Month: October 2022

Isaksson, Marléne; Karlberg, Ann-Therese; Nilsson, Ulrika published the artcile< Allergic contact dermatitis caused by oxidized linalool in a deodorant.>, Electric Literature of 78-70-6, the main research area is allergic contact dermatitis; armpit dermatitis; case report; chemical analysis; fragrances; hydroperoxides of linalool; linalool oxidation products; patch testing.

There is no abstract available for this document.

Contact dermatitis published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xiaorui; Chai, Liyuan; Ren, Junyu; Jin, Linfeng; Wang, Haiying; Li, Yiming; Ma, Shengqian published the artcile< Efficient collection of perrhenate anions from water using poly(pyridinium salts) via pyrylium mediated transformation>, SDS of cas: 76-84-6, the main research area is perrhenate anion collection water poly pyridinium salt pyrylium transformation.

Poly(pyridinium salts) (PPSs) with pos. charges on the backbones were designed and synthesized from the transformation of bispyrylium salts. Such materials exhibited good uptake capacity for rhenium capture from water, and excellent selectivity of ReO4- from competing anions. Furthermore, the advantages of facile synthesis and large-scale preparation make this material promising for practical use in industry.

Polymer Chemistry published new progress about Cationic polyelectrolytes. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, SDS of cas: 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghorbani-Choghamarani, Arash; Moradi, Parisa; Tahmasbi, Bahman published the artcile< Modification of boehmite nanoparticles with Adenine for the immobilization of Cu(II) as organic-inorganic hybrid nanocatalyst in organic reactions>, Formula: C8H10OS, the main research area is boehmite nanoparticle adenine immobilization copper organic hybrid nanocatalyst.

Boehmite nanoparticles are aluminum oxide hydroxide (γ-AlOOH) particles, which has large sp. surface area (>120 m2 g-1) and can be prepared using an inexpensive procedure in water. Herein, we present an economical, simple, and environmentally friendly route for the preparation of a copper catalyst on Adenine coated boehmite nanoparticles (Cu-Adenine@boehmite). This catalyst has been characterized by several techniques such as SEM, XRD, AAS, ICP and TGA anal. Cu-Adenine@boehmite was applied as highly efficient and reusable nanocatalyst in carbon-carbon coupling reactions between various aryl halides and sodium tetra-Ph borate, phenylboronic acid, or 3,4-diflorophenylboronic acid under aerobic conditions, palladium-free and phosphine-free ligand. Also this catalyst was applied for the synthesis of polyhydroquinoline derivatives In continuation, selective oxidation of sulfides to sulfoxides using hydrogen peroxide (H2O2) was studied in the presence of Cu-Adenine@boehmite as catalyst. The synthesis of sulfoxides using H2O2 in the presence of Cu-Adenine@boehmite does not generate waste and any byproducts. This catalyst was reused for several times in C-C coupling reaction without loss of its catalytic activity. Reused catalyst was characterized by SEM, XRD and ICP techniques. Heterogeneity and stability of Cu-Adenine@boehmite were studied by hot filtration test, poisoning test and ICP anal.

Polyhedron published new progress about Catalyst poisoning. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yadav, Anamika; Ambule, Mayur D.; Kant, Ruchir; Srivastava, Ajay K. published the artcile< Silver/Palladium Relay Catalyzed Cross-Coupling of N'-Acetyl-8-quinolinesulfonylhydrazide with Alcohols: An Easy Access to 8-Quinolinesulfinate Esters>, Application In Synthesis of 5344-90-1, the main research area is silver palladium catalyzed cross coupling quinolinesulfonyl hydrazide alc; quinolinesulfinate ester preparation.

An efficient strategy for the synthesis of unexplored 8-quinolinesulfinate esters has been reported. The method involves in situ generation of quinoline sulfinate from N’-acetylquinoline-8-sulfonohydrazide via silver mediated cleavage followed by palladium-catalyzed cross-coupling with 1° and 2° alcs. to yield sulfinate esters. A variety of substituted alcs. were successfully employed in the reaction. Control experiments performed to understand the mechanism, revealed that the transformation follows a radical pathway and the alc. oxygen get incorporated in the resulting sulfinate esters. Two of the chirally pure alcs. were also used in the transformation to study the diastereoselectivity in the reaction. In order to demonstrate the synthetic utility, a representative allyl quinoline-8-sulfinate (I) was successfully converted into the 8-(allylsulfonyl)quinoline (II) via palladium(II) acetate mediated isomerization.

European Journal of Organic Chemistry published new progress about Hydrazides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fraternale, Daniele; Flamini, Guido; Ascrizzi, Roberta published the artcile< In Vitro Anticollagenase and Antielastase Activities of Essential Oil of Helichrysum italicum subsp. italicum (Roth) G. Don>, Application of C10H18O, the main research area is collagenase elastase essential oil gas chromatog mass spectrometry; Helichrysum italicum; GC–MS; Helichrysum italicum subsp. italicum; antiaging activity; collagenase inhibition; elastase inhibition; essential oil.

The chem. composition of the essential oil of flowering aerial parts of Helichrysum italicum subsp. italicum cultivated in central Italy, Marche region, was analyzed by means of gas chromatog.-mass spectrometry. Seventy-eight components, accounting for 98.71% of the whole essential oil composition, were identified and quantified. Neryl acetate showed the largest relative abundance in the composition, accounting for 15.75% of the oil, followed by α-pinene (8.21%); 4,6,9-trimethyl-8-decene-3,5-dione, (Italidione I), (7.34%); ar-curcumene and β-selinene (5.37%); γ-curcumene (4.83%); nerol (4.75%); α-selinene (4.68%); limonene (4.55%); linalool (4.42%), and 2,4,6,9-tetramethyl-8-decene-3,5-dione (Italidione II), (4.26%). The oil inhibited in vitro collagenase and elastase activities, with IC50 values of 36.99 ± 1.52 and 135.43 ± 6.32μg/mL, resp. Neryl acetate, nerol, and linalool, distinctive compounds of the oil obtained from this plant, tested alone or in mixture, at the same percentages shown in the essential oil, exhibited no activity against the two enzymes. On the contrary, α-pinene and limonene, tested alone and in mixture, showed inhibitory activity on both collagenase and elastase.

Journal of Medicinal Food published new progress about Composition. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hailou; Xu, Xin; Tang, Zhigang; Zhao, Junwei; Chen, Lijuan; Yang, Guo-Yu published the artcile< Three Lanthanide-Functionalized Antimonotungstate Clusters with a {Sb4O4Ln3(H2O)8} Core: Syntheses, Structures, and Properties>, COA of Formula: C8H10OS, the main research area is sodium lanthanide antimonotungstate cluster complex preparation oxidation catalyst; thermal stability luminescence sodium lanthanide antimonotungstate cluster; crystal structure sodium lanthanide antimonotungstate cluster.

Three lanthanide (Ln)-functionalized antimonotungstate (AT) clusters with a {Sb4O4Ln3(H2O)8} core [H2N(CH3)2]14Na8H16[Sb4O4Ln3(H2O)8W2O4(H2O)2(B-α-SbW9O33)4]2·87H2O [Ln = Dy3+ (1), Ho3+ (2), Y3+ (3)] were synthesized in an acidic aqueous solution Their mol. structural unit comprises two {Sb4O4Ln3(H2O)8}-core-incorporated tetrameric [Sb4O4Ln3(H2O)8W2O4(H2O)2 (B-α-SbW9O33)4]19- polyanionic units, each of which is assembled from an unprecedented [Sb4O4Ln3(H2O)8W2O4(H2O)2]17+ heteroatom cluster surrounded by four trivacant [B-α-SbW9O33]9- subunits. What is noteworthy is that a tetrahedral {Sb4O4} cluster is located at the center of the polyanionic unit, as far as we know, which is very infrequent in multi-Ln-functionalized polyoxometalate chem. Solid-state luminescent properties and energy migration of AT ligands to Dy3+ and Ho3+ cations in 1 and 2 have been intensively probed at ambient temperature By varying the exciting wavelength from 250 to 450 nm, the emitting color could vary from blue to yellow for 1 and blue to green-yellow for 2, sep. In addition, high catalytic activities and good reusability of 2 as a heterogeneous catalyst for oxygenation reaction of sulfides have been systematically performed.

Inorganic Chemistry published new progress about Crystal structure. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, COA of Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Peladeau, Christine; Adam, Nadine; Bronicki, Lucas M.; Coriati, Adele; Thabet, Mohamed; Al-Rewashdy, Hasanen; Vanstone, Jason; Mears, Alan; Renaud, Jean-Marc; Holcik, Martin; Jasmin, Bernard J. published the artcile< Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles>, HPLC of Formula: 6054-98-4, the main research area is muscular dystrophy relaxant utrophin A eEF1A2 therapeutic target.

Abstract: Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with the 5’UTR of utrophin A to promote IRES-dependent translation. Here, we examine whether eEF1A2 directly regulates utrophin A expression and identify via an ELISA-based high-throughput screen, FDA-approved drugs that upregulate both eEF1A2 and utrophin A. Our results show that transient overexpression of eEF1A2 in mouse muscles causes an increase in IRES-mediated translation of utrophin A. Through the assessment of our screen, we reveal 7 classes of FDA-approved drugs that increase eEF1A2 and utrophin A protein levels. Treatment of mdx mice with the 2 top leads results in multiple improvements of the dystrophic phenotype. Here, we report that IRES-mediated translation of utrophin A via eEF1A2 is a critical mechanism of regulating utrophin A expression and reveal the potential of repurposed drugs for treating DMD via this pathway.

Nature Communications published new progress about Anterior tibial muscle. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, HPLC of Formula: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zou, Guo-Jun; Huang, Wei-Bo; Sun, Xin-Yuan; Tang, Gu-Hua; Ouyang, Jian-Ming published the artcile< Carboxymethylation of Corn Silk Polysaccharide and Its Inhibition on Adhesion of Nanocalcium Oxalate Crystals to Damaged Renal Epithelial Cells>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is corn silk polysaccharide nanocalcium oxalate carboxymethylation renal epithelial cell; carboxymethylation; cell adhesion; corn silk polysaccharide; nanocalcium oxalate; oxidative damage.

The purpose of this study was to explore the repair effect of carboxymethyl-modified corn silk polysaccharide (CSP) on oxidatively damaged renal epithelial cells and the difference in adhesion between cells and calcium oxalate crystals. The CSP was degraded and modified through carboxymethylation. An oxidatively damaged cell model was constructed by oxalate damage to human kidney proximal tubular epithelial (HK-2) cells. Then, the damaged cells were repaired by modified polysaccharides, and the changes in biochem. indexes and adhesion ability between cells and crystals before and after repair were detected. Four modified polysaccharides with carboxyl group (-COOH) contents of 3.92% (CSP0), 7.75% (CCSP1), 12.90% (CCSP2), and 16.38% (CCSP3) were obtained. Compared with CSP0, CCSPs had stronger antioxidant activity, could repair damaged HK-2 cells, and could reduce phosphorylated serine eversion on the cell membrane, the expression of osteopontin (OPN) and Annexin A1, and crystal adhesion. However, its effect on the expression of hyaluronic acid synthase was not substantial. The carboxymethyl modification of the CSP can improve its ability to repair cells and inhibit crystal adhesion and aggregation. A high carboxymethylation degree results in strong polysaccharide activity. CCSPs are expected to reduce the risk of kidney stone formation and recurrence.

ACS Biomaterials Science & Engineering published new progress about Aggregation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koczok, Katalin; Horvath, Laszlo; Korade, Zeljka; Mezei, Zoltan Andras; Szabo, Gabriella P.; Porter, Ned A.; Kovacs, Eszter; Mirnics, Karoly; Balogh, Istvan published the artcile< Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients>, Quality Control of 434-16-2, the main research area is vitamin E Hungarian Smith Lemli Opitz syndrome skin photosensitivity; Smith-Lemli-Opitz syndrome; behavioral disturbance; skin photosensitivity; vitamin A; vitamin E.

Smith-Lemli-Opitz syndrome (SLOS) is a severe monogenic disorder resulting in low cholesterol and high 7-dehydrocholesterol (7-DHC) levels. 7-DHC-derived oxysterols likely contribute to disease pathophysiol., and thus antioxidant treatment might be beneficial because of high oxidative stress. In a three-year prospective study, we investigated the effects of vitamin E supplementation in six SLOS patients already receiving dietary cholesterol treatment. Plasma vitamin A and E concentrations were determined by the high-performance liquid chromatog. (HPLC) method. At baseline, plasma 7-DHC, 8-dehydrocholesterol (8-DHC) and cholesterol levels were determined by liquid chromatog.-tandem mass spectrometry (LC-MS/MS) method. The clin. effect of the supplementation was assessed by performing structured parental interviews. At baseline, patients were characterized by low or low-normal plasma vitamin E concentrations (7.19-15.68μmol/L), while vitamin A concentrations were found to be normal or high (1.26-2.68μmol/L). Vitamin E supplementation resulted in correction or significant elevation of plasma vitamin E concentration in all patients. We observed reduced aggression, self-injury, irritability, hyperactivity, attention deficit, repetitive behavior, sleep disturbance, skin photosensitivity and/or eczema in 3/6 patients, with notable individual variability. Clin. response to therapy was associated with a low baseline 7-DHC + 8-DHC/cholesterol ratio (0.2-0.4). We suggest that determination of vitamin E status is important in SLOS patients. Supplementation of vitamin E should be considered and might be beneficial.

Biomolecules published new progress about Antioxidants. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts