Month: October 2022

Hollander, Amit; Yaron, Sima published the artcile< Pore-forming treatments induce aggregation of Salmonella Senftenberg through protein leakage>, Computed Properties of 78-70-6, the main research area is Salmonella senftenberg protein pore treatment aggregation; Aggregation; Antimicrobials; Food safety; Membrane damage; Salmonella.

Fresh herbs are not commonly associated with foodborne pathogens, due to the production of essential oils with antimicrobial activity. Recalls of contaminated basil, and basil outbreaks caused by Salmonella motivated studies aimed to comprehend the antimicrobial activity of basil essential oils, and to explore the mechanisms in which Salmonella can overcome them. Linalool, a major constituent of basil oil, increases the permeability of Salmonella Senftenberg cells by damaging their membrane. Linalool also induces bacterial aggregation. We hypothesized that the membrane perforation effect triggers cell aggregation through leakage of intracellular substances from live and dead cells. By exposing S. Senftenberg to addnl. phys. (sonication) or chem. (eugenol, Triton-X-100) treatments, we showed that the aggregation is caused by various membrane-targeted treatments. Enzymic degradation of leaked proteins restricted the bacterial aggregation, and disassembled existing aggregates. Moreover, supplemented proteins such as bacterial intracellular proteins or BSA also caused aggregation, further supporting the hypothesis that non-specific proteins trigger the bacterial aggregation. This study provides a novel understanding of the role of protein leakage in promoting bacterial aggregation. Since aggregation has significant roles in food safety and microbial ecol., this finding may establish future studies about microbial resistance via formation of clusters similar to biofilm development.

Food Microbiology published new progress about Aggregation. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zakany, Florina; Pap, Pal; Papp, Ferenc; Kovacs, Tamas; Nagy, Peter; Peter, Maria; Szente, Lajos; Panyi, Gyorgy; Varga, Zoltan published the artcile< Determining the target of membrane sterols on voltage-gated potassium channels>, Electric Literature of 434-16-2, the main research area is sterol voltage gated potassium channel intracellular domain transmembrane helix; Cholesterol; Ion channel gating; K(V)1.3; K(V)10.1; Pore domain; Voltage-sensor.

Cholesterol, an essential lipid component of cellular plasma membranes, regulates fluidity, mech.integrity, raft structure and may specifically interact with membrane proteins. Numerous effects on ion channels by cholesterol, including changes in current amplitude, voltage dependence and gating kinetics, have been reported. We have previously described such changes in the voltage-gated potassium channel Kv1.3 of lymphocytes by cholesterol and its analog 7-dehydrocholesterol (7DHC). In voltage-gated channels membrane depolarization induces movement of the voltage sensor domains (VSD), which is transmitted by a coupling mechanism to the pore domain (PD) to open the channel. Here, we investigated whether cholesterol effects were mediated by the VSD to the pore or the PD was the direct target. Specificity was tested by comparing Kv1.3 and Kv10.1 channels having different VSD-PD coupling mechanisms. Current recordings were performed with two-electrode voltage-clamp fluorometry, where movement of the VSDs was monitored by attaching fluorophores to external cysteine residues introduced in the channel sequence. Loading the membrane with cholesterol or 7DHC using methyl-β-cyclodextrin induced changes in the steady-state and kinetic parameters of the ionic currents while leaving fluorescence parameters mostly unaffected in both channels. Non-stationary noise anal.revealed that reductionof single channel conductance rather than that of open probability caused the observedcurrent decrease. Furthermore, confocal laser scanning and stimulated emission depletion microscopy demonstrated significant changes in the distribution of these ion channels in response to sterol loading. Our results indicate that sterol-induced effects on ion channel gating directly target the pore and do not act via the VSD.

Biochimica et Biophysica Acta, Molecular and Cell Biology of Lipids published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Electric Literature of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Yue; Li, Liang published the artcile< Structural characterization and antioxidant activity of polysaccharide from four auriculariales>, Electric Literature of 3458-28-4, the main research area is Auricularia natural antioxidant fucose mannose galactose polysaccharide; Antioxidant activity; Auricularia polysaccharides; Structural characterization.

The structural characterization and antioxidant activity of four Auricularia polysaccharides (A. cornea (ACP), A. auricula (AAP), A. polytricha (APP) and M.fungus (MFP)) were studied in this paper. The results shown: polysaccharides of four Auricularia were mainly composed of mannose and galactose, all polysaccharides contained uronic acid and pyran ring structure with spectroscopy and NMR anal. There was a significant difference in the total antioxidant capacity and APP was significantly higher than the other polysaccharides. The ability of APP to scavenge DPPH radicals and hydroxyl radicals was significantly higher than that of other polysaccharides, resp. The mol. weight was significantly pos. correlated with DPPH radicals, superoxide anion radicals and hydroxyl radicals. Total antioxidant capacity was significantly neg. correlated with fucose and galactose. The result indicated that fucose and galactose jointly determine total antioxidant capacity. The polysaccharide from four Auricularia had good oxidation resistance and could be used as natural antioxidants.

Carbohydrate Polymers published new progress about Auricularia auricula-judae. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Akhrem, Irena S.; Avetisyan, Dzhul’etta V.; Afanas’eva, Lyudmila V.; Artyushin, Oleg I. published the artcile< Simple and Efficient ""One-Pot"" Synthesis of Diphenylaryl (Heteroaryl) Methanols from Benzene>, Quality Control of 76-84-6, the main research area is diphenyl aryl methanol preparation.

A simple and efficient one-pot method for the synthesis of diphenyl(aryl)methanols I [Ar = Ph, 4-FC6H4, 2-thienyl, etc.] from benzene was developed using the known reaction of benzene with CCl4·AlCl3. This approach appeared fruitful when the reaction was performed uring CCl4 as a solvent. This method allowed the selective synthesis of Ph2CCl2 in good yield.

ChemistrySelect published new progress about Aromatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Quality Control of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kleban, Ihor; Krokhmaliuk, Yevhen; Reut, Sofiia; Shuvakin, Serhii; Pendyukh, Vyacheslav V.; Khyzhan, Oleksandr I.; Yarmoliuk, Dmytro S.; Tymtsunik, Andriy V.; Rassukana, Yuliya V.; Grygorenko, Oleksandr O. published the artcile< Multigram Synthesis of Heterabicyclo[n.1.0]alkan-1-yl Trifluoroborates>, Application of C4H8O, the main research area is enyne hetero preparation hydroboration; bromoallyl derivative preparation lithiation borylation; heterabicycloalkanyl trifluoroborate preparation.

An approach to the synthesis of oxa- and azabicyclo[n.1.0]alkan-1-yl trifluoroborates on a multigram scale was developed. Two synthetic strategies were evaluated: the 1st based on the lithiation-borylation of the corresponding 2-bromoallyl derivatives, and the other relying on regioselective hydroboration of the appropriate hetera-substituted enynes. The 2nd method appeared to be more efficient in terms of scalability and substrate scope. Further steps included ring closing-metathesis, mild Pd-catalyzed cyclopropanation with diazomethane, and reaction with KHF2 and furnished the title compounds in up to 50 g scale in a single run (10-41% overall yield, 4-5 steps).

European Journal of Organic Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mudududdla, Ramesh; Jain, Shreyans K.; Bharate, Jaideep B.; Gupta, Ajai P.; Singh, Baldev; Vishwakarma, Ram A.; Bharate, Sandip B. published the artcile< ortho-Amidoalkylation of phenols via tandem one-pot approach involving oxazine intermediate>, Quality Control of 4396-13-8, the main research area is hydroxybenzyl lactam regioselective preparation; phenol lactam tandem Knoevenagel condensation Diels Alder cycloaddition; perchloric acid amidoalkylation catalyst.

An efficient method for ortho-amidoalkylation of phenols via Mannich-type condensation with formaldehyde and lactams using recyclable solid acid catalyst is described. This is the first report for ortho-amidoalkylation of phenols by lactams via Mannich-type condensation. LC-ESI-MS/MS based mechanistic study revealed that reaction proceeds through o-quinone methide (o-QM) and an oxazine intermediate via tandem Knoevenagel condensation, formal [4 + 2]-Diels-Alder cycloaddition and acid catalyzed oxazine ring-opening.

Journal of Organic Chemistry published new progress about Amidoalkylation. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Quality Control of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brocklehurst, Cara E.; Laumen, Kurt; La Vecchia, Luigi; Shaw, Duncan; Vogtle, Markus published the artcile< Diastereoisomeric Salt Formation and Enzyme-Catalyzed Kinetic Resolution as Complementary Methods for the Chiral Separation of cis-/trans-Enantiomers of 3-Aminocyclohexanol>, SDS of cas: 6850-39-1, the main research area is aminocyclohexanol chiral separation diastereomeric salt formation enzymic kinetic resolution.

This contribution demonstrates the preparative-scale synthesis of (1S,3S)-3-aminocyclohexanol by either enzymic kinetic resolution of Cbz-protected 3-aminocyclohexanols or direct diastereoisomeric salt formation with (R)-mandelic acid. The salt formation demonstrates how a single enantiomer, (1S,3S)-3-aminocyclohexanol (R)-mandelate, can be effectively isolated from the cis/trans racemic mixture and subsequently converted to the free amine, (1S,3S)-3-aminocyclohexanol, by ion-exchange chromatog. We have also demonstrated how the other three enantiomers of 3-aminocyclohexanol can be prepared by either diastereoisomeric salt formation or enzymic kinetic resolution

Organic Process Research & Development published new progress about Chiral resolution (by diastereomeric salt formation). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rahman, Habibur Md.; Akter, Rokeya; Bhattacharya, Tanima; Abdel-Daim, Mohamed M.; Alkahtani, Saad; Arafah, Mohammed W.; Al-Johani, Norah S.; Alhoshani, Norah M.; Alkeraishan, Nora; Alhenaky, Alhanof; Abd-Elkader, Omar H.; El-Seedi, Hesham R.; Kaushik, Deepak; Mittal, Vineet published the artcile< Resveratrol and neuroprotection: impact and its therapeutic potential in Alzheimer's disease>, Reference of 501-36-0 , the main research area is review resveratrol neuroprotection Alzheimer disease; Alzheimer’s disease; bioavailability; neuroprotective; oxidative stress; resveratrol; therapeutic agent.

A review. Alzheimer’s disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of Aβ (β-amyloid peptides), phosphorylation of tau-proteins, and chronic inflammation. Exactly, resveratrol, a polyphenol present in red wine, and many plants are indicated to show the neuroprotective effect on mechanisms mostly above. Resveratrol plays an important role in promotion of non-amyloidogenic cleavage of the amyloid precursor protein. It also enhances the clearance of amyloid beta-peptides and reduces the damage of neurons. Most exptl. research on AD and resveratrol has been performed in many species, both in vitro and in vivo, during the last few years. Nevertheless, resveratrol’s effects are restricted by its bioavailability in the reservoir. Therefore, scientists have tried to improve its efficiency by using different methods. This review focuses on recent work done on the cell and animal cultures and also focuses on the neuroprotective mol. mechanisms of resveratrol. It also discusses about the therapeutic potential onto the treatment of AD.

Frontiers in Pharmacology published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts