in ACS Catalysis in 2021. The article was titled 《Redox-Neutral Imination of Alcohol with Azide: A Sustainable Alternative to the Staudinger/Aza-Wittig Reaction》.Application of 873-75-6 The article contains the following contents:

Here, a redox-neutral azide-alc. imination methodol. enabled by a base-metal nickel PN3 pincer catalyst were reported. The one-step, waste-free and high atom-economical features highlight its advantages further. Moreover, mechanistic insight suggested a non-metal-ligand cooperation pathway based on the observation of an intermediate and d. functional theory calculations In addition to this study using (4-Bromophenyl)methanol, there are many other studies that have used (4-Bromophenyl)methanol(cas: 873-75-6Application of 873-75-6) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Application of 873-75-6 It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Kaili; Xu, Xudong; Xu, Mengqiu; Deng, Ping; Wu, Wenbo; Ye, Wei; Weng, Zihui; Su, Yue; Wang, Huijie; Xiao, Fei; Fang, Zeping; Gao, Peng published their research in ChemElectroChem in 2021. The article was titled 《One-Pot Synthesis of Tensile-Strained PdRuCu Icosahedra toward Electrochemical Hydrogenation of Alkene》.Related Products of 821-41-0 The article contains the following contents:

Electrochem. hydrogenation (ECH) uses electricity to drive proton (H+) reduction for hydrogenation, which can greatly reduce energy supply and environmental pollution, representing an ideal alternative to traditional thermal hydrogenation. In this work, we put forward tensile-strained PdRuCu alloy to promote ECH. Tensile strain promotes the adsorption of C=C by changing the d-band center. Meanwhile, alloying Ru and Cu into Pd lattice facilitates hydrogenation by weakening Pd-H bonding. Therefore, PdRuCu icosahedra display excellent ECH performance of 2-methyl-3-buten-2-ol (MBE) with specific activity of 227.4μmolMBE nm-2 min-1 at -0.3 V vs. reversible hydrogen electrode (RHE), about 16.1 and 10.5 times higher than that of com. Pd/C and Ru/C, resp. In addition, PdRuCu icosahedra was excellent in the scaling up of substrate concentration combined with anisyl alc. oxidation to produce high-value added anisaldehyde at anode. This work provides a guideline for the rational design of highly active and durable metallic catalyst in ECH. The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Related Products of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Related Products of 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yasuno, Yoko; Yamaguchi, Shunsuke; Karita, Yuma; Sakai, Kenta; Okamura, Hironori; Nakayama, Atsushi; Shinada, Tetsuro published their research in Heterocycles in 2021. The article was titled 《Stereoselective synthesis of (2S,3R)- and (2S,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid》.Recommanded Product: 6381-59-5 The article contains the following contents:

Herein, stereoselective synthesis of (2S,3R)- and (2S,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acids (ADHP) equivalent I and II for the synthesis of ADHP containing natural products was reported. The synthesis was characterized by the stereocontrolled construction of the (2S,3R)- and (2S,3S)-stereocenters starting from Garner’s aldehyde as a common starting material. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: 6381-59-5 It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Ye; Zhang, Pengfei; Liu, Shan; Pahovnik, David; Zagar, Ema; Zhao, Junpeng; Zhang, Guangzhao published their research in ACS Macro Letters in 2021. The article was titled 《Noncovalent Protection for Direct Synthesis of α-Amino-ω-hydroxyl Poly(ethylene oxide)》.Formula: C3H9NO2 The article contains the following contents:

The synthesis of poly(ethylene oxide) (PEO) with amino end group, a key functionality for PEGylation, is a long-standing challenge. Multistep routes based on postmodification or covalent protection have been adopted to circumvent ethoxylation of the amino group by ethylene oxide (EO). Here, we report a noncovalent protection strategy for one-step synthesis of PEO amine. An amino (di)alc. is mixed with a small amount of mild phosphazene base and excess triethylborane (Et3B) before addition of EO. The complexation of the amino group with Et3B guarantees that polymerization of EO occurs selectively from the hydroxyl group through the bicomponent metal-free catalysis. Simply by precipitation in di-Et ether, the protective Et3B as well as the catalyst can be removed to afford α-amino-ω-hydroxyl PEO with controlled molar mass, low dispersity, and complete end functionality. The effect of initiator structure and retention of Et3B on the storage (oxidative) stability of PEO amine is also revealed. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Formula: C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yoneyama, Tohru; Hatakeyama, Shingo; Sutoh-Yoneyama, Mihoko; Yoshiya, Taku; Uemura, Tsuyoshi; Ishizu, Takehiro; Suzuki, Minoru; Hachinohe, Shingo; Ishiyama, Shintaro; Nonaka, Motohiro; Fukuda, Michiko N.; Ohyama, Chikara published their research in BMC Cancer in 2021. The article was titled 《Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy》.Formula: C3H9NO The article contains the following contents:

P-Boronophenylalanine (10BPA) is a powerful 10B drug used in current clin. trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of 10BPA must be administered over a few hours. Here, we report BNCT efficacy after rapid, ultralow-dose administration of either tumor vasculature-specific annexin A1-targeting IFLLWQR (IF7)-conjugated 10BPA or borocaptate sodium (10BSH). (1) IF7 conjugates of either 10B drugs i.v. injected into MBT2 bladder tumor-bearing mice and biodistribution of 10B in tumors and normal organs analyzed by prompt gamma-ray anal. (2) Therapeutic effect of IF7-10B drug-mediated BNCT was assessed by either MBT2 bladder tumor bearing C3H/He mice and YTS-1 tumor bearing nude mice. I.v. injection of IF7C conjugates of either 10B drugs into MBT2 bladder tumor-bearing mice promoted rapid 10B accumulation in tumor and suppressed tumor growth. Moreover, multiple treatments at ultralow (10-20 mg/kg) doses of IF7-10B drug-mediated BNCT significantly suppressed tumor growth in a mouse model of human YTS-1 bladder cancer, with increased Anxa1 expression in tumors and infiltration by CD8-pos. lymphocytes. We conclude that IF7 serves as an efficient 10B delivery vehicle by targeting tumor tissues via the tumor vasculature and could serve as a relevant vehicle for BNCT drugs. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ai, Liankun; Ajibola, Ibrahim Yusuf; Li, Baolin published their research in RSC Advances in 2021. The article was titled 《Copper-mediated construction of benzothieno[3,2-b]benzofurans by intramolecular dehydrogenative C-O coupling reaction》.Application In Synthesis of 2-Hydroxyphenylboronic acid The article contains the following contents:

An efficient method to synthesize benzothieno[3,2-b]benzofurans such as I [R = H, 3-Cl, 3-t-Bu; R1 = H, 7,8-di-F, 8-Me, etc.] via intramol. dehydrogenative C-H/O-H coupling had been developed. Good to excellent yields (64-91%) could be obtained no matter if the substituted group was electron-donating or electron-withdrawing. Notably, three-to-six fused ring thienofuran compounds I could be constructed using this method. A reaction mechanism study showed that 1,1-diphenylethylene could be completely inhibited the reaction. Therefore, it was a radical pathway initiated by single electron transfer between the hydroxyl of the substrate and the copper catalyst. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application In Synthesis of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts