Month: November 2022

In 2019,ACS Omega included an article by Xie, Jingwei; Ellebracht, Nathan C.; Jones, Christopher W.. Recommanded Product: 3-Aminopropan-1-ol. The article was titled 《Inter- and Intramolecular Cooperativity Effects in Alkanolamine-Based Acid-Base Heterogeneous Organocatalysts》. The information in the text is summarized as follows:

Intramol. cooperativity in heterogeneous organocatalysts is investigated using alkanolamine-functionalized silica acid-base catalysts for the aldol condensation reaction of 4-nitrobenzaldehyde and acetone. Two series of catalysts, one with and one without silanol-capping, are synthesized with varied alkyl linker lengths (two to five) connecting secondary amine and terminal hydroxyl functionalities. The reactivity of these catalysts is assessed to determine the relative potential for intermol. (silane amine-surface silanol) vs. intramol. (amine-hydroxyl within a single silane) cooperativity, the impact of inhibitory surface-silane interactions, and the role of alkyl linker length and flexibility. For the array of catalysts tested, those with longer linker lengths generally give increased catalytic activity, although the turnover frequency (TOF) trends differ between catalysts with and without surface silanol capping. Catalysts with alkyl substituted amines lacking a terminal hydroxyl demonstrate an adverse effect of chain length, where the larger alkyl substituent on the amine provides steric hindrance depressing catalytic activity, while giving addnl. evidence for improved rates afforded by intramol. cooperativity in the alkanolamine materials. The silanol-capped alkanolamine catalyst with the longest alkyl linker is found to be the most active alkanolamine catalyst due to its hydrophobized surface, which removes hypothesized silanol-alkanolamine inhibitory interactions, with the sufficient length and flexibility of its amine-hydroxyl linker allowing for favorable conformations for cooperativity. This study demonstrates the feasibility of and important factors affecting intramol. cooperative activity in acid-base heterogeneous organocatalysis. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Highly Efficient Metal-Free Nitrogen-Doped Nanocarbons with Unexpected Active Sites for Aerobic Catalytic Reactions》 were Lin, Yangming; Liu, Zigeng; Niu, Yiming; Zhang, Bingsen; Lu, Qing; Wu, Shuchang; Centi, Gabriele; Perathoner, Siglinda; Heumann, Saskia; Yu, Linhui; Su, Dang Sheng. And the article was published in ACS Nano in 2019. Related Products of 100-55-0 The author mentioned the following in the article:

Nitrogen (N)-doped nanocarbons (NDN) as metal-free catalysts have elicited considerable attention toward selective oxidation of alcs. with easily oxidizable groups to aldehydes in the past few years. However, finding a new NDN catalytic material that can meet the requirement of the feasibility on the aerobic catalytics for other complicated alcs. is a big challenge. The real active sites and the corresponding mechanisms on NDN are still unambiguous because of inevitable coexistence of diverse edge sites and N species based on recently reported doping methods. Here, four NDN catalysts with enriched pyridinic N species and without any graphitic N species are simply fabricated via a chem.-vapor-deposition-like method. The results of XPS and X-ray absorption near-edge structure spectra suggest that the dominating N species on NDN are pyridinic N. It is demonstrated that NDN catalysts perform impressive reactivity for aerobic oxidation of complicated alcs. at an atm. pressure. Eleven kinds of aromatic mols. with single N species and tunable π conjugation systems are used as model catalysts to exptl. identify the actual role of each N species at a real mol. level. It is suggested that pyridinic N species play an unexpected role in catalytic reactions. Neighboring carbon atoms in pyridinic N species are responsible for facilitating the rate-determining step process clarified by kinetic isotope effects, in situ NMR, in situ attenuated total reflectance IR, and theor. calculation Moreover, NDN catalysts exhibit a good catalytic feasibility on the synthesis of important natural products (e.g., intermediates of vitamin E and K3) from phenol oxidation After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Related Products of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Related Products of 100-55-0

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Degradation kinetics of target compounds and correlations with spectral indices during UV/H2O2 post-treatment of biologically treated acrylonitrile wastewater》 was published in Chemosphere in 2020. These research results belong to Tu, Xiang; Meng, Xiaoyang; Pan, Yang; Crittenden, John C.; Wang, Yaye. Reference of Oxetan-3-ol The article mentions the following:

In this study, the post-treatment of biol. treated acrylonitrile wastewater was investigated during UV/H2O2 process. Five contaminants in the effluent were selected as target compounds, including Furmaronitrile (FMN), 3-Pyridinecarbonitrile (3PCN), 1,3-Dicyanobenzene (1,3-DCB), 5-Methyl-1H-benzotriazole (5MBT), and 7-Azaindole (7AID). The UV/H2O2 post-treatment exhibited good performances in destruction of organic compounds and toxicity. The photo-chem. parameters of the target compounds were measured and it was found that 5MBT and 3PCN had fast degradation rate constants under direct UV photolysis. The second-order rate constants of the target compounds with hydroxyl radicals were determined to be in the range of (1.0-5.0) × 109 M-1 s-1 at pH 3.0 and 25°C. A simplified pseudo-first-order steady state (Sim-PSS) model, which considered direct UV photolysis and radical oxidation simultaneously, agreed well with the exptl. data. High-performance size exclusion chromatog. (HPSEC) coupled with diode-array detector (DAD) and fluorescence detector (FLD) anal. revealed that humic-like sub-peak signals from different mol. weights of fluorescent organic matter decreased consistently during the oxidation process, which made humic-like fluorescence exhibit higher correlation with the target compounds’ degradation than the spectral indexes of UV absorbance at 254 nm (UVA254) and protein-like fluorescence. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Selective Activation of Benzyl Alcohol Coupled with Photoelectrochemical Water Oxidation via a Radical Relay Strategy》 was published in ACS Catalysis in 2020. These research results belong to Luo, Lan; Wang, Zhou-jun; Xiang, Xu; Yan, Dongpeng; Ye, Jinhua. Category: alcohols-buliding-blocks The article mentions the following:

Selective oxidation to produce target chems. usually need activation of O2 at high temperature and/or pressure, which have largely restricted its practical operation and application. Here, we put forward a radical-relay strategy coupling photoelectrochem. (PEC) water oxidation towards efficiently selective conversion of benzyl alc. (BA) to benzaldehyde (BAD). An illuminated BiVO4 (BVO) photoanode covered with an ultrathin (∼3 nm) hydrothermally synthesized layered double hydroxide (U-LDH) catalyst and graphene (G) exhibited >99% selectivity to BAD (1.2 V vs. RHE). Mechanistic studies and DFT calculation verified that the hydroxyl radicals (•OH) generated from the oxidation of water are bound to the surface of U-LDH through hydrogen-bonding interactions and the energy is lowered. Fourier transform IR spectroscopy showed that BA is adsorbed to the U-LDH catalyst, but BAD is not. Thus, the selectivity is not only favored by the controlled oxidation capacity of •OH radicals, but the desorption of the desired product from the catalyst before further oxidation occurs. This work introduces an alternative PEC way to achieve mild and selective oxidation of BA derivatives based on ternary G@U-LDH@BVO catalysts. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Category: alcohols-buliding-blocks)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Category: alcohols-buliding-blocks It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rigo, Davide; Santos, Nadia Alessandra Carmo Dos; Perosa, Alvise; Selva, Maurizio published an article in 2021. The article was titled 《Concatenated batch and continuous flow procedures for the upgrading of glycerol-derived aminodiols via N-acetylation and acetalization reactions》, and you may find the article in Catalysts.Related Products of 534-03-2 The information in the text is summarized as follows:

An unprecedented two-step sequence was designed by combining batch and continuous flow (CF) protocols for the upgrading of two aminodiol regioisomers derived from glycerol, i.e., 3-amino-1,2-propanediol and 2-amino-1,3-propanediol (serinol). Under batch conditions, at 80-90°C, both substrates were quant. converted into the corresponding amides through a catalyst-free N-acetylation reaction mediated by an innocuous enol ester as isopropenyl acetate (iPAc). Thereafter, at 30-100°C and 1-10 atm, the amide derivatives underwent a selective CF-acetalisation in the presence of acetone and a solid acid catalyst, to afford the double-functionalized (amide-acetal) products. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Related Products of 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Villa, Marco; Angeloni, Sara; Bianco, Alberto; Gradone, Alessandro; Morandi, Vittorio; Ceroni, Paola published an article in 2021. The article was titled 《Luminescent silicon nanocrystals appended with photoswitchable azobenzene units》, and you may find the article in Nanoscale.Formula: C3H7BrO The information in the text is summarized as follows:

Confinement of multiple azobenzene chromophores covalently linked at the surface of luminescent silicon nanocrystals preserves the photoswitching behavior and modulates the nanocrystal polarity. Concomitantly, the thermal Z → E isomerization is strongly accelerated and the nanocrystal luminescence is reduced by an energy transfer process resulting in photosensitized E → Z isomerization. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Formula: C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Formula: C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Podjed, Nina; Modec, Barbara published an article in Molecules. The title of the article was 《Hydrogen Bonding and Polymorphism of Amino Alcohol Salts with Quinaldinate: Structural Study》.Synthetic Route of C3H9NO The author mentioned the following in the article:

Three amino alcs., 3-amino-1-propanol, 2-amino-1-butanol and 2-amino-2-methyl-1-propanol were reacted with quinoline-2-carboxylic acid, known as quinaldinic acid. This combination yielded three salts, I [R = 3-hydroxypropylammonium, 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium]. The 2-amino-1-butanol and 2-amino-2-methyl-1-propanol systems produced two polymorphs each, labeled as salts I [R = 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium] resp. The compounds were characterized by X-ray structure anal. on single-crystal. The crystal structures of all consisted of protonated amino alcs. with NH3+ moiety and quinaldinate anions with carboxylate moiety. The used amino alcs. contained one OH and one NH2 functional group, both proned to participate in hydrogen bonding. Therefore, similar connectivity patterns were expected. This proved to be true to some extent as all structures contained the NH3+•••-OOC heterosynthon. Nevertheless, different hydrogen bonding and π•••π stacking interactions were observed, leading to distinct connectivity motifs. The largest difference in hydrogen bonding occurred between polymorphs , I [R = 2-hydroxy-1,1-dimethyl-Et ammonium] as they had only one heterosynton in common. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Synthetic Route of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C3H7BrOIn 2020 ,《Screening Viologen Derivatives for Neutral Aqueous Organic Redox Flow Batteries》 was published in ChemSusChem. The article was written by Liu, Yahua; Li, Yuanyuan; Zuo, Peipei; Chen, Qianru; Tang, Gonggen; Sun, Pan; Yang, Zhengjin; Xu, Tongwen. The article contains the following contents:

Viologen derivatives have been developed as neg. electrolyte for neutral aqueous organic redox flow batteries (AOFBs), but the structure-performance relationship remains unclear. Here, it was investigated how the structure of viologens impacts their electrochem. behavior and thereby the battery performance, by taking hydroxylated viologens as examples. Calculations of frontier MO energy and mol. configuration promise to be an effective tool in predicting potential, kinetics, and stability, and may be broadly applicable. Specifically, a modified viologen derivative, BHOP-Vi, was proved to be the most favorable structure, enabling a concentrated 2 M battery to exhibit a power d. of 110.87 mW cm-2 and an excellent capacity retention rate of 99.953% h-1. In the experiment, the researchers used many compounds, for example, 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Computed Properties of C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C6H7NOIn 2019 ,《Alcohol Amination Catalyzed by Copper Powder as a Self-Supported Catalyst》 was published in ChemSusChem. The article was written by Wu, Yajuan; Huang, Yongji; Dai, Xingchao; Shi, Feng. The article contains the following contents:

N-Alkyl/aryl amines RNHCH2R1 [R = C6H5, t-BuC6H4, 4-ClC6H4, etc.; R1 = n-Bu, C6H5, 2-pyridyl] were synthesized via copper nanoparticles-catalyzed amination of alcs. with anilines. Homogeneous and supported copper catalysts were studied for this reaction and given some impressive results. In this study, copper powder was found to behave as an active catalyst for alc. amination, gave better catalytic performance than metal-oxide-supported nanocopper catalysts. Catalyst characterization suggested that the copper powder could be considered as a self-supported nanocopper catalyst (i.e., nanocopper supported on copper particles). These results promoted the study of unsupported transition metal powders in sustainable catalytic reactions.3-Pyridinemethanol(cas: 100-55-0COA of Formula: C6H7NO) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: Oxetan-3-olIn 2022 ,《Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions》 was published in Molecules. The article was written by Huang, Qing; Peng, Xiangjun; Li, Hong; He, Haiping; Liu, Liangxian. The article contains the following contents:

An efficient and general method for the synthesis of 3-sulfenylindoles and 3-selenylindoles employing visible-light irradiation with graphene oxide as a promoter at room temperature has been achieved. The reaction features are high yields, simple operation, metal-free and iodine-free conditions, an easy-to-handle oxidant, and gram-scalable synthesis. This simple protocol allows one to access a wide range of 3-arylthioindoles, 3-arylselenylindoles, and even 3-thiocyanatoindoles with good to excellent yields. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts