Month: October 2022

《Influence of catalyst nuclearity on copper-catalyzed aerobic alcohol oxidation》 was published in Dalton Transactions in 2020. These research results belong to Krittametaporn, Nuttaporn; Chantarojsiri, Teera; Virachotikul, Arnut; Phomphrai, Khamphee; Kuwamura, Naoto; Kojima, Tatsuhiro; Konno, Takumi; Sangtrirutnugul, Preeyanuch. Electric Literature of C7H7BrO The article mentions the following:

Reactions of CuX with the bis(triazolyl) ligand Hbtm [bis(1-benzyl-1H-1,2,3-triazol-4-yl)phenylmethanol] in CH2Cl2 afforded trinuclear copper(II) complexes with a core structure (μ-X)Cu3(μ-κ3-N,O,N-btm)3(L)2+ [X = Cl, L = CH3OH (1); X = Br, L = H2O (2)], while a similar reaction of [Cu(CH3CN)4](PF6) with the mono(triazolyl) ligand HPhtm [(1-benzyl-1H-1,2,3-triazol-4-yl)diphenylmethanol] resulted in the mononuclear complex [Cu(κ2-N,O-Phtm)(κ2-N,O-HPhtm)(κ1-N-HPhtm)][PF6] (3). The structural characterization of these complexes was made by single-crystal x-ray crystallog. in combination with elemental and ESI mass analyses. Catalytic studies toward aerobic oxidation of benzyl alc. to benzaldehyde revealed that the trinuclear 1 and 2 exhibited higher activities than the mononuclear 3 in both CH3CN and EtOH/H2O solvent systems. The experimental part of the paper was very detailed, including the reaction process of (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Photosensitized Intramolecular [2+2] Cycloaddition of 1H-Pyrrolo[2,3-b]pyridines Enabled by the Assistance of Lewis Acids》 was published in Journal of Organic Chemistry in 2020. These research results belong to Arai, Noriyoshi; Ohkuma, Takeshi. Recommanded Product: 7748-36-9 The article mentions the following:

The [2+2] photocycloaddition of alkenyl-tethered 1H-pyrrolo[2,3-b]pyridine derivatives sensitized with 3′,4′-dimethoxyacetophenone under irradiation by a high-pressure mercury lamp through Pyrex glass was dramatically accelerated by the addition of Lewis acids, preferably Mg(OTf)2, to give the products stereoselectively in high yields. The reaction without a Lewis acid gave only small amounts of the [2+2] cycloaddition products. Conformational fixation of the substrates by coordination with a Lewis acid was presumed to facilitate the cycloaddition In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Cyclometalated Ruthenium Pincer Complexes as Catalysts for the α-Alkylation of Ketones with Alcohols》 was published in Chemistry – A European Journal in 2020. These research results belong to Piehl, Patrick; Amuso, Roberta; Alberico, Elisabetta; Junge, Henrik; Gabriele, Bartolo; Neumann, Helfried; Beller, Matthias. Related Products of 100-55-0 The article mentions the following:

Ruthenium PNP pincer complexes bearing supplementary cyclometalated C,N-bound ligands have been prepared and fully characterized for the first time. By replacing CO and H- as ancillary ligands in such complexes, addnl. electronic and steric modifications of this topical class of catalysts are possible. The advantages of the new catalysts are demonstrated in the general α-alkylation of ketones with alcs. following a hydrogen autotransfer protocol. Herein, various aliphatic and benzylic alcs. were applied as green alkylating agents for ketones bearing aromatic, heteroaromatic or aliphatic substituents as well as cyclic ones. Mechanistic investigations revealed that during catalysis, Ru carboxylate complexes are predominantly formed whereas neither the PNP nor the CN ligand are released from the catalyst in significant amounts In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Related Products of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《One-Pot Generation of Functionalized Benzynes from Readily Available 2-Hydroxyphenylboronic Acids》 was written by Ikawa, Takashi; Sun, Jing Kai; Takagi, Akira; Akai, Shuji. Related Products of 89466-08-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A one-pot method for the generation of benzynes from a range of readily available 2-hydroxyphenylboronic acids 2-OH-3-R-4-R1-5-R2-C6HB(OH)2 (R = H, Me, F; R1 = H, F; R2 = H, F, CN, OCF3, etc.) was developed. This method features the in situ activation of both boronic acid and hydroxyl groups of the substrate to enhance benzyne generation at 60°C. Such mild conditions facilitate the generation of functionalized benzynes that immediately react with diverse arynophiles e.g., 1,3-diphenylisobenzofuran to produce multisubstituted fused benzenes e.g., 9,10-diphenyl-9,10-dihydro-9,10-epoxyanthracene. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Hybrid 3,4-dihydropyrimidin-2-(thi)ones as dual-functional bioactive molecules: fluorescent probes and cytotoxic agents to cancer cells》 was written by de Souza, Vanessa P.; Santos, Fabiano S.; Rodembusch, Fabiano S.; Braga, Carolyne B.; Ornelas, Catia; Pilli, Ronaldo A.; Russowsky, Dennis. Product Details of 100-83-4 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

A series of new hybrid fluorescent Biginelli compounds, including a Monastrol derivative, were designed and synthesized with good yields. The photophys. studies revealed dual fluorescence emission, attributed to excited enol forms (E*) and tautomeric (K*) species, resp., due to the ESIPT mechanism. The cytotoxic activity of all compounds was evaluated against MCF-7, Caco-2 and PC3 cancer cell lines and PNT2 normal prostate cells. The fluorescent Monastrol derivative 8f was the most active with cytotoxic activity very similar to cisplatin, whereas derivative 8c was the most selective towards the PC3 prostate cancer cells. The confocal laser scanning microscopy images of PC3 and MCF-7 cancer cell lines were acquired after incubation of the fluorescent Biginelli hybrids 8c and 8f, resp., demonstrating efficient cellular uptake of both compounds and strong fluorescence within the intracellular medium. These results show that the new hybrid 3,4-dihydropyrimidin-2-(thi)ones are dual-function bioactive compounds that act both as fluorescent probes and antineoplastic agents. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Product Details of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Product Details of 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iron-Catalyzed Direct Julia-Type Olefination of Alcohols》 was written by Landge, Vinod G.; Babu, Reshma; Yadav, Vinita; Subaramanian, Murugan; Gupta, Virendrakumar; Balaraman, Ekambaram. Synthetic Route of C6H7NO And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Herein, we report an iron-catalyzed, convenient, and expedient strategy for the synthesis of styrene and naphthalene derivatives with the liberation of dihydrogen. The use of a catalyst derived from an earth-abundant metal provides a sustainable strategy to olefins. This method exhibits wide substrate scope (primary and secondary alcs.) functional group tolerance (amino, nitro, halo, alkoxy, thiomethoxy, and S- and N-heterocyclic compounds) that can be scaled up. The unprecedented synthesis of 1-Me naphthalenes proceeds via tandem methenylation/double dehydrogenation. Mechanistic study shows that the cleavage of the C-H bond of alc. is the rate-determining step. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Synthetic Route of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Synthetic Route of C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases》 was written by Dang, Xiawei; Zhang, Lihong; Franco, Antonietta; Li, Jiajia; Rocha, Agostinho G.; Devanathan, Sriram; Dolle, Roland E.; Bernstein, Peter R.; Dorn, Gerald W.. Related Products of 27489-62-9 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Mutations in the mitochondrial fusion protein mitofusin (MFN) 2 cause the chronic neurodegenerative condition Charcot-Marie-Tooth disease type 2A (CMT2A), for which there is currently no treatment. Small-mol. activators of MFN1 and MFN2 enhance mitochondrial fusion and offer promise as therapy for this condition, but prototype compounds have poor pharmacokinetic properties. Herein, we describe a rational design of a series of 6-phenylhexanamide derivatives whose pharmacokinetic optimization yielded a 4-hydroxycyclohexyl analog, 13, with the potency, selectivity, and oral bioavailability of a preclin. candidate. Studies of 13cis- and trans-4-hydroxycyclohexyl isostereomers unexpectedly revealed functionality and protein engagement exclusively for the trans form, 13B(I). Preclin. absorption, distribution, metabolism, and excretion (ADME) and in vivo target engagement studies of 13B support further development of 6-phenylhexanamide derivatives as therapeutic agents for human CMT2A. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Understanding the molecular origin of shear thinning in associative polymers through quantification of bond dissociation under shear》 was written by Mahmad Rasid, Irina; Ramirez, Jorge; Olsen, Bradley D.; Holten-Andersen, Niels. Application In Synthesis of 3-Aminopropan-1-ol And the article was included in Physical Review Materials in 2020. The article conveys some information:

Understanding the physics of associative polymers is often limited by our inability to directly measure bond dissociation under deformation. In this work, we developed a rheo-fluorescence technique and applied it to characterize the nonlinear shear response of linear side-functionalized polymer chains crosslinked via nickel-terpyridine complexation. As the network was sheared, the fraction of dissociated bonds was quant. measured based upon a change in fluorescence with metal dissociation Shear thinning of the gel was accompanied by only a small increase in the fraction of dissociated bonds. Comparison with several transient network models shows that the shear thinning within the constraint of the measured fraction of dissociated bonds cannot be explained by classical theories that include retraction of dangling chains alone; the rheol. response likely involves alternative modes of stress relaxation. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application In Synthesis of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Application In Synthesis of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Photocatalytic C-X borylation of aryl halides by hierarchical SiC nanowire-supported Pd nanoparticles》 was written by Jiao, Zhi-Feng; Zhao, Ji-Xiao; Guo, Xiao-Ning; Guo, Xiang-Yun. COA of Formula: C12H17BO2 And the article was included in Chinese Journal of Catalysis in 2020. The article conveys some information:

Hierarchical SiC nanowire-supported Pd nanoparticles showed high photocatalytic activity for the C-X (X = Br, I) borylation of aryl halides at 30°C. The SiC/Pd Mott-Schottky contact enhances the rapid transfer of the photogenerated electrons from SiC to the Pd nanoparticles. As a result, the concentrated energetic electrons in the Pd nanoparticles can facilitate the cleavage of C-I or C-Br bonds, which normally requires high-temperature thermal processes. We show that the present Pd/SiC photocatalyst is capable of catalyzing the transformation of a large variety of aryl halides to their corresponding boronate esters under visible light irradiation, with excellent yields. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6COA of Formula: C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.COA of Formula: C12H17BO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Trifluoromethylselenolation and N-acylation of indoles with [Me4N][SeCF3]》 was written by Tan, Kai-Li; Wang, Hao-Nan; Dong, Tao; Zhang, Cheng-Pan. Name: Oxetan-3-ol And the article was included in Organic & Biomolecular Chemistry in 2021. The article conveys some information:

An efficient method for oxidative trifluoromethylselenolation/N-acylation of indoles with excess [Me4N][SeCF3] in the presence of acyl peroxides and their derivatives is described. The reaction is easy to handle, proceeds smoothly at room temperature under metal-free conditions, and shows advantages such as good functional group tolerance, excellent regioselectivity, and compatibility of a number of substrates, producing 1-acyl and 3-trifluoromethylselanyl substituted indoles I (R1 = H, 5-CN, 4-Cl, etc.; R2 = H, Me; Ar = Ph, 3-ClC6H4, 4-FC6H4, etc.) in good yields. Acyl peroxides and peroxycarboxylic acid behave as both oxidants and acyl sources in the transformation. This one-pot procedure provides a convenient access to a new class of indole derivatives, representing the first trifluoromethylselanyl bifunctionalization of indoles with the nucleophilic [Me4N][SeCF3] reagent. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts