Month: November 2022

Integrating the rapid constituent profiling strategy and multivariate statistical analysis for herb ingredients research, with Chinese official rhubarb and Tibetan rhubarb as an example was written by Luo, Dewei;He, Mingzhen;Li, Junmao;Du, Hui;Mao, Qiping;Pei, Na;Zhong, Guoyue;Ouyang, Hui;Yang, Shiling;Feng, Yulin. And the article was included in Arabian Journal of Chemistry in 2021.Name: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

The Chinese official rhubarb (COR), from the genus Rheum, is listed in the Chinese Pharmacopoeia, while many rhubarb plant sources include in the Tibetan rhubarb (TR) are not attributable to Chinese Pharmacopoeia. Tibetan rhubarb is widely used as a natural medicine in Tibet; however, the difference in plant endogenous phytochems. between the COR and TR remains largely unclear.To establish a method for evaluating the chem. composition and metabolic difference between COR and TR.Using UHPLC-QTOF-MS/MS, we established a strategy to quickly and comprehensively identify the chem. components of COR and TR. Furthermore, multivariate statistical anal. was applied to identify the significant metabolic differences between the two.In total, 209 chem. compounds, including 51 anthraquinones, 44 stilbenes, 26 tannins, 52 acyl glycosides, and 36 other compounds, were identified using the data mining strategy. Importantly, 47 compounds may be the potential new compounds, while 35 significant metabolic differences were revealed between COR and TR.This study offers significant insight into the chem. composition and differences between COR and TR that could be used to develop their varieties and clin. applications. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Name: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development and validation of a method for determination of 17 endocrine disrupting chemicals in milk, water, blood serum and feed by UHPLC-MS/MS was written by Di Marco Pisciottano, Ilaria;Albrizio, Stefania;Guadagnuolo, Grazia;Gallo, Pasquale. And the article was included in Food Additives & Contaminants, Part A in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:

The concern for human exposure to bisphenol A (BPA) has led to the introduction of other bisphenols to be used as substitutes in industrial processes. These compounds show activity similar to BPA as endocrine disruptors and could be already widespread both in the environment and in food. To monitor their possible occurrence in the food chain, an anal. method based on affinity chromatog. clean-up and UHPLC coupled to tandem mass spectrometry detection was developed and inhouse validated according to European law, for simultaneous determination of 17 bisphenols in milk and blood serum from bovine and buffalo, in drinking water and in feed. The anal. performance parameters of the method for these matrixes were determined The results showed satisfactory precision in terms of relative standard deviation (3.3%-21.4%), overall good trueness as mean percentage recoveries (77.0%-119.4%), with the only exception of bisphenol PH and bisphenol S in milk and BPA diglycidyl ether in serum. The high specificity and sensitivity of the method allowed us to determine the analytes at very low concentrations, i.e., 0.01-1.0 ng/mL in water, 0.1-2.0 ng/mL in milk, 0.01-1.0 ng/g in blood serum and 1.0-10.0 ng/g in feed. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Antibacterial effect of indene on Helicobacter pylori correlates with specific interaction between its compound and dimyristoyl-phosphatidylethanolamine was written by Wanibuchi, Kiyofumi;Takezawa, Motoki;Hosoda, Kouichi;Amgalanbaatar, Avarzed;Tajiri, Kentaro;Koizumi, Yuki;Niitsu, Sakura;Masui, Hisashi;Sakai, Yuki;Shoji, Mitsuru;Takahashi, Takashi;Hirai, Yoshikazu;Shimomura, Hirofumi. And the article was included in Chemistry and Physics of Lipids in 2020.Synthetic Route of C37H74NO8P The following contents are mentioned in the article:

In this study we synthesized a new VDP1 derivative to advance further investigation as for the correlative relationship between VDP1 structure and anti-H. pylori activity or PE vesicle collapse induction activity. The derivative VD3-7 [(1R,7aR)-4-fluoro-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-1H-indene] retained a fluorine atom in place of the oxygen atom of VDP1. The fluorination of the carbonyl portion of VDP1 forfeited the effective anti-H. pylori activity. We, therefore, prepared Coomassie brilliant blue (CBB)-containing unilamellar vesicles consisting of various PE mol. species, and examined the vesicle collapse induction activity of either VDP1 or VD3-7 by detecting the CBB eluted from the PE unilamellar vesicles. VDP1 strongly induced CBB elution from the unilamellar vesicles of rectus-PE retaining the same two fatty acid side-chains shorter than carbon numbers 14, indicating that VDP1 specifically disrupted the vesicular conformation of those PE unilamellar vesicles. Meanwhile, VD3-7 had no influence on the structural stability of any PE unilamellar vesicles. This study obtained addnl. evidence that VDP1 acts as a bactericidal agent on H. pylori by targeting the membranal di-14:0 PE. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Synthetic Route of C37H74NO8P).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C37H74NO8P

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Combined effects of sunlight and tempering treatment on the oligomeric procyanidin formation in dried ume (Prunus mume Sieb. et Zucc.) was written by Ma, Fu-Yuan;Huang, Tzou-Chi;Nayi, Pratik;Chen, Ho-Hsien. And the article was included in Drying Technology.Recommanded Product: (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol The following contents are mentioned in the article:

In this study, the combined effect of sunlight irradiation and tempering treatment on the promotion of oligomeric procyanidins (OPCs) formation in the dried ume (Prunus mume Sieb. et Zucc.) was investigated and firstly reported. Water content, water activity, and chem. structure of the OPCs were analyzed during the drying process. Two nights of tempering treatment reduced the water content and water activity significantly. Two major OPCs, procyanidin B2 and procyanidin C1 were characterized in sun-dried ume and the (-)-epicatechin model by both the pos. and neg. ionization modes using an electrospray ionization source (ESI). The concentration of procyanidin B2 and procyanidin C1 increased by 1.76 and 1.24 folds, resp. in the intermittently sun-dried ume. The developed photocatalytic closed-type dryer was used in this experiment confirmed successfully that tempering treatment enhanced the moisture redistribution and precursor accumulation leading to the subsequent photooxidation of (-)-epicatechin for OPCs. To minimize the drawback of outer drying under climatic change this is a possible protocol design with effective drying technol. to improve the quality and mass production of the functional umes. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8Recommanded Product: (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol).

(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enhanced degradation of bisphenol F in a porphyrin-MOF based visible-light system under high salinity conditions was written by Wang, Zhiwei;Li, Qian;Su, Ruidian;Lv, Guochun;Wang, Zhining;Gao, Baoyu;Zhou, Weizhi. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

The efficient degradation of organic contaminants in practical water treatment is a challenge for advanced oxidation processes via such as semiconductor photocatalysis due to interference from the inhibiting influence due to the reactions between radicals and coexisting anions in the actual water column. Herein, a porphyrinic zirconium metal-organic framework (PCN-223) is used in a visible light system to effectively decompose bisphenol F (BPF) in saline water. The PCN-223/visible-light system can effectively resist the influence of environmental coexisting anions and natural organic matter (NOM), thus demonstrating excellent performance in decomposing pollutants. Furthermore, the catalytic system is able to maintain stable contaminant degradation over a wide pH range and in five water matrixes. Coexisting anions promote the conductivity of electrons by forming ionic bonds with Zr, which enhances light-induced electron transfer under visible light. This work illustrates the mechanism and conditions under which porphyrin-MOF can resist high salt environments in photocatalysis, and provides a new perspective on the practical application of photocatalysis to overcome complex environmental disturbances. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8COA of Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel pyridoxal based molecular sensor for selective turn-on fluorescent switching functionality towards Zn(II) in live cells was written by Karthick, Kettalu Ananthan;Kaleeswari, Kalairajan;Uma Maheswari, C.;Sivaraman, Gandhi;Shankar, Bhaskaran;Tamilselvi, Arunachalam. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A new facile mol. sensor (HL), 4-((3-(cyclohexylamino)propylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, constructed with pyridoxal moiety, selectively detects Zn²⁺ ion in solid and solution medium. The structure of this newly synthesized sensor is confirmed by single crystal X-ray diffraction study. The rapid selective fluorescence ′turn-on′ response of Zn²⁺ ion in aqueous ethanolic (9:1, volume/volume) HEPES buffer (pH = 7.0) medium was studied. The synthesized mol. sensor shows the lowest limit of detection (LOD) for Zn²⁺ ion (9.5850 ± 0.3835 nM). The sensing behavior of the mol. sensor towards Zn²⁺ can be ascribed to the formation of complex. D. functional theory (DFT) and time dependent d. functional theory (TD-DFT) calculations were carried out to support the proposed tetrahedral geometry of zinc(II) complex and to explore the electronic properties of HL and its zinc complex (ZnL₂). The mol. sensor shows the practical application to detect zinc(II) qual. on TLC plate based test strips. In addition to that, it also gives insight into the design of protocols required for successful imaging of intracellular zinc(II) ions in HeLa cells. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A new pyridoxal based fluorescence chemo-sensor for detection of Zn(II) and its application in bio imaging was written by Mandal, Senjuti;Sikdar, Yeasin;Maiti, Dilip K.;Maiti, Guru Prasad;Mandal, Sushil Kumar;Biswas, Jayanta Kumar;Goswami, Sanchita. And the article was included in RSC Advances in 2015.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

This paper describes the activity of a Schiff base ligand, derived from pyridoxal, as a promising fluorescence probe for biol. important Zn(II) ion sensing. A physiol. compatible pyridoxal based chemosensor PydDmen was synthesized and evaluated for its fluorescent response towards metal ions. Chemosensor PydDmen exhibits a selective turn-on type response in the presence of Zn²⁺ in ethanol-water mixture The addition of EDTA quenches the fluorescence of receptor PydDmen-Zn²⁺, making the chemosensor PydDmen reversible. The response is specific for Zn(II) ions, and remains almost unaffected by the presence of alkali and alk. earth metals but is suppressed to varying degrees by transition metal ions. The selectivity mechanism of PydDmen for Zn²⁺ is the combined effects of proton transfer between the prevailing tautomeric forms, C=N isomerization and CHEF. The DFT optimized structure of the complex is compatible with elemental anal., mass spectrometry, FT-IR, electronic and NMR spectra. The exptl. and theor. support in terms of NMR spectroscopy and DFT are provided to establish the existence of Zn²⁺ induced transformation of PydDmen to a 3-pyridone tautomeric form. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Antioxidant and antibacterial activities of Pelargonium asperum and Ormenis mixta essential oils and their synergistic antibacterial effect was written by Ouedrhiri, Wessal;Balouiri, Mounyr;Bouhdid, Samira;Harki, El Houssaine;Moja, Sandrine;Greche, Hassane. And the article was included in Environmental Science and Pollution Research in 2018.Recommanded Product: 106-21-8 The following contents are mentioned in the article:

In this work, the chem. composition, the antioxidant, and the antibacterial activities of two Moroccan essential oils less studied, extracted from Pelargonium asperum and Ormenis mixta, were investigated. According to the gas chromatog. coupled to mass spectrometry anal., citronellol (25.07%), citronellyl ester (10.52%), geraniol (10.46%), and buthyl anthranilate (5.93%) were found to be the major components of P. asperum, while O. mixta was mainly composed of D-germacrene (11.46%), 1,8-cineole (10.28%), and cis-Me isoeugenol (9.04%). Moreover, O. mixta essential oil exhibited an important antioxidant activity being significantly higher than that exhibited by P. asperum oil (P < 0.001). As regards the antimicrobial activity of both essential oils, the zones of growth inhibition and the min. inhibitory concentration values showed that P. asperum essential oil was more active than that of O. mixta. Thereafter, the impact of the binary combination of essential oils on their antimicrobial effect was investigated against Staphylococcus aureus using the fractional inhibitory concentration index calculation The results showed a promising synergistic antibacterial interaction between essential oils studied. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Recommanded Product: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polyalcohols – important raw materials for the resin and paint industry was written by Soerensen, Kent. And the article was included in Faerg och Lack Scandinavia in 1992.Product Details of 115-84-4 The following contents are mentioned in the article:

A review with 12 references The most common polyalcs., their application in the resin and paint industry, their contribution to the properties of the resins and paints, especially alkyd resins, polyesters, and acrylic monomers, and their structure-property relationship are presented. Together with actual market prices, these data will allow the paint chemist to find the optimum formulation for performance and cost more rapidly, and avoid using unsuitable polyalcs., thereby decreasing the number of experiments and thus costs. The topics include: introduction; the significance of chem. structure (type of hydroxyl group, side groups, neo-structure, functionality); description of different polyalcs. [pentaerythritol (I), trimethylolpropane (II), glycerin, di-pentaerythritol, di-trimethylolpropane, alkoxylates of I and II, neopentylglycol, monoethyleneglycol, propyleneglycol, dimethylolpropionic acid, allyl ethers, and other polyalcs. (2-Et-2-Bu-1,3-propanediol, 1,6-hexanediol, 1,4-butanediol, 2,2,4-trimethyl-1,3-pentanediol, 1,4-cyclohexanediethanol, trimethylolethane, hydroxypivalyl hydroxypivalate, and cyclic II formal)]. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Product Details of 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effective stabilization of atomic hydrogen by Pd nanoparticles for rapid hexavalent chromium reduction and synchronous bisphenol A oxidation during the photoelectrocatalytic process was written by Li, Shanpeng;Liu, Chunlei;Liu, Haijin;Lv, Wenying;Liu, Guoguang. And the article was included in Journal of Hazardous Materials in 2022.HPLC of Formula: 620-92-8 The following contents are mentioned in the article:

Atomic hydrogen (H*) plays a vital role in the synchronous redox of metallic ions and organic mols. However, H* is extremely unstable as it is easily converted to hydrogen. Herein, we designed a novel strategy for the effective stabilization of H* to enhance its utility. The synthesized Pd nanoparticles grown on the defective MoS₂ (DMS) of TiO₂ nanowire arrays (TNA) (TNA/DMS/Pd) photocathode exhibited rapid Cr(VI) reduction (∼95% in 10 min) and bisphenol A (BPA) oxidation (∼97% in 30 min), with the kinetic constants almost 24- and 6-fold higher than those of the TNA photocathode, resp. This superior performances could be attributed to: (i) the generated interface heterojunctions between TNA and DMS boosted the separation efficiencies of photogenerated electrons, thereby supplying abundant valance electrons to lower the overpotential to create a suitable microenvironment for H* generation; (ii) the stabilization of H* by Pd nanoparticles resulted in a significant increase in the yield of hydroxyl radical (^•OH). This research provides a new strategy for the effective utilization of H* toward rapid reduction of heavy metals and synchronous oxidation of the refractory organics This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8HPLC of Formula: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts