Month: October 2022

Mukhopadhyay, Arindam; Bernard, Brianna; Liu, Kaixuan; Paulino, Victor; Liu, Chuan; Donley, Carrie; Olivier, Jean-Hubert published the artcile< Molecular Strategies to Modulate the Electrochemical Properties of P-Type Si(111) Surfaces Covalently Functionalized with Ferrocene and Naphthalene Diimide>, Name: (4-Ethynylphenyl)methanol, the main research area is electrochem silicon covalently functionalized ferrocene naphthalene diimide.

The surface coverage and mol. composition of redox-active mols. anchored on conductive surfaces regulate the kinetic and thermodn. parameters of charge transfer reactions, providing a means to tune the electrochem. properties of hybrid materials. Herein, anchoring strategies and structural properties of redox-active probes, derived from ferrocene (Fc) and naphthalene diimide (NDI), regulate the electrochem. properties of functionalized p-doped Si(111) surfaces. Covalent functionalization of H-terminated Si(111) surfaces with Fc and NDI affords redox-active hybrid interfaces characterized through microscopy, spectroscopy, and voltammetry methods. Mol. design and synthetic grafting strategies modulate the electrochem. properties of the Fc-functionalized Si surfaces with a much higher (∼25 times) surface coverage (1.25 × mol. cm-2) for 1-step photografting compared to divergent synthetic routes. The thermal grafting of an alkadiyne followed by click reaction with ferrocenyl-azide leads to one of the highest surface coverages ( 9.97 × 10-10 mol cm-2) of organo-Fe reported and a significant anodic shift of the half-potential (>350 mV) compared to photografting methods. Similar experiments with NDI units exhibited electrochem. properties that diverge from those recorded for NDI in solution The results presented herein offer access to novel redox-active Si interfaces that evidence tunable electrochem. properties of potential interest for microelectronics applications.

Journal of Physical Chemistry B published new progress about Chemically modified electrodes. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Name: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zmyslowski, Adam; Szterk, Arkadiusz published the artcile< Oxysterols as a biomarker in diseases>, Related Products of 434-16-2, the main research area is review atherosclerosis Alzheimers disease progression oxysterol biomarker diagnosis; 24(S)-hydroxycholesterol; 27-hydroxycholesterol; Atherosclerosis; Biomarker; Neurodegenerative diseases; Oxysterols.

A review. Cholesterol is one of the most important chem. substances as a structural element in human cells, and it is very susceptible to oxidation reactions that form oxysterol. Oxysterols exhibit almost the exact structure as cholesterol and a cholesterol precursor (7-dehydrocholesterol) with an addnl. hydroxyl, epoxy or ketone moiety. The oxidation reaction is performed via an enzymic or non-enzymic mechanism. The wide array of enzymic oxysterols encountered in the human body varies in origin and function. Oxysterols establish a concentration equilibrium in human body fluids. Disease may alter the equilibrium, and oxysterols may be used as a diagnostic tool. The current review presents the possibility of using non-enzymic oxysterols and disturbances in enzymic oxysterol equilibrium in the human body as a potential biomarker for diagnosing and/or monitoring of the progression of various diseases.

Clinica Chimica Acta published new progress about Alzheimer disease. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiu, Fu-Rong; Lu, Yongwei; Qi, Yingying published the artcile< DEHP degradation and dechlorination of polyvinyl chloride waste in subcritical water with alkali and ethanol: A comparative study>, Name: 2-Ethylhexan-1-ol, the main research area is polyvinyl chloride ethanol dechlorination diethylhexyl phthalate degradation wastewater treatment; DEHP; Degradation; PVC; Phthalic acid ester; Subcritical water.

In this study, subcritical water-NaOH (CW-NaOH) and subcritical water-C2H5OH (CW-C2H5OH) processes were developed for diethylhexyl phthalate (DEHP) degradation and dechlorination of polyvinyl chloride (PVC) waste. The introduction of NaOH or C2H5OH in subcritical water had a noticeable influence on the mechanism of DEHP degradation and dechlorination. For both CW-NaOH and CW-C2H5OH treatments, the increase in temperature could increase dechlorination efficiency (DE) of PVC. The DE of CW-NaOH is much higher than that of CW-C2H5OH under the same conditions. The DE of CW-NaOH could exceed 95% at 300°C. Hydroxyl nucleophilic substitution was the main dechlorination mechanism in CW-NaOH, while nucleophilic substitution and direct dehydrochlorination were equally important in CW-C2H5OH. In CW-NaOH treatment, 2-ethyl-1-hexanol, benzaldehyde, and toluene were obtained by hydrolysis and reduction reactions of DEHP. Acetophenone was produced by the further cyclization, dehydrogenation and rearrangement reactions of 2-ethyl-1-hexanol. Transesterification was the main degradation pathway of DEHP in CW-C2H5OH at 300°C. The cyclization and dehydration of 2-ethyl-1-hexanol resulted in producing a high level of ethyl-cyclohexane and 1-ethyl-cyclohexene in CW-C2H5OH at 350°C. Furthermore, high concentration of Et palmitate and Et stearate could be prepared in CW-C2H5OH system by the strong reactivity of C2H5OH with the lubricants in PVC.

Chemosphere published new progress about Cyclization. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Name: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shui, Hongling; Zhong, Yuhong; Ouyang, Lu; Luo, Nianhua; Luo, Renshi published the artcile< Iridium-Catalyzed Acceptorless Dehydrogenative Coupling of 2-Aminoarylmethanols with Amides or Nitriles to Synthesize Quinazolines>, Application In Synthesis of 5344-90-1, the main research area is quinazoline preparation; aminoarylmethanol amide nitrile acceptorless dehydrogenative coupling iridium catalyst.

An efficient iridium-catalyzed acceptorless dehydrogenative coupling (ADC) reaction for the preparation of various quinazolines from 2-aminoarylmethanols and amides or nitriles had been developed. A wide range of substituted 2-aminobenzyl alcs. and (hetero)aryl or alkyl benzamides and nitriles were well compatible to afford various quinazolines in excellent yields. Merits of this new strategy are the high atom-economy, mild reaction conditions, and simple operation, and the methodol. is suitable for a variety of substrates.

Synthesis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pandey, Akanksha M.; Digrawal, Naveen Kumar; Mohanta, Nirmala; Jamdade, Akash Bandu; Chaudhari, Moreshwar B.; Bisht, Girish Singh; Gnanaprakasam, Boopathy published the artcile< Catalytic Acceptorless Dehydrogenation of Amino Alcohols and 2-Hydroxybenzyl Alcohols for Annulation Reaction under Neutral Conditions>, Quality Control of 5344-90-1, the main research area is dicarbonyl amino alc domino enamine ruthenium oxidative cyclization green; tetrahydroindole preparation; tetrahydroacridinone preparation; hydroxybenzyl alc dicarbonyl ruthenium alkylation cyclization dehydrogenation condensation hydrogenation; tetrahydroxanthenone preparation.

A base-free and acceptorless Ru-catalyzed dehydrogenative approach has been developed for the synthesis of N-heterocycles by using 1,3-dicarbonyls and amino alcs. through a domino sequential enamine formation and intramol. oxidative cyclization strategy. This unified approach is also applicable for the synthesis of O-heterocycles involving 2-hydroxybenzyl alc. as a coupling reactant via consecutive C-alkylation and intramol. cyclization steps. The present protocol is general for the synthesis of varieties of biol. important scaffolds, such as tetrahydro-4H-indol-4-one, 3,4-dihydroacridin-1(2H)-one, and tetrahydro-1H-xanthen-1-ones derivatives using a single catalytic system, viz. RuH2CO(PPh3)3. Environmentally benign H2O and H2 are the only byproducts in this domino process. Moreover, RuH2CO(PPh3)3-catalyzed C3-alkylation of tetrahydro-4H-indol-4-one using alc. as a alkylating partner is also described in this report. For the first time, a solvent-free gram-scale reaction for the acceptorless dehydrogenative annulation has been demonstrated. A plausible mechanism for the Ru-catalyzed base-free and acceptorless dehydrogenative annulation of amino alcs. or 2-hydroxybenzyl alcs. has been provided with several exptl. investigations and spectroscopic evidence.

Journal of Organic Chemistry published new progress about Acridines Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (tetrahydroacridinone). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nazarzadeh, Somayeh; Ghorbani-Choghamarani, Arash; Tahanpesar, Elham published the artcile< Synthesis and characterization of MCM-41@XA@Ni(II) as versatile and heterogeneous catalyst for efficient oxidation of sulfides and acetylation of alcohols under solvent-free conditions>, Quality Control of 699-12-7, the main research area is mesoporous silica catalyst alc acetylation sulfide oxidation thermal property.

Herein, Ni(II) immobilized on modified mesoporous silica MCM-41 was designed and synthesized via a facile sequential strategy. The structure of the catalyst was characterized by X-ray diffraction. The thermal property of the as-synthesized materials was studied using thermogravimetric-DTA. The average particles size and morphol. of MCM-41@XA@Ni(II) were investigated using SEM and transmission electron microscopy. This nanostructure catalyst was effective for the selective oxidation of sulfides and acetylation of alcs. in solvent-free conditions. The easy recyclability of the catalyst and their complete chemoselectivity toward the sulfur group of substrates in the oxidation of sulfides are important “”green”” attributes of this catalyst.

Journal of the Iranian Chemical Society published new progress about Acetylation. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Quality Control of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Jie; Mu, Ran; Sun, Mingna; Zhao, Nan; Pan, Miaomiao; Li, Hongshuang; Dong, Yi; Sun, Zhaogang; Bai, Jie; Hu, Minwan; Nathan, Carl F.; Javid, Babak; Liu, Gang published the artcile< Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis>, Related Products of 4396-13-8, the main research area is agrimophol derivative antitubercular disruption pH homeostasis Mycobacterium tuberculosis; agrimophol; coumarin; diphenylmethane scaffold; intrabacterial pH homeostasis; pharmacophores.

This article reports the rational medicinal chem. of a natural product, agrimophol (1), as a new disruptor of intrabacterial pH (pHIB) homeostasis in Mycobacterium tuberculosis (Mtb). Through the systematic investigation of the structure-activity relationship of 1, scaffold-hopping of the diphenylmethane scaffold, pharmacophore displacement strategies, and studies of the structure-metabolism relationship, a new derivative 5a was achieved. Compound 5a showed 100-fold increased potency in the ability to reduce pHIB to pH 6.0 and similarly improved mycobactericidal activity compared with 1 against both Mycobacterium bovis-BCG and Mtb. Compound 5a possessed improved metabolic stability in human liver microsomes and hepatocytes, lower cytotoxicity, higher selectivity index, and similar pKa value to natural 1. This study introduces a novel scaffold to an old drug, resulting in improved mycobactericidal activity through decreasing pHIB, and may contribute to the critical search for new agents to overcome drug resistance and persistence in the treatment of tuberculosis.

ACS Infectious Diseases published new progress about Blood proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (human). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Zhuying; Xie, Qigui; Chen, Zhanlei; Ni, Haibin; Xia, Liang; Zhao, Qiufeng; Chen, Zhiyun; Chen, Peifeng published the artcile< Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1-mediated epithelial-to-mesenchymal transition>, SDS of cas: 501-36-0, the main research area is MALAT EM resveratrol invasion migration human gastric cancer cell; epithelial-to-mesenchymal transition; gastric cancer; invasion; metastasis-associated lung adenocarcinoma transcript 1; migration; resveratrol.

Resveratrol, a natural polyphenolic phytoalexin, was reported to exert multiple anticancer effects as a traditional Chinese medicine. However, research regarding the anticancer mechanism of resveratrol for the treatment and prevention of gastric cancer has reported conflicting results. In the present study, it was determined that resveratrol inhibited cell viability in a dose-dependent manner in the human gastric cancer cell line BGC823. Cell migration and invasion were suppressed significantly following treatment with 200μM resveratrol. Addnl., resveratrol inhibited metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression, which was overexpressed in gastric cancer cells. Further experiments revealed that MALAT1 knockdown suppressed cell viability, migration, invasion and epithelial-to-mesenchymal transition in BGC823 cells. The present study indicated that resveratrol inhibited migration and invasion in human gastric cancer cells via suppressing MALAT1-mediated epithelial-to-mesenchymal transition, providing novel evidence for understanding the anticancer mechanism of resveratrol.

Experimental and Therapeutic Medicine published new progress about Cell invasion. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kavitha, B.; Sravanthi, M.; Saritha Reddy, P. published the artcile< DNA interaction, docking, molecular modelling and biological studies of o-Vanillin derived Schiff base metal complexes>, Related Products of 5344-90-1, the main research area is copper cobalt chromium zinc vanillin Schiff base complex preparation; transition metal Schiff base DNA binding ESR cytotoxic antimicrobial.

In the present studies, [Cu(ABOVL)] 1, [Co(ABOVL)] 2, [Cr(ABOVL)] 3, and [Zn(ABOVL)] 4 complexes were prepared where ABOVL is the condensation product of 2-hydroxy-3-methoxybenzaldehyde (o-Vanillin) and (2-aminophenyl)methanol (2-aminobenzylalc.). To characterize ABOVL and its metal complexes standard anal. and spectral techniques were employed. From the spectral data, ABOVL acts as a bi-dentate ligand with O, N as donor atoms and complex 1 exhibited square planar geometry and complexes 2, 3, and 4 exhibited octahedral geometries resp. DNA binding studies were performed using fluorescence, viscosity and absorption studies. The binding constant from absorption studies was 6.23 ± 0.04 × 104 M-1, 5.76 ± 0.03 × 104 M-1, 4.95 ± 0.07 × 104 M-1 and 4.12 ± 0.06 × 104 M-1 for 1, 2, 3 and 4 complexes resp., and Stern-Volmer quenching constant, KSV from fluorescence studies was 3.99 × 103 M-1, 3.21 × 103 M-1, 2.78 × 103 M-1 and 2.53 × 103 M-1 for 1, 2, 3 and 4 complexes resp. The above data signifies intercalative mode of binding of complexes to CT-DNA. Viscosity studies further revealed the binding of complexes to CT-DNA through intercalation. Nuclease studies of the complexes were carried out using supercoiled pUC19 DNA with hydrogen peroxide as an oxidant and the results were discussed. GOLO 3.1 program (software) was used for docking studies and the results showed that complexes can effective bind with active receptor protein of DNA topoisomerase I involving hydrogen bonding interactions and the results were discussed. Antimicrobial studies performed by disk diffusion method showed that the complexes possess higher anti-microbial activity than compared to ABOVL. In-vitro cytotoxic studies were performed for the synthesized complexes against selected cell lines by MTT assay where Complex 1 showed potential inhibitory efficiency with an IC50 of 49.13 μg/mL as compared to other complexes. Mol. modeling studies were carried out using Argus laboratory

Journal of Molecular Structure published new progress about Antibacterial agents. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Agatonovic-Kustrin, S.; Kustrin, E.; Gegechkori, V.; Morton, D. W. published the artcile< Anxiolytic Terpenoids and Aromatherapy for Anxiety and Depression>, Synthetic Route of 78-70-6, the main research area is review anxiolytic terpenoid aromatherapy anxiety depression; Anxiety; Aromatherapy; Depression; Essential oil; Terpenoids.

A review. In our society, anxiety and depression are serious health issues that affect a large proportion of the population. Unfortunately, drug therapies are not always effective and can lead to drug abuse, delay of therapeutic effect, dependence, and tolerance. Traditionally, aromatherapy has also been used for anxiety relief and mood improvement. The use of essential oils, in relieving anxiety and depression, does not have the disadvantages associated with currently used drug therapies. In-vivo studies on animal models have verified the anxiolytic effects of these essential oils and the interactions of their major components with central nervous system receptors. Therefore, it seems reasonable to argue that the modulation of glutamate and GABA neurotransmitter systems are likely to be the critical mechanisms responsible for the sedative, anxiolytic, and anticonvulsant proprieties of linalool and essential oils containing linalool in significant proportions. Popular anxiolytic essential oils are generally rich in terpenoid alcs. like linalool, geraniol and citronellol, and the monoterpene limonene (or citral). Therefore, other essential oils or formulations that contain these terpenoids as major components may serve as important aromatherapeutics for relief of anxiety.

Advances in Experimental Medicine and Biology published new progress about Anticonvulsants. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Synthetic Route of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts