Month: October 2022

《In Situ-Generated Halogen-Bonding Complex Enables Atom Transfer Radical Addition (ATRA) Reactions of Olefins》 was written by Matsuo, Kazuki; Yamaguchi, Eiji; Itoh, Akichika. Application of 821-41-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Although organic-based photocatalysts provide an inexpensive, environmentally friendly alternative, many are incapable of absorption within the visible wavelength range; this ultimately influences their effectiveness. Photocatalytic reactions usually proceed via single electron transfer (SET) or energy transfer (ET) processes from the photoexcited mols. to the various substrates. In our study, the carbohalogenation of olefins was accomplished by combining CBr4 and 4-phenylpyridine under irradiation The atom transfer radical addition reaction of olefins was catalyzed by an in situ-formed photocatalyst via halogen bonding to afford a variety of products in moderate to good yields. Essential to the reaction is the formation of a CT complex with the haloalkane, which triggers charge separation processes and, ultimately, leads to the formation of the C-centered radical. While taking advantage of relatively inexpensive, readily available, and environmentally friendly reagents, the indirect activation of the substrate via the photoexcited catalyst paves the way for more efficient routes, especially for otherwise challenging chem. syntheses. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0Application of 821-41-0) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Application of 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Hypervalent Iodine(III)-Promoted Rapid Cascade Reaction of Quinoxalinones with Unactivated Alkenes and TMSN3》 was written by Shen, Jiabin; Xu, Jun; Huang, Lin; Zhu, Qing; Zhang, Pengfei. Product Details of 821-41-0 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

The first example of rapidly three-component cascade reaction of quinoxalinones I (R1 = 6-OCH3, 6,7-(CH3)2, 7-Br, etc.; R2 = H, CH3, CH2C6H5, cyclohexylmethyl, etc.) with unactivated alkenes R3R4C=CHR5 (R3 = R4 = R5 = Me; R3 = n-Pr, R4 = R5 = H; R4 = H; R3R5 = -(CH2)4-, etc.) and TMSN3 under mild condition has been described. This approach provides a practical solution for the rapid modification of quinoxalinones and enables new planning strategies for the synthesis of bioactive organoazides II. A radical mechanism is responsible for this three-component transformation. In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Product Details of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Product Details of 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis and catalytic activity of cationic dinuclear palladium(II) complexes supported by thioether ligands containing two di-(2-picolyl) amine arms》 was written by Sandoval-Chavez, Cesar Ignacio; Velazquez-Jimenez, Rene; Martinez-Otero, Diego; Salazar-Pereda, Veronica; Andrade-Lopez, Noemi; Gonzalez-Montiel, Simplicio. Category: alcohols-buliding-blocks And the article was included in Polyhedron in 2020. The article conveys some information:

The design, synthesis and characterization of a series of dithioether ligands featuring two di-(2-picolyl)amine arms (2a-2d) and their corresponding cationic dinuclear palladium(II) complexes (3a-d) are reported. Crystal structures of ligand 2b and complexes 3b and 3d were determined by x-ray diffraction studies. The mol. structures of 3b and 3d display each of the two di-(2-picolyl)amine fragments coordinated to one palladium(II) atom in a (κ3-N,N,N) tridentate fashion and with the cationic metal centers displaying square-planar geometries. Weak interactions between the metal centers and the thioether fragments are observed All bimetallic complexes 3a-d were tested as catalytic precursors in the Suzuki couplings of different o- or p-substituted iodo- or bromoaryls with boronic acids. The overall catalytic results indicate that complex 3b is the best precursor of the series demonstrating even more efficient performance compared to com. palladium sources such as Pd(OAc)2 and the Najera Catalysts. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Category: alcohols-buliding-blocks) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Nanoparticle depots for controlled and sustained gene delivery》 was written by Li, Zhongyu; Ho, William; Bai, Xin; Li, Fengqiao; Chen, Yen-jui; Zhang, Xue-Qing; Xu, Xiaoyang. Safety of 4-Aminobutan-1-ol And the article was included in Journal of Controlled Release in 2020. The article conveys some information:

Gene therapy is one of the most promising medical fields which holds the potential to rapidly advance the treatment of difficult ailments such as cancer as well as inherited genetic diseases. However, clin. translation is limited by several drug delivery hurdles including renal clearance, phagocytosis, enzymic degradation, protein absorption, as well as cellular internalization barriers. Addnl., successful treatments require sustained release of drug payloads to maintain the effective therapeutic level. As such, controlled and sustained release is a significant concern as the localization and kinetics of nucleic acid therapeutics can significantly influence the therapeutic efficacy. This is an unmet need which calls for the development of controlled-release nanoparticle (NP) technologies to further improve the gene therapy efficacy by prolonging the release of nucleic acid drug payload for sustained, long-term gene expression or silencing. Herein, we present a polymeric NP system with sustained gene delivery properties, which can be synthesized using biodegradable and biocompatible polymers via self-assembly. The NP delivery system is composed of a polymeric NP which acts as a drug depot encapsulating cationic polymer/nucleic acid complexes, facilitating the enhanced retention and prolonged release of the gene payload. The NPs showed excellent cellular biocompatibility and gene delivery efficacy using the green fluorescent protein (GFP) encoded DNA plasmid (pGFP) as a reporter gene. Sustained release of the pGFP payload was shown over a period of 8 days. The physicochem. properties such as morphol., particle size, zeta potential, pGFP encapsulation efficiency and biol. properties such as pGFP release profile, in vitro cytotoxicity and transfection efficacy in Hek 293 cells were characterized and evaluated. Importantly, the NP-mediated sustained release of pGFP generates enhanced GFP expression over time. We expect this NP-mediated gene delivery system to provide safe and sustained release of various nucleic acid-based therapeutics with applications in both fundamental biol. studies and clin. translations. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Safety of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Desai, Nisheeth C.; Jadeja, Krunalsinh A.; Jadeja, Dharmpalsinh J.; Khedkar, Vijay M.; Jha, Prakash C. published their research in Synthetic Communications in 2021. The article was titled 《Design, synthesis, antimicrobial evaluation, and molecular docking study of some 4-thiazolidinone derivatives containing pyridine and quinazoline moiety》.Application In Synthesis of 3-Hydroxybenzaldehyde The article contains the following contents:

A series of 5-aryl-3-(4-oxo-2-phenylquinazolin-3(4H)-yl)-2-(pyridin-4-yl)thiazolidin-4-ones I (R = H, 3-Me, 4-F, etc.) were synthesized and evaluated for their antibacterial and antifungal activities. The title compounds showed good to excellent inhibition potency for resp. Gram-pos. bacterial strains and Gram-neg. bacterial strains. These compounds exhibited a broad spectrum of inhibitory activity. Mol. docking studies against microbial DNA gyrase sub unit B could provide valuable insights into the binding affinity of these mols. and their plausible mechanism of antimicrobial action. Most of the compounds exhibited excellent activity against bacterial and fungal strains resp. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application In Synthesis of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Jinfeng; Ren, Yali; Ma, Jiaqi; Luo, Xi; Li, Jiaxin; Wu, Yihan; Gu, Huan; Fu, Chaomei; Cao, Zhixing; Zhang, Jinming published their research in Journal of Nanobiotechnology in 2021. The article was titled 《Novel CD44-targeting and pH/redox-dual-stimuli-responsive core-shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis》.Synthetic Route of C4H11NO The article contains the following contents:

The toxicity and inefficient delivery of triptolide (TPL) in tumor therapy have greatly limited the clin. application. Thus, we fabricated a CD44-targeting and tumor microenvironment pH/redox-sensitive nanosystem composed of hyaluronic acid-vitamin E succinate and poly (β-amino esters) (PBAEss) polymers to enhance the TPL-mediated suppression of breast cancer proliferation and lung metastasis. The generated TPL nanoparticles (NPs) had high drug loading efficiency (94.93% ± 2.1%) and a desirable average size (191 nm). Mediated by the PBAEss core, TPL/NPs displayed a pH/redox-dual-stimuli-responsive drug release profile in vitro. Based on the hyaluronic acid coating, TPL/NPs exhibited selective tumor cellular uptake and high tumor tissue accumulation capacity by targeting CD44. Consequently, TPL/NPs induced higher suppression of cell proliferation, blockage of proapoptotic and cell cycle activities, and strong inhibition of cell migration and invasion than that induced by free TPL in MCF-7 and MDA-MB-231 cells. Importantly, TPL/NPs also showed higher efficacy in shrinking tumor size and blocking lung metastasis with decreased systemic toxicity in a 4T1 breast cancer mouse model at an equivalent or lower TPL dosage compared with that of free TPL. Histol. immunofluorescence and immunohistochem. analyses in tumor and lung tissue revealed that TPL/NPs induced a high level of apoptosis and suppressed expression of matrix metalloproteinases, which contributed to inhibiting tumor growth and pulmonary metastasis. Collectively, our results demonstrate that TPL/NPs, which combine tumor active targeting and pH/redox-responsive drug release with proapoptotic and antimobility effects, represent a promising candidate in halting breast cancer progression and metastasis while minimizing systemic toxicity. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Synthetic Route of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Synthetic Route of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brantley, Timothy J.; Mitchelson, Fernie G.; Khattak, Sarwat F. published their research in Biotechnology Progress in 2021. The article was titled 《A class of low-cost alternatives to kifunensine for increasing high mannose N-linked glycosylation for monoclonal antibody production in Chinese hamster ovary cells》.Recommanded Product: 534-03-2 The article contains the following contents:

N-linked glycosylation of therapeutic monoclonal antibodies is an important product quality attribute for drug safety and efficacy. An increase in the percent of high mannose N-linked glycosylation may be required for drug efficacy or to match the glycosylation profile of the innovator drug during the development of a biosimilar. In this study, the addition of several chem. additives to a cell culture process resulted in high mannose N-glycans on monoclonal antibodies produced by Chinese hamster ovary (CHO) cells without impacting cell culture performance. The additives, which include known mannosidase inhibitors (kifunensine and deoxymannojirimycin) as well as novel inhibitors (tris, bis-tris, and 1-amino-1-methyl-1,3-propanediol), contain one similar mol. structure: 2-amino-1,3-propanediol, commonly referred to as serinol. The shared chem. structure provides insight into the binding and inhibition of mannosidase in CHO cells. One of the novel inhibitors, tris, is safer compared to kifunensine, 35x as cost-effective, and stable at room temperature In addition, tris and bis-tris provide multiple low-cost alternatives to kifunensine for manipulating glycosylation in monoclonal antibody production in a cell culture process with minimal impact to productivity or cell health. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Recommanded Product: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jonsson, Helgi Freyr; Orthaber, Andreas; Fiksdahl, Anne published their research in Dalton Transactions in 2021. The article was titled 《Studies on gold(I) and gold(III) alcohol functionalised NHC complexes》.Recommanded Product: 126456-43-7 The article contains the following contents:

Five pairs of novel chiral alc. functionalized gold(I) and gold(III) NHC complexes derived from chiral amino alcs., were synthesized and characterized (NMR, IR, HRMS). Single crystal x-ray diffraction data of gold(I) and gold(III) complexes are reported and discussed. The chiral imidazolium preligands were readily synthesized via the oxalamides, subsequent reduction and final orthoformate condensation. An improved method was used for generation of gold(I) NHC complexes (up to 92%) and further oxidation afforded the corresponding gold(III) NHC complexes (up to 99%). All the Au(I) and Au(III) NHC complexes proved far more catalytically active in a 1,6-enyne alkoxycyclization test reaction than our previously tested N,N- and P,N-ligated Au(III) complexes. Comparative gold(I) and gold(III) catalytic studies demonstrated different catalytic ability, depending on the NHC ligand flexibility and bulkiness. Excellent yields (92-99%) of target alkoxycyclization product were obtained with both gold(I) and gold(III) complexes with the bulky N1-Mes-N2-ethanol based NHC ligand. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Lianghan; Li, Zhaoting; Liu, Ning; Sun, Honghao; Wang, Yixin; Sun, Minjie published their research in Advanced Functional Materials in 2021. The article was titled 《Dynamically Deformable Protein Delivery Strategy Disassembles Neutrophil Extracellular Traps to Prevent Liver Metastasis》.HPLC of Formula: 534-03-2 The article contains the following contents:

Neutrophil extracellular traps (NETs), consisting of chromatin DNA filaments coated with granule proteins, promote metastasis by enhancing tumor cell migration to distant organs. Recent studies indicate that NETs adhere to cancer cell membranes and enhance cell motility significantly to induce liver metastasis in patients with breast and colon cancers. Herein, a dynamically deformable protein delivery strategy is developed to prevent liver metastasis by disassembling NETs. Specifically, poly amino acid conjugating with polyethylene glycol (PAAP) is explored and synthesized for DNase-1 delivery. Notably, PAAP/DNase-1 degrades chromatin to induce apoptosis, followed by cell membrane rupture and remaining DNase-1 releases to the extracellular. More importantly, the released DNase-1 disassembles NET-DNA to prevent liver metastasis induced by NET. In all, PAAP/DNase-1 treatment not only suppresses tumor growth by degrading intracellular chromatin, but also prevents the liver metastasis by disassembling the NET-NDA. This strategy may provide brand-new inspiration to prevent the liver metastasis fundamentally in patients with metastatic colon and breast cancer. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Fengqian; Ai, Han-Jun; Wu, Xiao-Feng published an article in 2021. The article was titled 《Radical Carbonylation under Low CO Pressure: Synthesis of Esters from Activated Alkylamines at Transition Metal-Free Conditions》, and you may find the article in Chinese Journal of Chemistry.Product Details of 100-55-0 The information in the text is summarized as follows:

High CO pressure (> 40 bar) is usually needed in radical carbonylation reactions in the absence of metal catalyst. In this communication, a transition-metal-free radical carbonylation of activated alkylamines with phenols and alcs. under low CO pressure (1-6 bar) was developed. Various esters were obtained in moderate to excellent yields under simple reaction conditions with good functional group compatibility. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Product Details of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts