Month: October 2022

Laengle, D.; Wesseler, F.; Floetgen, D.; Leek, H.; Plowright, A. T.; Schade, D. published the artcile< Unique photoaffinity probes to study TGFβ signaling and receptor fates>, COA of Formula: C4H8N2O, the main research area is dihydropyridine annulated preparation transforming growth factor beta pharmacophore SAR.

A novel synthetic approach is used to prepare a diverse set of “”first-in-class”” dihydropyridine-based TGFβ receptor degraders bearing photoaffinity labels. These probes serve as valuable tools to study TGFβ receptor fates and dynamics – an important challenge in chem. biol.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dihydropyridines Role: DGN (Diagnostic Use), PAC (Pharmacological Activity), PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, COA of Formula: C4H8N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Panda, Chakadola; Doyle, Lorna M.; Gericke, Robert; McDonald, Aidan R. published the artcile< Rapid Iron(III)-Fluoride-Mediated Hydrogen Atom Transfer>, Product Details of C19H16O, the main research area is pyridylmethylamine iron fluoride preparation oxidant hydrogen atom transfer; crystal mol structure pyridylmethylamine iron fluoride; hydrocarbon oxidative carbon hydrogen activation kinetics pyridylmethylamine iron fluoride; biomimetic chemistry; fluoride oxidant; high-valent oxidants; nonheme iron; proton-coupled electron transfer.

Authors anticipate high-valent metal-fluoride species will be highly effective hydrogen atom transfer (HAT) oxidants because of the magnitude of the H-F bond (in the product) that drives HAT oxidation They prepared a dimeric FeIII(F)-F-FeIII(F) complex (1) by reacting [FeII(NCCH3)2(TPA)](ClO4)2 (TPA = tris(2-pyridylmethyl)amine) with difluoro(phenyl)-λ3-iodane (difluoroiodobenzene). 1 Was a sluggish oxidant, however, it was readily activated by reaction with Lewis or Broensted acids to yield a monomeric [FeIII(TPA)(F)(X)]+ complex (2) where X = F/OTf. 1 And 2 were characterized using NMR, EPR, UV/Vis, and FT-IR spectroscopies and mass spectrometry. 2 Was a remarkably reactive FeIII reagent for oxidative C-H activation, demonstrating reaction rates for hydrocarbon HAT comparable to the most reactive FeIII and FeIV oxidants.

Angewandte Chemie, International Edition published new progress about Activation energy. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Balamurugan, Gunasekaran; Balaji, Sundarraman; Ramesh, Rengan; Bhuvanesh, Nattamai S. P. published the artcile< Synthesis and Structures of Arene Ruthenium (II)-NHC Complexes: Efficient Catalytic α-alkylation of ketones via Hydrogen Auto Transfer Reaction>, Formula: C7H9NO, the main research area is arene ruthenium heterocyclic compound complex preparation; aryl alkyl ketone alkanol ruthenium catalyst chemoselective alkylation; alkyl aryl ketone preparation; hydroxymethyl aniline ketone ruthenium catalyst heterocyclization; quinoline preparation.

A panel of six new arene Ru (II)-NHC complexes (NHC = 1,3-diethyl-(5,6-dimethyl)benzimidazolin-2-ylidene, 1,3-dicyclohexylmethyl-(5,6-dimethyl)benzimidazolin-2-ylidene and 1,3-dibenzyl-(5,6-dimethyl)benzimidazolin-2-ylidene) were synthesized from the transmetallation reaction of Ag-NHC with [(η6-arene)RuCl2]2 and characterized. The ruthenium (II)-NHC complexes were developed as effective catalysts for α-alkylation of ketones and synthesis of bioactive quinoline using primary/amino alcs. as coupling partners resp. The reactions were performed with 0.5 mol% catalyst load in 8 h under aerobic condition and the maximum yield was up to 96%. Besides, the different alkyl wingtips on NHC and arene moieties were studied to differentiate the catalytic robustness of the complexes in the transformations.

Applied Organometallic Chemistry published new progress about Alkylation catalysts, regioselective. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ueno, Masaharu; Kusaka, Ryo; Ohmura, Satoshi D.; Miyoshi, Norikazu published the artcile< Environmentally Benign Ritter Reaction Using Bismuth Salts as a Catalyst>, Computed Properties of 76-84-6, the main research area is Ritter bismuth salt catalyst green.

The authors developed an environmentally benign Ritter reaction of alcs. with nitriles using a com. available bismuth salt as a less harmful catalyst. The detailed reaction profiles revealed that consumption of the ether byproduct as the reaction proceeded was the key for optimizing this reaction, and the yield of the target amide was improved by adding a small amount of water. This finding clearly reveals the significance of using a bismuth salt as the catalyst, as it is not deactivated in the presence of water. This catalyst system has a broad substrate scope, and even with 1 mol-% of the catalyst, the reaction progresses smoothly. It is also possible to react stoichiometric amounts of nitriles and alcs., thus reducing the amount of organic solvent required for the reaction. Furthermore, as the inexpensive bismuth catalyst can be easily removed using aqueous hydrochloric acid, a purification process that only required washing and drying without any organic solvents was successfully established.

European Journal of Organic Chemistry published new progress about Green chemistry. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nikoorazm, Mohsen; Moradi, Parisa; Noori, Nourolah; Azadi, Gouhar published the artcile< L-Arginine complex of copper on modified core-shell magnetic nanoparticles as reusable and organic-inorganic hybrid nanocatalyst for the chemoselective oxidation of organosulfur compounds>, Synthetic Route of 699-12-7, the main research area is arginine copper complex magnetic nanocatalyst preparation crystallinity; organosulfur compound chemoselective oxidation; sulfoxide green preparation.

The fabrication and characterization of a stable heterogeneous nanostructure catalyst of copper immobilized on Fe3O4@SiO2@L-Arginine, for the oxidation of sulfides and oxidative coupling of thiols was reported. The prepared nanocatalyst was characterized by different techniques such as FTIR, XRD, SEM, TEM and TGA. These nanoparticles were the effective catalyst for selective oxidation of sulfides and oxidative coupling of thiols using 30% H2O2. The suggested method offered several prominent advantages such as mild condition, use of magnetically reusable catalyst, simple workup procedure, good to high yields of products and great selectivity.

Journal of the Iranian Chemical Society published new progress about Crystallinity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Synthetic Route of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiu, Xiang; Sun, Yi; Wu, Yaokang; Jin, Ke; Qu, Lisha; Liu, Yanfeng; Li, Jianghua; Du, Guocheng; Lv, Xueqin; Liu, Long published the artcile< Modular remodeling of sterol metabolism for overproduction of 7-dehydrocholesterol in engineered yeast>, Category: alcohols-buliding-blocks, the main research area is 7-Dehydrocholesterol; CRISPR-mediated regulatory system; Compartmentalization; Endoplasmic reticulum; Saccharomyces cerevisiae.

Vitamin D3 is a fat-soluble vitamin essential for the human body, and the biosynthesis of its precursor, 7-dehydrocholesterol (7-DHC), gains extensive attention. In this work, six genes (tHMG1, IDI1, ERG1, ERG11, ADH2, ERG7) and a transcription factor mutant UPC2G888A were overexpressed, increasing the 7-DHC titer from 1.2 to 115.3 mg/L. The CRISPR-mediated activation and repression systems were constructed and applied to the synthesis of 7-DHC, increasing the 7-DHC titer to 312.4 mg/L. Next, enzymes were compartmentalized into the endoplasmic reticulum (ER) and the ER lumen was enlarged by overexpressing INO2. The 7-DHC titer of the finally engineered yeast reached 455.6 mg/L in a shake flask and 2870 mg/L in a 5 L bioreactor, the highest 7-DHC titer reported so far. Overall, this study achieved a highly efficient 7-DHC synthesis by remodeling the complicated sterol synthesis modules, paving the way for large-scale 7-DHC bioprodn. in the future.

Bioresource Technology published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Semeniuchenko, Volodymyr; Sharif, Sepideh; Day, Jonathan; Chandrasoma, Nalin; Pietro, William J.; Manthorpe, Jeffrey; Braje, Wilfried M.; Organ, Michael G. published the artcile< (DiMeIHeptCl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination>, Electric Literature of 5344-90-1, the main research area is halobenzene amine palladium catalyst aryl amination; phenyl amine preparation.

(DiMeIHeptCl)Pd, a hyper-branched N-aryl Pd NHC catalyst, was shown to be efficient at performing amine arylation reactions in solvent-free (“”melt””) conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center served as lubricant to allow the complex to navigate through the paste-like environment of these mixtures The protocol was used on a multi-gram scale to make a variety of aniline derivatives, including substrates containing alc. moieties.

Journal of Organic Chemistry published new progress about Amination. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

da Silva, Mateus V. C.; Souza, Amanda B.; de Castro, Heizir F.; Aguiar, Leandro G.; de Oliveira, Pedro C.; de Freitas, Larissa published the artcile< Synthesis of 2-ethylhexyl oleate catalyzed by Candida antarctica lipase immobilized on a magnetic polymer support in continuous flow>, Reference of 104-76-7, the main research area is ethylhexyl oleate Candida antarctica lipase immobilization; Esterification; Immobilized lipase; Kinetic modeling; Magnetic polymer; Packed-bed reactor.

This study investigated the synthesis of 2-ethylhexyl oleate catalyzed by Candida antarctica lipase immobilized on magnetic poly(styrene-co-divinylbenzene) particles in a continuous packed-bed bioreactor. Runs were carried out in a solvent-free system at 50°C. The performance of the reactor was evaluated for substrates composed by oleic acid and 2-ethylhexanol at five molar ratios (1:4-4:1), determining its operation limits in terms of substrate flow rate. The system performance was quantified for three different flow rates corresponding to space-time between 3 and 12 h. For each condition, the influence of the space-time in the ester formation, esterification yield and productivity was determined The molar ratio of acid-to-alc. interfered, in a remarkable way, in the formation of 2-ethylhexyl oleate and the best performance was attained for substrate at equimolar ratio running at 12 h space-time. Under this condition, average 2-ethylhexyl oleate concentration was 471.65 ± 2.98 g L-1 which corresponded to ester productivity of 23.16 ± 0.49 mmol g-1 L-1 h-1. This strategy also gave high biocatalyst operational stability, revealing a half-life time of 2063 h. A model based on the ping-pong Bi-Bi mechanism was developed to describe the kinetics of the esterification reaction and validated using exptl. data. The goodness of fit of the model was satisfactory (R2 = 0.9310-0.9952).

Bioprocess and Biosystems Engineering published new progress about Growth, microbial. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Reference of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yueting; Weng, Yuanyuan; Zhou, Min; Meng, Yiyu; Liu, Jialu; Yang, Lin; Zuo, Zhaojiang published the artcile< Linalool- and α-terpineol-induced programmed cell death in Chlamydomonas reinhardtii>, SDS of cas: 78-70-6, the main research area is Chlamydomonas programmed cell death linalool alpha terpineol algaecide; Algaecide; Chlamydomonas reinhardtii; Linalool; Programmed cell death; α-Terpineol.

Plant allelochems. effectively inhibit and/ or control algal growth, and have potential to use as algaecide. To uncover the lethal mechanism of 2 anti-algal compounds linalool and α-terpineol identified from Cinnamomum camphora extracts, and promote their development as algaecide, the H2O2 production, photosynthetic abilities, H2O2 content burst in linalool treatment at 0.5 h and in α-terpineol treatment at 1 h, with increases of 2.7 folds and 1.3 folds, resp., compared to that at 0 h. The photosynthetic pigments gradually degraded, and Fv/Fm gradually declined to zero, indicating that the cell death was not a necrosis due to the gradual disappearance of physiol. process. In C. reinhardtii cells, the caspase-9-like and caspase-3-like were activated in the treatments with the 2 compounds for 1 h. With prolonging the treatment time, the fluorescent intensity of the cell nucleuses stained by DAPI gradually enhanced and then faded, and the genomic DNA isolated from the cells gradually degraded. These hallmarks indicated that the death of C. reinhardtii cells in linalool and α-terpineol treatments was a (PCD) triggered by the increased reactive oxygen species (ROS). Compared to α-terpineol treatment, linalool treatment showed stronger promoting effects on PCD at the same time point, which may be caused by the higher ROS content inducing higher caspase-9-like and caspase-3-like activities in a short time.

Ecotoxicology and Environmental Safety published new progress about Algicides. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Zhengyu; Zhou, Hongli; Li, Yaping; Wu, Meifu; Yu, Ming; Sun, Xinshun published the artcile< Optimized purification process of polysaccharides from Carex meyeriana Kunth by macroporous resin, its characterization and immunomodulatory activity>, Electric Literature of 3458-28-4, the main research area is Carex polysaccharide macroporous resin purification immunomodulation; Carex meyeriana Kunth; Polysaccharides; Purification.

The anal. hierarchy process (AHP) combined with response surface methodol. (RSM) was used to optimize the purification conditions of crude polysaccharides from Carex meyeriana Kunth (CMKP) by macroporous resin. The optimal purification conditions as follows: elution volume of 2.74 BV, flow rate of 1.88 BV/h, and sample concentration of 2.10 mg/mL. Under the optimal conditions, the purification comprehensive score was 63.59 ± 1.56% (n = 3), which was agreed closely to the predicted value (64.02%). Two fractions of polysaccharides (CMKP-1 and CMKP-2) were obtained using a DEAE-52 column. Fourier Transform IR (FTIR) spectroscopy spectra revealed the general characteristic absorption peaks of CMKP-1 and CMKP-2. Congo-red test indicated that CMKP-1 and CMKP-2 have triple helix conformation. CMKP-1 and CMKP-2 were both composed of Man, Rib, Rha, GluA, GalA, Glu, Gal, Xyl, Ara and Fuc in a molar ratio of 8.93:1:4.62:1.41:1.78:10.7:24.69:4.51:15.92:1.27 and 7.85:1:5.05:1.99:3.15:12.47:15.41:1.54:6.91:3.15, resp. The major mol. weight of CMKP-1 and CMKP-2 was 22.30 kDa and 48.10 kDa, resp. Moreover, CMKP-1 and CMKP-2 had immunostimulatory effects on RAW264.7 cells in a certain concentration range. It could be used as potential immunomodulatory agents in medicine or functional food fields.

International Journal of Biological Macromolecules published new progress about Carex meyeriana. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts