Month: October 2022

Zhang, Xinyu; Li, Linxuan; Zanoni, Giuseppe; Han, Xinyue; Bi, Xihe published the artcile< Direct gem-Difluoroalkenylation of X-H Bonds with Trifluoromethyl Ketone N-Triftosylhydrazones for Synthesis of Tetrasubstituted Heteroatomic gem-Difluoroalkenes>, Quality Control of 627-27-0, the main research area is heteroatomic gem difluoroalkene preparation DFT; trifluoromethyl ketone triftosylhydrazone amine difluoroalkenylation silver catalyst; alc trifluoromethyl ketone triftosylhydrazone difluoroalkenylation silver catalyst; carbene; difluoroalkene; difluoroalkenylation; rhodium catalysis; silver catalysis.

Here, the first direct X-H bond gem-difluoroalkenylation of amines, e.g., N-methylaniline and alcs., e.g., methanol with trifluoromethyl ketone N-triftosylhydrazones, e.g., benzenesulfonic acid, 2-(trifluoromethyl)-, 2-(2,2,2-trifluoro-1-phenylethylidene)hydrazide under silver (for (hetero)aryl hydrazones) or rhodium (for alkyl hydrazones) was reported, thereby providing a most powerful method for the synthesis of tetrasubstituted heteroat. gem-difluoroalkenes, e.g., (2,2-difluoro-1-phenyl-vinyl)-methyl-phenyl-amine/1,1-difluoro-2-methoxy-2-phenylethene. This method features a broad substrate scope, high product yield, excellent functional group tolerance, and operational simplicity (open air conditions). Moreover, the site-specific replacement of the carbonyl group with a gem-difluorovinyl ether bioisostere in drug Trimebutine and the post-modification of bioactive mols. demonstrates potential use in medicinal research. Finally, the reaction mechanism was investigated by combining experiments and DFT calculations, and disclosed that the key step of HF elimination occurred via five-membered ring transition state, and the difference in the electrophilicity of Ag- and Rh-carbenes as well as the multiple intermol. interactions rendered the effectiveness of Rh catalyst selectively for alkyl hydrazones.

Chemistry – A European Journal published new progress about Alkenylation (difluoro-). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Angulo, Beatriz; Fraile, Jose M.; Gil, Laura; Herrerias, Clara I. published the artcile< Comparison of Chemical and Enzymatic Methods for the Transesterification of Waste Fish Oil Fatty Ethyl Esters with Different Alcohols>, Category: alcohols-buliding-blocks, the main research area is enzyme transesterification waste fish oil fatty ethyl ester alc.

Fatty acid esters of 2-ethyl-1-hexanol (EH), 2-hexyl-1-decanol (HD), and isopropanol have been obtained from a mixture of Et esters obtained as a fish oil byproduct. Homogeneous base catalysis with alk. hydroxides and alkoxides has been compared with the use of two com. available immobilized lipases. The enzymic methodol. is more efficient in the case of the largest alc. (HD) mainly because of the high stability of the immobilized enzymes upon recovery and reuse. In contrast, the use of a base as a catalyst is highly favorable in the case of isopropanol because of the rather poor activity of the lipases and the low price of the bases. With EH, the activity of lipases is good but the recoverability is not as efficient; hence, basic catalysts are again the most attractive alternative. The mixtures of esters obtained may be useful as hydraulic liquids given their viscosity values.

ACS Omega published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qu, Lisha; Xiu, Xiang; Sun, Guoyun; Zhang, Chenyang; Yang, Haiquan; Liu, Yanfeng; Li, Jianghua; Du, Guocheng; Lv, Xueqin; Liu, Long published the artcile< Engineered yeast for efficient de novo synthesis of 7-dehydrocholesterol>, Quality Control of 434-16-2, the main research area is 7-dehydrocholesterol; CRISPRi system; TY1 transposon; metabolic engineering; metabolic network model.

The synthesis of vitamin D3 precursor 7-dehydrocholesterol (7-DHC) by microbial fermentation has much attracted attention owing to its advantages of environmental protection. In this study, Saccharomyces cerevisiae was engineered for a de novo biosynthesis of 7-DHC. First, seven essential genes (six endogenous genes and one heterologous gene) were overexpressed, and the ROX1 gene (heme-dependent repressor of hypoxic genes) was knocked out. The resulting strain produced 82.6 mg/L 7-DHC from glucose. Then, we predicted five gene knockout targets for 7-DHC overproduction by the reconstruction of genome-scale metabolic model. GDH1 gene knockout increased the 7-DHC titer from 82.6 to 101.5 mg/L, and the specific growth rate of the ΔGDH1 mutant was also increased by 28%. Next, Ty1 transposon in S. cerevisiae was applied to increase the copies of the ERG1 gene and DHCR24 gene, resulting in a 120% increase in 7-DHC titer to 223.3 mg/L. Besides, to optimize the metabolic flux distribution, Clustered Regularly Interspaced Short Palindromic Repeats interference (CRISPRi) system was used to dynamically inhibit the competitive pathway, and the best binding site of ERG6 (delta (24)-sterol C-methyltransferase) promoter was screened out. The OD600 value of ERG6 regulated cells increased by 43% than knocking out ERG6 directly, and 7-DHC titer increased to 365.5 mg/L in a shake flask. Finally, the 7-DHC titer reached 1328 mg/L in 3-L bioreactor and the specific titer of 7-DHC reached up to 114.7 mg/g dry cell weight). Overall, this study constructed a yeast chassis for the highly efficient production of 7-DHC by systems metabolic engineering.

Biotechnology and Bioengineering published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Shuhuan; Liu, Chen; Song, Bin; Wang, Liang; Qi, Yan; Liu, Yongjun published the artcile< Samarium-based Grignard-type addition of organohalides to carbonyl compounds under catalysis of CuI>, Synthetic Route of 76-84-6, the main research area is alc ketone aldehyde preparation chemoselective; organohalide carbonyl compound Grignard addition copper catalysis.

Grignard-type additions were readily achieved under the mediation of CuI (10 mol%) and samarium (2 equivalent) by employing various organohalides, e.g. benzyl, aryl, heterocyclic and aliphatic halides (Cl, Br or I), and diverse carbonyl compounds (e.g. carbonic esters, carboxylic esters, acid anhydrides, acyl chlorides, ketones, aldehydes, propylene epoxides and formamides) to afford alcs., ketones and aldehydes, resp., with high efficiency and chemoselectivity, in which the organosamarium intermediate might be involved.

Chemical Communications (Cambridge, United Kingdom) published new progress about Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lian, Chen; Li, Hai-Lou; Yang, Guo-Yu published the artcile< A μ-AsO4-Bridging Hexadecanuclear Ni-Substituted Polyoxotungstate>, Product Details of C8H10OS, the main research area is crystal structure arsenate bridging hexadecanuclear nickel substituted silicotungstate; nickel substituted silicotungstate preparation electrochem reduction oxidation catalyst.

A novel tetrahedral μ-AsO4-bridging hexadecanuclear nickel-substituted silicotungstate (ST) Na21H10[(AsO4){Ni8(OH)6(H2O)2(CO3)2(A-α-SiW9O34)2}2]·60H2O (1) was made by the reactions of trivacant [A-α-SiW9O34]10- ({SiW9}) units with Ni2+ cations and Na3AsO4·12H2O and characterized by IR spectrometry, elemental anal., TGA, and powder x-ray diffraction (PXRD). 1 Contains [(AsO4){Ni8(OH)6(H2O)2(CO3)2(A-α-SiW9O34)2}2]31-, a novel polyoxoanion built by four trivacant Keggin [A-α-SiW9O34]10- fragments linked through an unprecedented [(AsO4){Ni8(OH)6(H2O)2(CO3)2}2]9+ cluster, where the tetrahedral AsO4 acts as an exclusively μ2-bridging unit to link multiple Ni centers; such a connection mode appears for the 1st time in polyoxometalate chem. Also, the electrochem. and catalytic oxidation properties of 1 were studied.

Inorganic Chemistry published new progress about Aromatic compounds, sulfones Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Product Details of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Shi-Yue; Gong, Wei-Tao; Qu, Wei-Dong; Deng, Xiao-Rong; Dong, Kai-Xun; Zhang, Shu-Guang; Ning, Gui-Ling published the artcile< Construction of Ionic Porous Organic Polymers (iPOPs) via Pyrylium Mediated Transformation>, Formula: C19H16O, the main research area is chromium carbon dioxide ionic porous organic polymer adsorption.

Two new ionic porous organic polymers (iPOPs) with different counter anions were successfully fabricated via well-known pyrylium mediated transformation into pyridinium. 13C solid-state NMR, XPS, and FTIR were analyzed and confirmed the formation of pyridinium in the network. Containing charged and aromatic networks, both iPOPs exhibit a high affinity towards toxic hexavalent chromium Cr(VI) ions. What is more, it has been demonstrated that both CO2 adsorption and Cr(VI) removal properties can be tuned by simply varying counter anions.

Chinese Journal of Polymer Science published new progress about Adsorption. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Chun-Ping; Li, Xiong; Lai, Ge-Na; Li, Jin-Hua; Jia, Wen-Yu; Cao, Ying-Ying; Xu, Wen-Xing; Tan, Qing-Long; Zhou, Chang-Yuan; Luo, Min; Zhang, Xue-Ying; Yuan, Dao-Qing; Tian, Jin-Ying; Zhang, Xian; Zeng, Xing published the artcile< Mechanisms of macrophage immunomodulatory activity induced by a new polysaccharide isolated from Polyporus umbellatus (Pers.) Fries>, Related Products of 492-62-6, the main research area is Polyporus extract polysaccharide anticancer immunomodulator NFkB NLRP3 bladder cancer; NF-κB pathway; NLR P3 inflammasome; Polyporus umbellatus; immunomodulatory activity; polysaccharide.

Bladder cancer is one of the most malignant tumors closely associated with macrophage immune dysfunction. The Chinese medicine polyporus has shown excellent efficacy in treating bladder cancer, with minimal side effects. However, its material basis and mechanism of action remain unclear. A new water-soluble polysaccharide (HPP) with strong immunomodulatory activity was isolated from the fungus Polyporus umbellatus (Pers.) Fries. HPP had an average mol. weight of 6.88 kDa and was composed mainly of an <-(1→ 4)-linked D-galactan backbone. The immunomodulatory activity of HPP was determined in vitro, and the results revealed that it could obviously increase the secretion of immune factors by IFN-γ-stimulated macrophages, including nitric oxide (NO), interleukin-6 (IL-6), interleukin-1β (IL-1β), RANTES and interleukin-23 (IL-23), and the expression of the cell membrane mol. CD80. In addition, HPP was recognized by Toll-like receptor 2 (TLR2) and activated the signaling pathways of NF-κB and NLRP3 in a bladder cancer microenvironment model, indicating that HPP could enhance host immune system function. These findings demonstrated that HPP may be a potential immune modulator in the treatment of immunol. diseases or bladder cancer therapy. Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Antitumor agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kajiki, Takahito; Komba, Shiro; Iwaura, Rika published the artcile< Supramolecular Organogelation Directed by Weak Noncovalent Interactions in Palmitoylated 1,5-Anhydro-D-Glucitol Derivatives>, COA of Formula: C6H12O6, the main research area is palmitoylated anhydro glucitol supramol organogelation noncovalent interaction; carbohydrates; gelators; hydrogen bonding; nanofibers; self-assembly.

We synthesized a series of novel alicyclic compounds by modifying 1,5-anhydro-D-glucitol with two to four palmitoyl chains, and we explored their self-assembly and gelation behaviors in paraffin. The obtained organogels were studied by field emission SEM, at. force microscopy, variable-temperature Fourier transform IR spectroscopy, X-ray diffraction anal., polarized optical microscopy, and transmission spectroscopy. While all the palmitoylated derivatives spontaneously formed fibrous networks and gelated the paraffin, an acetylated derivative of 1,5-anhydro-D-glucitol did not gelatinize the solvent, thus indicating the importance of aliphatic chains for gelation. Interestingly, α- and β- D-glucopyranose with five palmitoyl chains neither gelatinized the solvent nor formed fibrous networks, thus suggesting that the absence of C-1 substitution in 1,5-anhydro-D-glucitol is important for gelation. Fourier transform IR spectroscopy suggested that the formation of weak hydrogen bonds between the carbonyl groups and the C-H groups was the driving force for formation of the supramol. fibers and for gelation of the solvent.

ChemPlusChem published new progress about Gelation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Hong; Sun, Jian; Liu, Jun; Gou, Yarun; Zhang, Xin; Wu, Xiaonan; Sun, Rui; Tang, Sixue; Kan, Juan; Qian, Chunlu; Zhang, Nianfeng; Jin, Changhai published the artcile< Structural characterization and anti-inflammatory activity of alkali-soluble polysaccharides from purple sweet potato>, Reference of 3458-28-4, the main research area is purple sweet potato polysaccharide structural property antiinflammatory; Alkali-soluble polysaccharide; Anti-inflammation activity; Purple sweet potato; Structural characterization.

In this study, the structural characterization and anti-inflammation effect of dilute alkali-soluble polysaccharides from purple sweet potato were investigated. Three fractions (F-1, F-2 and F-3) were obtained by purifying crude polysaccharides on DEAE-52 cellulose column. The main fraction (F-1) was further purified on Sephadex G-200 column to afford purified alkali-soluble sweet potato polysaccharide (ASPP). The chem. structure of ASPP was analyzed by gas chromatog., Fourier transform IR spectroscopy, methylation anal. and NMR spectroscopy. Monosaccharide compositional anal. showed ASPP was composed of rhamnose, arabinose, xylose, mannose and glucose in the molar ratio of 2.8:1.9:1.0:7.6:53.3. Moreover, the backbone of ASPP was composed of 1,4-linked Glcp with side chains attached to the O-6 position. The anti-inflammation effect of ASPP was further investigated by in vitro and in vivo experiments Results showed ASPP could inhibit the levels of nitric oxide, interleukin (IL)-6, IL-1β and TNF-α but increase the production of IL-10 in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. In addition ASPP could reduce the secretion of IL-6, IL-1β and TNF-α in LPS-treated mice. Our results suggest ASPP can be developed as a novel anti-inflammation agent.

International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hiessl, Robert; Hennecke, Leon; Plass, Carmen; Kleber, Joscha; Wahlefeld, Stefan; Otter, Rainer; Groeger, Harald; Liese, Andreas published the artcile< FTIR based kinetic characterisation of an acid-catalysed esterification of 3-methylphthalic anhydride and 2-ethylhexanol>, Recommanded Product: 2-Ethylhexan-1-ol, the main research area is methylphthalic anhydride ethylhexanol esterification kinetics FTIR spectra.

In this study, an inline anal. method was designed and applied in process characterization and development. The model reaction is the two-step diesterification of 3-methylphthalic anhydride with 2-ethylhexanol consisting of alcoholysis as the first step, followed by an acid-catalyzed, second esterification step leading to the corresponding diester. The final product is a potential, alternative plasticiser. For the inline measurements, attenuated total reflection Fourier transformed IR spectroscopy (ATR-FTIR) was implemented. In order to evaluate the spectra recorded during the reaction, a chemometric model was established. In this work, Indirect Hard Modeling (IHM), a non-linear modeling approach was employed. The resp. model was calibrated by using offline samples analyzed with gas (GC) and liquid chromatog. (HPLC). After successful validation of the chemometric model, the inline measurements were utilized for reaction characterization. The acid-catalyzed, second esterification step was identified as the limiting reaction step. From batch reactions conducted at different temperatures, the energy of activation of this step was determined to be 79.5 kJ mol-1. Addnl., kinetics were shown to follow a pseudo-first order with respect to the monoester formation and a kinetic model was established. The model was validated in simulations with changed reaction conditions.

Analytical Methods published new progress about Activation energy. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Recommanded Product: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts