Month: November 2022

Product Details of 26153-38-8In 2018 ,《Substituents modification of meso-aryl BODIPYs for tuning photophysical properties》 appeared in Tetrahedron. The author of the article were Ko, Sangwon; Kim, Cheul Yong; Damodar, Kongara; Lim, Hyun Min; Kim, Jin Ho; Lee, Chang-Hee; Lee, Jeong Tae. The article conveys some information:

The authors successfully synthesized eight meso-aryl BODIPYs with 2,6-diethyl- or 1,2,6,7-tetra-Et substituents and characterized their photophys. properties. The steric hindrance resulting from the phenolic group in the meso-aryl moiety and the Et groups on the BODIPY core affected the synthesis of dipyrromethanes as an intermediate as well as the UV-visible absorption and fluorescence emission of the BODIPYs due to the constrained rotation of the aryl ring. The potential use of the meso-hydroxyphenyl BODIPY as a pH sensor was also shown by the pH-dependent fluorescence emissions. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Product Details of 26153-38-8

Referemce:
Alcohol – Wikipedia,
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SDS of cas: 627-18-9In 2021 ,《Ultrahigh-Throughput Detection of Enzymatic Alcohol Dehydrogenase Activity in Microfluidic Droplets with a Direct Fluorogenic Assay》 appeared in ChemBioChem. The author of the article were Klaus, Miriam; Zurek, Paul Jannis; Kaminski, Tomasz S.; Pushpanath, Ahir; Neufeld, Katharina; Hollfelder, Florian. The article conveys some information:

The exploration of large DNA libraries of metagenomic or synthetic origin is greatly facilitated by ultrahigh-throughput assays that use monodisperse water-in-oil emulsion droplets as sequestered reaction compartments. Millions of samples can be generated and analyzed in microfluidic devices at kHz speeds, requiring only micrograms of reagents. The scope of this powerful platform for the discovery of new sequence space is, however, hampered by the limited availability of assay substrates, restricting the functions and reaction types that can be investigated. Here, we broaden the scope of detectable biochem. transformations in droplet microfluidics by introducing the first fluorogenic assay for alc. dehydrogenases (ADHs) in this format. We have synthesized substrates that release a pyranine fluorophore (8-hydroxy-1,3,6-pyrenetrisulfonic acid, HPTS) when enzymic turnover occurs. Pyranine is well retained in droplets for >6 wk (i. e. 14-times longer than fluorescein), avoiding product leakage and ensuring excellent assay sensitivity. Product concentrations as low as 100 nM were successfully detected, corresponding to less than one turnover per enzyme mol. on average The potential of our substrate design was demonstrated by efficient recovery of a bona fide ADH with an >800-fold enrichment. The repertoire of droplet screening is enlarged by this sensitive and direct fluorogenic assay to identify dehydrogenases for biocatalytic applications. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.SDS of cas: 627-18-9

Referemce:
Alcohol – Wikipedia,
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Reference of 3-Aminopropan-1-olIn 2020 ,《Carbon utilization based on post-treatment of desalinated reject brine and effect of structural properties of amines for CaCO3 polymorphs control》 appeared in Desalination. The author of the article were Yoo, Yunsung; Kang, Dongwoo; Park, Sangwon; Park, Jinwon. The article conveys some information:

This study proposed simultaneous disposal and utilization process of desalinated reject brine and CO2, or brine-based carbon capture and utilization (CCU). Using metal cations in desalinated reject brine, the feasibility of amines with different structural properties as crystallization inhibitors, morphol. controller of calcium carbonate formation was investigated in this study. Ca2+ ions were separated from desalinated reject brine in a salt refining plant by using a pH swing method and used for CaCO3 formation. Through this process, disposal of the large amount of metal cations in the desalinated reject brine was achieved. CO2 was selectively captured by alkanolamine, alkylamine, and multi-amine CO2 carriers with numerous amino groups and carried into the separated Ca(OH)2 to generate CaCO3. X-ray diffraction (XRD), SEM (SEM), and Fourier-transform IR spectroscopy (FT-IR) were used to investigate crystal shape and polymorph of the product. Addnl., thermogravimetric/derivative thermogravimetric anal. (TG/DTG) was used for purity anal. The results demonstrated that crystallization inhibition depending on structural properties of amines was possible, leading to successful CaCO3 polymorph control. The results of this research can be applied to process where the industrial production of metal carbonates based on inorganic CCU and disposal of the desalinated reject brine were involved. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Reference of 3-Aminopropan-1-ol

Referemce:
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Quality Control of Oxetan-3-olIn 2022 ,《Trifluoromethyl Selenoxides: Electrophilic Reagents for C-H Trifluoromethylselenolation of (Hetero)Arene》 was published in Organic Letters. The article was written by Li, Yang; Wang, Yanan; Ye, Zhegao; Zhang, Shangbiao; Ye, Xiaodong; Yuan, Zheliang. The article contains the following contents:

Herein, designed and synthesized the new electrophilic trifluoromethylselenolation reagents, trifluoromethyl selenoxides I [X = H, CF3, CN], which were easy to prepare and easy-to-handle and were not moisture or air sensitive. The selenoxides are successfully applied to metal-free C-H trifluoromethylselenolation of a series of (hetero)arenes to gave ((trifluoromethyl)selanyl)aryl ArSeCF3 [Ar = 4-HOC6H4, 1H-indol-3-yl, (5-methoxycarbonyl-1H-pyrrol-3-yl), etc.]. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Quality Control of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Quality Control of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
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Related Products of 1195-59-1In 2021 ,《A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(I)》 was published in RSC Advances. The article was written by Liu, Yiqing; Kang, Ting; He, Qian; Hu, Yuefu; Zuo, Zeping; Cao, Zhihua; Ke, Bowen; Zhang, Weiyi; Qi, Qingrong. The article contains the following contents:

The disruption of copper homeostasis (Cu+/Cu2+) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu+ in physiol. and pathol. processes prompted the development of improved methods of Cu+ anal. Herein, a new near-IR (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu+ was developed based on a Cu+-mediated benzylic ether bond cleavage mechanism. The probe showed high selectivity and sensitivity toward Cu+, and was successfully applied for bioimaging of Cu+ in living cells. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 1195-59-1

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 627-18-9In 2022 ,《Design and Self-Assembly of Sugar-Based Amphiphiles: Spherical to Cylindrical Micelles》 was published in Langmuir. The article was written by Argudo, Pablo G.; Spitzer, Lea; Jerome, Francois; Cramail, Henri; Camacho, Luis; Lecommandoux, Sebastien. The article contains the following contents:

Sugar-based amphiphiles are a relevant natural alternative to synthetic ones due to their biodegradable properties. An understanding of their structure-assembly relationship is needed to allow the concrete synthesis of suitable derivatives Here, four different mannose-derivative surfactants are characterized by pendant drop, dynamic light scattering, small-angle X-ray scattering, cryotransmission electron microscopy, and mol. dynamics techniques in aqueous media. Measurements denote how the polysaccharide average d.p. () and the addition of a hydroxyl group to the hydrophobic tail, and thus the presence of a second hydrophilic moiety, affect their self-assembly. A variation in the of the amphiphile has no effect in the critical micelle concentration in contrast to a change in the hydrophobic mol. region. Moreover, high- amphiphiles self-assemble into spherical micelles irresp. of the hydroxyl group presence. Low- amphiphiles with only one hydrophilic moiety form cylindrical micelles, while the addition of a hydroxyl group to the tail leads to a spherical shape. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5-Hexen-1-olIn 2021 ,《Spreading Dynamics of a Precursor Film of Ionic Liquid or Water on a Micropatterned Polyelectrolyte Brush Surface》 was published in Langmuir. The article was written by Shiomoto, Shohei; Higuchi, Hayato; Yamaguchi, Kazuo; Takaba, Hiromitsu; Kobayashi, Motoyasu. The article contains the following contents:

Time evolution of the microscopic wetting velocity of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMI-TFSI) or water on a micrometer-scale line-patterned surface with a poly(3-sulfopropyl methacrylate) brush and a hydrophobic perfluoroalkyl monolayer was precisely measured by direct observation using optical microscopy and a selective dyeing method over a long period (178 days). When a liquid droplet was placed on the dyed line-patterned brush surface, the liquid penetrated and spread into the polymer brush layer, forming a precursor thin film that extended beyond the macroscopic contact line. The elongation proceeded in two stages by an adiabatic process followed by a diffusive process. The elongation distance X increased with time in proportion to t2.6 for water and t0.81 for EMI-TFSI during the adiabatic process. In a diffusive process, the advancing velocity of the precursor film was markedly reduced to be expressed as X t0.66 for water and Xn t0.21 for EMI-TFSI, indicating that the diffusive process was affected by the energy dissipation of the wetting system. The high viscosity and the strong mol. interaction of EMI-TFSI with the polymer brush gave a large entropy change during the wetting process to result in a slower spreading velocity. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0Reference of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Reference of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
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Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolaneIn 2019 ,《Tuning the Optical Properties of Sulfonylaniline Derivatives: Degeneracy Breaking of Benzene Orbitals and Linkage through Nodal Planes》 was published in ChemPhysChem. The article was written by Kudo, Shoh; Hoshino, Nanami; Beppu, Teruo; Katagiri, Hiroshi. The article contains the following contents:

The orbital degeneracy of benzene rings is resolved by an asym. push-pull system in 2,6-bis(methylsulfonyl)aniline (BMeSA), in which the HOMO is located at the 4-position, while the LUMO is located at a different position and has a nodal plane through the carbon atoms at the 1- and 4-positions. Therefore, the π-extension of BMeSA at the 4-position reveals a strong overlap in the HOMO and a minimal overlap in the LUMO. Consequently, π-extended BMeSA derivatives exhibit longer absorbance and emission wavelengths in the order of the electron-donating abilities of their substituents at the 4-position, which is based on a decrease in an absolute HOMO-level-dependent HOMO-LUMO gap in accordance with the nodal arrangement. Pos. fluorescent solvatochromism with polarity-dependent decrease in fluorescent intensity was also observed The biaryls exhibited more planar geometries in the excited state than in the ground state. The charge transfer mechanism, which can be described as node-induced intramol. charge transfer (NICT), differs from the planar intramol. charge transfer (PICT) and twisted intramol. charge transfer (TICT). The experimental part of the paper was very detailed, including the reaction process of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A Zirconium Indazole Carboxylate Coordination Polymer as an Efficient Catalyst for Dehydrogenation-Cyclization and Oxidative Coupling Reactions》 was written by Sang, Xinxin; Hu, Xinyu; Tao, Rong; Zhang, Yilin; Zhu, Haiyan; Wang, Dawei. Category: alcohols-buliding-blocksThis research focused onzirconium indazole carboxylate coordination polymer catalyst preparation; disubstituted benzimidazole preparation; phenylenediamine benzyl alc dehydrogenative cyclization zirconium catalyst; alkyl ester preparation; benzyl cyanide alkyl hydroperoxide oxidative coupling zirconium catalyst. The article conveys some information:

A novel porous zirconium coordination polymer (Zr-IDA) from 1-(carboxymethyl)-1H-indazole-5-carboxylic acid was developed and characterized. The Zr-IDA catalyst contains porous and highly crystalline particles with a quasi-spherical morphol. around 100 nm in size and Zr was coordinated with both O and N as shown by FT-IR and XPS measurements. The catalyst showed good catalytic activity in the synthesis of 1,2-disubstituted-benzimidazoles I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = H, Me] via dehydrogenative cyclization reaction of benzyl alcs. with phenylenediamines. Similarly, alkyl-esters R2C(O)OC(CH3)2R3 [R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R3 = Me, Et, Ph] were synthesized via oxidative coupling of benzyl cyanides with alkyl-hydroperoxides. Mechanistic investigations were carried out to study these reactions and the developed catalytic system in more detail.(4-Bromophenyl)methanol(cas: 873-75-6Category: alcohols-buliding-blocks) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Category: alcohols-buliding-blocks It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
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《Biophysical, Biochemical, and Molecular Docking Investigations of Anti-Glycating, Antioxidant, and Protein Structural Stability Potential of Garlic》 was published in Molecules in 2022. These research results belong to Khan, Mohd W. A.; Otaibi, Ahmed A.; Alsukaibi, Abdulmohsen K. D.; Alshammari, Eida M.; Al-Zahrani, Salma A.; Sherwani, Subuhi; Khan, Wahid A.; Saha, Ritika; Verma, Smita R.; Ahmed, Nessar. Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The article mentions the following:

Garlic has been reported to inhibit protein glycation, a process that underlies several disease processes, including chronic complications of diabetes mellitus. Biophys., biochem., and mol. docking investigations were conducted to assess anti-glycating, antioxidant, and protein structural protection activities of garlic. Results from spectral (UV and fluorescence) and CD (CD) anal. helped ascertain protein conformation and secondary structure protection against glycation to a significant extent. Further, garlic showed heat-induced protein denaturation inhibition activity (52.17%). It also inhibited glycation, advanced glycation end products (AGEs) formation as well as lent human serum albumin (HSA) protein structural stability, as revealed by reduction in browning intensity (65.23%), decrease in protein aggregation index (67.77%), and overall reduction in cross amyloid structure formation (33.26%) compared with pos. controls (100%). The significant antioxidant nature of garlic was revealed by FRAP assay (58.23%) and DPPH assay (66.18%). Using mol. docking anal., some of the important garlic metabolites were investigated for their interactions with the HSA mol. Mol. docking anal. showed quercetin, a phenolic compound present in garlic, appears to be the most promising inhibitor of glucose interaction with the HSA mol. Our findings show that garlic can prevent oxidative stress and glycation-induced biomol. damage and that it can potentially be used in the treatment of several health conditions, including diabetes and other inflammatory diseases. After reading the article, we found that the author used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Referemce:
Alcohol – Wikipedia,
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