Month: October 2022

Kephart, Jonathan A.; Hecht, Zachary; Livesay, Brooke N.; Bhowmick, Indrani; Shores, Matthew P.; Popescu, V. Codrina; Arulsamy, Navamoney; Hulley, Elliott B. published the artcile< Self-assembly of an organometallic Fe9O6 cluster from aerobic oxidation of (tmeda)Fe(CH2tBu)2>, Product Details of C19H16O, the main research area is magnetic susceptibility moment iron oxygen cluster optimized preparation; crystal structure mol iron oxygen cluster optimized preparation.

Aerobic oxidation of (tmeda)Fe(CH2tBu)2 in toluene or THF solution leads to the self-assembly of a magic-sized all-ferrous oxide cluster containing the Fe9O6 subunit and bearing organometallic and diamine ligands. Moessbauer studies of the cluster are consistent with an all-ferrous assignment and magnetometry reveals complex intracluster and intercluster magnetic interactions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cluster compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yalcinkaya, Sueleyman; Cakmak, Didem; Seymen, Kuebra; Demetguel, Cahit published the artcile< Electrochemical synthesis and characterization of poly (o-amino benzyl alcohol) and poly (o-amino benzyl alcohol-co-o-anisidine)>, Synthetic Route of 5344-90-1, the main research area is electrochem synthesis polyamino benzyl alc anisidine copolymer.

In this study; poly (o-amino benzyl alc.) and poly (o-amino benzyl alc.-co-o-anisidine) copolymer films were electrochem. synthesized by cyclic voltammetry technique on the platinum electrode. The synthesis of copolymer films was achieved in various monomers feed ratio (o-amino benzyl alc.: o-anisidine; 8:2, 1:1, 2:8) of o-amino benzyl alc. and o-anisidine. Different solution types were tested in aqueous and non-aqueous media, especially during the synthesis process, as the electrolyte medium. As a result of the experiments, it was determined that sulfuric acid solution was the most suitable solution for both homopolymer and copolymer film growth. Homopolymer and copolymer samples were characterized by FT-IR, cyclic voltammetry (CV), SEM, digital images and TGA/DTA techniques. The CV, SEM and digital images results indicated that the solution which has high ratio of monomer is more effective in copolymer film synthesis mechanism. TGA results showed that the 1:1 copolymer film had higher thermal stability than the films at other monomer ratios. Also, electrochem. studies exhibited that the copolymer film in 1:1 ratio is partially more electrochem. stable than other copolymer films.

Journal of Applied Polymer Science published new progress about Conducting polymers. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich published the artcile< The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship>, SDS of cas: 45434-02-4, the main research area is thiourea imidazolylpropyl human glutaminyl cyclase inhibitor; Alzheimer disease treatment imidazolylpropylthiourea preparation; human glutaminyl cyclase inhibitor imidazolylpropylthiourea library preparation.

The first effective inhibitors for human glutaminyl cyclase (QC) are described. The structures are developed by applying a ligand-based optimization approach starting from imidazole. Screening of derivatives of that heterocycle led to compounds of the imidazol-1-yl-alkyl thiourea type as a lead scaffold. A library of thiourea derivatives was synthesized, resulting in an inhibitory improvement by 2 orders of magnitude, leading to 1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea as a potent inhibitor. Systematic exploitation of the scaffold revealed a strong impact on the inhibitory efficacy and resulted in the development of imidazole-propyl-thioamides as another new class of potent inhibitors. A flexible alignment of the most potent compounds of the thioamide and thiourea class and a QC substrate revealed a good match of characteristic features of the mols., which suggests a similar binding mode of both inhibitors and the substrate to the active site of QC.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, SDS of cas: 45434-02-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Fei; Liu, Huijun; Zhang, Ruifen; Dong, Lihong; Liu, Lei; Ma, Yongxuan; Jia, Xuchao; Wang, Guangjin; Zhang, Mingwei published the artcile< Physicochemical properties and prebiotic activities of polysaccharides from longan pulp based on different extraction techniques>, Product Details of C6H12O6, the main research area is prebiotic polysaccharide longan extraction sugar viscosity solubility; Different extraction methods; Glycosidic linkage; Longan polysaccharides; Probiotic proliferation.

Longan pulp polysaccharides were extracted with hot water (LP-H), superfine grinding (LP-S) and superfine grinding-assisted enzymic treatments (LP-SE). The yields, physicochem. properties and prebiotic activities of polysaccharides were investigated. Compared with LP-H and LP-S, the yield, sugar content, solubility, arabinose and mannose percentage of LP-SE increased while its apparent viscosity, particle size, Mw and glucose percentage declined. Three LPs contained similar glycosidic linkage of →3)-α-L-Araf-(1→, →3,6)-β-D-Galp-(1→ and α-L-Rhap(l→, while they each contained specific glycosidic linkage of →4)-β-D-Glcp(l→, →4)-β-D-Galp-(1→ and →5)-α-L-Araf-(1→ in LP-H, LP-S and LP-SE, resp. Moreover, LP-SE exhibited stronger stimulation than LP-H and LP-S on the proliferation of Lactobacillus plantarum, Lactobacillus bulgaricus, Lactobacillus fermentum and Leuconostoc mesenteroides. The results indicated three extraction methods had some effect on chem. composition and structure of polysaccharide. LP-SE extracted by superfine grinding-assisted enzymic treatment exhibited the highest prebiotic activities, which have a great potential in applying in functional food and medical industry.

Carbohydrate Polymers published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hou, Jianshen; Gao, Cong; Guo, Liang; Nielsen, Jens; Ding, Qiang; Tang, Wenxiu; Hu, Guipeng; Chen, Xiulai; Liu, Liming published the artcile< Rewiring carbon flux in Escherichia coli using a bifunctional molecular switch>, Category: alcohols-buliding-blocks, the main research area is glucaric acid shikimic acid Escherichia coli metabolic engineering; Dynamic regulation; Metabolic engineering; Metabolic flux regulation; Synthetic biology.

The unbalanced distribution of carbon flux in microbial cell factories can lead to inefficient production and poor cell growth. Uncoupling cell growth and chem. synthesis can therefore improve microbial cell factory efficiency. Such uncoupling, which requires precise manipulation of carbon fluxes, can be achieved by up-regulating or down-regulating the expression of enzymes of various pathways. In this study, a dynamic turn-off switch (dTFS) and a dynamic turn-on switch (dTNS) were constructed using growth phase-dependent promoters and degrons. By combining the dTFS and dTNS, a bifunctional mol. switch that could orthogonally regulate two target proteins was introduced. This bifunctional mol. switch was used to uncouple cell growth from shikimic acid and D-glucaric acid synthesis, resulting in the production of 14.33 g/L shikimic acid and the highest reported productivity of D-glucaric acid (0.0325 g/L/h) in Escherichia coli MG1655. This proved that the bifunctional mol. switch could rewire carbon fluxes by controlling target protein abundance.

Metabolic Engineering published new progress about Escherichia coli. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthireddy, S. N. R.; Singh, Vivek Kumar; Rit, Arnab published the artcile< A heteroditopic NHC and phosphine ligand supported ruthenium(II)-complex: an effective catalyst for the N-alkylation of amides using alcohols>, Name: (2-Aminophenyl)methanol, the main research area is alkylation aromatic amide aralkyl alc ruthenium chelate carbene catalyst; ruthenium imidazolylidene triazolylidene mesoionic carbene preparation amide alkylation catalyst; secondary aromatic amide benzyl preparation alkylation arenemethanol ruthenium catalyst.

A ruthenium(II) complexes [(p-cymene)RuCl(1-MeIm-3-CH2Trz-1-C6H4R)] (Im = 2-imidazolylidene, Trz = 1,2,3-triazol-4-yl-5-ylidene; R = 2,4,6-Me3, 4-MeO, 4-CF3) supported by chelate NHC and mesoionic carbene ligands in combination with a diphosphine ligand (dppe, dppf) was shown to be a highly effective catalyst for the N-alkylation of diverse aromatic amides ArCONH2 using readily available primary aralkyl alcs. Ar1CH2OH, yielding N-benzylamides ArCONHCH2Ar1 (Ar, Ar1 = substituted Ph, pyridyl, thienyl, naphthyl). A wide range of secondary amides was thus obtained in excellent yields (up to 98%) employing a low catalyst loading of 0.2 mol% and a substoichiometric amount of base. The 1H NMR and ESI-MS analyses support the participation of a N-heterocyclic carbene and phosphine supported Ru-H species in the catalytic cycle and the mechanistic studies including the deuterium labeling experiment suggest the involvement of a borrowing hydrogen protocol. Addnl., the present catalytic system was also revealed to be efficient for the selective mono-alkylation and unsym. di-alkylation of 4-aminobenzamides which have not been studied before to the extent of our knowledge.

Catalysis Science & Technology published new progress about Alkylation catalysts. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aman, Hasil; Chen, Yuan-Ching; Tu, Jing-Wen; Chang, Chia-Chi; Chuang, Gary Jing published the artcile< Catalyst/Additive Free Oxidation of Benzyl Bromides to Benzaldehydes>, Recommanded Product: Triphenylmethanol, the main research area is benzyl bromide Kornblum oxidation; benzaldehyde preparation green chem.

An effective approach for the synthesis of aryl aldehydes from the corresponding benzyl bromides was accomplished. Without need of addnl. additives or stoichiometric oxidants, this environmental friendly and milder version of Kornblum oxidation simply utilized the irradiation of visible light in DMSO under O2, and was compatible with the substrate with different functional groups.

ChemistrySelect published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Labarthe, Benoit; Idee, Jean-Marc; Burnett, Roger; Corot, Claire published the artcile< In Vivo Comparative Antithrombotic Effects of Ioxaglate and Iohexol and Interaction With the Platelet Antiaggregant Clopidogrel>, Synthetic Route of 35564-86-4, the main research area is ionic nonionic contrast media antithrombotic interaction clopidogrel.

RATIONALE AND OBJECTIVES. Experiments were designed to (1) compare the effects of iodinated contrast media (CM) on a rat model of arterial thrombosis, (2) evaluate which element of the ioxaglate solution supports its antithrombotic activity, and (3) investigate the interaction of ionic and non-ionic CM with the antiplatelet agent clopidogrel. MATERIALS AND METHODS. Carotid thrombosis was induced in rats by extravascular application of a filter paper soaked in FeCl (35% vol/wt), proximal to an ultrasonic flow probe. (1) The antithrombotic potential of low-osmolar ionic (ioxaglate Na/meglumine) or nonionic contrast media (iohexol and iodixanol) (all 1600 mg iodine/kg, IV) was assessed by measuring the time to occlusion (TTO) of the carotid artery and the thrombus weight (TW). (2) Isotonic saline and iso-osmolar (280 mOsm/kg) and hyperosmolar (560 mOsm/kg) solutions of meglumine hydrochloride, meglumine ioxaglate (560 mOsm/kg), sodium ioxaglate (600 mOsm/kg) and sodium and meglumine ioxaglate (com. solution) were tested under similar conditions. (3) Interaction with clopidogrel was tested by injecting lower dose of CM (960 mg iodine/kg) 2 h after clopidogrel (2 mg/kg per os). RESULTS: (1) Ioxaglate prolonged TTO when compared with saline (30.0 ± 1.1 min vs. 19.6 ± 2.4 min, <0.001), whereas iohexol had no effect (21.3 ± 1.3 min). Ioxaglate's effect was associated with a reduction in TW with ioxaglate vs. saline (2.6 ± 0.4 mg and 4.7 ± 0.7 mg, resp., <0.05) whereas TW remained unchanged in the iohexol group (4.2 ± 0.4 mg). The nonionic dimer iodixanol induced a direct vasoconstrictor effect on the carotid artery and was consequently excluded from the study. (2) Neither iso-osmolar nor hyperosmolar solutions of meglumine had any effect on TTO whereas both sodium and meglumine salts of ioxaglic acid prolonged TTO, suggesting that the antithrombotic effect of ioxaglate is mediated by the ioxaglic acid moiety alone as neither meglumine, osmolality or sodium played a significant role. (3) A synergistic effect on TTO was found when ioxaglate was associated with clopidogrel whereas no such effect was observed with iohexol. CONCLUSIONS: These data show a greater in vivo antithrombotic potential for the ionic contrast medium ioxaglate than for the non-ionic contrast medium iohexol and, for the first time, a synergistic effect between a contrast medium and a platelet antiaggregant drug in vivo. Investigative Radiology published new progress about Anticoagulants. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pandey, Akanksha M.; Mondal, Shankhajit; Gnanaprakasam, Boopathy published the artcile< Continuous Flow Direct Azidation of Alcohols and Peroxides for the Synthesis of Quinoxalinones, Benzooxazinone and Triazole Derivatives>, Recommanded Product: Triphenylmethanol, the main research area is aryl azide preparation; aromatic alc azidation continuous flow; azide benzoxazinone preparation; peroxide indole ring expansion azidation continuous flow; quinoxalinone azide preparation; indole azide ring expansion skeletal rearrangement continuous flow.

The continuous flow direct azidation of various alcs. by using TMSN3 as an azide transfer reagent in the presence of Amberlyst-15 as a recyclable catalyst was reported. Numerous 3-hydroxy-2-oxindoles e.g., diphenylmethanol effectively undergo azide transfer reaction to afford azide functionalized quaternary stereocenter e.g., [azido(phenyl)methyl]benzene under continuous flow module. Interestingly, peroxyoxindole undergoes sequential skeletal rearrangement to generate carbocation and followed by nucleophilic azidation to afford a library of substituted-2-azido-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives I (R = 4-methoxyphenyl, Me, Bn, etc.; R1 = H, Me, Bn) under continuous flow. Furthermore, a continuous-flow Cu-catalyzed Click reaction afforded triazole functionalized derivatives II (R2 = Me, Ph). Next, reduction of azide in the presence of PPh3 results the amine derivatives in good yield. The continuous-flow application was extended further for the thermolytic skeletal rearrangement of 3-azide-2-oxindole for the synthesis of biol. important quinoxalin-2(1H)-ones III (R3 = Me, Bn, 4-MeC6H4, etc.) under reagentless condition. Furthermore, this continuous-flow direct azidation reaction is scaled up to 6.144 g of azides with TON = 9.24 under safer condition.

Journal of Organic Chemistry published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safaiee, Maliheh; Moeinimehr, Mahtab; Zolfigol, Mohammad Ali published the artcile< Pyridiniumporphyrazinato oxo-vanadium tribromomethanide as a new source of Br+ catalyst for the chemo and homoselective oxidation of sulfides and benzylic alcohols>, SDS of cas: 699-12-7, the main research area is pyridiniumporphyrazinato oxo vanadium tribromomethanide preparation catalyst chemoselective homoselective oxidation; sulfide benzylic alc oxidation catalyst pyridiniumporphyrazinato oxo vanadium tribromomethanide; sulfoxide benzaldehyde preparation.

The present study describes the design and synthesis of novel nano N-bromo porphyrazin (N-bromo tetra-2,3-pyridiniumporphyrazinato oxo-vanadium tribromomethanide [VO(TPPABr)] CBr3) as an efficient, recyclable and thermal stable heterogeneous catalyst for chemo and homoselective oxidation of sulfides to sulfoxides and benzyl alcs. to benzaldehydes. This ecofriendly heterogeneous catalyst was fully characterized by FT-IR spectra, UV-Vis spectra, x-ray diffraction (XRD), SEM (SEM), transmission electron microscopy (TEM), and thermal gravimetric anal. (TGA), energy-dispersive x-ray spectroscopy (EDX) and elemental anal. (CHN). The synthesized catalyst exhibited a high-performance and considerable reusability.

Polyhedron published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, SDS of cas: 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts