Month: October 2022

Herron, Josi M.; Hines, Kelly M.; Tomita, Hideaki; Seguin, Ryan P.; Cui, Julia Yue; Xu, Libin published the artcile< Multiomics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain>, Application In Synthesis of 434-16-2, the main research area is multiomic benzalkonium chloride disinfectant mouse sterol lipid brain neurotoxicity; benzalkonium chloride; in utero exposure; lipids; multi-omics; neurodevelopment; sterols.

Lipids are critical for neurodevelopment; therefore, disruption of lipid homeostasis by environmental chems. is expected to have detrimental effects on this process. Previously, we demonstrated that the benzalkonium chlorides (BACs), a class of commonly used disinfectants, alter cholesterol biosynthesis and lipid homeostasis in neuronal cell cultures in a manner dependent on their alkyl chain length. However, the ability of BACs to reach the neonatal brain and alter sterol and lipid homeostasis during neurodevelopment in vivo has not been characterized. Therefore, the goal of this study was to use targeted and untargeted mass spectrometry and transcriptomics to investigate the effect of BACs on sterol and lipid homeostasis and to predict the mechanism of toxicity of BACs on neurodevelopmental processes. After maternal dietary exposure to 120 mg BAC/kg body weight/day, we quantified BAC levels in the mouse neonatal brain, demonstrating for the first time that BACs can cross the blood-placental barrier and enter the developing brain. Transcriptomic anal. of neonatal brains using RNA sequencing revealed alterations in canonical pathways related to cholesterol biosynthesis, liver X receptor-retinoid X receptor (LXR/RXR) signaling, and glutamate receptor signaling. Mass spectrometry anal. revealed decreases in total sterol levels and downregulation of triglycerides and diglycerides, which were consistent with the upregulation of genes involved in sterol biosynthesis and uptake as well as inhibition of LXR signaling. In conclusion, these findings demonstrate that BACs target sterol and lipid homeostasis and provide new insights for the possible mechanisms of action of BACs as developmental neurotoxicants.

Toxicological Sciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (AACS). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application In Synthesis of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Groot, Anton published the artcile< Linalool Hydroperoxides>, Synthetic Route of 78-70-6, the main research area is review linalool hydroperoxide.

A review. Linalool is a fragrance widely used in cosmetics and household products. Until recently, contact allergy to linalool was considered rare because pos. patch tests to it were infrequently observed In recent years, however, it has been demonstrated that exposure of linalool to oxygen (air) results in formation of a number of oxidation products, of which the hydroperoxides have a far stronger sensitizing potency than the pure compound By routine testing of patients suspected of having contact dermatitis with hydroperoxides of linalool, high frequencies of pos. reactions were found, indicating these chems. are important fragrance allergens. It should be realized, however, that a number of “”pos.”” reactions may well be false-pos., irritant responses.

Dermatitis published new progress about Odor and Odorous substances. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Synthetic Route of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Huiping; Fan, Yaling; Krishna, Rajamani; Feng, Xuefeng; Wang, Li; Luo, Feng published the artcile< Robust metal-organic framework with multiple traps for trace Xe/Kr separation>, Synthetic Route of 6054-98-4, the main research area is metal organic framework adsorption direct separation simulation.

Direct separation of Xe and Kr from air or UNF off-gas by means of porous adsorbents is of industrial importance but is a very challenging task. In this work, we show a robust metal-organic framework (MOF), namely ECUT-60, which renders not only high chem. stability, but also unique structure with multiple traps. This leads to the ultrahigh Xe adsorption capacity, exceeding most reported porous materials. Impressively, this MOF also enables high selectivity of Xe over Kr, CO2, O2, and N2, leading to the high-performance separation for trace quantitites of Xe/Kr from a simulated UNF reprocessing off-gas. The separation capability has been demonstrated by using dynamic breakthrough experiments, giving the record Xe uptake up to 70.4 mmol/kg and the production of 19.7 mmol/kg pure Xe. Consequently, ECUT-60 has promising potential in direct production of Xe from UNF off-gas or air. The separation mechanism, as unveiled by theor. calculation, is attributed to the multiple traps in ECUT-60 that affords rigid restrict for Xe atom via van der Waals force.

Science Bulletin published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiao, Meng-Jie; Hu, Qiang; Hu, Xiu-Qin; Xu, Peng-Fei published the artcile< Visible-Light-Promoted Multistep Tandem Reaction of Vinyl Azides toward the Formation of 1-Tetralones>, Application of C9H8O, the main research area is tetralone preparation green chem; vinyl azide alkyl bromide tandem cyclization reaction photocatalyst.

A visible-light-driven multistep tandem reaction between vinyl azides 2-R-3-R1-4-R2-C6H2C(=CH2)N3 (R = H, Cl, Me; R1 = H, Me; R2 = H, Br, CN, Ph, etc.) and alkyl bromides R3CH(R4)C((C(O)OCH2CH3)2)Br (R3 = H, prop-1-yn-1-yl, Ph, naphthalen-1-yl, etc.; R4 = H, Me; R3R4 = -(CH2)4-) has been developed leading to the formation of tetralone skeletons I (R5 = H, Me) under mild conditions, which can be easily scaled up to the gram scale. Various 1-tetralone derivatives I are synthesized and transformed into desired products in good to high yields.

Journal of Organic Chemistry published new progress about Azides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (vinyl). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Application of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Zewei; Lv, Kang; Yuan, Taoyue; Zhang, Xuguang; Yao, Weiwei; Ma, Mengtao published the artcile< Electrochemical hydroboration of carbonyl compounds>, Computed Properties of 403-41-8, the main research area is aryl alkyl alc preparation; boronic ester preparation regioselective green chem hydrolysis; carbonyl compound tetramethyl dioxaborolane electrochem hydroboration.

A green and sustainable electrochem. hydroboration of carbonyl compounds RC(O)R1 (R = Bu, Ph, cyclohexyl, pyridin-4-yl, etc.; R1 = H, Me, Ph, i-Pr, 2-fluorophenyl) with HBpin has been reported for the first time. Under catalyst-free and additive-free mild reaction conditions the corresponding boronic esters RR1CHOBpin were obtained in excellent yields via the simple electrochem. hydroboration of various aldehydes and ketones with HBpin at room temperature The scale-up reaction demonstrated potential practical applications. A plausible reaction mechanism was proposed based on the corresponding deuterium-labeling, radical inhibition and cyclic voltammetry experiments

Dalton Transactions published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yun, Xue-Jing; Zhu, Jing-Wei; Jin, Yan; Deng, Wei; Yao, Zi-Jian published the artcile< Half-Sandwich Ruthenium Complexes for One-Pot Synthesis of Quinolines and Tetrahydroquinolines: Diverse Catalytic Activity in the Coupled Cyclization and Hydrogenation Process>, Application In Synthesis of 5344-90-1, the main research area is ruthenium half sandwich cyclometalated complex preparation hydrogenation catalyst; amine ketone hydrogenation catalyst ruthenium half sandwich cyclometalated complex.

Four types of half-sandwich ruthenium complexes with an N,O-coordinate mode based on hydroxyindanone-imine ligands have been prepared in good yields. These stable ruthenium complexes exhibited high activity in the catalytic synthesis of quinolines from the reactions of amino alcs. with different types of ketones or secondary alcs. under very mild conditions. Moreover, the methodol. for the direct one-pot synthesis of tetrahydroquinoline derivatives from amino alcs. and ketones has been also developed on the basis of the continuous catalytic activity of this ruthenium catalyst in the selective hydrogenation of the obtained quinoline derivatives with a low catalyst loading. The corresponding products, quinolines and tetrahydroquinoline derivatives, were afforded in good to excellent yields. The efficient and diverse catalytic activity of these ruthenium complexes suggested their potential large-scale application. All of the ruthenium complexes were characterized by various spectroscopies to confirm their structures. Half-sandwich ruthenium complexes based on hydroxyindanone-imine ligands exhibited high activity in the catalytic synthesis of quinoline derivatives starting from amino alcs. and ketones as well as secondary alcs. under very mild conditions. One-pot synthesis of tetrahydroquinoline has been also developed on the basis of the continuous catalytic activity of these ruthenium catalysts in selective hydrogenation.

Inorganic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sarkar, Parijat; Kumar, G. Aditya; Shrivastava, Sandeep; Chattopadhyay, Amitabha published the artcile< Chronic cholesterol depletion increases F-actin levels and induces cytoskeletal reorganization via a dual mechanism>, Formula: C27H44O, the main research area is chronic cholesterol depletion Factin cytoskeletal reorganization dual mechanism; F-actin; MβCD; Rho GTPase; actin polymerization; cholesterol; confocal microscopy; methyl-β-cyclodextrin; phosphatidylinositol; plasma membrane; statins.

Previous work from us and others has suggested that cholesterol is an important lipid in the context of the organization of the actin cytoskeleton. However, reorganization of the actin cytoskeleton upon modulation of membrane cholesterol is rarely addressed in the literature. In this work, we explored the signaling crosstalk between cholesterol and the actin cytoskeleton by using a high-resolution confocal microscopic approach to quant. measure changes in F-actin content upon cholesterol depletion. Our results show that F-actin content significantly increases upon chronic cholesterol depletion, but not during acute cholesterol depletion. In addition, utilizing inhibitors targeting the cholesterol biosynthetic pathway at different steps, we show that reorganization of the actin cytoskeleton could occur due to the synergistic effect of multiple pathways, including prenylated Rho GTPases and availability of membrane phosphatidylinositol 4,5-bisphosphate. These results constitute one of the first comprehensive dissections of the mechanistic basis underlying the interplay between cellular actin levels and cholesterol biosynthesis. We envision these results will be relevant for future understating of the remodeling of the actin cytoskeleton in pathol. conditions with altered cholesterol.

Journal of Lipid Research published new progress about Apoptosis. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Formula: C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yavuz, Ulas; Alaylioglu, Merve; Sengul, Busra; Karras, Spyridon N.; Gezen-Ak, Duygu; Dursun, Erdinc published the artcile< Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is cortical neuron protein disulfide isomerase vitamin D treatment; 24-dehydrocholesterol reductase; Neurodegeneration; Primary neuronal culture; Protein disulfide isomerase A3; Vitamin D.

Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3). From a physiol. perspective, there is also a well-established association of cholesterol and vitamin D synthesis, since both share a common metabolic substrate, 7 dehydrocholesterol (7-DHC). Yet, the potential basic pathways, of the biol. interplay of DHCR24 and vitamin D equilibrium, on neuronal level, are yet to be determined In this study, we aimed to investigate the relation between vitamin D pathways and DHCR24 in primary cortical neuron cultures. The neocortex of Sprague-Dawley rat embryos (E16) was used for the preparation of primary cortical neuron cultures. DHCR24 mRNA and protein expression levels were determined by qRT-PCR, Western blotting, and immunofluorescent labeling in 1,25-dihydroxyvitamin D3-treated or VDR/PDIA3-silenced primary cortical neurons. The mRNA expression of DHCR24 was significantly decreased in the cortical neurons treated with 10-8M 1,25-dihydroxyvitamin D3 (p<0.001). In parallel with the mRNA results, DHCR24 protein expression in cortical neurons treated with 10-8M 1,25-dihydroxyvitamin D3 was also significantly lower than untreated neurons (p<0.05). These data were also confirmed with immunofluorescent labeling and fluorescence intensity measurements of DHCR24 (p<0.001). Finally, DHCR24 mRNA expression level was significantly increased in PDIA3 siRNA-treated neurons (p<0.05). Similar to the mRNA results, the DHCR24 protein expression of PDIA3 siRNA-treated neurons was also statistically higher than the other groups (p<0.05). Results of this mechanistic exptl. basic study demonstrate that DHCR24 mRNA expression and protein concentrations attenuated in response to vitamin D treatment. Furthermore, we observed that PDIA3 might be involved in this modulatory effect. Our findings indicate a complex interaction of DHCR24 and vitamin D equilibrium, through the involvement of PDIA3 and vitamin D in the modulation of cholesterol metabolism in neuronal cells, requiring future studies on the field. In Vitro Cellular & Developmental Biology: Animal published new progress about Cerebral neocortex. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Haifan; Saltzberg, Daniel J.; Kratochvil, Huong T.; Jo, Hyunil; Sali, Andrej; DeGrado, William F. published the artcile< Glutamine Side Chain 13C=18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly>, Synthetic Route of 76-84-6, the main research area is glutamine carbon oxygen isotope amyloid fibril IR spectroscopy.

IR spectroscopy has provided considerable insight into the structures, dynamics, and formation mechanisms of amyloid fibrils. IR probes, such as main chain 13C=18O, have been widely employed to obtain site-specific structural information, yet only secondary structures and strand-to-strand arrangements can be probed. Very few nonperturbative IR probes are available to report on the side-chain conformation and environments, which are critical to determining sheet-to-sheet arrangements in steric zippers within amyloids. Polar residues, such as glutamine, contribute significantly to the stability of amyloids and thus are frequently found in core regions of amyloid peptides/proteins. Furthermore, polyglutamine (polyQ) repeats form toxic aggregates in several neurodegenerative diseases. Here the authors report the synthesis and application of a new nonperturbative IR probe-glutamine side chain 13C=18O. The authors use side chain 13C=18O labeling and isotope dilution to detect the presence of intermolecularly hydrogen-bonded arrays of glutamine side chains (Gln ladders) in amyloid-forming peptides. Moreover, the line width of the 13C=18O peak is highly sensitive to its local hydration environment. The IR data from side chain labeling allows us to unambiguously determine the sheet-to-sheet arrangement in a short amyloid-forming peptide, GNNQQNY, providing insight that was otherwise inaccessible through main chain labeling. With several different fibril samples, the authors also show the versatility of this IR probe in studying the structures and aggregation kinetics of amyloids. Finally, the authors demonstrate the capability of modeling amyloid structures with IR data using the integrative modeling platform (IMP) and the potential of integrating IR with other biophys. methods for more accurate structural modeling. Together, the authors believe that side chain 13C=18O will complement main chain isotope labeling in future IR studies of amyloids and integrative modeling using IR data will significantly expand the power of IR spectroscopy to elucidate amyloid assemblies.

Journal of the American Chemical Society published new progress about Amyloid fibril. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Wei; Zhou, Yiming; He, Yanlin; Huang, You published the artcile< DABCO catalyzed [4+2] annulations of Morita-Baylis-Hillman carbonates with isocyanates>, COA of Formula: C7H9NO, the main research area is alkoxy oxopropenyl dihydroquinazoline carboxylate preparation; MBH carbonate preparation isocyanate DABCO catalyst chemoselective cycloaddition.

A highly concise method for 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyzed [4+2] annulations of o-amino-acylation of aryl Morita-Baylis-Hillman (MBH) carbonates with isocyanates was developed. For the first time, MBH carbonates served as 1,4-dipoles, providing functionalized 3,4-dihydroquinazolinones in mild conditions with good to excellent yields. The d. functional theory calculations of the mechanism supports this hypothesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about [4+2] Cycloaddition reaction (chemoselective). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts