Month: November 2022

Electric Literature of C4H12KNaO10In 2015 ,《Rochelle salt – a structural reinvestigation with improved tools. I. The high-temperature paraelectric phase at 308 K》 was published in IUCrJ. The article was written by Mo, Frode; Mathiesen, Ragnvald H.; Beukes, Jon Are; Vu, Khanh Minh. The article contains the following contents:

The crystal structure of the high-temperature paraelec. phase of Rochelle salt (K+·Na+·C4H4O6 2-·4H2O) at 308 K has been reinvestigated using synchrotron X-ray diffraction with refinement parameters R(int) = 0.0123, final (shift/e.s.d.)max = 0.019, R 1(all) = 0.0371 and wR 2(all) = 0.0608. The application of a new gas-flow sample cell designed to control both temperature and relative humidity permitted collection of data of excellent quality and enabled unrestrained refinement of all parameters, including those of the isotropic hydrogen atoms. A precise description of the structure has ensued. One K atom is disordered between two symmetry-equivalent sites; three O atoms in three of the four water mols. exhibit very strong anisotropy. Refining one O atom as a split atom was successful, yielding small improvements in the bonding parameters of several H atoms. The H atoms of all water mols. behave as single pairs. Their final U values are of moderate magnitude indicating that these atoms do not participate in the anisotropy of the parent O atoms. It is suggested that the three water O atoms are in part statically disordered, while the bonded H atoms are not. Except for the split K atom and the three water O atoms there is no evidence of general disorder in the structure.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Electric Literature of C4H12KNaO10) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Electric Literature of C4H12KNaO10 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

Referemce:
Alcohol – Wikipedia,
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Product Details of 6346-09-4On November 14, 2019 ,《Direct Dearomatization of Pyridines via an Energy-Transfer-Catalyzed Intramolecular [4+2] Cycloaddition》 appeared in Chem. The author of the article were Ma, Jiajia; Strieth-Kalthoff, Felix; Dalton, Toryn; Freitag, Matthias; Schwarz, J. Luca; Bergander, Klaus; Daniliuc, Constantin; Glorius, Frank. The article conveys some information:

A catalytic, dearomative cycloaddition reaction with pyridines, e.g., I using photoinduced energy transfer catalysis has been reported, thereby advancing dearomatization methodol. and increasing the topol. of pyridine dearomatization products, e.g., II. This unprecedented method features high yields, broad substrate scope, excellent functional group tolerance, and facile scalability. Furthermore, a recyclable and sustainable polymer immobilized photocatalyst was employed. Computational and exptl. investigations support a mechanism in which a cinnamyl moiety is promoted to its corresponding excited triplet state through visible-light-mediated energy transfer catalysis, followed by a regioselective and dearomative [4+2] cycloaddition to pyridines. This work demonstrates the contribution of visible light catalysis toward enabling thermally challenging organic transformations. In the part of experimental materials, we found many familiar compounds, such as 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Product Details of 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Product Details of 6346-09-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2021,mBio included an article by Guo, Shuaiqi; Vance, Tyler D. R.; Zahiri, Hossein; Eves, Robert; Stevens, Corey; Hehemann, Jan-Hendrik; Vidal-Melgosa, Silvia; Davies, Peter L.. Quality Control of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol. The article was titled 《Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multispecies biofilm formation》. The information in the text is summarized as follows:

Carbohydrate recognition by lectins governs critical host-microbe interactions. MpPA14 (Marinomonas primoryensis PA14 domain) lectin is a domain of a 1.5-MDa adhesin responsible for a symbiotic bacterium-diatom interaction in Antarctica. Here, we show that MpPA14 binds various monosaccharides, with l-fucose and N-acetylglucosamine being the strongest ligands (dissociation constant [Kd], ~150μM). High-resolution structures of MpPA14 with 15 different sugars bound elucidated the mol. basis for the lectin’s apparent binding promiscuity but underlying selectivity. MpPA14 mediates strong Ca2+-dependent interactions with the 3,4-diols of l-fucopyranose and glucopyranoses, and it binds other sugars via their specific minor isomers. Thus, MpPA14 only binds polysaccharides like branched glucans and fucoidans with these free end groups. Consistent with our findings, adhesion of MpPA14 to diatom cells was selectively blocked by l-fucose, but not by N-acetyl galactosamine. The MpPA14 lectin homolog present in a Vibrio cholerae adhesin was produced and was shown to have the same sugar binding preferences as MpPA14. The pathogen’s lectin was unable to effectively bind the diatom in the presence of fucose, thus demonstrating the antiadhesion strategy of blocking infection via ligand-based antagonists. In addition to this study using rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, there are many other studies that have used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Quality Control of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Quality Control of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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Alcohol – Wikipedia,
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The author of 《Tuning Hot Carrier Cooling Dynamics by Dielectric Confinement in Two-Dimensional Hybrid Perovskite Crystals》 were Yin, Jun; Maity, Partha; Naphade, Rounak; Cheng, Bin; He, Jr-Hau; Bakr, Osman M.; Bredas, Jean-Luc; Mohammed, Omar F.. And the article was published in ACS Nano in 2019. Application of 156-87-6 The author mentioned the following in the article:

Hot carrier (Hc) cooling is a critical photophys. process that significantly influences the optoelectronic performance of hybrid perovskite-based devices. The hot carrier extraction at the device interface is very challenging because of its ultrashort lifetime. Ultrafast transient reflectance spectroscopy measurements and time-domain ab initio calculations show how the dielec. constant of the organic spacers can control and slow the Hc cooling dynamics in single-crystal 2D Ruddlesden-Popper hybrid perovskites. (EA)2PbI4 (EA = HOC2H4NH3+) that correspond to a high dielec. constant organic spacer has a longer Hc cooling time compared to that of (AP)2PbI4 (AP = HOC3H6NH3+) and (PEA)2PbI4 (PEA = C6H5C2H4NH3+). The slow Hc relaxation process in the former case can be ascribed to a stronger screening of the Coulomb interactions, a small nonradiative internal conversion within the conduction bands, as well as a weak electron-phonon coupling. The findings provide a strategy to prolong the hot carrier cooling time in low-dimensional hybrid perovskite materials by using organic spacers with reduced dielec. confinement. Crystallog. data are given. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Ambroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells》 was published in Gels in 2021. These research results belong to Md, Shadab; Abdullah, Samaa T.; Alhakamy, Nabil A.; Bani-Jaber, Ahmad; Radhakrishnan, Ammu Kutty; Karim, Shahid; Shahzad, Naiyer; Gabr, Gamal A.; Alamoudi, Abdulmohsin J.; Rizg, Waleed Y.. Application of 23828-92-4 The article mentions the following:

This study aimed to develop gastro-retentive sustained-release ambroxol (ABX) nanosuspensions utilizing ambroxol-kappa-carrageenan (ABX-CRGK) complexation formulations. The complex was characterized by differential scanning calorimetry, powder x-ray diffractometer, and SEM. The prepared co-precipitate complex was used for the development of the sustained-release formulation to overcome the high metabolic and poor solubility problems associated with ABX. Furthermore, the co-precipitate complex was formulated as a suspension in an aqueous floating gel-forming vehicle of sodium alginate with chitosan, which might be beneficial for targeting the stomach as a good absorption site for ABX. The suspension exhibited rapid floating gel behavior for more than 8 h, thus confirming the gastro-retentive effects. Particle size anal. revealed that the optimum nanosuspension (ABX-NS) had a mean particle size of 332.3 nm. Afterward, the ABX released by the nanoparticles would be distributed to the pulmonary tissue as previously described. Based on extensive pulmonary distribution, the developed nanosuspension-released ABX nanoparticles showed significant cytotoxic enhancement compared to free ABX in A549 lung cancer cells. However, a significant loss of mitochondrial membrane potential (MMP) also occurred. The level of caspase-3 was the highest in the ABX-NS-released particle-treated samples, with a value of 416.6 ± 9.11 pg/mL. Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumor necrosis alpha (NF-kB, IL-6, IL-1β, and TNF-α, resp.) were lower for ABX-NS compared to free ABX (p < 0.05). In caspase-3, Bax, and p53, levels significantly increased in the presence of ABX-NS compared to free ABX. Overall, ABX-NS produced an enhancement of the anticancer effects of ABX on the A549 cells, and the developed sustained-release gel was successful in providing a gastro-retentive effect. In addition to this study using trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, there are many other studies that have used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Application of 23828-92-4) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Application of 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
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In 2019,Molecules included an article by Shao, Yu; Chen, Jia; Ren, Xiang-Kui; Zhang, Xinlin; Yin, Guang-Zhong; Li, Xiaopeng; Wang, Jing; Wesdemiotis, Chrys; Zhang, Wen-Bin; Yang, Shuguang; Sun, Bin; Zhu, Meifang. Safety of 3-Aminopropan-1-ol. The article was titled 《Synthesis, self-assembly and characterization of tandem triblock BPOSS-PDI-X shape amphiphiles》. The information in the text is summarized as follows:

The authors report the facile synthesis, self-assembly, and characterization of shape amphiphiles (BPOSS-PDI-X) based on isobutyl-functionalized polyhedral oligomeric silsesquioxane (BPOSS), perylene tetracarboxylic diimide (PDI), and (60)fullerene (C60) moieties. Firstly, an asym. functionalized diblock shape amphiphile precursor (BPOSS-PDI-OH) was obtained through the 1-pot reaction between perylene-3,4,9,10-tetracarboxylic dianhydride and two different amines, BPOSS-NH2 and 3-amino-1-propanol. It was further conjugated with C60-COOH to give a tri-block shape amphiphile (BPOSS-PDI-C60). Their chem. structures were thoroughly characterized by NMR, IR and MALDI-TOF MS spectrometry. To gain insights on the structure-property relation, their self-assembly in gas phase, in solution, and in solid state were characterized using traveling wave ion mobility mass spectrometry (TWIM-MS), UV/visible absorption, fluorescence emission spectrophotometer, and TEM, resp. BPOSS-PDI-OH formed more complicated dimers than BPOSS-PDI-C60. Both samples showed unique aggregation behaviors in solution with increasing concentration, which could be attributed neither to H- nor to J-type and might be related to the discrete dimers. While BPOSS-PDI-C60 could hardly crystallize into ordered structures, BPOSS-PDI-OH could form nanobelt-shaped single crystals, which may hold potential applications in microelectronics. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Safety of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
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In 2022,Liu, Qianhui; Wang, Siyang; Zhao, Zeyu; Tong, Jianhua; Urban, Marek W. published an article in Small. The title of the article was 《Electrically Accelerated Self-Healable Polyionic Liquid Copolymers》.Related Products of 627-18-9 The author mentioned the following in the article:

Elec. accelerated self-healable poly(ionic liquids) copolymers that exhibit resistor-capacitor (RC) circuit properties are developed. At low a.c. (AC) frequencies these materials behave as a resistor (R), whereas at higher frequencies as a capacitor (C). These properties are attributed to a combination of dipolar and electrostatic interactions in (1-[(2-methacryloyloxy)ethyl]-3-butylimidazolium bis(trifluoromethyl-sulfonyl)imide) copolymerized with Me methacrylate (MMA) monomers to form p(MEBIm-TSFI/MMA) copolymers. When the monomer molar ratio (MEBIm-TSFI:MMA) is 40/60, these copolymers are capable of undergoing multiple damage-repair cycles and self-healing is accelerated by the application of alternating 1.0-4.0 V elec. field (EF). Self-healing in the absence of EFs is facilitated by van der Waals (vdW) interactions, but the application of AC EF induces back and forth movement of charges against the opposing force that result in dithering of electrostatic dipoles giving rise to interchain phys. crosslinks. Electrostatic inter- and intrachain interactions facilitated by copolymerization of ionic liquid monomers with typically dielec. acrylic-based monomers result in enhanced cohesive energy densities that accelerate the recovery of vdW forces facilitating self-healing. Incorporating ionic liquids into commodity polymers offers promising uses as green conducting solid polyelectrolytes in self-healable energy storage, energy-harvesting devices, and many other applications. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

Referemce:
Alcohol – Wikipedia,
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Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeIn 2021 ,《Covalent organic framework-graphene oxide composite: A superior adsorption material for solid phase microextraction of bisphenol A》 was published in Talanta. The article was written by Gao, Wei; Cheng, Jiawen; Yuan, Xiaoli; Tian, Yong. The article contains the following contents:

Novel materials with high adsorption and desorption efficiencies are significant for studying compounds at ultra-trace level. Herein, covalent organic framework-graphene oxide (COF-GO) composite materials are synthesized, and tested for solid phase microextraction (SPME) of bisphenol A (BPA) at ultra-trace level. With GO modified successively by 3-aminopropyltriethoxysilane, 1,3,5-triformylphloroglucinol (Tp), and different ratios of COF monomers (Tp and benzidine (BD)), the composites of TpBD-GO-n (n = 1-4) are synthesized. By coating the composites on a glass fiber, the extraction performances of the composites for BPA are tested with constant flow desorption ionization mass spectrometry (CFDI-MS). The extraction efficiency of the composite TpBD-GO-2 is 2.2 and 4.7 times higher than those of TpBD and GO, resp. The chromatog. separation becomes a non-essential step for detection of BPA, the anal. time for each sample is reduced to 8 min. The limits of detection and quantification of MS for BPA anal. are improved to be 22.2 and 73.9 ng L-1. The linear range is extended to be 10.0 μg L-1 (R2 = 0.9990), and the relative standard deviations of one fiber (n = 11) and fiber-to-fiber (n = 8) are 4.3% and 5.6% (1 μg L-1), resp. With this method, ultra-trace levels of BPA present in river water and sea water samples can be successfully detected and quantified. The results indicate that the TpBD-GO-n composites possess superior extraction performance, and their various applications could be expected. The experimental process involved the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

Referemce:
Alcohol – Wikipedia,
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In 2019,Small included an article by Cao, Shoupeng; Shao, Jingxin; Xia, Yifeng; Che, Hailong; Zhong, Zhiyuan; Meng, Fenghua; van Hest, Jan C. M.; Abdelmohsen, Loai K. E. A.; Williams, David S.. Safety of 3-Bromopropan-1-ol. The article was titled 《Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers》. The information in the text is summarized as follows:

Engineering biodegradable nanostructures with precise morphol. characteristics is a key objective in nanomedicine. In particular, asym. (i.e., nonspherical) nanoparticles are desirable due to the advantageous effects of shape in a biomedical context. Using mol. engineering, it is possible to program unique morphol. features into the self-assembly of block copolymers (BCPs). However, the criteria of biocompatibility and scalability limit progress due to the prevalence of nondegradable components and the use of toxic solvents during fabrication. To address this shortfall, a robust strategy for the fabrication of morphol. asym. nanoworms, comprising biodegradable BCPs, has been developed. Modular BCPs comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-PCLgTMC), with a terminal chain of quaternary ammonium-TMC (PTMC-Q), undergo self-assembly via direct hydration into well-defined nanostructures. By controlling the solution ionic strength during hydration, particle morphol. switches from spherical micelles to nanoworms (of varying aspect ratio). This ionically-induced switch is driven by modulation of chain packing with salts screening interchain repulsions, leading to micelle elongation. Nanoworms can be loaded with cytotoxic cargo (e.g., doxorubicin) at high efficiency, preferentially interact with cancer cells, and increase tumor penetration. This work showcases the ability to program assembly of BCPs and the potential of asym. nanosystems in anticancer drug delivery. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Safety of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Safety of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Polymer included an article by Cao, Yufeng; Hu, Guangwei; Lin, Shaohui; Rempel, Garry L.; Pan, Qinmin. Electric Literature of C6H12O. The article was titled 《Synthesis of precisely diphenyl ether-functionalized polyethylene via acyclic diene metathesis polymerization》. The information in the text is summarized as follows:

We demonstrated the facile synthesis of a new class of functionalized polyethylene containing precisely sequenced di-Ph ether moieties via acyclic diene metathesis (ADMET) polymerization of a series of α, ω-diene monomers (M1-M3) with central di-Ph ether segments and subsequent exhaustive hydrogenation. 1H and 13C NMR spectroscopy have provided unambiguous evidence for precise primary architectures of the synthesized monomers and the resulting polymers. The thermal behaviors of all polymers were systematically investigated by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC). The results indicate that the introduction of di-Ph ether segments significantly enhanced the thermal stability of the polyethylenes. Ring-opening insertion metathesis polymerization (ROIMP) of M1-M3 with cis-cyclooctene was also performed, and after exhaustive hydrogenation, a series of irregularly sequenced copolymers with less regular chain structure and lower di-Ph ether content were yielded. Those copolymers possess a broad and ill-defined melting transition compared with the precisely-defined saturated homopolymers. In the part of experimental materials, we found many familiar compounds, such as 5-Hexen-1-ol(cas: 821-41-0Electric Literature of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Electric Literature of C6H12O

Referemce:
Alcohol – Wikipedia,
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