Month: October 2022

《Nano-WO3-SO3H as a New Photocatalyst Insight Through Covalently Grafted Bronsted Acid: Highly Efficient Selective Oxidation of Benzyl Alcohols to Aldehydes》 was written by Hosseini, Saber; Amoozadeh, Ali; Akbarzadeh, Yasaman. Electric Literature of C7H7BrOThis research focused ontungsten oxide benzyl alc aldehyde Bronsted acid oxidation. The article conveys some information:

Modification of nano-WO3 with -SO3H groups as a covalently grafted solid acid reduced its band-gap energy from 2.8 to 2.4 eV and made it an ideal nominee for photocatalytic reaction under visible light irradiation This nano-photocatalyst has been successfully used for the selective oxidation of different benzyl alcs. to corresponding aldehydes under blue LED irradiation The reaction became approx. two times faster with excellent yields. It has shown that the nitrobenzene as an available industrial oxidant is applicable for photocatalytic oxidation of benzyl alc.; remarkably high yield and selectivity have been observed The experimental process involved the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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Alcohol – Wikipedia,
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《Novel two-chain fatty acid-based lipids for development of vancomycin pH-responsive liposomes against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA)》 was written by Makhathini, Sifiso S.; Kalhapure, Rahul S.; Jadhav, Mahantesh; Waddad, Ayman Y.; Gannimani, Ramesh; Omolo, Calvin A.; Rambharose, Sanjeev; Mocktar, Chunderika; Govender, Thirumala. SDS of cas: 534-03-2This research focused onvancomycin liposome drug delivery system Staphylococcus cancer; MRSA; Vancomycin; fatty acid-based lipids; pH-responsive liposome; targeted drug delivery. The article conveys some information:

The development of bacterial resistance against antibiotics is attributed to poor localization of lethal antibiotic dose at the infection site. This study reports on the synthesis and use of novel two-chain fatty acid-based lipids (FAL) containing amino acid head groups in the formulation of pH-responsive liposomes for the targeted delivery of vancomycin (VAN). The formulated liposomes were characterized for their size, polydispersity index (PDI), surface charge and morphol. The drug-loading capacity, drug release, cell viability, and in vitro and in vivo efficacy of the formulations were investigated. A sustained VAN release profile was observed and in vitro antibacterial studies against S. aureus and MRSA showed superior and prolonged activity over 72 h at both pH 7.4 and 6.0. Enhanced antibacterial activity at pH 6.0 was observed for the DOAPA-VAN-Lipo and DLAPA-VAN-Lipo formulations. Flow cytometry studies indicated a high killing rate of MRSA cells using DOAPA-VN-Lipo (71.98%) and DLAPA-VN-Lipo (73.32%). In vivo studies showed reduced MRSA recovered from mice treated with formulations by four- and two-folds lower than bare VN treated mice, resp. The targeted delivery of VAN can be improved by novel pH-responsive liposomes from the two-chain (FAL) designed in this study. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.SDS of cas: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Solvolytic Reactivity of Heptafluorobutyrates and Trifluoroacetates》 was written by Denegri, Bernard; Kronja, Olga. Name: (3-Chlorophenyl)(phenyl)methanol And the article was included in Journal of Organic Chemistry on August 21 ,2009. The article conveys some information:

X,Y-substituted benzhydryl heptafluorobutyrates and trifluoroacetates were subjected to solvolysis in various methanol/water, ethanol/water, and acetone/water mixtures at 25 °C. The LFER equation log k = sf(Ef + Nf) was used to derive the nucleofuge-specific parameters (Nf and sf) for SN1-type reaction. In comparison with TFA, the HFB leaving group is a better nucleofuge for <0.5 unit of Nf. X,Y-Substituted benzhydryl trifluoroacetates solvolyze by way of SN1 reactions unless electron-withdrawing groups are attached to aromatic rings. In such cases the substrates solvolyze faster than predicted for the SN1 route because of the change in mechanism. X,Y-Substituted benzhydryl heptafluorobutyrates examined here (Ef ≥ -7.7) solvolyze according to the SN1 pathway. The almost parallel log k vs. Ef lines in various solvents for HFBs and TFAs, and the corresponding slope parameters (sf are in the range of 0.91 and 0.83), indicate early TS with moderately advanced charge separation NBO charges of HFB and TFA anions and the affinities obtained, all calculated at the PCM-B3LYP/6-311+G(2d,p)//PCM-B3LYP/6-311+G(2d,p) level, revealed that the HFB anion slightly better delocalizes the developing neg. charge than TFA, and that the affinity of the benzhydrylium ion is slightly larger toward TFA than toward the HFB anion, which is in accordance with the greater solvolytic reactivity of HFB.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Name: (3-Chlorophenyl)(phenyl)methanol) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Name: (3-Chlorophenyl)(phenyl)methanol

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Alcohol – Wikipedia,
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《Towards Photochromic Azobenzene-Based Inhibitors for Tryptophan Synthase》 was written by Simeth, Nadja A.; Kinateder, Thomas; Rajendran, Chitra; Nazet, Julian; Merkl, Rainer; Sterner, Reinhard; Koenig, Burkhard; Kneuttinger, Andrea C.. HPLC of Formula: 156-87-6This research focused ontryptophan synthase inhibitor antibiotics photoresponsive; antibiotics; azo compounds; enzymes; inhibitors; photopharmacology. The article conveys some information:

Light regulation of drug mols. has gained growing interest in biochem. and pharmacol. research in recent years. In addition, a serious need for novel mol. targets of antibiotics has emerged presently. Herein, the development of a photocontrollable, azobenzene-based antibiotic precursor towards tryptophan synthase (TS), an essential metabolic multienzyme complex in bacteria, is presented. The compound exhibited moderately strong inhibition of TS in its E configuration and five times lower inhibition strength in its Z configuration. A combination of biochem., crystallog., and computational analyses was used to characterize the inhibition mode of this compound Remarkably, binding of the inhibitor to a hitherto-unconsidered cavity results in an unproductive conformation of TS leading to noncompetitive inhibition of tryptophan production In conclusion, we created a promising lead compound for combating bacterial diseases, which targets an essential metabolic enzyme, and whose inhibition strength can be controlled with light. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.HPLC of Formula: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《U(VI) adsorption onto covalent organic frameworks-TpPa-1》 was written by Li, Zhuo Dai; Zhang, Huai Qiang; Xiong, Xiao Hong; Luo, Feng. Related Products of 34374-88-4This research focused onuranium adsorption wastewater triformylphloroglucinol phenylenediamine covalent organic framework adsorbent. The article conveys some information:

Covalent organic frameworks (COFs) represent an exciting new type of porous organic materials, which are constructed with organic building units via strong covalent bonds. Here in, the COF-2,4,6-Triformylphloroglucinol p-Phenylenediamine (COF-TpPa-1) was synthesized by solvothermal method for the removal of U(VI) from aqueous solution Effects of pH, adsorption dose, contact time, uranium solution concentration, temperature and adsorption and desorption cycle on the efficiency of COF-TpPa-1 removal of U(VI) are investigated. SEM, XRD, TGA and FT-IR were employed to characterize the samples and analyze adsorption mechanism. The results manifested COF-TpPa-1 has the high adsorption capacity (qm = 152 mg/g), quick adsorption kinetic, high selectivity, outstanding recycle performance and good resistance to acids, bases and high temperature The experimental process involved the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Related Products of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Related Products of 34374-88-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn September 30, 2019 ,《Novel sugar based acrylate: synthesis, characterization and polymerization》 was published in Journal of Polymer Materials. The article was written by Koruyucu, Meryem; Saltan, Fehmi; Kok, Gokhan; Akat, Hakan; Salman, Yesim. The article contains the following contents:

The present study has demonstrated that novel acrylic glycopolymers are successfully prepared by using monosaccharides containing an acrylate group (9-12). For this purpose, sugar based acrylate monomers were synthesized via ring opening method (Method B) and homopolymerization of this sugar oxypropylacrylates was performed using free radical polymerization The characterization of all the monomers and polymers were verified by 1HNMR, 13CNMR, FTIR and GPC techniques. The Glass transition temperatures and thermal characteristics of the polymers were also analyzed by using DSC and TG techniques. The thermal stability of prepared polymers have changed with the stereochem. of the carbohydrate moiety. Also, the mol. weight of the polymers has affected the thermal stability. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
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Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn June 3, 2022, Yoshida, Tatsuki; Honda, Yuki; Morofuji, Tatsuya; Kano, Naokazu published an article in Journal of Organic Chemistry. The article was 《Transition-Metal-Free O-Arylation of Alcohols and Phenols with S-Arylphenothiaziniums》. The article mentions the following:

Herein, authors report the transition-metal-free O-arylation of alcs. and phenols with S-arylphenothiaziniums, which can be easily synthesized from boronic acids. Aryl substituents derived from arylboronic acids were selectively introduced into the hydroxy groups in alcs. and phenols, and a variety of aryl ethers were synthesized. This selectivity is supported by theor. calculations In addition to this study using ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, there are many other studies that have used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol) was used in this study.

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 6346-09-4On October 15, 2021 ,《Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach》 was published in Journal of Organic Chemistry. The article was written by Skrotzki, Eric A.; Vandavasi, Jaya Kishore; Newman, Stephen G.. The article contains the following contents:

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to overoxidize organic mols., including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time to achieve improved control and chemoselectivity over this challenging transformation. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C-H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.4,4-Diethoxybutan-1-amine(cas: 6346-09-4SDS of cas: 6346-09-4) was used in this study.

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.SDS of cas: 6346-09-4

Referemce:
Alcohol – Wikipedia,
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In 2015,Chemistry – A European Journal included an article by Kamikawa, Ken; Arae, Sachie; Wu, Wei-Yi; Nakamura, Chihiro; Takahashi, Tamotsu; Ogasawara, Masamichi. SDS of cas: 329735-68-4. The article was titled 《Simultaneous induction of axial and planar chirality in arene-chromium complexes by molybdenum-catalyzed enantioselective ring-closing metathesis》. The information in the text is summarized as follows:

1,3-Diisopropenyl-2-R-benzene ligands (Ar, R = 1-pyrrolyl, halo, methoxy, 1-indenyl, 1-naphthyl) in arenechromium allylphosphine complexes [(η6-Ar)Cr(CO)2(tBu2PCH2CH:CH2)] (1a-r) undergo asym. ring-closing metathesis between isopropenyl and allyl groups, catalyzed by molybdenum RCM catalysts, giving planar chiral arenechromium complexes with pendant phosphine, [(η6,κP-1-tBu2PCH2CH:CMe-2-R-3-isopropenylbenzene)Cr(CO)2] (2a-r), which, in the case of unsym. R groups, such as 1-indolyl or 1-naphthyl, also feature atropisomeric axial chirality of the arene-R bond. The molybdenum-catalyzed asym. ring-closing metathesis of the various Cs-sym. (π-arene)chromium substrates provides the corresponding bridged planar-chiral (π-arene)chromium complexes in excellent yields with up to >99 % ee. The axial chirality is retained even after the removal of the dicarbonylchromium fragment, and the chiral biaryl/heterobiaryl compounds are obtained with complete retention of the enantiopurity. The experimental part of the paper was very detailed, including the reaction process of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4SDS of cas: 329735-68-4)

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).SDS of cas: 329735-68-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Frontiers in Pharmacology included an article by Bouscary, Alexandra; Quessada, Cyril; Mosbach, Althea; Callizot, Noelle; Spedding, Michael; Loeffler, Jean-Philippe; Henriques, Alexandre. Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride. The article was titled 《Ambroxol hydrochloride improves motor functions and extends survival in a mouse model of familial amyotrophic lateral sclerosis》. The information in the text is summarized as follows:

Amyotrophic lateral sclerosis (ALS) is a multifactorial and fatal neurodegenerative disease. Growing evidence connects sphingolipid metabolism to the pathophysiol. of ALS. In particular, levels of ceramides, glucosylceramides, and gangliosides are dysregulated in the central nervous system and at the neuromuscular junctions of both animal models and patients. Glucosylceramide is the main precursor of complex glycosphingolipids that is degraded by lysosomal (GBA1) or non-lysosomal (GBA2) glucocerebrosidase. Here, we report that GBA2, but not GBA1, activity is markedly increased in the spinal cord, of SOD1G86R mice, an animal model of familial ALS, even before disease onset. We therefore investigated the effects of ambroxol hydrochloride, a known GBA2 inhibitor, in SOD1G86R mice. A presymptomatic administration of ambroxol hydrochloride, in the drinking water, delayed disease onset, protecting neuromuscular junctions, and the number of functional spinal motor neurons. When administered at disease onset, ambroxol hydrochloride delayed motor function decline, protected neuromuscular junctions, and extended overall survival of the SOD1G86R mice. In addition, ambroxol hydrochloride improved motor recovery and muscle re-innervation after transient sciatic nerve injury in non-transgenic mice and promoted axonal elongation in an in vitro model of motor unit. Our study suggests that ambroxol hydrochloride promotes and protects motor units and improves axonal plasticity, and that this generic compound is a promising drug candidate for ALS. In the experiment, the researchers used many compounds, for example, trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts