Month: October 2022

Kirhan, Idris; Kas, Fehmi; Taskiran, Huseyin; Buyukhatipoglu, Hakan; Gonel, Ataman; Koyuncu, Ismail published the artcile< Evaluation of Micro-RNA Levels, Apoptosis and Oxidative Stress Markers in Patients Recieving Chemotherapy>, SDS of cas: 1492-18-8, the main research area is cancer microRNA apoptosis oxidative stress marker chemotherapy; DNA damage; Micro-RNA; apoptosis; cancer; chemotherapy; damage; injury; metastasis; miR-29a; miRNA; prognosis..

Objective: The primary objective of this study was to compare oxidative DNA damage markers, apoptosis markers and changes in miRNA levels in patients diagnosed with cancer and treated through chemotherapy. Our secondary objective was also to evaluate tumor responses that can be determined after post-chemotherapy clin. evaluations by phys. examinations, laboratory results and radiol. imagings, and to compare the clin. results to oxidative stress and apoptosis markers and micro RNA levels. Materials and Methods: To do that we designed a prospective observational cross-sectional study. A total of 34 cancer patients and 27 healthy controls were included in the study from the Harran University School of Medicine Department of Oncol. Newly diagnosed chemotherapy or radiotherapy naive patients without any chronic diseases were included into the study. Patients with a poor performance status (ECOG 2 and 3) and patients who did not meet the inclusion criteria were excluded. The cancer patients received chemotherapy according to their scheduled periods. Blood samples were taken from the patients before the first chemotherapy course and before the second chemotherapy round. Patients were called for toxicity control on the 10th day after the chemotherapy. However, there were subtle differences between pre-chemotherapy and post-chemotherapy levels. Mir-29a expressions were lower in cancer patients as compared to controls.

Combinatorial Chemistry & High Throughput Screening published new progress about Apoptosis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, SDS of cas: 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gardelli, Cecilia; Russo, Laura; Cipolla, Laura; Moro, Massimo; Andriani, Francesca; Rondinone, Ornella; Nicotra, Francesco; Sozzi, Gabriella; Bertolini, Giulia; Roz, Luca published the artcile< Differential glycosylation of collagen modulates lung cancer stem cell subsets through β1 integrin-mediated interactions>, COA of Formula: C6H12O6, the main research area is beta1 integrin collagen glycosylation lung cancer; cancer stem cells; collagen; glycans; lung cancer; tumor-extracellular matrix interactions.

In lung cancer, CD133+ cells represent the subset of cancer stem cells (CSC) able to sustain tumor growth and metastatic dissemination. CSC function is tightly regulated by specialized niches composed of both stromal cells and extracellular matrix (ECM) proteins, mainly represented by collagen. The relevance of collagen glycosylation, a fundamental post-translational modification controlling several biol. processes, in regulating tumor cell phenotype remains, however, largely unexplored. To investigate the bioactive effects of differential ECM glycosylation on lung cancer cells, we prepared collagen films functionalized with glucose (Glc-collagen) and galactose (Gal-collagen) exploiting a neoglycosylation approach based on a reductive amination of maltose and lactose with the amino residues of collagen lysines. We demonstrate that culturing of tumor cells on collagen determines a glycosylation-dependent pos. selection of CSC and triggers their expansion/generation. The functional relevance of CD133+ CSC increase was validated in vivo, proving an augmented tumorigenic and metastatic potential. High expression of integrin β1 in its active form is associated with an increased proficiency of tumor cells to sense signaling from glycosylated matrixes (glyco-collagen) and to acquire stemness features. Accordingly, inhibition of integrin β1 in tumor cells prevents CSC enrichment, suggesting that binding of integrin β1 to Glc-collagen subtends CSC expansion/generation. We provide evidence suggesting that collagen glycosylation could play an essential role in modulating the creation of a niche favorable for the generation and selection/survival of lung CSC. Interfering with this crosstalk may represent an innovative therapeutic strategy for lung cancer treatment.

Cancer Science published new progress about Activated leukocyte cell adhesion molecules Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Guilin; Zhao, Hang; Guo, Dezheng; Liu, Zhenguo; Wang, Hongfang; Sun, Qinghua; Liu, Qingxin; Xu, Baohua; Guo, Xingqi published the artcile< Distinct molecular impact patterns of abamectin on Apis mellifera ligustica and Apis cerana cerana>, Name: D-Glucosaccharic acid, the main research area is abamectin mortality metabolism Apis; Abamectin; Bees; Comparison analysis; Molecular effects; Mortality rate; Multiomics.

The effects of insecticides on bee health are a topic of intensive research. Although abamectin is toxic to bees, the mol. impact of abamectin needs to be clarified. Here, we found that Apis cerana cerana exhibited a higher mortality rate when exposed to abamectin than Apis mellifera ligustica. In addition, A. cerana cerana had markedly higher numbers of differentially expressed genes (DEGs), differentially expressed proteins (DEPs) and differentially expressed metabolites (DEMs) than A. mellifera ligustica during exposure to abamectin. These results indicate that abamectin exposure exerts stronger effects on A. cerana cerana than on A. mellifera ligustica. In addition, six DEGs, two DEPs and two DEMs overlapped between the two bee species under abamectin exposure; however, some genes or proteins from the zinc finger protein, superoxide dismutase and peroxiredoxin families and the energy metabolism pathway were only unregulated in A. cerana cerana, which indicates a significant difference in the impact of abamectin on the two bee species. Despite these differences, several of the same gene families, such as heat shock proteins, cytochrome P 450, odorant-binding proteins and cuticle proteins, and pathways, including the carbohydrate metabolism, immune system, lipid metabolism, amino acid metabolism, sensory system, locomotion and development pathways, were influenced by abamectin exposure in both A. cerana cerana and A. mellifera ligustica. Together, our results indicate that abamectin causes adverse effects on bees and thus poses a risk to bee populations and that abamectin exposure affects A. cerana cerana more strongly than A. mellifera ligustica. These findings improve our understanding of the behavioral and physiol. effects of abamectin on bees.

Ecotoxicology and Environmental Safety published new progress about Amino acid metabolism disorders. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Yanfen; Li, Hongjian; Gao, Lihui; Lin, Hua; Kung, Hsiangfu; Lin, Marie Chia-mi; Leung, Kwong-Sak; Wong, Man-Hon; Xiong, Wenyong; Li, Ling published the artcile< old drug, new indication: olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is olsalazine sodium xanthine oxidase dehydrogenase inhibitor hyperuricemia; Hyperuricemia; Olsalazine sodium; Uric acid; Xanthine oxidase.

Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. The inhibitory activities of the ten compounds with the highest scores were tested on XOD in vitro. Interestingly, all the ten compounds inhibited the activity of XOD at certain degrees. Particularly, the anti-ulcerative-colitis drug olsalazine sodium demonstrated a great inhibitory activity for XOD (IC50 = 3.4 mg/L). Enzymic kinetic studies revealed that the drug was a hybrid-type inhibitor of xanthine oxidase. Furthermore, the drug strikingly decreased serum urate levels, serum/hepatic activities of XOD at a dose-dependent manner in vivo. Thus, we demonstrated a successful hunting process of compounds/drugs for hyperuricemia through virtual screening, supporting a potential usage of olsalazine sodium in the treatment of hyperuricemia.

Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about Gout. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xiaoda; Gao, Yuan; Li, Chaoqun; Huang, Zhixian; Qiu, Ting published the artcile< Liquid-Liquid Equilibria for the Ternary Systems of Water + Thioglycolic Acid + 2-Ethyl-1-hexyl Thioglycolate and Water + 2-Ethyl-1-hexyl Thioglycolate + 2-Ethyl-1-hexanol at 293.15, 303.15, and 313.15 K under 101 kPa>, Formula: C8H18O, the main research area is liquid equilibrium ternary system; water thioglycolic acid ethylhexyl thioglycolate ethylhexanol.

Liquid-liquid equilibrium data were determined for the two ternary systems of water + thioglycolic acid (TGA) + 2-ethyl-1-hexyl thioglycolate (ETE) and water + 2-ethyl-1-hexyl thioglycolate (ETE) + 2-ethyl-1-hexanol (EHL) at 293.15, 303.15, and 313.15 K under 101 kPa. The nonrandom two-liquid (NRTL) and universal quasi-chem. (UNIQUAC) activity coefficient models were used to correlate the exptl. LLE data. The LLE data calculated by the NRTL and UNIQUAC models were in good agreement with the exptl. ones.

Journal of Chemical & Engineering Data published new progress about Liquid-liquid equilibrium. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Jing-xiu; Pan, Nan-lian; Chen, Jia-xi; Zhao, Jin-wu published the artcile< Visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols enabled by an organic photocatalyst>, Computed Properties of 5344-90-1, the main research area is photocatalysis photocyclization benzyl alc quinoline.

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcs. and secondary alcs. to produce quinolines at room temperature This photocatalytic method employed anthraquinone as an organic small-mol. catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Lichen; Uemura, Nao; Nakao, Yoshiaki published the artcile< meta-Selective C-H Borylation of Benzamides and Pyridines by an Iridium-Lewis Acid Bifunctional Catalyst>, Related Products of 660867-80-1, the main research area is meta selective borylation benzamide pyridine iridium aluminum bifunctional catalyst; borane pyridyl benzamide derivative preparation.

The authors report herein the Ir-catalyzed meta-selective C-H borylation of benzamides by using a newly designed 2,2′-bipyridine (bpy) ligand bearing an alkylaluminum biphenoxide moiety. The authors also demonstrate the Ir-catalyzed C3-selective C-H borylation of pyridine with a 1,10-phenanthroline (Phen) ligand bearing an alkylborane moiety. Probably the Lewis acid-base interaction between the Lewis acid moiety and the aminocarbonyl group or the sp2-hybridized N atom accelerates the reaction and controls the site-selectivity.

Journal of the American Chemical Society published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Related Products of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Munoz-Gonzalez, Carolina; Canon, Francis; Feron, Gilles; Guichard, Elisabeth; Pozo-Bayon, Maria Angeles published the artcile< Assessment wine aroma persistence by using an in vivo PTR-ToF-MS approach and its relationship with salivary parameters>, Formula: C10H18O, the main research area is wine aroma persistence salivary parameter; PTR-ToF-MS; commercial tannin extracts; in vivo aroma release; interindividual differences; saliva; wine aroma persistence.

To better understand wine aroma persistence, the nasal cavity of nine volunteers was monitored by Proton Transfer Reaction-Time of Flight-Mass Spectrometry (PTR-ToF-MS) after they rinsed their mouths with three rose wines (one control and the same wine supplemented with two tannin extracts) during four minutes. Wines were aromatized with a mixture of five target aroma compounds Results showed that wine aroma persistence was highly compound-dependent: while esters disappeared very fast, other compounds such as linalool remained in the oral cavity for longer times after wine expectoration. A low effect of tannins (at 50 mg/L) on nasal cavity parameters was observed, with the exception for the compound Et decanoate that was significantly higher released in the presence of tannins. Strong interindividual differences on aroma persistence were also found. Significant pos. correlations with the salivary total protein content and neg. with the salivary flow were observed for specific compounds This work has studied for the first time in vivo wine aroma persistence in real time from an anal. perspective.

Molecules published new progress about Decay (biological). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Yuan; Yuan, Qin; Lin, Shang; Liu, Wen; Du, Gang; Zhao, Li; Zhang, Qing; Lin, De-Rong; Liu, Yun-Tao; Qin, Wen; Li, De-Qiang; Wu, Ding-Tao published the artcile< Physicochemical characteristics and biological activities of polysaccharides from the leaves of different loquat (Eriobotrya japonica) cultivars>, Formula: C6H12O6, the main research area is Eriobotrya leaf physicochem polysaccharide; Binding properties; Enzyme inhibition; Eriobotrya japonica; Loquat; Polysaccharides; Weight-average molecular weights.

In order to explore polysaccharides from loquat leaves (LLPs) as functional food ingredients for prevention and treatment of obesity and type 2 diabetes, the physicochem. characteristics, in vitro binding properties, and inhibitory effects on α-amylase and α-glucosidase of polysaccharides from the leaves of different loquat cultivars, including ‘Baiyu’, ‘Chuannong8’, ‘Yuanbao’, and ‘Dawuxing’, were investigated and compared. Results showed that the contents of total uronic acids and degree of esterification in LLPs ranged from (27.04 ± 1.76)% to (41.46 ± 1.91)%, and from (20.54 ± 0.11)% to (26.90 ± 0.10)%, resp. The weight-average mol. weights of LLPs ranged from 4.307 × 106 Da to 5.101 × 106 Da, and the major constituent monosaccharides of LLPs were rhamnose, galacturonic acid, arabinose, and galactose. Furthermore, LLPs exerted strong in vitro fat binding, cholesterol binding, and bile acid binding capacities, as well as remarkable inhibitory effects on α-amylase and α-glucosidase, which might be attributed to their mol. weights, mol. weight distributions, and degree of esterification. Results are helpful for better understanding of chem. structures and bioactivities of polysaccharides from loquat leaves, and LLPs had good potential to be explored as functional food ingredients for prevention and treatment of obesity and type 2 diabetes.

International Journal of Biological Macromolecules published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Vivek Kumar; Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab published the artcile< RuII-Complexes of heteroditopic chelating NHC ligands: effective catalysts for the β-alkylation of secondary alcohols and the synthesis of 2-alkylaminoquinoline derivatives following the dehydrogenative protocol>, Application In Synthesis of 5344-90-1, the main research area is ruthenium NHC imidazolylidene triazolylidene cymene complex preparation coupling catalyst; coupling primary secondary alc preparation aralkyl alc ruthenium catalyst; quinoline amine preparation cyclization amino alc nitrile ruthenium catalyst.

RuII-Complexes of chelating heteroditopic N-heterocyclic carbene ligands I·BF4 (1a-c; R = 2,4,6-Me3, 4-OMe, 4-CF3) featuring imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) donors connected via a CH2 spacer, were found to be very effective catalysts for the cross-coupling of secondary alcs. ArCH(OH)Me and primary alcs. RCH2OH with the elimination of H2O, yielding aralkyl alcs. ArCH(OH)CH2CH2R (Ar = substituted Ph, 2-naphthyl, 2-thienyl; R = aryl, hetaryl, C5H11). Diverse β-alkylated secondary alcs. were thus obtained by following this method in excellent yields of up to 95% by employing a very low catalyst 1a loading of 0.01-0.001 mol% along with the inexpensive base KOH. Mechanistically, the present protocol follows the borrowing hydrogen strategy which was established by various control experiments including deuterium labeling experiments and importantly, 1H NMR and ESI-MS analyses validated the participation of a Ru-H species in the catalytic cycle. Remarkably, the present system displayed the highest Ru-based TON of 396 000 for the β-benzylation of 1-phenylethanol with a catalyst loading of 1 ppm (0.0001 mol%). Addnl., diverse 2-alkylaminoquinoline derivatives were synthesized in a one-pot manner from 2-aminobenzyl alc., 2-arylacetonitrile, and various primary alcs.

Organic & Biomolecular Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts