Month: October 2022

《Palladium-Catalyzed Para-Selective Difluoromethylation of Arene Esters》 was written by Tu, Guangliang; Wang, Dongjie; Yuan, Chunchen; Zhang, Jingyu; Zhao, Yingsheng. Product Details of 2240-88-2 And the article was included in Journal of Organic Chemistry on August 21 ,2020. The article conveys some information:

Highly efficient, palladium-catalyzed, para-selective difluoromethylation of arene esters has been developed using [1,1′-biphenyl-2-yl]dicyclohexylphosphine as the effective ligand. A wide variety of arene esters bearing various functional groups were all compatible with the reaction conditions, leading to para-difluoromethylated products in moderate to good yields. Moreover, benzamide and benzenesulfonamide were also well-tolerated, suggesting that this novel catalyst system has broad applications to a variety of substrates. The experimental process involved the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Product Details of 2240-88-2)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Product Details of 2240-88-2

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《Probing the Edges between Stability and Degradation of a Series of ZnSe-Based Layered Hybrid Semiconductors》 was written by Yan, Mengwen; Myers, Christopher A.; John, Gregory M.; Meyers, Vincent E.; Chen, Alan A.; Feldblyum, Jeremy I.. Name: 4-Aminobutan-1-olThis research focused onzinc selenium layered hybrid semiconductor degradation density functional theory. The article conveys some information:

The discovery of layered materials with potentially unique elec. and chem. properties has become a major focus of materials research in the past decade. 2D II-VI layered hybrids (LHs) are a family of ligand-protected layered materials capable of isolation in few-layer form and possess emissive and electronic properties of potential relevance to semiconductor device technologies. The authors showed previously that, akin to black phosphorus and transition metal dichalcogenides, 2D II-VI LHs are sensitive to ambient atm. conditions. However, the causes for degradation of these ligand-protected materials remain unclear. Using ZnSe-based LHs, it is shown herein that the stability of these materials is related to the length and chem. of the organic ligands coordinated to the LH surfaces. Furthermore, exposure to isotopically enriched H218O and 18O2 reveals that H2O and O2 are both reactants contributing to ZnSe-LH degradation An H2O-initiated degradation pathway is proposed and is supported by d. functional theory calculations The findings contribute to the discovery of protection strategies for layered materials and elucidate a degradation pathway that may also be applicable to other layered materials.4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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《Regioselective C(sp3)-H alkylation of a fructopyranose derivative by 1,6-HAT》 was published in Organic & Biomolecular Chemistry in 2021. These research results belong to Li, Yanru; Miyamoto, Shoto; Torigoe, Takeru; Kuninobu, Yoichiro. Recommanded Product: 20880-92-6 The article mentions the following:

Regioselective C(sp3)-H alkylation of a fructopyranose derivative using electron-deficient alkenes as alkylation reagents was achieved. The reaction proceeded via 1,6-hydrogen atom transfer under photoredox iridium catalysis. Several functional groups were introduced into the fructopyranose derivative The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Recommanded Product: 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Recommanded Product: 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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《Synthesis of the C50 diastereomers of the C33-C51 fragment of stambomycin D》 was published in Organic Chemistry Frontiers in 2022. These research results belong to Wang, Yongchen; Chintalapudi, Venkaiah; Gudmundsson, Haraldur G.; Challis, Gregory L.; Anderson, Edward A.. Formula: C3H6O2 The article mentions the following:

Herein, syntheses of the two C50 diastereomers of the C33-C51 region of the stambomycins I and II, which support the polyketide synthase-based configurational assignment were described, and established a strategy suitable for access to the extended stambomycin framework. The experimental part of the paper was very detailed, including the reaction process of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Formula: C3H6O2)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Formula: C3H6O2

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Application of 54-17-1On October 31, 2020 ,《New caryophyllene-type sesquiterpene and flavonol tetraglycoside with sixteen known compounds from sword bean (Canavalia gladiata)》 was published in Food Science and Biotechnology. The article was written by An, Hyun Jeong; Kim, Eun Hee; Lee, Hyoung Jae; Cho, Jeong-Yong; Moon, Jae-Hak. The article contains the following contents:

Eighteen compounds including new caryophyllene-type sesquiterpene and flavonol tetraglycoside were purified and isolated from sword beans (Canavalia gladiata). Two new compounds, (Z,1R,7S,9S)-7-hydroxy-11,11-dimethyl-8-methylenebicyclo[7.2.0]undec-4-ene-4-carboxylic acid (2) and kaempferol-7-O-α-L-dirhamnopyranosyl(1 → 2;1 → 6)-O-β-D-glucopyranosyl(1 → 2)-O-α-L-rhamnopyranoside (9), were identified. Other known compounds including Me gallate (1), (2S,3S,4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol 1-O-β-D-glucopyranoside (3), (2S,3S,4E,8Z)-2-aminooctadeca-4,8-diene-1,3-diol 1-O-β-D-glucopyranoside (4), lupeol (5), trilinolein (6), 1,6-di-O-galloyl β-D-glucopyranoside (7), N-(2-methoxybenzoyl)homoserine (8), dihydrophaseic acid (10), dillenetin (11), kaempferol-7-O-[2-O-β-D-glucopyranosyl-6-O-α-L-rhamnopyranosyl]-α-L-rhamnopyranoside (12), canavalioside (13), kaempferol-3-O-[2-O-β-D-glucopyranosyl-6-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (14), kaempferol-3-O-(2,6-O-α-L-dirhamnopyranosyl)-β-D-glucopyranoside (15), kaempferol-3-O-rutinoside (16), gladiatoside A1 (17), and gladiatoside B1 (18) were identified. The chem. structures of these compounds were determined by ESI-MS and NMR analyses. In the experiment, the researchers used many compounds, for example, rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Application of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Application of 54-17-1

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Product Details of 63012-03-3On November 30, 2021 ,《Regio- and Stereoselective Synthesis of (Z)- 3-Ylidenephthalides via H3PMo12O40-Catalyzed Cyclization of 2-Acylbenzoic Acids with Benzylic Alcohols》 appeared in Chinese Journal of Chemistry. The author of the article were Yang, Guoping; Li, Ke; Lin, Xiaoling; Li, Yijin; Cui, Chengxing; Li, Shixiong; Cheng, Yuanyuan; Liu, Yufeng. The article conveys some information:

Author report an exclusively tandem C-O and C-C bond forming beyond the esterification and cyclization reaction of 2-acylbenzoic acids with alcs. to regio- and stereoselective synthesis of the (Z)-3-ylidenephthalides. The reaction uses the nontoxic, inexpensive H3PMo12O40 as catalyst and produces water as the sole byproduct, making the reaction environmentally benign and sustainable. Moreover, this reaction features an eco-friendly reaction condition, facile scalability, and easy derivatization of the products to drugs and bioactive compounds The mechanism studies and d. functional theory calculations reveal that the appropriate acid catalyst is the key to the selectivity of this transformation. The experimental part of the paper was very detailed, including the reaction process of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Product Details of 63012-03-3

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Recommanded Product: 76931-93-6On November 1, 2021 ,《Generation and characterisation of a semi-synthetic siderophore-immunogen conjugate and a derivative recombinant triacetylfusarinine C-specific monoclonal antibody with fungal diagnostic application》 appeared in Analytical Biochemistry. The author of the article were Moloney, Nicola M.; Larkin, Annemarie; Xu, Linan; Fitzpatrick, David A.; Crean, Holly L.; Walshe, Kieran; Haas, Hubertus; Decristoforo, Clemens; Doyle, Sean. The article conveys some information:

Invasive pulmonary aspergillosis (IPA) is a severe life-threatening condition. Diagnosis of fungal disease in general, and especially that caused by Aspergillus fumigatus is problematic. A. fumigatus secretes siderophores to acquire iron during infection, which are also essential for virulence. We describe the chemoacetylation of ferrated fusarinine C to diacetylated fusarinine C (DAFC), followed by protein conjugation, which facilitated triacetylfusarinine C (TAFC)-specific monoclonal antibody production with specific recognition of the ferrated form of TAFC. A single monoclonal antibody sequence was ultimately elucidated by a combinatorial strategy involving protein LC-MS/MS, cDNA sequencing, and RNAseq. The resultant murine IgG2a monoclonal antibody was secreted in, and purified from, mammalian cell culture (5 mg) and demonstrated to be highly specific for TAFC detection by competitive ELISA (detection limit: 15 nM) and in a lateral flow test system (detection limit: 3 ng), using gold nanoparticle conjugated-DAFC-bovine serum albumin for competition. Overall, this work reveals for the 1st time a recombinant TAFC-specific monoclonal antibody with diagnostic potential for IPA diagnosis in traditional and emerging patient groups (e.g., COVID-19) and presents a useful strategy for murine Ig sequence determination, and expression in HEK293 cells, to overcome unexpected limitations associated with aberrant or deficient murine monoclonal antibody production In addition to this study using 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate, there are many other studies that have used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Recommanded Product: 76931-93-6) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Recommanded Product: 76931-93-6

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Chapuis, Christian; Buchi, George H.; Wuest, Hans published their research in Helvetica Chimica Acta on December 23 ,2005. The article was titled 《Synthesis of cis-Hedione and methyl jasmonate via cascade Baylis-Hillman reaction and Claisen ortho ester rearrangement》.Product Details of 329735-68-4 The article contains the following contents:

The exocyclically unsaturated conjugated keto esters I (R = n-Bu, n-hexyl, PhCH2OCH2, etc., R1 = Me, Et), obtained via a Claisen ortho ester rearrangement of the allylic hydroxy ketones II, were either directly hydrogenated or partially isomerized into the endocyclically unsaturated tetrasubstituted didehydrojasmonoid intermediates III, prior to a more selective hydrogenation with Pd/C in cyclohexane to the disubstituted oxocyclopentaneacetates IV. The key intermediates II were obtained either by a four-step sequence, including acetal protection/deprotection from enone V, in the specific case of hydroxy ketone II (R = n-Bu), or more directly and generally by a Baylis-Hillman reaction from cyclopent-2-en-1-one and the appropriate aldehydes RCHO. The judicious choice of these aldehydes opens versatile modifications for the stereoselective introduction of the partially cis- or epimerized trans-C(2) jasmonoid side chain, while the Baylis-Hillman reaction, catalyzed by chiral [1,1′-binaphthalene]-2,2′-diols (BINOLs), may be efficiently conducted in a one-pot cascade fashion including the ortho ester Claisen rearrangement.(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Product Details of 329735-68-4) was used in this study.

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).Product Details of 329735-68-4

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In 2011,Organic & Biomolecular Chemistry included an article by Nie, Yao; Xiao, Rong; Xu, Yan; Montelione, Gaetano T.. Related Products of 133082-13-0. The article was titled 《Novel anti-Prelog stereospecific carbonyl reductases from Candida parapsilosis for asymmetric reduction of prochiral ketones》. The information in the text is summarized as follows:

The application of biocatalysis to the synthesis of chiral mols. is one of the greenest technologies for the replacement of chem. routes due to its environmentally benign reaction conditions and unparalleled chemo-, regio- and stereoselectivities. We have been interested in searching for carbonyl reductase enzymes and assessing their substrate specificity and stereoselectivity. We now report a gene cluster identified in Candida parapsilosis that consists of four open reading frames including three putative stereospecific carbonyl reductases (scr1, scr2, and scr3) and an alc. dehydrogenase (cpadh). These newly identified three stereospecific carbonyl reductases (SCRs) showed high catalytic activities for producing (S)-1-phenyl-1,2-ethanediol from 2-hydroxyacetophenone with NADPH as the coenzyme. Together with CPADH, all four enzymes from this cluster are carbonyl reductases with novel anti-Prelog stereoselectivity. SCR1 and SCR3 exhibited distinct specificities to acetophenone derivatives and chloro-substituted 2-hydroxyacetophenones, and especially very high activities towards Et 4-chloro-3-oxobutyrate, a β-ketoester with important pharmaceutical potential. Our study also showed that genomic mining is a powerful tool for the discovery of new enzymes. In the part of experimental materials, we found many familiar compounds, such as (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Related Products of 133082-13-0)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Related Products of 133082-13-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Liu, Xiaocui; Zhang, Zhicai; Xu, Ling; Shi, Wenjing; Sun, Quanshan; Ding, Chongyang; Zheng, Huihua; Wang, Feng published an article in LWT–Food Science and Technology. The title of the article was 《Dioscorea saponin transforms the structure of truffle exo-polysaccharide and enhances its antioxidant activity》.COA of Formula: C6H12O6 The author mentioned the following in the article:

Dioscorea saponin (DS) can increase the exo-polysaccharide production of Tuber melanosporum. In the present study, we assessed the effect of DS on the structure and antioxidant activity of exo-polysaccharide. In the absence of DS, only one exo-polysaccharide (TP1) composed of mannose, rhamnose and glucose was isolated. However, two exo-polysaccharides (STP1 and STP2) were isolated in the presence of DS. STP1 was composed of glucose, galactose and arabinose, and STP2 consisted of rhamnose, glucose, galactose and arabinose. The skeletal structure of TP1, STP1 and STP2 was composed of α-D-glucopyranose. The antioxidant activity of exo-polysaccharide exhibited a concentration-dependent manner. The DPPH radical-scavenging rate (61.37%) and total antioxidant activity (50.02%) of STP were higher compared with TP1. The STP increased the DPPH radical-scavenging rate depending on the increase of the maximum rate of the reaction at saturating substrate concentrations (kcat), while STP increased the reducing power depending on the kcat and affinity of substrate to STP. The inhibitory action of STP on hydroxyl radical generation depended on the blockage of Fe2+ by STP, making it unable to react with H2O2 to form ·OH, and STP could bind to the Fe2+- H2O2 complex and prevent the Fe2+ from turning H2O2 into product. In the part of experimental materials, we found many familiar compounds, such as rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1COA of Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.COA of Formula: C6H12O6

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